Trevor Greenhough

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Biography

Having graduated from Nottingham with a BSc in Physics in 1971, I took a year out (working as a milkman, foundry worker, teacher of English and busker) before embarking on an MSc in Chemical Physics at Surrey.

My PhD in Crystallography was completed at Surrey in early 1975 and before taking an appointment as Lecturer in Physics at Keele University in April 1986 (transferred to Life Sciences in 1999), I worked as a Research Fellow in Chemistry at Warwick and UBC Vancouver, in Physics at Keele, in Cancer Research in Birmingham Alabama, and as a support scientist at the Daresbury synchrotron radiation source (SRS).

The research at Keele included the design, construction and commissioning of the world's first dedicated Synchrotron radiation protein crystallography station at the SRS, and more recently, as part of a small UK team, development of the Laue crystallographic method for proteins and viruses. Involvement with the development of the SRS, including extended periods of part-secondment, continued until its closure in 2008. I now lead the Midlands UK Structural Biology consortium at the new UK SR source at Diamond.

Research and scholarship

My current research interests are in the structure and function of biological macromolecules with a particular emphasis on molecular structure, recognition and effector mechanisms in the innate immune system. This ancient arm of the immune system is somewhat less fashionable than the much more recently evolved adaptive, immunoglobulin-based response.

Nevertheless, its importance as a defence mechanism preserved throughout evolution is beginning to receive the attention it deserves as its roles in the recognition and clearance of foreign, and self, pathogens and its links with the antibody response become clearer. Two of the major families of innate immune proteins are the pentraxins, including C-reactive protein, and the collectins, including lung surfactant protein D. Current research is focused on various members of these two protein families from creatures as diverse as man and the horseshoe crab Limulus polyphemus. I am part of the Structural Biology Research Group.

Teaching

Year 1

LSC-10034 Nature’s Tools: Proteins and Enzymes

Year 2

LSC-20015 Molecular, Cellular & Structural Immunology

Year 3

LSC-30016 Structural Biology & Macromolecular Function (Module manager)
LSC-30007 Biology dissertation
LSC-30008/35 Biochemistry Experimental Research project
LSC-30014 Biochemistry Research project (Non-experimental)
LSC-30015 Biology of Disease
LSC-30023 Neuroscience Dissertation

Selected Publications

Williams RD, Moran JA, Fryer AA, Littlejohn JR, Williams HM, Greenhough TJ, Shrive AK. 2020. Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein. Front Immunol, 115, vol. 11. link> doi> full text>
Paterson JM, Shaw AJ, Burns I, Dodds AW, Prasad A, Reid KB, Greenhough TJ, Shrive AK. 2019. Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine. J Biol Chem, 17155-17165, vol. 294(45). link> doi> full text>
Littlejohn JR, da Silva RF, Neale WA, Smallcombe CC, Clark HW, Mackay R-MA, Watson AS, Madsen J, Hood DW, Burns I, Greenhough TJ, Shrive AK. 2018. Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS. PLoS One, e0199175, vol. 13(6). link> doi> full text>
Clark HW, Mackay R-M, Deadman ME, Hood DW, Madsen J, Moxon ER, Townsend JP, Reid KBM, Ahmed A, Shaw AJ, Greenhough TJ, Shrive AK. 2016. Crystal Structure of a Complex of Surfactant Protein D (SP-D) and Haemophilus influenzae Lipopolysaccharide Reveals Shielding of Core Structures in SP-D-Resistant Strains. Infect Immun, 1585-1592, vol. 84(5). link> doi> full text>
Shrive AK, Moeller JB, Burns I, Paterson JM, Shaw AJ, Schlosser A, Sorensen GL, Greenhough TJ, Holmskov U. 2014. Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen C domain containing 1 (FIBCD1) protein. J Biol Chem, 2880-2887, vol. 289(5). link> doi>

