Dr Heidi Fuller

Title: Lecturer in Medical Science
Phone: +44 (0)1691 404693 (RJAH)
+44 (0)1782 734546 (Keele Hall)
Email: h.r.fuller@keele.ac.uk
Location: 1. Wolfson Centre for Inherited Neuromuscular Disease, TORCH Building, RJAH Orthopaedic Hospital
Oswestry, SY10 7AG
2. Room 76, Keele Hall, University of Keele, Staffordshire, ST5 5BG
Role: ISTM Research theme: Therapeutics
Contacting me: By phone or e-mail
Heidi_Fuller_2012_200x275
2016-present Lecturer in Medical Science, School of Medicine, Keele University
2018 – present

Deputy Director of the ​Wolfson Centre for Inherited Neuromuscular Disease, RJAH Orthopaedic Hospital, Shropshire

2016 – present Director of the Masters in Medical Science, Postgraduate Medicine, Keele
2013 – 2016

Research Fellow (80% FTE), Institute for Science, Technology and Medicine (ISTM), University of Keele (based at the RJAH Orthopaedic Hospital)

2013 – 2016 Teaching Fellow (20% FTE), Postgraduate Medicine, University of Keele
2011

Visiting Postdoctoral Researcher: Harvard University, Boston Children’s Hospital.

2006 – 2013

Manager of the Keele University Mass Spectrometry Facility, RJAH Orthopaedic Hospital, Shropshire

2005 – 2013 Postdoctoral Research Scientist, Wolfson Centre for Inherited Neuromuscular Disease, RJAH Orthopaedic Hospital, Shropshire
2002 – 2005 

Ph.D.; Biochemistry (EPSRC Industrial CASE award), Prof Glenn Morris’ lab, University of Wales, Wrexham, UK.

1999 – 2002  B.Sc. Honours; Biomolecular Science, University of Wales, Bangor, UK.
1998 – 1999 

Research Assistant, Prof Mike Doenhoff’s Laboratory, University of Wales, Bangor.

ISTM Research theme: Therapeutics

My research group is based at the Wolfson Centre for Inherited Neuromuscular Disease (RJAH Orthopaedic Hospital), where we focus on several of the most severe muscle-wasting diseases, including muscular dystrophy, and the childhood form of motor neuron disease, spinal muscular atrophy. By combining the use of cutting edge proteomics and bioinformatics tools with biochemical approaches our aim is to understand disease mechanisms and to identify novel proteins and pathways that can be modulated by drug treatment.

External collaborators include:

  • Prof Tom Gillingwater (Edinburgh University, UK)
  • Prof Kevin Talbot (Oxford University, UK)
  • Dr Gillian Hunter (Glasgow Caledonian University)
  • Dr Tom Wishart (The Roslin Institute, Edinburgh)
  • Dr Dhruv Sareen (Ceders Sinai Medical Center, Los Angeles)
  • Prof Goran Simic (University of Zagreb, Croatia)
Funded projects (current):

Joint Sparks and GOSH Charity National Funding (UK) - £192,945
Therapy development for childhood motor neuron disease
Awarded to Heidi Fuller (Principle Applicant)

Keele University - £57,017.
Funding for 3-year PhD studentship
Awarded to Heidi Fuller (Principle Applicant)

Newlife Foundation for Disabled Children, UK - £14,800
Omics-assisted drug discovery for childhood motor neuron disease
Awarded to Heidi Fuller (Principle Applicant)

Spinal Injuries Fund, RJAH Orthopaedic Hospital (UK) - £95,675
A Systems Biology Approach to Identify Prognostic Indicators and New Targets for the Treatment of Spinal Cord Injury
Awarded to Karina Wright (Principle Applicant) and Heidi Fuller (Co-applicant)

Keele University - £67,000
Funding for 3-year PhD studentship
Awarded to Monte Gates (Principle Applicant) and Heidi Fuller (Co-applicant)

Arthritis Research (UK) - £189,195
Individualisation of biological therapies for osteoarthritis – understanding and reducing failures. Awarded to Karina Wright (Principle Applicant), and co-applicants Sally Roberts, Heidi Fuller and James Richardson.

