Dr Pensee Wu

Title: Lecturer in Obstetrics & Gynaecology,
Honorary Consultant Obstetrician and Fetal Medicine Subspecialist at UHNM
Phone: +44 (0)1782 674387
Email: p.wu@keele.ac.uk
Location: Institute for Science and Technology in Medicine, Keele University,
Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM Research theme: Regenerative Medicine
Contacting me: By e-mail please.
Pensee_Wu_250x175

Dr. Wu studied Medicine at the University of Edinburgh and did her clinical training in Obstetrics and Gynaecology in Edinburgh and Oxford, followed by a National Training number in the Eastern Deanery. 

Taking time out of programme for an MD(Res) degree at Imperial College London, Dr. Wu was funded y Wellbeing of Women to assess the potential intrauterine cell transplantation in treating muscular dystrophy and completed her clinical training in Glasgow, subspecialising in Maternal Fetal Medicine. 

Dr. Wu's interests are in pregnancy complications, such as pre-eclampsia, gestational diabetes and preterm labour, and their long-term health impact. Her research group studies these areas through applied clinical research and translational approaches. 

At Keele, Dr. Wu is a member of ethics and peer review committees. Nationally, she has been the Clinical Speciality Lead in Reproductive health and childbirth for NIHR CRN West Midlands and currently sits on the NICE committee for multiple obstetric guidelines. 

Research interests 

  • Gestational hypertensive disease in pregnancy 
  • Gestational diabetes 
  • Preterm labour
  • Metabolic syndrome 

Selected Publications

  • Su Y-C, Feng Y-H, Wu H-T, Huang Y-S, Tung C-L, Wu P, Chang C-J, Shiau A-L, Wu C-L. 2018. Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Sci Rep, vol. 8(1), 6586. link> doi> full text>
  • Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O'Brien S, Chew-Graham CA, Verma G, Kadam UT, Mamas MA. 2018. Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. J Am Heart Assoc, vol. 7(2). link> doi> full text>
  • Heald AH, Livingston M, Holland D, Robinson J, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA. 2018. Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Int J Clin Pract, vol. 72(1). link> doi>
  • Heald A, Livingstone M, Holland D, Robinson J, Moreno G, Donnahey G, Duff C, Wu P, Fryer A. 2017. Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Endocrine Abstracts. doi> link>
  • Livingston M, Holland D, Kalansooriya A, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA, Heald AH. 2017. Polycystic ovarian syndrome: Social situation influences outcome. Int J Clin Pract, vol. 71(8). link> doi>

