Professor Ying Yang

Title: Professor in Biomaterials and Tissue Engineering
Phone: +44 (0)1782 674386
Email: y.yang@keele.ac.uk
Location: Institute for Science & Technology in Medicine Keele University Thronburrow Drive, Hartshill Stoke-on-Trent, ST4 7QB United Kingdom
Role: ISTM Research theme: Regenerative Medicine
Contacting me: By phone or email please
Ying_Yang_136x178

I completed my PhD at Manchester University in Materials Science and Technology in 1994. Before that, I obtained a BSc in Chemistry Engineering and a MSc in Polymer Science and Technology in Hunan University in 1981 and 1987 respectively. Between 1995 and 1997, I took up a postdoctoral research fellow in Tokyo Institute of Technology working on engineering polymer blends aiming to develop new automobile industrial materials. In the late 1997, I took a research associate position in Keele University and starting my materials research in medical field. I was appointed to a lecturer in Biomaterials and Tissue engineering in 2001 and promoted to senior lecturer in 2006 and reader in 2009. In December 2015, I was appointed as a chair in Biomaterials and Tissue engineering.

Ying_Yang_inaugural_lecture_03Jul2017_IMG_0208_350x350 Inaugural Lecture 3 July 2017 available on YouTube: https://www.youtube.com/watch?v=7LjN-hLJyZI&feature=youtu.be

ISTM Research theme: Regenerative Medicine

My current research has been focused on the application of engineering strategies in translational medicine. Great effort has been made to establish systematic study methods in utilizing smart/unique materials that trigger and detect specific cellular responses and application of non-destructive monitoring modalities for complicate cellular systems. The research includes smart nanofiber design and applications, detection of variation of cell adhesion capacities, exploring unique techniques to detect heterogeneous cellular populations and correlating the structures of collagen based matrices to diseases. A few clinical relevant projects are being undertaken in relation to different tissues and organs, from colony growth of stem cells for cell therapy, rapid bone formation, osteogenic potency assay, pathological calcification of heart valves, the relation of pelvic organ prolapse and ageing. My regeneration medicine research is centralized on bone, cartilage, blood vessel, cornea, retina pseudoislets, skin, nerve generation and characterization.

The on-going projects including:

  • Detection the donor dependent heterogeneity in bone marrow derived stem cells
  • Separation and characterization of the progenitor cells in cardiac cell mixture
  • Fabricating and characterization of fully functional blood vessel for homeostatic and vascular disease study
  • Establishment of retinal explant culture model to assess photoreceptor cells and study retinal diseases
  • Exploring novel nanofabrication protocols as matrix for stem cells expansion and control differentiation
  • Development of better pseudoislet model for diabetes treatment
  • Development and characterization of new protocols for stimulation of rapid bone formation
  • Identification of the pathway of pathological calcification in heart valve and establishment of an in vitro calcification model for drug screening
  • Investigation of relation of ageing and connective tissue disorder including prolapse, preterm premature rupture of membranes
  • Development implantable 3D neuron circuits for treatment of disorder in CNS
  • Application of FTIR techniques as diagnostic and characterization tool for disease and regenerative tissues
  • Establishment of novel non-destructive optical modalities (OCT, Raman spectroscopy, microindentation) for tissue regeneration applications

At the present, I am the member of EU TERMIS and Biomaterial society, The Society of Photographic Instrumentation Engineers (SPIE), and the committee member of the annual conference of ‘Optics in Tissue Engineering and Regenerative Medicine’, SPIE, Bios, USA

Selected Publications

  • Kumar D, Dale TP, Yang Y, Forsyth NR. 2015. Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers. Biomed Mater, vol. 10(6), 065017. link> doi>
  • Roach P, Kamudzandu M, Yang Y, Fricker R. 2015. Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, vol. 2015(3), 123-131. doi>
  • Deegan AJ, Cinque G, Wehbe K, Konduru S, Yang Y. 2015. Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Anal Bioanal Chem, vol. 407(4), 1097-1105. link> doi>
  • Deegan AJ, Aydin HM, Hu B, Konduru S, Kuiper JH, Yang Y. 2014. A facile in vitro model to study rapid mineralization in bone tissues. Biomed Eng Online, vol. 13, 136. link> doi>
  • Jozwiak A, Liu Y, Yang Y, Gates MA. 2014. Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. Biomed Res Int, vol. 2014, 651236. link> doi>

Full Publications List show

Books

  • LI J, YANG Y, GU K, DONG G. Li J, Yang Y, Gu K, Dong G (Eds.). 2004. Biological micro- and nanotribology - Nature?s solutions. China Machine Press, Beijing, China.
  • YANG Y and EL HAJ AJ. Ashammaki N and Waris T (Eds.). 2004. Enhancement of mechanical signals for tissue engineering bone. e-book, ..