Full Publications Listshow

Journal Articles

Williams RD, Moran JA, Fryer AA, Littlejohn JR, Williams HM, Greenhough TJ, Shrive AK. 2020. Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein. Front Immunol, 115, vol. 11. link> doi> full text>
Paterson JM, Shaw AJ, Burns I, Dodds AW, Prasad A, Reid KB, Greenhough TJ, Shrive AK. 2019. Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine. J Biol Chem, 17155-17165, vol. 294(45). link> doi> full text>
Littlejohn JR, da Silva RF, Neale WA, Smallcombe CC, Clark HW, Mackay R-MA, Watson AS, Madsen J, Hood DW, Burns I, Greenhough TJ, Shrive AK. 2018. Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS. PLoS One, e0199175, vol. 13(6). link> doi> full text>
Clark HW, Mackay R-M, Deadman ME, Hood DW, Madsen J, Moxon ER, Townsend JP, Reid KBM, Ahmed A, Shaw AJ, Greenhough TJ, Shrive AK. 2016. Crystal Structure of a Complex of Surfactant Protein D (SP-D) and Haemophilus influenzae Lipopolysaccharide Reveals Shielding of Core Structures in SP-D-Resistant Strains. Infect Immun, 1585-1592, vol. 84(5). link> doi> full text>
Shrive AK, Moeller JB, Burns I, Paterson JM, Shaw AJ, Schlosser A, Sorensen GL, Greenhough TJ, Holmskov U. 2014. Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen C domain containing 1 (FIBCD1) protein. J Biol Chem, 2880-2887, vol. 289(5). link> doi>
Garnett DJ and Greenhough TJ. 2012. Statins Cause Profound Effects on Gene Expression in Human Cancer Cells In Vitro: The Role of Membrane Microdomains. GENE EXPRESSION, 225-234, vol. 15(5-6). link> doi>
Shrive AK, Martin C, Burns I, Paterson JM, Martin JD, Townsend JP, Waters P, Clark HW, Kishore U, Reid KBM, Greenhough TJ. 2009. Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325. J Mol Biol, 776-788, vol. 394(4). link> doi>
Shrive AK, Burns I, Chou H-T, Stahlberg H, Armstrong PB, Greenhough TJ. 2009. Crystal structures of Limulus SAP-like pentraxin reveal two molecular aggregations. J Mol Biol, 1240-1254, vol. 386(5). link> doi>
MacCarthy EM, Burns I, Irnazarow I, Polwart A, Greenhough TJ, Shrive AK, Hoole D. 2008. Serum CRP-like protein profile in common carp Cyprinus carpio challenged with Aeromonas hydrophila and Escherichia coli lipopolysaccharide. Dev Comp Immunol, 1281-1289, vol. 32(11). link> doi>
Kishore U, Greenhough TJ, Waters P, Shrive AK, Ghai R, Kamran MF, Bernal AL, Reid KBM, Madan T, Chakraborty T. 2006. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol, 1293-1315, vol. 43(9). link> doi>
Kishore U, Ghai R, Greenhough TJ, Shrive AK, Bonifati DM, Gadjeva MG, Waters P, Kojouharova MS, Chakraborty T, Agrawal A. 2005. Structural and functional anatomy of the globular domain of complement protein C1q (vol 95, pg 113, 2004). IMMUNOLOGY LETTERS, II, vol. 101(1). link> doi>
GREENHOUGH TJ, Gaboriaud C, Kishore U, Waters P. 2004. C1q and tumor necrosis factor superfamily: modularity and versatility. Trends in Immunology, 551-561, vol. 25(10). doi>
Kishore U, Ghai R, Greenhough TJ, Shrive AK, Bonifati DM, Gadjeva MG, Waters P, Kojouharova MS, Chakraborty T, Agrawal A. 2004. Structural and functional anatomy of the globular domain of complement protein Clq. Immunology Letters, 113-128, vol. 95(2). doi>
Cartwright JR, Tharia HA, Burns I, Shrive AK, Hoole D, Greenhough TJ. 2004. Isolation and characterisation of pentraxin-like serum proteins from the common carp Cyprinus carpio. Dev Comp Immunol, 113-125, vol. 28(2). link> doi>
