Dr Pensee Wu

Title: Lecturer in Obstetrics & Gynaecology,
Honorary Consultant Obstetrician and Fetal Medicine Subspecialist at UHNM
Phone: +44 (0)1782 674387
Email: p.wu@keele.ac.uk
Location: Institute for Science and Technology in Medicine, Keele University,
Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM Research theme: Regenerative Medicine
Contacting me: By e-mail please.
Pensee_Wu_250x175

I studied medicine at University of Edinburgh and did my clinical training in Obstetrics and Gynaecology in Edinburgh and Oxford, followed by a National Training number in the Eastern Deanery.

I took time out of programme for an MD(Res) degree at Imperial College London, funded by Wellbeing of Women, to assess the potential of intrauterine stem cell transplantation in treating muscular dystrophy. I completed my clinical training in Glasgow, subspecialising in Maternal Fetal Medicine.

My research interests are: pre-eclampsia, gestational diabetes and congenital diseases. My group research these topics through translational medicine using regenerative medicine and molecular biology approaches, as well as through clinical research using epidemiological approaches.

At Keele, I am a member of Athena Swan, Ethics and Peer Review committees. Nationally, I am the Clinical Specialty lead in Reproductive health and childbirth for NIHR CRN West Midlands.

ISTM Research theme: Regenerative Medicine

Research interests 

  • Regenerative medicine approaches in congenital disorders and high-risk pregnancies
  • Long-term health following pregnancy complications e.g. pre-eclampsia and gestational diabetes
  • Epigenetics in metabolic syndrome

Selected Publications

  • Heald A, Livingstone M, Holland D, Robinson J, Moreno G, Donnahey G, Duff C, Wu P, Fryer A. 2017. Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Endocrine Abstracts. doi> link>
  • Livingston M, Holland D, Kalansooriya A, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA, Heald AH. 2017. Polycystic ovarian syndrome: Social situation influences outcome. Int J Clin Pract, vol. 71(8). link> doi>
  • Ou H-Y, Wu H-T, Lin C-H, Du Y-F, Hu C-Y, Hung H-C, Wu P, Li H-Y, Wang S-H, Chang C-J. 2017. The hepatic protection effects of hepassocin in hyperglycemic crisis. Journal of Clinical Endocrinology and Metabolism. link> doi> link>
  • Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MA. 2017. Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi>
  • Wu P, Kwok CS, Haththotuwa R, Kotronias RA, Babu A, Fryer AA, Myint PK, Chew-Graham CA, Mamas MA. 2016. Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi>