Journal Articles

  • Gillies D, Gamal W, Downes A, Reinwald Y, Yang Y, El Haj AJ, Bagnaninchi PO. 2017. Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods. link> doi>
  • Weli H, Cooper J, Yang Y. 2017. Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy. Medical Hypotheses, -. doi> link>
  • Owida HA, De Las Heras Ruiz T, Dhillon A, Yang Y, Kuiper NJ. 2017. Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production. Histochem Cell Biol. link> doi>
  • Weli HK, Akhtar R, Chang Z, Li W-W, Cooper J, Yang Y. 2017. Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy. Eur J Obstet Gynecol Reprod Biol, vol. 214, 78-85. link> doi>
  • Bardsley K, Yang Y, El Haj AJ. Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. Tissue Eng Part C Methods, vol. 23(4), 228-236. link> doi>
  • Hendrikson WJ, Deegan AJ, Yang Y, van Blitterswijk CA, Verdonschot N, Moroni L, Rouwkema J. 2017. Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation. Front Bioeng Biotechnol, vol. 5, 6. link> doi>
  • Bardsley K, Deegan AJ, El Haj A, Yang Y. 2017. Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging. Adv Exp Med Biol, vol. 1035, 3-18. link> doi>
  • Williams DJ, Archer R, Archibald P, Bantounas I, Baptista R, Barker R, Barry J, Bietrix F, Blair N, Braybrook J, Campbell J, Canham M, Chandra A, Foldes G, Gilmanshin R, Girard M, Gorjup E, Hewitt Z, Hourd P, Hyllner J, Jesson H, Kee J, Kerby J, Kotsopoulou N, Kowalski S, Leidel C, Marshall D, Masi L, McCall M, McCann C, Medcalf N, Moore H, Ozawa H, Pan D, Parmar M, Plant AL, Reinwald Y, Sebastian S, Stacey G, Thomas RJ, Thomas D, Thurman-Newell J, Turner M, Vitillo L, Wall I, Wilson A, Wolfrum J, Yang Y, Zimmerman H. 2016. Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. Regen Med, vol. 11(5), 483-492. link> doi>
  • Law JX, Musa F, Ruszymah BHI, El Haj AJ, Yang Y. 2016. A comparative study of skin cell activities in collagen and fibrin constructs. Med Eng Phys, vol. 38(9), 854-861. link> doi>
  • Lyu LX, Huang NP, Yang Y. 2016. Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. Journal of biomaterials science. Polymer edition, vol. 27(11), 1155-1169. doi> link>
  • Yang Y. 2016. Correction: Optofluidic lens with low spherical and low field curvature aberrations. Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering. doi>
  • Bardsley K, Wimpenny I, Yang Y, El Haj AJ. 2016. Fluorescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC ADVANCES, vol. 6(50), 44364-44370. link> doi>
  • Musa F, Harper AGS, Yang Y. 2016. A real-time monitoring system to assess the platelet aggregatory capacity of components of a tissue-engineered blood vessel wall. Tissue Engineering Part C: Methods. doi>
  • Kumar D, Dale TP, Yang Y, Forsyth NR. 2015. Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers. Biomed Mater, vol. 10(6), 065017. link> doi>
  • Yang Y and Wimpenny I. 2015. 9 - Image analysis and quantification of tissue scaffolds. Characterisation and Design of Tissue Scaffolds, 201-223. doi>
  • Yang Y. 2015. First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST. Nuclear Fusion. doi>
  • Roach P, Kamudzandu M, Yang Y, Fricker R. 2015. Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, vol. 2015(3), 123-131. doi>
  • Lally F, Soorani M, Woo T, Nayak S, Jadun C, Yang Y, McCrudden J, Naire S, Grunwald I, Roffe C. 2016. In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow. J Neurointerv Surg, vol. 8(9), 969-972. link> doi>
  • Mázl Chánová E, Knotek P, Yang Y, Machová L, Proks V, Kučka J, Popelka Š, Pop-Georgievski O, El Haj A, Kubies D, Rypáček F. 2015. Nano-colloid printing of functionalized PLA-b-PEO copolymers: tailoring the surface pattern of adhesive motif and its effect on cell attachment. Physiol Res, vol. 64 Suppl 1, S61-S73. link>
  • Yang Y. 2015. Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions. Physical Review C: Nuclear Physics, vol. 92(1). doi>
  • Kamudzandu M, Yang Y, Roach P, Fricker RA. 2015. Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC ADVANCES, vol. 5(28), 22053-22059. link> doi>
  • Deegan AJ, Cinque G, Wehbe K, Konduru S, Yang Y. 2015. Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Anal Bioanal Chem, vol. 407(4), 1097-1105. link> doi>
  • Naslim N, Kemper F, Madden SC, Hony S, Chu Y-H, Galliano F, Bot C, Yang Y, Seok J, Oliveira JM, van Loon JT, Meixner M, Li A, Hughes A, Gordon KD, Otsuka M, Hirashita H, Morata O, Lebouteiller V, Indebetouw R, Srinivasan S, Bernard J-P, Reach WT. 2015. Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud. MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, vol. 446(3), 2490-2504. link> doi>
  • Guilbert M, Eklouh-Molinier C, Wehbe K, Sulé-Suso J, Yang Y, Cinque G, Jeannesson P, Sockalingum GD. 2014. Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. J Biomed Opt, vol. 19(11), 111612. link> doi>
  • Deegan AJ, Aydin HM, Hu B, Konduru S, Kuiper JH, Yang Y. 2014. A facile in vitro model to study rapid mineralization in bone tissues. Biomed Eng Online, vol. 13, 136. link> doi>
  • Rutter AV, Siddique MR, Filik J, Sandt C, Dumas P, Cinque G, Sockalingum GD, Yang Y, Sulé-Suso J. 2014. Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry A, vol. 85(8), 688-697. link> doi>
  • Weightman AP, Pickard MR, Yang Y, Chari DM. 2014. An in vitro spinal cord injury model to screen neuroregenerative materials. Biomaterials, vol. 35(12), 3756-3765. link> doi>
  • Jozwiak A, Liu Y, Yang Y, Gates MA. 2014. Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. Biomed Res Int, vol. 2014, 651236. link> doi>
  • Guan G, Li C, Ling Y, Yang Y, Vorstius JB, Keatch RP, Wang RK, Huang Z. 2013. Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. J Biomed Opt, vol. 18(11), 111417. link> doi>
  • Weightman A, Jenkins S, Pickard M, Chari D, Yang Y. 2014. Alignment of multiple glial cell populations in 3D nanofiber scaffolds: toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine, vol. 10(2), 291-295. link> doi>
  • Wilson SL, Guilbert M, Sulé-Suso J, Torbet J, Jeannesson P, Sockalingum GD, Yang Y. 2014. A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response. FASEB J, vol. 28(1), 14-25. link> doi>