Shrive AK, Tharia HA, Strong P, Kishore U, Burns I, Rizkallah PJ, Reid KBM, Greenhough TJ. 2003. High-resolution structural insights into ligand binding and immune cell recognition by human lung surfactant protein D. J Mol Biol, 509-523, vol. 331(2). link> doi>
Hoole D, Lewis JW, Schuwerack PMM, Chakravarthy C, Shrive AK, Greenhough TJ, Cartwright JR. 2003. Inflammatory interactions in fish exposed to pollutants and parasites: a role for apoptosis and C reactive protein. Parasitology, S71-S85, vol. 126 Suppl. link> doi>
Ramadan MAM, Shrive AK, Holden D, Myles DAA, Volanakis JE, DeLucas LJ, Greenhough TJ. 2002. The three-dimensional structure of calcium-depleted human C-reactive protein from perfectly twinned crystals. Acta Crystallographica, Section D. doi>
Tharia HA, Shrive AK, Mills JD, Arme C, Williams GT, Greenhough TJ. 2002. Complete cDNA sequence of SAP-like pentraxin from Limulus polyphemus: implications for pentraxin evolution. J Mol Biol, 583-597, vol. 316(3). link> doi>
Agrawal A, Shrive AK, Greenhough TJ, Volanakis JE. 2001. Topology and structure of the C1q-binding site on C-reactive protein. J Immunol, 3998-4004, vol. 166(6). link> doi>
Shrive AK, Metcalfe AM, Cartwright JR, Greenhough TJ. 1999. C-reactive protein and SAP-like pentraxin are both present in Limulus polyphemus haemolymph: crystal structure of Limulus SAP. J Mol Biol, 997-1008, vol. 290(5). link> doi>
Szalai AJ, Agrawal A, Greenhough TJ, Volanakis JE. 1997. C-reactive protein: structural biology, gene expression, and host defense function. Immunol Res, 127-136, vol. 16(2). link> doi>
Agrawal A, Lee S, Carson M, Narayana SV, Greenhough TJ, Volanakis JE. 1997. Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67. J Immunol, 345-350, vol. 158(1). link>
Shrive AK, Holden D, Myles DA, Greenhough TJ. 1996. Structure solution of C-reactive proteins: molecular replacement with a twist. Acta Crystallogr D Biol Crystallogr, 1049-1057, vol. 52(Pt 6). link> doi>
Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ. 1996. Three dimensional structure of human C-reactive protein. Nat Struct Biol, 346-354, vol. 3(4). link> doi>
SHRIVE AK and GREENHOUGH TJ. 1994. LAUE IMAGE-ANALYSIS .3. THE COLLECTION AND ANALYSIS OF DELIBERATELY STREAKED LAUE EXPOSURES. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 532-542, vol. 27. link> doi>
GREENHOUGH TJ and SHRIVE AK. 1994. LAUE IMAGE-ANALYSIS .2. VARIABLE RADIAL ELLIPTIC MASKING AND ITS APPLICATION IN STUDIES INVOLVING INHERENTLY STREAKED LAUE EXPOSURES. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 111-121, vol. 27. link> doi>
Hopkins M, Flanagan PA, Bailey S, Glover ID, Myles DA, Greenhough TJ. 1994. Crystallization and preliminary X-ray analysis of C-reactive protein from rat. J Mol Biol, 767-771, vol. 235(2). link> doi>
Vellieux FM, Hajdu J, Verlinde CL, Groendijk H, Read RJ, Greenhough TJ, Campbell JW, Kalk KH, Littlechild JA, Watson HC. 1993. Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data. Proc Natl Acad Sci U S A, 2355-2359, vol. 90(6). link> doi>
Myles DA, Rule SA, DeLucas LJ, Babu YS, Xu Y, Volanakis JE, Bugg CE, Bailey S, Greenhough TJ. 1990. Rotation function studies of human C-reactive protein. J Mol Biol, 491-496, vol. 216(3). link> doi>
Campbell JW, Clifton IJ, Greenhough TJ, Hajdu J, Harrison SC, Liddington RC, Shrive AK. 1990. Calcium binding sites in tomato bushy stunt virus visualized by Laue crystallography. J Mol Biol, 627-632, vol. 214(3). link> doi>
SHRIVE AK, CLIFTON IJ, HAJDU J, GREENHOUGH TJ. 1990. LAUE FILM INTEGRATION AND DECONVOLUTION OF SPATIALLY OVERLAPPING REFLECTIONS. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 169-174, vol. 23. link> doi>