Full Publications List show

Journal Articles

  • Su Y-C, Feng Y-H, Wu H-T, Huang Y-S, Tung C-L, Wu P, Chang C-J, Shiau A-L, Wu C-L. 2018. Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Sci Rep, vol. 8(1), 6586. link> doi> full text>
  • Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O'Brien S, Chew-Graham CA, Verma G, Kadam UT, Mamas MA. 2018. Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. J Am Heart Assoc, vol. 7(2). link> doi> full text>
  • Heald AH, Livingston M, Holland D, Robinson J, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA. 2018. Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Int J Clin Pract, vol. 72(1). link> doi>
  • Livingston M, Holland D, Kalansooriya A, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA, Heald AH. 2017. Polycystic ovarian syndrome: Social situation influences outcome. Int J Clin Pract, vol. 71(8). link> doi>
  • Ou H-Y, Wu H-T, Lin C-H, Du Y-F, Hu C-Y, Hung H-C, Wu P, Li H-Y, Wang S-H, Chang C-J. 2017. The hepatic protection effects of hepassocin in hyperglycemic crisis. Journal of Clinical Endocrinology and Metabolism. link> doi> link>
  • Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MA. 2017. Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi> full text>
  • Wu P, Kwok CS, Haththotuwa R, Kotronias RA, Babu A, Fryer AA, Myint PK, Chew-Graham CA, Mamas MA. Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi> full text>
  • Lu C-S, Shieh G-S, Wang C-T, Su B-H, Su Y-C, Chen Y-C, Su W-C, Wu P, Yang W-H, Shiau A-L, Wu C-L. 2017. Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer. Oncotarget, vol. 8(19), 30844-30858. link> doi> full text>
  • Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW, Fryer AA. 2018. Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, vol. 13(2), 122-128. link> doi> full text>
  • Wu P, van den Berg C, Alfirevic Z, O'Brien S, Röthlisberger M, Baker PN, Kenny LC, Kublickiene K, Duvekot JJ. 2015. Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis. Int J Mol Sci, vol. 16(9), 23035-23056. link> doi> full text>
  • Wu P, Whiteford M, Cameron A. 2014. Preimplantation Genetic Diagnosis. Obstetrics, Gynaecology and Reproductive Medicine, vol. 24(3), 67-73. doi>
  • Su B-H, Tseng Y-L, Shieh G-S, Chen Y-C, Shiang Y-C, Wu P, Li K-J, Yen T-H, Shiau A-L, Wu C-L. 2013. Prothymosin α overexpression contributes to the development of pulmonary emphysema. Nat Commun, vol. 4, 1906. link> doi> full text>
  • Wu P, Poole TC, Pickett JA, Bhat A, Lees CC. 2013. Current obstetric guidelines on thromboprophylaxis in the United Kingdom: evidence based medicine?. Eur J Obstet Gynecol Reprod Biol, vol. 168(1), 7-11. link> doi>
  • Shaw C, Wu P, Sriemevan A. 2011. First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. BMJ Case Reports. doi>
  • Abouzeid H, Wu P, Mohammed N, Al-Samarrai M. 2009. Group A streptococcal puerperal sepsis: The return of a potentially fatal disease. Journal of Obstetrics and Gynaecology, vol. 25(8), 806-808. doi>
  • Chang C-C, Shieh G-S, Wu P, Lin C-C, Shiau A-L, Wu C-L. 2008. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res, vol. 68(15), 6281-6291. link> doi>
  • Wu C-L, Shieh G-S, Chang C-C, Yo Y-T, Su C-H, Chang M-Y, Huang Y-H, Wu P, Shiau A-L. 2008. Tumor-selective replication of an oncolytic adenovirus carrying oct-3/4 response elements in murine metastatic bladder cancer models. Clin Cancer Res, vol. 14(4), 1228-1238. link> doi>
  • Wu CL, Wu P, Shiau AL. 1999. A Computerized Management System for Cell Bank. Analytical Biochemistry, vol. 275(2), 260-262. doi>
  • Shiau AL, Yang HM, Wu P, Wu CL. 1998. Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Therapy (Basingstoke), vol. 5(11), 1571-1574.
  • Shiau AL, Su YC, Feng YH, Wu HT, Huang YS, Wu P, Chang CJ, Wu CL. 2014. Elovl6 overexpression promotes liver carcinogenesis. EUROPEAN JOURNAL OF CANCER, vol. 50, S75. link> doi>
  • Lawrie SM, Martin K, McNeill G, Drife J, Chrystie P, Reid A, Wu P, Nammary S, Ball J. 1998. General practitioners' attitudes to psychiatric and medical illness. Psychol Med, vol. 28(6), 1463-1467. link> doi>
  • Morganstein DL, Wu P, Mane MR, Fisk NM, White R, Parker MG. 2010. Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Cell Res, vol. 20(4), 434-444. link> doi> full text>
  • Wong CW, Kwok CS, Narain A, Gulati M, Mihalidou AS, Wu P, Alasnag M, Myint PK, Mamas MA. 2018. Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis. Heart. link> doi> full text>
  • Su B-H, Tseng Y-L, Shieh G-S, Chen Y-C, Wu P, Shiau A-L, Wu C-L. 2016. Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema. J Pathol, vol. 238(3), 412-422. link> doi>
  • Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O’Brien S, Chew-Graham C, Verma G, Kadam U, Mamas M. Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. Journal of the American Heart Association. full text>
  • Su Y-C, Ou H-Y, Wu H-T, Wu P, Chen Y-C, Su B-H, Shiau A-L, Chang C-J, Wu C-L. 2015. Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance. J Clin Endocrinol Metab, vol. 100(11), 4114-4123. link> doi>

Other

  • Heald A, Livingstone M, Holland D, Robinson J, Moreno G, Donnahey G, Duff C, Wu P, Fryer A. 2017. Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Endocrine Abstracts. doi> link>
  • Wu CL, Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Chang CJ, Shiau AL. 2016. Lentivirus-mediated silencing of prothymosin a expression ameliorates high-fat diet-induced insulin resistance in mice. HUMAN GENE THERAPY (vol. 27, pp. A177-A178). link>
  • Fernando T, Nayak A, Indusekhar R, Varadhan L, Wu P. 2016. Women at high risk for gestational diabetes but with normal glucose tolerance test - do they have more adverse outcomes than women at low risk for gestational diabetes?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (vol. 123, p. 35). link>
  • Wu H-T, Su M-T, Tsai P-Y, Ou H-Y, Chang C-J, Wu C-L, Wu P. 2015. The role of hepassocin in gestational diabetes mellitus. DIABETOLOGIA (vol. 58, p. S491). link>

MBChB teaching: Women’s Health module, Student Selected Components in Women’s Health, Case Illustrated Learning and Professional Development Tutor.

Master and PhD student supervision: MPhil/MMedSci in Clinical/Atonomical Sciences, MSc/PhD in Cell and Tissue Engineering 

Dr. Wu is interested in working with researchers and students on projects involving women's health. Please contact her by email to discuss research opportunities and collaborations.