  • Wilson SL, Yang Y, El Haj AJ. 2014. Corneal stromal cell plasticity: in vitro regulation of cell phenotype through cell-cell interactions in a three-dimensional model. Tissue Eng Part A, vol. 20(1-2), 225-238. link> doi>
  • Pijanka JK, Stone N, Rutter AV, Forsyth N, Sockalingum GD, Yang Y, Sulé-Suso J. 2013. Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation. Analyst, vol. 138(17), 5052-5058. link> doi>
  • Rutter AV, Chippendale TWE, Yang Y, Španěl P, Smith D, Sulé-Suso J. 2013. Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. Analyst, vol. 138(1), 91-95. link> doi>
  • Yang Y, Rupani A, Bagnaninchi P, Wimpenny I, Weightman A. 2013. Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography. J Biomed Opt, vol. 18(1), 19801. link> doi>
  • Kumar D, Gupta S, Yang Y, Forsyth NR. 2013. αV β5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors. Biomed Res Int, vol. 2013, 729281. link> doi>
  • Wilson SL, Wimpenny I, Ahearne M, Rauz S, El Haj AJ, Yang Y. 2012. Chemical and Topographical Effects on Cell Differentiation and Matrix Elasticity in a Corneal Stromal Layer Model. ADVANCED FUNCTIONAL MATERIALS, vol. 22(17), 3641-3649. link> doi>
  • Weightman A, Pickard M, Jenkins S, Chari D, Yang Y. 2012. Development of 3D co-culture of aligned glial cells in nanofibre scaffolds for implantation into neural injury sites. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 88-89. link>
  • Wimpenny I, Ahearne M, Yang Y. 2012. Dictation of cell orientation throughout three dimensional hydrogels. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 386. link>
  • Bolgen N, Yang Y, Korkusuz P, Guzel E, El Haj AJ, Piskin E. 2012. Ingrowth of bone cells within cryogels under compression and perfusion. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 241. link>
  • Wilson S, El Haj A, Yang Y. 2012. Regulation of genotype and phenotype of corneal stromal cells. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 137-138. link>
  • Kumar D, Roach P, Forsyth NR, Yang Y. 2012. Study of adsorbed proteins on nanofibrous substrates. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 210. link>
  • Yang Y, Rupani A, Bagnaninchi P, Wimpenny I, Weightman A. 2012. Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography. JOURNAL OF BIOMEDICAL OPTICS, vol. 17(8), Article ARTN 081417. link> doi>
  • Weeks S, Kulkarni A, Smith H, Whittall C, Yang Y, Middleton J. 2012. The effects of chemokine, adhesion and extracellular matrix molecules on binding of mesenchymal stromal cells to poly(l-lactic acid). Cytotherapy, vol. 14(9), 1080-1088. link> doi>
  • Wilson SL, El Haj AJ, Yang Y. 2012. Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering. J Funct Biomater, vol. 3(3), 642-687. link> doi>
  • Cunha-Reis C, El Haj AJ, Yang X, Yang Y. 2013. Fluorescent labeling of chitosan for use in non-invasive monitoring of degradation in tissue engineering. J Tissue Eng Regen Med, vol. 7(1), 39-50. link> doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2011. 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med, vol. 5(10), 770-779. link> doi>
  • Wimpenny I, Lahteenkorva K, Suokas E, Ashammakhi N, Yang Y. 2012. Improvement and characterization of the adhesion of electrospun PLDLA nanofibers on PLDLA-based 3D object substrates for orthopedic application. J Biomater Sci Polym Ed, vol. 23(14), 1863-1877. link> doi>
  • Wilson SL, El Haj AJ, Wimpenny I, Yang Y. 2011. REGULATION AND CHARACTERISATION OF CORNEAL STROMAL CELL CONTRACTION. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol. 34(8), 694. link>
  • Yang Y, Rupani A, Wimpenny I. 2011. THE STUDY OF OPTICAL PROPERTIES AND PROTEOGLYCAN CONTENT OF NATIVE AND TISSUE ENGINEERING TENDONS BY PS-OCT. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol. 34(8), 641. link>
  • Wimpenny I, Ashammakhi N, Yang Y. 2012. Chondrogenic potential of electrospun nanofibres for cartilage tissue engineering. J Tissue Eng Regen Med, vol. 6(7), 536-549. link> doi>
  • Yang Y, Wimpenny I, Ahearne M. 2011. Portable nanofiber meshes dictate cell orientation throughout three-dimensional hydrogels. Nanomedicine, vol. 7(2), 131-136. link> doi>
  • Aydin HM, Hu B, Sule-Suso JS, El Haj AJ, Yang Y. 2011. Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, vol. 4, 775-780. doi>
  • Then KY, Yang Y, Ahearne M, El Haj AJ. 2011. Effect of microtopographical cues on human keratocyte orientation and gene expression. Curr Eye Res, vol. 36(2), 88-93. link> doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2010. 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med. doi>
  • Aydin HM, Hu B, Suso JS, El Haj A, Yang Y. 2011. Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, vol. 136(4), 775-780. link> doi>
  • Pijanka JK, Kumar D, Dale T, Yousef I, Parkes G, Untereiner V, Yang Y, Dumas P, Collins D, Manfait M, Sockalingum GD, Forsyth NR, Sulé-Suso J. 2010. Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells. Analyst. doi>
  • Ahearne M, Wilson SL, Liu KK, Rauz S, El Haj AJ, Yang Y. 2010. Influence of Cell and Collagen Concentration on the Cell-Matrix Mechanical Relationship in a Corneal Stroma Wound Healing Model. Exp Eye Res. doi>
  • Bagnaninchi PO, Yang Y, Bonesi M, Maffulli G, Phelan C, Meglinski I, El Haj A, Maffulli N. 2010. In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography. Phys Med Biol, vol. 55(13), 3777-3787. doi>
  • Baas E, Kuiper JH, Yang Y, Wood MA, El Haj AJ. 2010. In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds. JOURNAL OF BIOMECHANICS, vol. 43(4), 733-739. link> doi>
  • Pijanka J, Sockalingum GD, Kohler A, Yang Y, Draux F, Parkes G, Lam K-P, Collins D, Dumas P, Sandt C, van Pittius DG, Douce G, Manfait M, Untereiner V, Sulé-Suso J. 2010. Synchrotron-based FTIR spectra of stained single cells. Towards a clinical application in pathology. Lab Invest, vol. 90(5), 797-807. link> doi>
  • Araujo JV, Cunha-Reis C, Rada T, da Silva MA, Gomes ME, Yang Y, Ashammakhi N, Reis RL, El-Haj AJ, Neves NM. 2010. Dynamic culture of osteogenic cells in biomimetically coated poly(caprolactone) nanofibre mesh constructs. Tissue Eng Part A, vol. 16(2), 557-563. link> doi>