Myles DA, Bailey S, Rule SA, Jones GR, Greenhough TJ. 1990. Preliminary crystallographic study of C-reactive protein from Limulus polyphemus. J Mol Biol, 223-225, vol. 213(2). link> doi>
Ealick SE, Rule SA, Carter DC, Greenhough TJ, Babu YS, Cook WJ, Habash J, Helliwell JR, Stoeckler JD, Parks RE. 1990. Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution. J Biol Chem, 1812-1820, vol. 265(3). link> doi>
HELLIWELL JR, HABASH J, CRUICKSHANK DWJ, HARDING MM, GREENHOUGH TJ, CAMPBELL JW, CLIFTON IJ, ELDER M, MACHIN PA, PAPIZ MZ, ZUREK S. 1989. THE RECORDING AND ANALYSIS OF SYNCHROTRON X-RADIATION LAUE DIFFRACTION PHOTOGRAPHS. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 483-497, vol. 22. link> doi>
Hajdu J, Machin PA, Campbell JW, Greenhough TJ, Clifton IJ, Zurek S, Gover S, Johnson LN, Elder M. 1987. Millisecond X-ray diffraction and the first electron density map from Laue photographs of a protein crystal. Nature, 178-181, vol. 329(6135). link> doi>
DeLucas LJ, Greenhough TJ, Rule SA, Myles DA, Babu YS, Volanakis JE, Bugg CE. 1987. Preliminary X-ray study of crystals of human C-reactive protein. J Mol Biol, 741-742, vol. 196(3). link> doi>
GREENHOUGH TJ and SUDDATH FL. 1986. OSCILLATION CAMERA DATA-PROCESSING .4. RESULTS AND RECOMMENDATIONS FOR THE PROCESSING OF SYNCHROTRON RADIATION DATA IN MACROMOLECULAR CRYSTALLOGRAPHY. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 400-409, vol. 19. link> doi>
Babu YS, Sack JS, Greenhough TJ, Bugg CE, Means AR, Cook WJ. 1985. Three-dimensional structure of calmodulin. Nature, 37-40, vol. 315(6014). link> doi>
EALICK SE, GREENHOUGH TJ, BABU YS, CARTER DC, COOK WJ, BUGG CE, RULE SA, HABASH J, HELLIWELL JR, STOECKLER JD, CHEN SF, PARKS RE. 1985. 3-DIMENSIONAL STRUCTURE OF HUMAN ERYTHROCYTIC PURINE NUCLEOSIDE PHOSPHORYLASE. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 311-312, vol. 451(OCT). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1985. CARBABORANE DERIVATIVES OF THE LATE-TRANSITION AND POST-TRANSITION ELEMENTS .3. STRUCTURAL CONSEQUENCES OF LIGAND SUBSTITUTION IN PALLADADICARBADODECABORANES 3-L2-3,1,2-PDC2B9H11 - THE CRYSTAL AND MOLECULAR-STRUCTURES OF 3-[ME2N(CH2)2NME2]-3,1,2-PDC2B9H11 AND 3-(PME3)2-3,1,2-PDC2B9H11. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 761-769. link> doi>
PAINE JB, DOLPHIN D, TROTTER J, GREENHOUGH TJ. 1985. CORRELATIONS BETWEEN C-13 NUCLEAR MAGNETIC-RESONANCE AND X-RAY CRYSTALLOGRAPHY FOR PYRROLES CONTAINING ELECTRON-WITHDRAWING GROUPS. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 2683-2690, vol. 63(10). link> doi>
GREENHOUGH TJ, SCHEFFER JR, SECCO AS, TROTTER J, WALSH L. 1985. THE EFFECT OF TEMPERATURE ON COMPETING PHOTOCHEMICAL HYDROGEN ABSTRACTION REACTIONS IN THE SOLID-STATE. ISRAEL JOURNAL OF CHEMISTRY, 297-299, vol. 25(3-4). link> doi>
EALICK SE, GREENHOUGH TJ, BABU YS, COOK WJ, BUGG CE, RULE S, HABASH G, HELLIWELL J. 1984. THE CRYSTAL-STRUCTURE OF HUMAN ERYTHROCYTIC PURINE NUCLEOSIDE PHOSPHORYLASE AT 6A RESOLUTION. ACTA CRYSTALLOGRAPHICA SECTION A, C30, vol. 40. link> doi>
SCHEFFER JR, TROTTER J, APPEL WK, GREENHOUGH TJ, JIANG ZQ, SECCO AS, WALSH L. 1983. CRYSTAL-LATTICE CONTROL OF UNIMOLECULAR PHOTO-REARRANGEMENTS - MEDIUM-DEPENDENT PHOTOCHEMISTRY OF CYCLOHEXENONES. MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 1-15, vol. 93(1-4). link> doi>
SCHEFFER JR, TROTTER J, APPEL WK, GREENHOUGH TJ, JIANG ZQ, SECCO AS, WALSH L. 1983. CRYSTAL-LATTICE CONTROL OF UNIMOLECULAR PHOTO-REARRANGEMENTS - MEDIUM-DEPENDENT PHOTOCHEMISTRY OF CYCLOHEXENONES. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 56-ORGN, vol. 185(MAR). link>