Funded projects (completed):

The SMA Trust (UK) - £81,029
Two-year Career Development Fellowship: The molecular consequences of reduced SMN in iPS-derived human motor neurons
Awarded to Heidi Fuller (Principle Applicant)

Henry Smith Charity (UK) - £16,500
Identifying and Quantifying Growth Promoting Signals in the Developing Spinal Cord
Awarded to Monte Gates (Principle Applicant) and Heidi Fuller (Co-applicant)

RJAH Charitable Funds (UK) - £25,000
Anti-epileptic drugs and bone loss
Awarded to Heidi Fuller (Principle Applicant), and co-applicants Mark Garton & Glenn Morris

Henry Smith Charity (UK) - £44,871
Identifying and Quantifying Growth Promoting Signals in the Developing Spinal Cord
Awarded to Monte Gates (Principle Applicant) and Heidi Fuller (Co-applicant)

RJAH Institute of Orthopaedics (UK) - £12,917
Human stem-cell-derived motor neurons for testing potential therapeutic pathways in Spinal Muscular Atrophy (SMA), using both targeted and proteomic approaches
Awarded to Heidi Fuller (Principle Applicant).

RJAH Institute of Orthopaedics (UK) - £19,500, Childwick Trust - £2,500, and Lord Leverhulme’s Charitable Trust (UK) - £3,000
Nutritional protection against neurodegenerative disease
Awarded to Heidi Fuller (Principle Applicant).

North Staffordshire Medical Institute (UK) - £10,000
Identification of biomarkers using mass spectrometry
Awarded to Paul Roach (Principle Applicant), Heidi Fuller (co-applicant), et al.

RJAH Institute of Orthopaedics (UK) - £24,700
Funding awarded to support the service contract of the 4800 MALDI TOF/TOF mass spectrometer. Awarded to Glenn Morris (Principle Applicant) and Heidi Fuller (co-applicant).

Selected Publications

  • Gul W, Fuller HR, Wright H, Sen J. 2018. A Systematic Review And Meta-Analysis Of The Effectiveness Of Surgical Decompression In Treating Patients With Malignant Middle Cerebral Artery Infarction. World Neurosurg. link> doi> full text>
  • Chen CPC, Preston JE, Zhou S, Fuller HR, Morgan DGA, Chen R. 2018. Proteomic analysis of age-related changes in ovine cerebrospinal fluid. Exp Gerontol, vol. 108, 181-188. link> doi> full text>
  • Hulme CH, Wilson EL, Fuller HR, Roberts SR, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS CHONDROCYTE IMPLANTATION. OSTEOARTHRITIS AND CARTILAGE (vol. 26, p. S167). link> doi> full text>
  • Hulme CH, Wilson EL, Fuller HR, Roberts S, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Res Ther, vol. 20(1), 87. link> doi> full text>
  • Lake B, Fuller HR, Rastall S, Usman T. 2017. Breast reconstruction affects coping mechanisms in breast cancer survivors. Indian Journal of Surgery. doi> link> full text>

Full Publications List show

Books

  • Fuller HR and Gates MA (Eds.). 2016. Recovery of Motor Function Following Spinal Cord Injury. (12 vols.). Intech. link>