  • Jozwiak A, Gates MA, Liu Y, Yang Y. 2010. A novel technology and stereotactic accessory for implanting engineered tissues, cells, and scaffold materials into the brain. Tissue Eng Part C Methods, vol. 16(3), 469-470. link> doi>
  • Wimpenny I, Hampson K, Yang Y, Ashammakhi N, Forsyth NR. 2010. One-step recovery of marrow stromal cells on nanofibers. Tissue Eng Part C Methods, vol. 16(3), 503-509. link> doi>
  • Aydin HM, El Haj AJ, Pişkin E, Yang Y. 2009. Improving pore interconnectivity in polymeric scaffolds for tissue engineering. J Tissue Eng Regen Med, vol. 3(6), 470-476. link> doi>
  • Aydin HM, Yang Y, Kohler T, El Haj A, Mueller R, Piskin E. 2009. Interaction of Osteoblasts with Macroporous Scaffolds Made of PLLA/PCL Blends Modified with Collagen and Hydroxyapatite. ADVANCED ENGINEERING MATERIALS, vol. 11(8), B83-B88. link> doi>
  • Ahearne M, Liu K-K, El Haj AJ, Then KY, Rauz S, Yang Y. 2010. Online monitoring of the mechanical behavior of collagen hydrogels: influence of corneal fibroblasts on elastic modulus. Tissue Eng Part C Methods, vol. 16(2), 319-327. link> doi>
  • Ahearne M, Siamantouras E, Yang Y, Liu K-K. 2009. Mechanical characterization of biomimetic membranes by micro-shaft poking. J R Soc Interface, vol. 6(34), 471-478. link> doi>
  • Jia Y, Bagnaninchi PO, Yang Y, El Haj A, Hinds MT, Kirkpatrick SJ, Wang RK. 2009. Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds. JOURNAL OF BIOMEDICAL OPTICS, vol. 14(3), Article ARTN 034014. link> doi>
  • Ashammakhi N, Wimpenny I, Nikkola L, Yang Y. 2009. Electrospinning: methods and development of biodegradable nanofibres for drug release. J Biomed Nanotechnol, vol. 5(1), 1-19. link> doi>
  • Ahearne M, Bagnaninchi PO, Yang Y, El Haj AJ. 2008. Online monitoring of collagen fibre alignment in tissue-engineered tendon by PSOCT. J Tissue Eng Regen Med, vol. 2(8), 521-524. link> doi>
  • Yang Y, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Characterisation of scaffold architecture and tendons using optical coherence tomography and polarisation-sensitive optical coherence tomography. Optoelectronics, IET, vol. 2, 188-194. doi> link>
  • Wood MA, Yang Y, Baas E, Meredith DO, Richards RG, Kuiper JH, El Haj AJ. 2008. Correlating cell morphology and osteoid mineralization relative to strain profile for bone tissue engineering applications. J R Soc Interface, vol. 5(25), 899-907. link> doi>
  • Ashammakhi N, Ndreu A, Nikkola L, Wimpenny I, Yang Y. 2008. Advancing tissue engineering by using electrospun nanofibers. Regen Med, vol. 3(4), 547-574. link> doi>
  • Baas E, Kuiper JH, Yang Y, Wood MA, El Haj AJ. 2010. In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds. J Biomech, vol. 43(4), 733-739. link> doi>
  • Kohler A, Sule-Suso J, Sockalingum GD, Tobin M, Bahrami F, Yang Y, Pijanka J, Dumas P, Cotte M, van Pittius DG, Parkes G, Martens H. 2008. Estimating and correcting Mie scattering in synchrotron-based microscopic Fourier transform infrared spectra by extended multiplicative signal correction. APPLIED SPECTROSCOPY, vol. 62(3), 259-266. link> doi>
  • Whiteman SC, Yang Y, Jones JM, Spiteri MA. 2008. FTIR spectroscopic analysis of sputum: preliminary findings on a potential novel diagnostic marker for COPD. Ther Adv Respir Dis, vol. 2(1), 23-31. link> doi>
  • Ahearne M, Yang Y, Then KY, Liu K-K. 2008. Non-destructive mechanical characterisation of UVA/riboflavin crosslinked collagen hydrogels. Br J Ophthalmol, vol. 92(2), 268-271. link> doi>
  • Yang Y, Bagnaninchi PO, Ahearne M, Wang RK, Liu K-K. 2007. A novel optical coherence tomography-based micro-indentation technique for mechanical characterization of hydrogels. J R Soc Interface, vol. 4(17), 1169-1173. link> doi>
  • Ahearne M, Yang Y, Then KY, Liu K-K. 2007. An indentation technique to characterize the mechanical and viscoelastic properties of human and porcine corneas. Ann Biomed Eng, vol. 35(9), 1608-1616. link> doi>
  • Bagnaninchi P-O, Yang Y, El Haj AJ, Maffulli N. 2007. Tissue engineering for tendon repair. Br J Sports Med, vol. 41(8), e10. link> doi>
  • EL HAJ AJ. 2007. Chitosan Microchannel Scaffolds for Tendon Tissue Engineering Characterized Using Optical Coherence Tomography. Tissue Engineering, vol. 13(2), 323-331. link> doi>
  • Ashammakhi N, Ndreu A, Yang Y, Ylikauppila H, Nikkola L, Hasirci V. 2007. Tissue engineering: a new take-off using nanofiber-based scaffolds. J Craniofac Surg, vol. 18(1), 3-17. link> doi>
  • Prabhudesai V, Phelan C, Yang Y, Wang RK, Cowling MG. 2006. The potential role of optical coherence tomography in the evaluation of vulnerable carotid atheromatous plaques: A pilot study. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, vol. 29(6), 1039-1045. link> doi>
  • Wood MA, Yang Y, Thomas PBM, Haj AJE. 2006. Using dihydropyridine-release strategies to enhance load effects in engineered human bone constructs. Tissue Eng, vol. 12(9), 2489-2497. link> doi>
  • Yang Y and El Haj AJ. 2006. Biodegradable scaffolds--delivery systems for cell therapies. Expert Opin Biol Ther, vol. 6(5), 485-498. link> doi>
  • Wood MA, Hughes S, Yang Y, El Haj AJ. 2006. Characterizing the efficacy of calcium channel agonist-release strategies for bone tissue engineering applications. J Control Release, vol. 112(1), 96-102. link> doi>
  • Yang Y, Dubois A, Qin X-P, Li J, El Haj A, Wang RK. 2006. Investigation of optical coherence tomography as an imaging modality in tissue engineering. Phys Med Biol, vol. 51(7), 1649-1659. link> doi>
  • Whiteman SC, Yang Y, Gey van Pittius D, Stephens M, Parmer J, Spiteri MA. 2006. Optical coherence tomography: real-time imaging of bronchial airways microstructure and detection of inflammatory/neoplastic morphologic changes. Clin Cancer Res, vol. 12(3 Pt 1), 813-818. link> doi>
  • Ahearne M, Yang Y, El Haj AJ, Then KY, Liu K-K. 2005. Characterizing the viscoelastic properties of thin hydrogel-based constructs for tissue engineering applications. J R Soc Interface, vol. 2(5), 455-463. link> doi>
  • El Haj AJ, Wood MA, Thomas P, Yang Y. 2005. Controlling cell biomechanics in orthopaedic tissue engineering and repair. Pathol Biol (Paris), vol. 53(10), 581-589. link> doi>