GREENHOUGH TJ, HELLIWELL JR, RULE SA. 1983. OSCILLATION CAMERA DATA-PROCESSING .3. GENERAL DIFFRACTION SPOT SIZE, SHAPE AND ENERGY PROFILE - FORMALISM FOR POLYCHROMATIC DIFFRACTION EXPERIMENTS WITH MONOCHROMATIZED SYNCHROTRON X-RADIATION FROM A SINGLY BENT TRIANGULAR MONOCHROMATOR. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 242-250, vol. 16(APR). link> doi>
Greenhough TJ and Helliwell JR. 1983. The uses of synchrotron X-radiation in the crystallography of molecular biology. Prog Biophys Mol Biol, 67-123, vol. 41(2). link> doi>
HELLIWELL JR, GREENHOUGH TJ, CARR PD, RULE SA, MOORE PR, THOMPSON AW, WORGAN JS. 1982. CENTRAL DATA-COLLECTION FACILITY FOR PROTEIN CRYSTALLOGRAPHY, SMALL-ANGLE DIFFRACTION AND SCATTERING AT THE DARESBURY-LABORATORY SYNCHROTRON RADIATION SOURCE (SRS), ENGLAND. JOURNAL OF PHYSICS E-SCIENTIFIC INSTRUMENTS, 1363-1372, vol. 15(12). link> doi>
ARNDT UW, GREENHOUGH TJ, HELLIWELL JR, HOWARD JAK, RULE SA, THOMPSON AW. 1982. OPTIMIZED ANOMALOUS DISPERSION IN CRYSTALLOGRAPHY - A SYNCHROTRON X-RAY POLYCHROMATIC SIMULTANEOUS PROFILE METHOD. NATURE, 835-838, vol. 298(5877). link> doi>
GREENHOUGH TJ and HELLIWELL JR. 1982. OSCILLATION CAMERA DATA-PROCESSING - REFLECTING RANGE AND PREDICTION OF PARTIALITY .1. CONVENTIONAL X-RAY SOURCES. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 338-351, vol. 15(JUN). link> doi>
GREENHOUGH TJ and HELLIWELL JR. 1982. OSCILLATION CAMERA DATA-PROCESSING - REFLECTING RANGE AND PREDICTION OF PARTIALITY .2. MONOCHROMATIZED SYNCHROTRON X-RADIATION FROM A SINGLY BENT TRIANGULAR MONOCHROMATOR. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 493-508, vol. 15(OCT). link> doi>
GREENHOUGH TJ. 1981. CORRECTION. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 780, vol. 37(MAR). link> doi>
GREENHOUGH TJ and TROTTER J. 1981. THE STRUCTURE OF 4A-BETA,5,8,8A-BETA-TETRAHYDRO-1-NAPHTHOQUIN-4ALPHA-OL AND COMPARISON WITH SOME OF ITS DERIVATIVES. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 126-132, vol. 37(JAN). link> doi>
GREENHOUGH TJ and TROTTER J. 1980. 1-BETA,3,4-BETA,6-BETA,8-PENTAMETHYL-9-EXO-METHYLENETRICYCLO[4.4.0.03,8]DECANE-2,5-DIONE (A TWISTANE DERIVATIVE). ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 478-480, vol. 36(FEB). link> doi>
GREENHOUGH TJ and TROTTER J. 1980. 2,3,4A-BETA,8A-BETA-TETRAMETHYL-4A,5,8,8A-TETRAHYDRO-1-NAPHTHOQUIN-4ALPHA-01. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2843-2846, vol. 36(NOV). link> doi>
GREENHOUGH TJ and TROTTER J. 1980. 4A,5,8,8A-TETRAHYDRO-5,8-ETHANO-1,4-NAPHTHOQUINONE. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2840-2843, vol. 36(NOV). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1980. ARACHNO-METALLACARBABORANE CONTAINING INTERMOLECULAR HYDROGEN BRIDGES - CRYSTAL AND MOLECULAR-STRUCTURE OF BIS-[11-TRIPHENYL-PHOSPHINE-11-ARGENTA-5,6-DICARBAUNDECABORANE(11)]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 192-194. link> doi>
APPEL WK, GREENHOUGH TJ, SCHEFFER JR, TROTTER J, WALSH L. 1980. CRYSTAL-LATTICE CONTROL OF UNIMOLECULAR PHOTOREARRANGEMENTS - DIFFERENCES IN CYCLOHEXENONE PHOTOCHEMISTRY IN SOLUTION AND THE SOLID-STATE - SOLID-STATE RESULTS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1160-1161, vol. 102(3). link> doi>
APPEL WK, GREENHOUGH TJ, SCHEFFER JR, TROTTER J, WALSH L. 1980. CRYSTAL-LATTICE CONTROL OF UNIMOLECULAR PHOTOREARRANGEMENTS - DIFFERENCES IN CYCLOHEXENONE PHOTOCHEMISTRY IN SOLUTION AND THE SOLID-STATE - SOLUTION RESULTS. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1158-1160, vol. 102(3). link> doi>
