Molecular Structure and Signalling
Theme Lead: Dr Annette Shrive
Our research involves using a range of biochemical approaches to address underlying mechanisms and processes in a range of biological and health related areas including innate immunity, rheumatoid arthritis, cancer, virology and parasitology. This includes a wide range of complementary techniques and expertise in molecular biology and cellular signalling, glycobiology, and structural biology and is underpinned by a wide range of national and international collaborations and access to world-leading Central Facilities including Diamond Light Source and Harwell Campus, Institute Laue Langevin, Liverpool Technology Directorate and Midlands Innovation.
Key areas of research and techniques include the following:
- Cellular and molecular pathways in cell fate decision
- Development of custom next generation sequencing and bioinformatic workflows
- RNA sequencing, de novo assembly and discovery of novel functional ncRNAs
- Conjugative DNA transfer in gram-positive pathogens
- Microbiome characterization
- Biomarker discovery and characterisation
- Structural biology, including x-ray crystallography and cryo-electron microscopy
- Effector mechanisms in innate immunity
- Characterisation of pathogen-host interactions
- Structure, function and recognition properties of secreted pattern recognition receptors
- Glycosaminoglycan research
- Role of heparin in health and disease
- Characterisation of cellular mechanotransduction pathways
- Mechanical manipulation of cells and tissues
Academic staff
Dr Hamish Gilbert
Lecturer in Molecular Cell Biology
- Office - Huxley Building : 302b; Laboratory - Guy Hilton Research Centre
- h.gilbert@keele.ac.uk
Professor Trevor Greenhough
Professor of Structural Biology
- Huxley Building : 203A
- +44 (0)1782 733405
- t.j.greenhough@keele.ac.uk
Dr Mirna Maarabouni
Senior Lecturer in Bioscience
- Huxley Building: 164
- +44 (0)1782 733679
- m.m.maarabouni@keele.ac.uk
Trish Procter
Lecturer in Biomedical Science
- Huxley Building : 304
- +44 (0)1782 733771
- p.procter@keele.ac.uk
Dr Annette Shrive
Senior Lecturer
- Huxley Building : 212A
- +44 (0)1782 733419
- a.k.shrive@keele.ac.uk
Dr Mark Skidmore
Senior Lecturer in Biochemistry
- Huxley Building : 174
- +44 (0)1782 733945
- m.a.skidmore@keele.ac.uk
Dr Charlie Softley
Lecturer in Pharmacology
- Huxley building: 027
- +44 1782732050
- c.a.softley@keele.ac.uk
Dr Dan Tonge
Senior Lecturer in Biosciences, Director of Postgraduate Research
- Huxley Building : 302B
- +44 (0)1782 733418
- d.p.tonge@keele.ac.uk
Dr David Watson
Senior Lecturer in Biochemistry
- Huxley Building : 169
- +44 (0)1782 733676
- d.watson@keele.ac.uk
Dr Anja Winter
Lecturer in Biophysics/Biochemistry
- Huxley Building : 202
- +44 (0)1782 733117
- a.winter@keele.ac.uk