  • Yang Y, Yiu HHP, El Haj AJ. 2005. On-line fluorescent monitoring of the degradation of polymeric scaffolds for tissue engineering. Analyst, vol. 130(11), 1502-1506. link> doi>
  • Sule-Suso J, Yang Y, Tobin M, Bahrami F, Sockalingum G, Kohler A, Manfait M, El Haj AJ. 2005. Sensitivity of single, in vitro growing lung cancer cells to gemcitabine measured with synchrotron based fourier transform infrared microspectroscopy. EJC SUPPLEMENTS, vol. 3(2), 51. link>
  • Yang Y, Sulé-Suso J, Sockalingum GD, Kegelaer G, Manfait M, El Haj AJ. 2005. Study of tumor cell invasion by Fourier transform infrared microspectroscopy. Biopolymers, vol. 78(6), 311-317. link> doi>
  • Yang Y, Bagnaninchi PO, Whiteman SC, van Pittius DG, El Haj AJ, Spiteri MA, Wang RKK. 2005. A naturally occurring contrast agent for OCT imaging of smokers' lung. JOURNAL OF PHYSICS D-APPLIED PHYSICS, vol. 38(15), 2590-2596. link> doi>
  • Freyria A-M, Yang Y, Chajra H, Rousseau CF, Ronzière M-C, Herbage D, El Haj AJ. 2005. Optimization of dynamic culture conditions: effects on biosynthetic activities of chondrocytes grown in collagen sponges. Tissue Eng, vol. 11(5-6), 674-684. link> doi>
  • YANG Y, Then KY, Ahearne M, Liu KK. 2005. A New Technique for Mechanically Characterising Hydrogels for Tissue Engineering Cornea. Investigative Ophthalmology Visual Science, vol. 46, 2185.
  • YANG Y, Wang RK, Dubois A. 2005. Ultrahigh-resolution optical imaging of cellular structures of high-scattering biological tissues with whole-field optical coherence microcopy. SPIE, vol. 5690, 39-43. doi>
  • YANG Y, SULE-SUSO J, EL HAJ AJ, HOBAN PR, WANG R. 2004. Monitoring of lung tumour cell growth in artificial membranes. Biosens Bioelectron, vol. 20(3), 442-447. doi>
  • Wickramasinghe Y, Yang Y, Spencer SA. 2004. Current problems and potential techniques in in vivo glucose monitoring. J Fluoresc, vol. 14(5), 513-520. link> doi>
  • Korchazhkina O and Yang Y. 2004. Methyl malondialdehyde is not suitable as an internal standard for malondialdehyde detection in urine after derivatisation with 2,4-dinitrophenylhydrazine. J Chromatogr B Analyt Technol Biomed Life Sci, vol. 806(2), 295-298. link> doi>
  • Yang Y, Whiteman S, Gey van Pittius D, He Y, Wang RK, Spiteri MA. 2004. Use of optical coherence tomography in delineating airways microstructure: comparison of OCT images to histopathological sections. Phys Med Biol, vol. 49(7), 1247-1255. link> doi>
  • YANG Y and EL HAJ AJ. 2004. Bone tissue engineering. Scope, vol. 13(3), 33-35.
  • Yang Y, Magnay J, Cooling L, Cooper JJ, El Haj AJ. 2004. Effects of substrate characteristics on bone cell response to the mechanical environment. Med Biol Eng Comput, vol. 42(1), 22-29. link> doi>
  • MULLENDER M, EL HAJ AJ, YANG Y, VAN DUIN MA, BURGER EH. 2004. Mechanotransduction of bone cells in vitro; mechanobiology of bone tissue. Med Biol Eng Comput, vol. 42(1), 14-21. doi>
  • WHITEMAN S, YANG Y, GEY VAN PITTIUS D, HE Y, SPITERI M, WANG RK. 2004. Optical coherence tomography imaging of structural components of the respiratory tract. Proceedings of SPIE. doi>
  • Yang Y, Zhang S, Jones G, Morgan N, El Haj AJ. 2004. Phosphorylcholine-containing polymers for use in cell encapsulation. Artif Cells Blood Substit Immobil Biotechnol, vol. 32(1), 91-104. link> doi>
  • YANG Y, SULE-SUSO J, EL HAJ AJ, HOBAN PR, WANG RK. 2004. Use of OCT to study tumor cell growth in 3D membranes. Proceedings of SPIE. doi>
  • Yang Y, Porte MC, Marmey P, El Haj AJ, Amedee J, Baquey C. 2003. Covalent bonding of collagen on poly(L-lactic acid) by gamma irradiation. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, vol. 207(2), 165-174. link> doi>
  • Yang Y, Wu L, Feng YQ, Wang RK. 2003. Observations of birefringence in tissues from optic-fibre-based optical coherence tomography. MEASUREMENT SCIENCE AND TECHNOLOGY, vol. 14(1), 41-46. link> doi>
  • Yang Y, Magnay JL, Cooling L, El HAJ. 2002. Development of a 'mechano-active' scaffold for tissue engineering. Biomaterials, vol. 23(10), 2119-2126. link> doi>
  • Yang Y, Magnay J, El Haj AJ. 2002. Development of a mechno responsive scaffold for tissue engineering. Biomaterials.
  • YANG Y, Stanford JL, Ryan AJ. 2001. Reactive processing of acrylic–polyurea interpenetrating networks: reaction kinetic studies. Polymer International, vol. 50(9), 1035-1045. doi>
  • YANG Y, Inoue T, Fujinami T, Mehta MA. 2001. Blended lithium ion conducting polymer electrolytes based on boroxine polymers. Solid State Ionic, vol. 140(3-4), 353-359. doi>
  • Wang RK, Yang Y, El Haj A, Elder JB. 2001. High resolution optical tomographic imaging of biological tissues. Scope, vol. 10, 12-14.
  • Yang Y, Zhang SF, Kingston MA, Jones G, Wright G, Spencer SA. 2000. Glucose sensor with improved haemocompatibilty. Biosens Bioelectron, vol. 15(5-6), 221-227. link> doi>
  • Zhang S, Wright G, Yang Y. 2000. Materials and techniques for electrochemical biosensor design and construction. Biosens Bioelectron, vol. 15(5-6), 273-282. link> doi>
  • Sule-Suso J, Zhang S, Yang Y, Forster A, Hand PA, El Haj AJ. 1999. Study of lung cancer cells by Fourier Transform Infrared spectroscopy. THORAX, vol. 54, A83. link>
  • Bardsley K, Wimpenny I, Wechsler R, Shachaf Y, Yang Y, El Haj AJ. 2016. Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques. Acta biomaterialia. doi> link>
  • Cao P, Yuan CQ, Ma CY, Yang Y, Bai XQ, Wang XJ, Ren XY, Xie H, Yan XP. 2015. Preparation and analysis of a new bioorganic metallic material. RSC ADVANCES, vol. 5(95), 78030-78037. link> doi>
  • Ren XY, Bai XQ, Yuan CQ, Yang Y, Xie H, Cao P, Ma CY, Wang XJ, Yan XP. 2015. Protein engineering of a new recombinant peptide to increase the surface contact angle of stainless steel. RSC ADVANCES, vol. 5(123), 101309-101318. link> doi>
  • Dong CL, Yuan CQ, Bai XQ, Yang Y, Yan XP. 2015. Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions. WEAR, vol. 332, 1012-1020. link> doi>
  • Musa FI, Harper AGS, Yang Y. 2015. Validating A 3D tissue-engineered human blood vessel model for use as a novel model system for the assessment of thrombus formation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 13, 110-111. link>