GREENHOUGH TJ and TROTTER J. 1980. CRYSTAL-STRUCTURES OF 2,3,4A-BETA,6,7,8A-BETA-HEXAMETHYL-4A,5,8,8A-TETRAHYDRO-1-NAPHTHOQUIN-4-ALPHA-OL AND 4-BETA-OL. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1831-1835, vol. 36(AUG). link> doi>
GREENHOUGH TJ and TROTTER J. 1980. CRYSTAL-STRUCTURES OF 2,3,4A-BETA,8A-BETA-TETRAMETHYL-4A,5,8,8A-TETRAHYDRO-1-NAPHTHOQUIN-4-BETA-O1-STAR AND ITS SOLID-STATE PHOTOPRODUCT. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1835-1839, vol. 36(AUG). link> doi>
ALCOCK NW, GREENHOUGH TJ, HIRST DM, KEMP TJ, PAYNE DR. 1980. RING ASYMMETRY IN 4-MORPHOLINOBENZENEDIAZONIUM TETRAFLUOROBORATE - CRYSTALLOGRAPHIC AND SCF STUDIES. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 8-12. link> doi>
GREENHOUGH TJ and TROTTER J. 1980. STRUCTURE OF 2,3,4A-BETA,6,7-BETA,8A-BETA-HEXAMETHYL-4A,7,8,8A-TETRAHYDRO-1,4-NAPHTHOQUINONE. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 368-373, vol. 36(FEB). link> doi>
GREENHOUGH TJ and TROTTER J. 1980. THE STRUCTURE OF 5-ALPHA,8ALPHA-DIMETHYL-4A-BETA,5,8,8ABETA-TETRAHYDRO-1-NAPHTHOQUIN-4ALPHA-OL. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2091-2094, vol. 36(SEP). link> doi>
GREENHOUGH TJ, KOLTHAMMER BWS, LEGZDINS P, TROTTER J. 1980. X-RAY STRUCTURAL CHARACTERIZATION OF THE CONGENERIC COMPLEXES[(ETA-5-C5H5)CR(NO)2CL] [(ETA-5-C5H5)W(NO)2CL]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 795-799, vol. 36(APR). link> doi>
GREENHOUGH TJ and TROTTER J. 1979. 3,4,6,8-BETA,9,10-HEXAMETHYLTETRACYCLO[4.3.1.03,10.04,9]DECANE-2,5-DIONE. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 3084-3087, vol. 35(DEC). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1979. 7,8-DICARBA-9-ARSA-NIDO-UNDECABORANE(11) AND RELATED COMPOUNDS. JOURNAL OF CHEMICAL RESEARCH-S, 248. link>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1979. CARBABORANE DERIVATIVES OF THE LATE-TRANSITION AND POST-TRANSITION ELEMENTS .2. DICARBAUNDECABORANYL COMPOUNDS OF COPPER(I), GOLD(I), AND MERCURY(II) - CRYSTAL AND MOLECULAR-STRUCTURE OF 3-TRIPHENYL-PHOSPHINE-3-MERCURA-1,2-DICARBADODECABORANE(II), A PSEUDO-SIGMA-BONDED METALLACARBABORANE. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 619-628. link> doi>
GREENHOUGH TJ, KOLTHAMMER BWS, LEGZDINS P, TROTTER J. 1979. CRYSTAL AND MOLECULAR-STRUCTURES OF BIS[(ETA-5-CYCLOPENTADIENYL)DICARBONYLCHROMIUM] SULFIDE, A NOVEL ORGANOMETALLIC COMPLEX POSSESSING A CR=S=CR LINKAGE. INORGANIC CHEMISTRY, 3543-3548, vol. 18(12). link> doi>
APPEL WK, GREENHOUGH TJ, SCHEFFER JR, TROTTER J. 1979. CRYSTAL-LATTICE CONTROL OF A UNIMOLECULAR PHOTOREARRANGEMENT - DIVERGENT BEHAVIOR OF A BETA-UNSATURATED, GAMMA-UNSATURATED KETONE IN SOLUTION AND SOLID-STATE. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 213-215, vol. 101(1). link> doi>
GREENHOUGH TJ, SCHEFFER JR, TROTTER J, WONG YF. 1979. FORMATION OF TWISTANE DERIVATIVES VIA A NOVEL BASE-CATALYZED REARRANGEMENT - X-RAY CRYSTAL-STRUCTURE OF 1,3,4,6,8-PENTAMETHYL-EXO-9-METHYLENETRICYCLO[4.4.0.03,8]DECANE-2,5-DIONE. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 933-934. link> doi>
APPEL WK, GREENHOUGH TJ, SCHEFFER JR, TROTTER J, WALSH L. 1979. ORGANIC-PHOTOCHEMISTRY IN THE SOLID-STATE. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 17. link>
GREENHOUGH TJ, KOLTHAMMER BWS, LEGZDINS P, TROTTER J. 1979. ORGANOMETALLIC NITROSYL CHEMISTRY .10. SYNTHESIS, X-RAY STRUCTURAL CHARACTERIZATION, AND PROPERTIES OF DICARBONYL(ETA-5-CYCLOPENTADIENYL)(THIONITROSYL)CHROMIUM. INORGANIC CHEMISTRY, 3548-3554, vol. 18(12). link> doi>