Full Publications List show

Journal Articles

  • Livingston M, Holland D, Kalansooriya A, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA, Heald AH. 2017. Polycystic ovarian syndrome: Social situation influences outcome. Int J Clin Pract, vol. 71(8). link> doi>
  • Ou H-Y, Wu H-T, Lin C-H, Du Y-F, Hu C-Y, Hung H-C, Wu P, Li H-Y, Wang S-H, Chang C-J. 2017. The hepatic protection effects of hepassocin in hyperglycemic crisis. Journal of Clinical Endocrinology and Metabolism. link> doi> link>
  • Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MA. 2017. Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi>
  • Wu P, Kwok CS, Haththotuwa R, Kotronias RA, Babu A, Fryer AA, Myint PK, Chew-Graham CA, Mamas MA. 2016. Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi>
  • Lu C-S, Shieh G-S, Wang C-T, Su B-H, Su Y-C, Chen Y-C, Su W-C, Wu P, Yang W-H, Shiau A-L, Wu C-L. 2017. Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer. Oncotarget, vol. 8(19), 30844-30858. link> doi>
  • Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW, Fryer AA. 2016. Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 0. link> doi>
  • Wu P, van den Berg C, Alfirevic Z, O'Brien S, Röthlisberger M, Baker PN, Kenny LC, Kublickiene K, Duvekot JJ. 2015. Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis. Int J Mol Sci, vol. 16(9), 23035-23056. link> doi>
  • Wu P, Whiteford M, Cameron A. 2014. Preimplantation Genetic Diagnosis. Obstetrics, Gynaecology and Reproductive Medicine, vol. 24(3), 67-73. doi>
  • Su B-H, Tseng Y-L, Shieh G-S, Chen Y-C, Shiang Y-C, Wu P, Li K-J, Yen T-H, Shiau A-L, Wu C-L. 2013. Prothymosin α overexpression contributes to the development of pulmonary emphysema. Nat Commun, vol. 4, 1906. link> doi>
  • Wu P, Poole TC, Pickett JA, Bhat A, Lees CC. 2013. Current obstetric guidelines on thromboprophylaxis in the United Kingdom: evidence based medicine?. Eur J Obstet Gynecol Reprod Biol, vol. 168(1), 7-11. link> doi>
  • Shaw C, Wu P, Sriemevan A. 2011. First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. BMJ Case Reports. doi>
  • Abouzeid H, Wu P, Mohammed N, Al-Samarrai M. 2009. Group A streptococcal puerperal sepsis: The return of a potentially fatal disease. Journal of Obstetrics and Gynaecology, vol. 25(8), 806-808. doi>
  • Chang C-C, Shieh G-S, Wu P, Lin C-C, Shiau A-L, Wu C-L. 2008. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res, vol. 68(15), 6281-6291. link> doi>
  • Wu C-L, Shieh G-S, Chang C-C, Yo Y-T, Su C-H, Chang M-Y, Huang Y-H, Wu P, Shiau A-L. 2008. Tumor-selective replication of an oncolytic adenovirus carrying oct-3/4 response elements in murine metastatic bladder cancer models. Clin Cancer Res, vol. 14(4), 1228-1238. link> doi>
  • Wu CL, Wu P, Shiau AL. 1999. A Computerized Management System for Cell Bank. Analytical Biochemistry, vol. 275(2), 260-262. doi>
  • Shiau AL, Yang HM, Wu P, Wu CL. 1998. Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Therapy (Basingstoke), vol. 5(11), 1571-1574.
  • Shiau AL, Su YC, Feng YH, Wu HT, Huang YS, Wu P, Chang CJ, Wu CL. 2014. Elovl6 overexpression promotes liver carcinogenesis. EUROPEAN JOURNAL OF CANCER, vol. 50, S75. link> doi>
  • Lawrie SM, Martin K, McNeill G, Drife J, Chrystie P, Reid A, Wu P, Nammary S, Ball J. 1998. General practitioners' attitudes to psychiatric and medical illness. Psychol Med, vol. 28(6), 1463-1467. link> doi>
  • Morganstein DL, Wu P, Mane MR, Fisk NM, White R, Parker MG. 2010. Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Cell Res, vol. 20(4), 434-444. link> doi>
  • Su B-H, Tseng Y-L, Shieh G-S, Chen Y-C, Wu P, Shiau A-L, Wu C-L. 2016. Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema. J Pathol, vol. 238(3), 412-422. link> doi>
  • Wu P, Gulati M, Kwok CS, Wong C, Narain A, O'Brien S, Chew-Graham C, Verma G, Kadam UT, Mamas M. Preterm birth and maternal cardiovascular outcomes: a systematic review and meta-analysis. Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.
  • Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O’Brien S, Chew-Graham C, Verma G, Kadam U, Mamas M. Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. Journal of the American Heart Association.
  • Su Y-C, Ou H-Y, Wu H-T, Wu P, Chen Y-C, Su B-H, Shiau A-L, Chang C-J, Wu C-L. 2015. Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance. J Clin Endocrinol Metab, vol. 100(11), 4114-4123. link> doi>

Other

  • Heald A, Livingstone M, Holland D, Robinson J, Moreno G, Donnahey G, Duff C, Wu P, Fryer A. 2017. Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Endocrine Abstracts. doi> link>
  • Wu CL, Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Chang CJ, Shiau AL. 2016. Lentivirus-mediated silencing of prothymosin a expression ameliorates high-fat diet-induced insulin resistance in mice. HUMAN GENE THERAPY (vol. 27, pp. A177-A178). link>
  • Fernando T, Nayak A, Indusekhar R, Varadhan L, Wu P. 2016. Women at high risk for gestational diabetes but with normal glucose tolerance test - do they have more adverse outcomes than women at low risk for gestational diabetes?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (vol. 123, p. 35). link>
  • Wu H-T, Su M-T, Tsai P-Y, Ou H-Y, Chang C-J, Wu C-L, Wu P. 2015. The role of hepassocin in gestational diabetes mellitus. DIABETOLOGIA (vol. 58, p. S491). link>

MBChB teaching: Women’s Health module, Student Selected Components in Women’s Health, Case Illustrated Learning and Professional Development Tutor.

Master and PhD student supervision: MSc in Cell and Tissue Engineering, MMedSci in Anatomical Sciences, MPhil in Clinical Sciences, and PhD in Regenerative Medicine