Other

  • Ozdil D, Wimpenny I, Yang Y, Aydin HM. 2016. Biocompatibility of biodegradable medical polymers. Science and Principles of Biodegradable and Bioresorbable Medical Polymers. Elsevier. doi>
  • Smith WA, Lam K-P, Dempsey KP, Mazzocchi-Jones D, Richardson JB, Yang Y. 2014. Label free cell tracking in 3-D tissue engineering constructs with high resolution imaging. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS XI (vol. 8942). link> doi>
  • Judd AM, Moss GP, Heylings J, Wan K-W, Yang Y. 2013. Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS IX (vol. 8580). link> doi>
  • Wilson SL, Guilbert M, Sule-Suso J, Torbet J, Jeannesson P, Sockalingum GD, Yang Y. 2012. The effect of collagen ageing on its structure and cellular behaviour. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS IX (vol. 8222). link> doi>
  • Aydin HM, Hu B, Kesri S, El Haj AJ, Yang Y. 2011. A Morphological Study of Cell Aggregations on Mineralization. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (vol. 30, pp. 9-12). link>
  • Hu B, Yang Y, Dobson JP, El Haj AJ. 2011. Mechanical Conditioning Using Magnetic Nanoparticles Bound to PDGF Receptors on HBMSCs Promotes the Smooth Muscle Alpha Actin (SMA) Expression. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (vol. 30, pp. 23-25). link>
  • Ahearne M, El Haj AJ, Rauz S, Yang Y. 2011. Online Monitoring the Mechanical Remodeling of Hydrogels by Corneal Fibroblasts. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (vol. 30, pp. 1-+). link>
  • Yang Y, Rupani A, Weightman A, Wimpenny I, Bagnaninchi P, Ahearne M. 2011. The study of optical properties and proteoglycan content of tendons by PS-OCT. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS VIII (vol. 7898). link> doi>
  • Pijanka JK, Stone N, Cinque G, Yang Y, Kohler A, Wehbe K, Frogley M, Parkes G, Parkes J, Dumas P, Sandt C, van Pittius DG, Douce G, Sockalingum GD, Sule-Suso J. 2010. FTIR microspectroscopy of stained cells and tissues. Application in cancer diagnosis. SPECTROSCOPY-AN INTERNATIONAL JOURNAL (vol. 24, pp. 73-78). link> doi>
  • Yang Y, Iftimia A, Jia Y, Gould T, El Haj A, Wang RK. 2010. The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE IV (vol. 7566). link> doi>
  • Yang Y, Aydin HM, Piskin E, El Haj AJ. 2009. Assessment of a new biomimetic scaffold and its effects on bone formation by OCT. OPTICS IN BONE BIOLOGY AND DIAGNOSTICS (vol. 7166). link> doi>
  • Ahearne M, Liu KK, Yang Y. 2009. Dual-Camera Spherical Indentation System for Examining the Mechanical Characteristics of Hydrogels. 4TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING (vol. 22, pp. 2011-2014). link>
  • Pijanka JK, Yang Y, Bagnaninchi PO, Debelle L, Sockalingum GD, Sule-Suso J. 2009. Elastin peptides increase lung cancer cell growth in 3D models. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE III (vol. 7179). link> doi>
  • Yang Y, Ahearne M, Wimpenny I, Torbet J. 2009. Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by PSOCT. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE III (vol. 7179). link> doi>
  • Pijanka JK, Kohler A, Yang Y, Dumas P, Chio-Srichan S, Manfait M, Sockalingum GD, Sulé-Suso J. 2009. Spectroscopic signatures of single, isolated cancer cell nuclei using synchrotron infrared microscopy. Analyst (vol. 134, pp. 1176-1181). link> doi>
  • Yang Y, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Characterisation of scaffold architecture and tendons using optical coherence tomography and polarisation-sensitive optical coherence tomography. IET OPTOELECTRONICS (vol. 2, pp. 188-194). link> doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2008. Three-dimensional ingrowth of bone cells within biodegradable cryogel scaffolds in bioreactors at different regimes. Tissue Eng Part A (vol. 14, pp. 1743-1750). link> doi>
  • Bagnaninchi PO, Churmakov D, Bonesi M, Yang Y, Phelan C, Maffulli N, Meglinski I, El Haj A. 2008. Tendon collagen orientation and crimp pattern characterized by PSOCT. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A28-A29). link>
  • Araujo JV, Cunha-Reis C, Gogniat G, Yang Y, Ashammakhi N, Reis RL, El Haj AJ, Neves NM. 2008. Dynamic studies of biomimetic coated polycaprolactone nanofiber meshes as bone extracellular matrix analogues. TISSUE ENGINEERING PART A (vol. 14, pp. 723-724). link>
  • Wimpenny I, Yang Y, Ashammakhi N. 2008. Modified collector geometry for electrospun nanofibers. TISSUE ENGINEERING PART A (vol. 14, pp. 881-882). link>
  • Aydin HM, Yang Y, Kohler T, Piskin E. 2008. Novel technique for HA particle coating within 3D polymeric structures. TISSUE ENGINEERING PART A (vol. 14, p. 890). link>
  • Cunha-Reis C, El Haj AJ, Yang Y. 2008. Real time monitoring of scaffold degradation under culture conditions. TISSUE ENGINEERING PART A (vol. 14, p. 903). link>
  • Yang Y, Ahearne M, Bagnaninchi PO, El Haj AJ. 2008. Visualization of structural evolution in tissue engineering tendon. TISSUE ENGINEERING PART A (vol. 14, p. 795). link>
  • Yang Y, Ahearne M, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Application of polarization OCT in tissue engineering - art. no. 68580K. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE II (vol. 6858, p. K8580). link> doi>