GREENHOUGH TJ, LEGZDINS P, MARTIN DT, TROTTER J. 1979. ORGANOMETALLIC NITROSYL CHEMISTRY .9. (ETA-C5H5)W(NO)(ETA-3-C3H5)I, A CHIRAL ORGANOMETALLIC COMPLEX CONTAINING A VERY ASYMMETRIC ALLYL LIGAND. INORGANIC CHEMISTRY, 3268-3270, vol. 18(11). link> doi>
GREENHOUGH TJ, SCHEFFER JR, TROTTER J, WALSH L. 1979. PHOTO-CHEMICAL RING EXPANSION OF A BRIDGED CYCLOBUTANONE - CRYSTAL AND MOLECULAR-STRUCTURE OF THE PHOTOPRODUCT ACETAL. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 2669-2676, vol. 57(19). link> doi>
GREENHOUGH TJ and LADD MFC. 1978. BIS(4-FORMYL-2-METHOXYPHENOLATO)(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II) TETRAHYDRATE. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2619-2621, vol. 34(AUG). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1978. CARBABORANE DERIVATIVES OF LATE-TRANSITION AND POST-TRANSITION ELEMENTS .1. PREPARATION AND X-RAY CRYSTAL-STRUCTURE OF 3-DIETHYLDITHIOCARBAMATO-1,2-DICARBA-3-AURADODECABORANE(11). JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 303-309. link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH, HERMANEK S, PLESEK J. 1978. CHARACTERIZATION OF DEGRADATION PRODUCTS IN OXIDATION OF DODE-CAHYDRO-7,8-DICARBA-NIDO-UNDECABORATE(1-) ION - NEW SYNTHESIS OF 4,5-DICARBA-NIDO-NONABORANE(11). JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 944-947. link> doi>
GREENHOUGH TJ and LADD MFC. 1978. CRYSTAL AND MOLECULAR-STRUCTURE OF RED ISOMER OF BIS(4-FORMYL-2-METHOXYPHENOLATO)(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II). ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2744-2752, vol. 34(SEP). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1978. METHYLTRIPHENYLPHOSPHONIUM UNDECAHYDRO-1,2-DICARBA-3-THALLA-CLOSO-DODECABORATE-TETRAHYDROFURAN, [PPH3ME]+[3,1,2-T1C2B9H11]-.1/2(C4H8O), AT 173-K. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2373-2376, vol. 34(JUL). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1978. STRUCTURAL CONSEQUENCES OF LIGAND AND METAL SUBSTITUTION IN METALLACARBABORANES - CRYSTAL AND MOLECULAR-STRUCTURES OF 3-[C2H4(NME2)2]3,1,2-PDC2B9H11 AND 3,3-(PME3)2-3,1,2-PDC2B9H11. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 322-324. link> doi>
GREENHOUGH TJ, KOLTHAMMER BWS, LEGZDINS P, TROTTER J. 1978. THIONITROSYL LIGAND - X-RAY MOLECULAR-STRUCTURE OF DICARBONYL(ETA-5-CYCLOPENTADIENYL)THIONITROSYLCHROMIUM. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1036-1037. link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1977. BIS(N,N-DIETHYLDITHIOCARBAMATO)GOLD(III) 3,3'-BIS(1,2-DICARBOLLYL)AURATE, [3,3'-AU(1,2-C2B9H11)2]-[(ET2NCS2)2AU]+. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 3604-3607, vol. 33(NOV). link> doi>
GREENHOUGH TJ and LADD MFC. 1977. NEW INVESTIGATION OF [(NH3.CH2.CH2)2NH2](CUCL4) AT 20DEGREESC. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1266-1269, vol. 33(APR15). link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1977. PROGRESSIVE CAGE-OPENING IN D6, D8, D10, AND D10S2 METALLACARBABORANES - CRYSTAL AND MOLECULAR-STRUCTURES OF 3-TRIPHENYLPHOSPHINO-3-MERCURA-1,2-DICARBADODECABORANE AND TRIPHENYLMETHYLPHOSPHONIUM 3-THALLA-1,2-DICARBADODECABORATE. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 737-738. link> doi>
COLQUHOUN HM, GREENHOUGH TJ, WALLBRIDGE MGH. 1976. SYNTHESIS AND X-RAY CRYSTAL-STRUCTURE OF 3-DIETHYLDITHIOCARBAMATO-3-AURA-1,2-DICARBADODECABORANE - SLIPPED 18-ELECTRON METALLACARBORANE. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1019-1020. link> doi>