Journal Articles

  • Gul W, Fuller HR, Wright H, Sen J. 2018. A Systematic Review And Meta-Analysis Of The Effectiveness Of Surgical Decompression In Treating Patients With Malignant Middle Cerebral Artery Infarction. World Neurosurg. link> doi> full text>
  • Chen CPC, Preston JE, Zhou S, Fuller HR, Morgan DGA, Chen R. 2018. Proteomic analysis of age-related changes in ovine cerebrospinal fluid. Exp Gerontol, vol. 108, 181-188. link> doi> full text>
  • Hulme CH, Wilson EL, Fuller HR, Roberts S, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Res Ther, vol. 20(1), 87. link> doi> full text>
  • Lake B, Fuller HR, Rastall S, Usman T. 2017. Breast reconstruction affects coping mechanisms in breast cancer survivors. Indian Journal of Surgery. doi> link> full text>
  • Hurtado ML, Fuller HR, Wong AMS, Eaton SL, Gillingwater TH, Pennetta G, Cooper JD, Wishart TM. 2017. Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. SCIENTIFIC REPORTS, vol. 7, Article ARTN 12412. link> doi> full text>
  • Fuller HR, Shorrock HK, Gillingwater TH, Pigott A, Smith V, Kulshrestha R, Sewry CS, Willis TA. Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis. Journal of Neuromuscular Diseases. doi> full text>
  • Fuller HR. Reflections on an issue of student diversity: unintentional plagiarism among international students. The Journal of Academic Development and Education. full text>
  • Brown SJ, Fuller HR, Jones P, Caterson B, Shirran SL, Botting CH, Roberts S. Contaminants in commercial preparations of 'purified' small leucine-rich proteoglycans may distort mechanistic studies. Biosci Rep, vol. 37(1). link> doi> full text>
  • Hulme CH, Brown SJ, Fuller HR, Riddell J, Osman A, Chowdhury J, Kumar N, Johnson WE, Wright KT. 2017. The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood. Spinal Cord, vol. 55(2), 114-125. link> doi> full text>
  • Mladinov M, Sedmak G, Fuller HR, Babić Leko M, Mayer D, Kirincich J, Štajduhar A, Borovečki F, Hof PR, Šimić G. 2016. Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia. Transl Neurosci, vol. 7(1), 139-150. link> doi> full text>
  • Fuller HR, Gillingwater TH, Wishart TM. Commonality amid diversity: Multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy. Neuromuscul Disord, vol. 26(9), 560-569. link> doi> full text>
  • Doenhoff MJ, El-Faham M, Liddell S, Fuller HR, Stanley RG, Schramm G, Igetei JE. 2016. Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs). PLoS One, vol. 11(7), e0159542. link> doi> full text>
  • Fuller HR, Graham LC, Llavero Hurtado M, Wishart TM. Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation. Expert Rev Proteomics, vol. 13(7), 659-671. link> doi> full text>
  • Fuller HR, Marani L, Holt I, Woodhams PL, Webb MM, Gates MA. Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain. Brain Struct Funct, vol. 222(2), 867-879. link> doi> full text>
  • Wilson EL, Garton M, Fuller HR. 2016. Anti-epileptic drugs and bone loss: Phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells. Epilepsy Res, vol. 122, 97-101. link> doi> full text>
  • Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, Morris GE, Sareen D. 2015. Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Front Cell Neurosci, vol. 9, 506. link> doi> full text>
  • Fuller HR, Slade R, Jovanov-Milošević N, Babić M, Sedmak G, Šimić G, Fuszard MA, Shirran SL, Botting CH, Gates MA. 2015. Stathmin is enriched in the developing corticospinal tract. Mol Cell Neurosci, vol. 69, 12-21. link> doi> full text>
  • Walter MNM, Kohli N, Khan N, Major T, Fuller H, Wright KT, Kuiper J-H, Johnson WEB. 2015. Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. J Stem Cells Regen Med, vol. 11(1), 18-24. link> full text>
  • Hunter G, Roche SL, Somers E, Fuller HR, Gillingwater TH. 2014. The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: implications for pre-clinical studies and clinical trials for spinal muscular atrophy. Neuromuscul Disord, vol. 24(11), 973-977. link> doi>
  • Fuller HR, Hurtado ML, Wishart TM, Gates MA. 2014. The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Sci, vol. 12, 20. link> doi> full text>
  • Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH. 2014. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. J Clin Invest, vol. 124(4), 1821-1834. link> doi> full text>
  • Fuller HR, Humphrey EL, Morris GE. 2013. Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases. Future Med Chem, vol. 5(17), 2091-2101. link> doi>
  • Lam LT, Fuller HR, Morris GE. 2013. The gemin2-binding site on SMN protein: accessibility to antibody. Biochem Biophys Res Commun, vol. 438(4), 624-627. link> doi>
  • Humphrey EL, Morris GE, Fuller HR. 2013. Valproate reduces collagen and osteonectin in cultured bone cells. Epilepsy Res, vol. 106(3), 446-450. link> doi>
  • Roberts S, Fuller H, Caterson B. 2013. Uphold standards for lab reagents. NATURE, vol. 496(7445), 300. link> doi>
  • Humphrey E, Fuller HR, Morris GE. 2012. Current research on SMN protein and treatment strategies for spinal muscular atrophy. Neuromuscul Disord, vol. 22(2), 193-197. link> doi>
  • Comley LH, Fuller HR, Wishart TM, Mutsaers CA, Thomson D, Wright AK, Ribchester RR, Morris GE, Parson SH, Horsburgh K, Gillingwater TH. 2011. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. HUMAN MOLECULAR GENETICS, vol. 20(12), 2406-2421. link> doi>
  • Fuller HR and Morris GE. 2010. SMN COMPLEXES OF NUCLEUS AND CYTOPLASM: A PROTEOMIC STUDY FOR SMA THERAPY. TRANSLATIONAL NEUROSCIENCE, vol. 1(4), 261-267. link> doi>
  • Fuller HR, Barisic M, Seso-Simic D, Speljko T, Morris GE, Simic G. 2010. TREATMENT STRATEGIES FOR SPINAL MUSCULAR ATROPHY. TRANSLATIONAL NEUROSCIENCE, vol. 1(4), 308-321. link> doi>
  • Fuller HR, Man NT, Lam LT, Shamanin VA, Androphy EJ, Morris GE. 2010. Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells. JOURNAL OF PROTEOME RESEARCH, vol. 9(8), 4228-4233. link> doi>
  • Walter MNM, Wright KT, Fuller HR, MacNeil S, Johnson WEB. 2010. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res, vol. 316(7), 1271-1281. link> doi>
  • Fuller HR, Man NT, Lam LT, Thanh LT, Keough RA, Asperger A, Gonda TJ, Morris GE. 2010. The SMN Interactome Includes Myb-Binding Protein 1a. JOURNAL OF PROTEOME RESEARCH, vol. 9(1), 556-563. link> doi>
  • Nguyen thi Man, Humphrey E, Lam LT, Fuller HR, Lynch TA, Sewry CA, Goodwin PR, Mackenzie AE, Morris GE. 2008. A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy. Neurology, vol. 71(22), 1757-1763. link> doi>
  • Hao LT, Fuller HR, Lam LT, Le TT, Burghes AHM, Morris GE. 2007. Absence of gemin5 from SMN complexes in nuclear Cajal bodies. BMC CELL BIOLOGY, vol. 8, Article ARTN 28. link> doi>
  • Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding CG, Galle J, Fuller H, Stanley RG, Chiodini PL, Haas H, Doenhoff MJ. 2006. IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 147(1), 9-19. link> doi>
  • Fuller HR, Goodwin PR, Morris GE. 2006. An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food. FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 17(1), 43-52. link> doi>
  • Fuller HR, Goodwin PR, Morris GE. 2004. Shellfish allergen testing kit for food manufacturers. Advances Wales, 12.