  • Liu K-K, Ahearne M, Siamantouras E, Yang Y. 2008. Micro-Shaft-Poking - a Novel Instrument for Mechanically Characterizing Soft Biomimetic Membrance. In TFB. Filho & H. Gamboa (Eds.). BIODEVICES (2) (pp. 210-215). INSTICC - Institute for Systems and Technologies of Information, Control and Communication. link>
  • Bagnaninchi PO, Churmakov D, Bonesi M, Yang Y, Phelan C, Maffulli N, Meglinski I, El Haj A. 2008. Optical properties of human tendons characterized by PSOCT and their relation to tendinopothy: A clinical study. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XIX (vol. 6854). link> doi>
  • Yang Y, Sule-Suso J, Sockalingum GD. 2008. Study of melanoma invasion by FTIR spectroscopy - art. no. 68591U. IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES VI (vol. 6859, p. U8591). link> doi>
  • Cunha-Reis C, Bagnaninchi PO, El Haj AJ, Yang Y. 2007. Exploring fluorescence as a tool for real-time monitoring of scaffolds degradation. TISSUE ENGINEERING (vol. 13, p. 1694). link>
  • Bolgen N, Yang Y, Korkusuz P, El Haj AJ, Piskin E. 2007. Interaction of cells with novel biodegradable cryogels in bioreactors. TISSUE ENGINEERING (vol. 13, p. 1718). link>
  • Cunha-Reis C, TuzlaKoglu K, Baas E, Yang Y, El Haj A, Reis RL. 2007. Influence of porosity and fibre diameter on the degradation of chitosan fibre-mesh scaffolds and cell adhesion. J Mater Sci Mater Med (vol. 18, pp. 195-200). link> doi>
  • Yang Y, Bagnaninchi PO, Ahearne M, Wang RK, Liu K-K. 2007. A novel OCT-based micro-indentation technique for mechanical characterization of soft tissues. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
  • Yang Y, Bagnaninchi PO, Cunha-Reis C, Aydin HM, Piskin E, El Haj A. 2007. Characterisation of scaffold architecture by optical coherence tomography. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
  • Bagnaninchi PO, Yang Y, El Haj A, Hinds MT, Wang RK. 2007. Characterization of local fluid flow in 3D porous construct characterized by fourier domain doppler optical coherence tomography. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
  • Bagnaninchi PO, El Haj A, Yang Y. 2007. Continuous monitoring of tissue growth inside a perfusion bioreactor by optical coherence tomography. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
  • Bagnaninchi PO, Yang Y, Maffulli N, Wang RK, El Haj A. 2006. Monitoring tissue formation and organization of engineered tendon by optical coherence tomography. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XVII (vol. 6084). link> doi>
  • Yang Y, Hoban PR, Sule-Suso J, Holley S, El Haj AJ, Bahrami F, Wang RK. 2006. Study cell invasion by optical techniques. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XVII (vol. 6084). link> doi>
  • Yang Y, Wang RKK, Guyot E, El Haj A, Dubois A. 2005. Application of optical coherence tomography for issue engineering. Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX (vol. 5690, pp. 18-23). link> doi>
  • Yang Y, Bagnaninch PO, Wood MA, El Haj AJ, Guyot E, Dubois A, Wang RKK. 2005. Monitoring cell profile in tissue engineered constructs by OCT. Optical Interactions with Tissue and Cells XVI (vol. 5695, pp. 51-57). link> doi>
  • HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. A study of the effects of seeding density, media flow and biochemical stimuli on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of the Combined Meeting of the Tissue Engineering Society International ? European Tissue Engineering Society Meeting.
  • HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. The effects of a 3D environment on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of Tissue and Cell Engineering Society Spring Meeting.
  • Then KY, Yang Y, Curtis A, Monaghan W, Shah S, McDonnell P, El Haj AJ. 2003. Effect of microtopographical cue on human corneal keratocytes orientation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (vol. 44, p. U254). link>
  • Then KY, Yang Y, Shah S, McDonnell P, El Haj AJ, IPD, IPD. 2003. Reconstruction of 3D human cornea using processed porcine cornea as a biological scaffold. SOE 2003: XIV CONGRESS OF THE EUROPEAN SOCIETY OF OPHTHALMOLOGY (pp. 275-280). link>
  • Cowell A, Yang Y, Rolfe P, El Haj AJ. 1998. In vitro monitoring of cytochrome oxidase activity in neuronal cells. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2939-2940). link>
  • Guan G, Song S, Huang Z, Yang Y. 2015. Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS XII (vol. 9322). link> doi>
  • Yang Y, Bhunia S, Kontronias R, Qamar S, Srinivasan L, Ipek T, Deegan A, Lyu L. 2015. Engineering In Vitro Differentiation Microenvironments to Study Heart Valve Calcification. TISSUE ENGINEERING PART A (vol. 21, p. S29). link>
  • Guler S, Aydin HM, Lü L-X, Yang Y. 2017. Improvement of Decellularization Efficiency of Porcine Aorta Using Dimethyl Sulfoxide as a Penetration Enhancer. Artif Organs. link> doi>
  • Lyu L and Yang Y. 2015. Multi-functional PLGA Scaffolds For Vascularization In Bone Tissue Constructs. TISSUE ENGINEERING PART A (vol. 21, p. S126). link>