Other

Uche F, Li WW, Richardson A, Greenhough TJ. 2014. Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea). PLANTA MEDICA (p. 813, vol. 80). link>
Uche FI, Li WW, Richardson A, Greenhough TJ. 2014. Anticancer activities of cyclotides from Viola yedeonsis Makino (Violaceae). PLANTA MEDICA (p. 818, vol. 80). link>
Williams R, Moran JA, Burns I, Greenhough TJ, Shrive AK. 2013. Structural Studies of C-reactive Protein. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. S317, vol. 69). link> doi>
da Silva R, Burns I, Greenhough TJ, Shrive AK. 2013. Structural Studies of Innate Immune Proteins. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. S322, vol. 69). link> doi>
Shrive A, Hood D, Clark H, Madsen J, Greenhough T. 2013. Structural basis of bacterial recognition by surfactant protein D. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. S358, vol. 69). link> doi>
Shrive AK, Shaw AJ, Ahmed A, Paterson JM, Smallcombe C, Reid KBM, Deadman ME, Hood DW, Holmskov U, Clark HW, Madsen J, Greenhough TJ. 2011. Structural basis of ligand and pathogen recognition by the collectins. Acta Crystallographica Section A: Foundations of Crystallography (p. C472, vol. A67). doi>
Greenhough TJ, Mold M, Moran J, Burns I, Paterson JM, Bailey SJ, Bailey J, Armstrong PB, Shrive AK. 2011. Structure, function and evolution of the serum pentraxins. Acta Crystallographica Section A: Foundations of Crystallography (p. C546, vol. A67). doi>
Shrive A, Martin C, Burns I, Paterson J, Martin J, Kishore U, Reid K, Greenhough T. 2005. Structural Basis of Ligand Recognition by the Collectins. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. C91, vol. 61). link> doi>
Greenhough T, Burns I, Paterson J, Armstrong P, Shrive A. 2005. Structure, Function and Evolution of the Serum Pentraxins. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. C230, vol. 61). link> doi>
Cartwright JR, MacCarthy E, Greenhough TJ, Shrive A, Wiegertjes GF, Hoole D. 2003. Pentraxin-like serum proteins from common carp \fI(Cyprinus carpio)\fP. Proceedings of the 11th International Conference of the European Association of Fish Pathologists.
Cartwright JR, MacCarthy E, Greenhough TJ, Shrive A, Wiegertjes GF, Hoole D. 2003. Pentraxin-like serum proteins from common carp \fI(Cyprinus carpio)\fP. Proceedings of the 11th International Conference of the European Association of Fish Pathologists.
Shrive AK, Tharia HA, Martin C, Burns I, Rizkallah PJ, Kishore U, Strong P, Reid KBM, Greenhough TJ. 2002. HIGH RESOLUTION NATIVE AND LIGAND-BOUND STRUCTURES OF AN ACTIVE TRIMERIC FRAGMENT OF HUMAN SP-D. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. C282, vol. 58). link> doi>
Greenhough TJ, Ramadan MAM, Shrive AK, Holden D, Myles DAA, DeLucas LJ, Volanakis JE. 2002. THE 3-DIMENSIONAL STRUCTURE OF Ca-DEPLETED HUMAN C-REACTIVE PROTEIN FROM PERFECTLY TWINNED CRYSTALS. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. C77, vol. 58). link> doi>
Cartwright JR, Greenhough TJ, Shrive AK, Hoole D. 2001. Isolation of C-reactive protein from the common carp \fI(Cyprinius carpio)\fP. Proceedings of the International Conference of the European Association of Fish Pathologists.
Cartwright JR, Greenhough TJ, Shrive AK, Hoole D. 2001. Isolation of C-reactive protein from the common carp \fI(Cyprinius carpio)\fP. Proceedings of the International Conference of the European Association of Fish Pathologists.
Szalai AJ, Agrawal A, Greenhough TJ, Volanakis JE. 1999. C-reactive protein: structural biology and host defense function. Clin Chem Lab Med (pp. 265-270, vol. 37). link> doi>
Greenhough TJ, Shrive AK, Ramadan MA, Metcalfe AM, Cartwright JR, Hopkins M. 1999. STRUCTURE, FUNCTION AND EVOLUTION OF SERUM PENTRAXINS FROM INVERTEBRATES TO HUMANS. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. 355, vol. 55). link>
Shrive AK, Cartwright JR, Metcalfe AM, Greenhough TJ. 1999. THE CRYSTAL STRUCTURE OF AN INVERTEBRATE PENTRAXIN-LECTIN WITH A NOVEL MOLECULAR ASSEMBLY. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. 197, vol. 55). link>
Ramadan MAM, Shrive AK, Greenhough TJ, Volanakis JE, DeLucas LJ. 1999. THE STRUCTURE OF CALCIUM-DEPLETED HUMAN C-REACTIVE PROTEIN FROM PERFECTLY TWINNED CRYSTALS. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. 350, vol. 55). link>
Shrive AK, Holden D, Metcalfe A, Myles DAA, Hopkins M, Glover ID, Hoole D, Bloomer AC, Greenhough TJ. 1996. STRUCTURE SOLUTION OF SOME C-REACTIVE PROTEINS. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. C240, vol. 52). link> doi>
Greenhough TJ, Cheetham GMT, Holden D, Myles DAA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Shrive AK. 1996. THREE DIMENSIONAL STRUCTURE OF HUMAN C-REACTIVE PROTEIN. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (p. C168, vol. 52). link> doi>
Hajdu J, Greenhough TJ, Clifton IJ, Campbell JW, Shrive AK, Harrison SC, Liddington RC. 1989. Laue crystallography: application to virus crystals. Basic Life Sci (pp. 331-339, vol. 51). link> doi>
Shrive A and Greenhough T. X-Ray diffraction data for structure associated with PDB ID: 6ZQY. doi>
Shrive A and Greenhough T. X-Ray diffraction data for structure associated with PDB ID: 6ZR4. doi>
Shrive A and Greenhough T. X-Ray diffraction data relating to protein structure PDB ID: 6RYG. Synchrotron station DLSI03, Diamond Light Source I03.doi> link>
Shrive A and Greenhough T. X-Ray diffraction data relating to protein structure PDB ID: 6RYM. Synchrotron station SRS 14.1, Daresbury SRS 14.1doi>
Shrive A and Greenhough T. X-Ray diffraction data relating to protein structure PDB ID: 6RYN. Synchrotron station DLS I04, Diamond Light Source I04.doi> link>
Shrive A and Greenhough T. X-ray diffraction data for structure associated with PDB ID: 6ZQR. doi>
Shrive A and Greenhough T. X-ray diffraction data for structure associated with PDB ID: 6ZQX. doi>
Shrive A and Greenhough T. X-ray diffraction data for structure associated with PDB ID: 6ZR0. doi>
Shrive A and Greenhough T. X-ray diffraction data for structure associated with PDB ID: 6ZR3. doi>

Prof Trevor J Greenhough