Chapters

  • Fuller HR and Morris GE. 2012. Quantitative proteomics using iTRAQ labeling and mass spectrometry” in Integrative Proteomics. Eastwood Leung HC (Ed.). InTech. doi>

Other

  • Hulme CH, Wilson EL, Fuller HR, Roberts SR, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS CHONDROCYTE IMPLANTATION. OSTEOARTHRITIS AND CARTILAGE (vol. 26, p. S167). link> doi> full text>
  • Owen SJ, Fuller HR, Jones P, Caterson B, Shirran SL, Botting CH, Roberts S. 2017. We may not be buying what the label says on the tin: a cautionary tale from a study of the influence of proteoglycans on nerve growth. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 98, p. A4). link>
  • Hulme CH, Wilson EL, Peffers MJ, Peffers MJ, Fuller H, Roberts S, Simpson DM, Richardson JB, Gallacher P, Wright KT. 2017. POOR CLINICAL RESPONSE TO AUTOLOGOUS CHONDROCYTE IMPLANTATION IS ASSOCIATED WITH A UNIQUE SYNOVIAL FLUID PROTEOME PROFILE. OSTEOARTHRITIS AND CARTILAGE (vol. 25, p. S92). link> doi> full text>
  • Lake B, Fuller HR, Rastall S, Usman T. 2016. Breast reconstruction changes coping mechanisms in breast cancer survivorship. CANCER RESEARCH (vol. 76). link> doi>
  • Wright K, Richardson JB, Fuller H, Humphrey E, Jones P, Kerr A, Roberts S. 2013. Biomarker discovery for autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 94, p. A46). link>
  • Nguyen Thi M, Humphrey E, Le T, Fuller H, Lynch T, Sewry C, MacKenzie A, Goodwin P, Morris G. 2007. A two-site ELISA for measurement of SMN protein and its application to finding drugs for treatment of spinal muscular atrophy (SMA). NEUROMUSCULAR DISORDERS (vol. 17, pp. 781-782). link> doi>