MSc courses in

MTE-40036 Biomaterials, module leader
MTE-40024 Human Anatomy and Physiology, module leader
MTE-40033 Cell and Tissue Engineering, contributor
MTE-40034 Cell Biomechanics, contributor
MTE-40022 Bioreactor and Growth Environment, contributor
MTE-30002 Introduction of Biomedical Engineering, module leader

Coordinator: 3+1+1 programme with Guangzhou University

Supervising final year student projects in Life Science, Medicine and MSc projects

University Duties

  • Chair of Postgraduate Medical School Safety Committee 2006-2015
  • Departmental Safety adviser in Postgraduate Medical School 2004-
  • Departmental COSHH Officer in Postgraduate Medical School 2004-
  • Departmental Laser Safety Adviser in Postgraduate Medical School 2004-
  • Departmental Radiotion Safety Adviser in Postgraduate Medical School 2004-
  • MSc course director of Biomedical Engineering 2008-2014

 

Membership of Professional Associations

  • Member of European Biomaterials Society
  • 2003-2006 Member of IPEM (SIG)
  • 2005-present member of SPIE
  • 2006-present EPSRC College membership

 

  • 2016 £6000, The British Council Newton Fund: PhD Placement grant (PI)
  • 2015 £55,000, EPSRC CDT PhD studentship (PI), ‘Tissue engineering retinal and glaucoma eye models for better clinical treatment’
  • 2015 £30,000, EPSRC, min-project (PI), Diagnostic tool to identify donor dependent heterogeneity population
  • 2015 £29,000 , Acorn fund (Co-I), ‘A tissue engineering approach to improve lung function and clinical outcome in patients with emphysema’
  • 2015 £195,000, MRC (Co-I), ‘Hub of engineering and exploiting the stem cell niche’
  • 2015 £12,000 Chinese Studentship Council (PI), One year joint PhD studentship, ‘Novel peptides and surface modification strategies for anti-microbial devices’
  • 2014 €181,000 EC Maria Curie incoming fellowship (PI), ‘Smart scaffolds for bone regeneration’
  • 2014 £12,000 UHNS fund (PI), ‘Prolapse mechanism study with ethical approval for 100 patient samples’
  • 2014 £81,000 PhD studentship (PI), Jordan local organization, ‘New strategies for cartilage regeneration’
  • 2014 £100,000 PhD studentship (PI), Iraqi Government, ‘Pseudoislet formation on diabetes study’
  • 2014 £72,000 PhD studentship (PI), Rivers state sustainable development agency, Nigeria, ‘Prolapse and ageing study’
  • 2014 £100,000 Medical Institute of North Staffordshire (PI), ‘Better glaucoma treatment’
  • 2013 ¥880,000 Chinese NSFC (Co-I), ‘New bioorganic-metal for ship antifouling and drag reduction’
  • 2013 £100,000 EPSRC manufacture centre (Co-I), ‘Challenge-Led Regenerative Medicine Manufacturing Research’
  • 2012 £104,000 BHF PhD Studentship (PI), ‘Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis’
  • 2012 £20,000 NHS Charitable fund (PI), ‘Development of a rapid bone formation technique for clinical applications’
  • 2012 £371,000 EU FP7 project (Co-I), ‘Biodesign’
  • 2012 £11,400 Royal society of International exchange (PI), ‘Control and mapping of mechanical signals in pre-vascularized engineered bone’
  • 2012 £25,000 Acorn fund (PI), PhD studentship, ‘Acceleration of bone formation’
  • 2011 2 month high magnetic field time and secondment funding, EuroMagNET II (PI), ‘Generation of orthogonal aligned fibers in hybrid hydrogels for corneal regeneration’
  • 2011 £68,000 EPSRC DTC PhD studentship (Co-I), ‘Generating 3D neuronal networks in vitro – towards therapies for Huntington’s disease’
  • 2010 £68,000 EPSRC DTC PhD studentship (Co-I), ‘Development new nanotechnology for spinal cord repair’
  • 2010 £21,000 Acorn fund (PI), PhD studentship, ‘Study of calcification mechanism in heart valve’
  • 2009 £68,000 EPSRC DTC PhD studentship (PI), ‘Development new corneal model for drug screening’
  • 2009 € 90,000 EU, 7th Framework, Marie Curie Action (PI), ‘Development of new strategies for osteochondral regeneration
  • 2008 £9,000 BBSRC pathfinder (PI), ‘Development and commercialization of a surgical phantom system for the brain research, therapy and education’
  • 2008 £10,000 The Innovation Keele (PI), one postdoctoral, ‘Development of phantom kit for mammal brain therapeutic surgery’
  • 2007 £413,000 BBSRC (PI), one postdoctoral, ‘Novel in vitro corneal model with on-line mechanical characterisation for pharmaceutical screening and tissue engineering’
  • 2007 £22,000 Acorn fund (Co-I), PhD student, ‘Study of cancer cell sensitivity to chemotherapy and tumour cell invasion’
  • 2007 £525,000 BBSRC (Co-I), two postdoctorals, ‘In vitro (pre)construction of neural circuits in transplantable, biodegradable scaffolds for CNS repair in vivo’
  • 2006 £54,000 BBSRC CASE studentship (PI), ‘Development of degradable nanofiber scaffolds for regenerative medicine’
  • 2006 £20,000 Institute of orthopaedics, Oswestry (Co-I), ‘Development of nanofiber based constructs for regenerative medicine’
  • 2005 £280,000 EU network, EXPERTISSUE (Co-PI), ‘Novel therapeutic strategies for tissue engineering of bone and cartilage using second generation biomimetic scaffolds’
  • 2005 £60,000 Marie Curie scholarship (PI), PhD studentship, ‘Novel sensing scaffolds for tissue engineering’
  • 2004 £171,000 BBSRC (Co-I), one postdoctoral, ‘Quantitative on-line assessment of collagen fibre organization in connective tissue in vivo and during conditioning in vitro’
  • 2003 £207,000 EPSRC (PI), one postdoctoral and one PhD studentship, ‘Development of mechano-active scaffolds for tissue engineering’