Prof Christine Roffe

Title: Consultant in Stroke Medicine
Reader and Honorary Senior Research Fellow
Phone: +44 (0)300 123 1465
Email: Christine.roffe@northstaffs.nhs.uk
Location: Institute for Science & Technology in Medicine, Keele University,
c/o Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM Research themes: 1. Neuroscience
2. Rehabilitation
3. Health Services Research
Contacting me: By phone or email me
Christine Roffe 2016 200x244

Professor Christine Roffe took up her post as consultant/senior lecturer in October 1996 and was promoted to a Keele chair in 2010. Her Inaugural Lecture “Stroke in Stoke and beyond” took place on Tuesday, 5 October, 2010 in the Westminster Theatre at Keele. 

Prof Roffe has shaped the development of the acute and rehabilitation stroke services in North Staffordshire, with positive impact on regional and national practice. She is the Clinical Lead for the West Midlands Stroke Local Research Network. As the North Staffordshire Stroke Lead, the Clinical Lead of the Shropshire and Staffordshire Heart and Stroke Network, and a member of the Clinical Standards Committee of the British Association of Stroke Physicians she is involved in the planning organization of stroke services locally and nationally.  Prof Roffe has also become involved in European stroke research studies and has a range of collaborations in many aspects of stroke treatment and rehabilitation.

ISTM Research themes: 1. Neuroscience
                                        2. Rehabilitation
                                        3. Health Services Research

Background and Research Interests:

Prof Christine Roffe's research interests are acute stroke, stroke rehabilitation and ethics. Ongoing projects include the Stroke Oxygen Study, a clinical trial of oxygen supplementation after acute stroke, a study of the effect of thickeners in drinks on oxygen saturation in dysphagic stroke patients, a questionnaire survey of consumer views of artificial feeding after stroke, and, in collaboration with researchers from the School of Health and Rehabilitation, studies of Botulinum toxin and electrical stimulation early after stroke. She is the Clinical Lead for the West Midlands Stroke Local Research Network.

Research grants held at Keele:

The Stroke Oxygen Study (SO2S): a multi-centre, prospective, randomised, open, blinded-endpoint study of routine oxygen treatment in the first 72 hours after a stroke. C. Roffe, P. Crome, R. Gray, P. Jones, L. Handy/ Strokes R Us. NIHR RfPB £249,500.

Leadership of the West Midlands Local Stroke Research. C. Roffe, RJ McManus, GW Humphries, C Sackley, I. Shannon, S Herron-Marx, P Mayer, S Lamb, F Cappuccio. NIHR Network £3,000,000 (£400,000 per annum, 3 year rolling contract, last renewed in 2009).

 

A study of the effect swallowing different consistencies of water (plain water or water with thickener) on oxygen saturation in the blood. Investigators: Natarajan I, Roffe C.

Key Publications:

Original Research papers

Ali K, Roffe C, Crome P. What patients want: consumer involvement in the design of a randomized controlled trial of routine oxygen supplementation after acute stroke. Stroke 2006;37:865-71.

Scott F, Beech R, Smedley F, Timmis L, Stokes E, Jones P, Roffe C, Bowling T. A prospective randomized controlled single-blind trial of the costs and consequences of systematic nutrition team follow-up over 12 months after percutaneous endoscopic gastrostomy. Nutrition 2005; 21: 1071-1077.

Arora A, Gray R, Crome P, Roffe C. What do physicians with an interest in stroke consider to be best practice in the diagnosis and treatment of hypoxia after acute stroke? Br J Cardiol 2005;12:456-458.

Arora A, Arora M, Roffe C. Mystery of the missing denture: an unusual cause of respiratory arrest in a nonagenarian. Age and Ageing 005;34: 519-520.

Ali K, Sills S, Roffe C. The effect of different doses and routes of oxygen administration on oxygen saturation in stroke patients. Neurocritical Care 2005;3:24-26.

Srinivasan M, Srinivasan KS, Mansur A, Roffe C. Central nervous system infections in the elderly. Geriatric Medicine 2005;35:15-18.

Arora A, Roffe C, Crome P. An unusual and overlooked complication of nasogastric tube feeding. Age Ageing 2005;34:84-5.

Roffe C, Halim M, Wilde K, Crome P. Feasibility of the Divided Attention Steering Simulator (DASS) for the Assessment of Vigilance in Stroke Patients. Middle-East Journal of Age & Ageing 2004. http://www.me-jaa.com/mejaa2/DASS.htm

Srinivasan M, Roffe C. Cold agglutinin induced anaemia in the elderly. Geriatric Medicine 2004;34:27-30.

Roffe C, Sil ls S, Halim M, Wilde K, Allen MB, Jones PW, Crome P. Unexpected nocturnal hypoxia in patients with acute stroke. Stroke 2003;34:2641-2645.

Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Medical Science Monitor 2002;8(5):CR236-330.

Roffe C, Sills S, Wilde K, Come P. Effect of hemiparetic stroke on pulse oximetry readings on the affected side. Stroke 2001;32:1808-1810.

Roffe C, McDiarmaid-Gordon A, Hollis S, Ohanian V, Heagerty AM. The effect of afterload and angiotensin II on proto-oncogene mRNA levels in the isolated working rat heart. Cardiovascular Research 1996;31:907-916.

Roffe D, Roffe C. Madness and care in the community: a medieval perspective. BMJ 1995; 311:1708-1712.

Roffe C, Fletcher S, Woods KL. Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm after acute myocardial infarction. British Heart Journal 1994;71:141-145.

Roffe C, Smith M, Basran GSB. Is anticholinergic premedication necessary for fibreoptic bronchoscopy? Monaldi Archives for Chest Disease 1994;49(2): 101-106.

Woods KL, Fletcher S, Roffe C, Haider Y. A randomised trial of intravenous magnesium sulphas in suspected acute myocardial infarction; results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1992; 339: 1553-58.

Roffe C, Tidmarsh M, Howlett TA. Ketanserin overdose. A case report. Postgrad Med J 1991;67:857.

Roffe C, Czapla K, Patel P, Abbott RJ. Peripheral neuropathy as a complication of neuroleptic malignant syndrome. Journal of Neurology, Neurosurgery and Psychiatry 1991; 54 (3); 378-9.

Roffe C, Cahill MR, Samanta A, Bricknell S, Durrant STS. Aplastic anaemia in systemic lupus erythematosus. A cellular immune mechanism? British Journal of Rheumatology 1991; 30:301-304.

Samanta A, Haider Y, Roffe C. An audit of patients attending a general medical follow-up clinic. JR Coll Physicians London 1991; 25(1) 33-35.

Samanta A, Roffe C. Woods KL, Accidental self administration of xylazine in a veterinary nurse. Postgrad Med J 1990; 66:244-245.

Selected Publications

  • Shi Y, Cheshire D, Lally F, Roffe C. 2017. Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study. Physics in Medicine, vol. 3, 1-8. doi> link>
  • Ferdinand P and Roffe C. 2016. Hypoxia after stroke: a review of experimental and clinical evidence. Experimental and Translational Stroke Medicine, vol. 8(9). doi> link>
  • Netzer N, Ancoli-Israel S, Bliwise D, Fulda S, Roffe C, Almeida F, Onen H, Onen F, Raschke F, Garcia M, Frohnhofen H. 2016. Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force. European Respiratory Journal, vol. 48(2). doi> link>
  • Kishore A, Vail A, Bray B, Chamorro A, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd A, Tyrrell A, Van de Beek D, Woodhead M, Meisel A, Smith C. 2016. Clinical risk scores for predicting stroke-associated pneumonia: A systematic review. European Stroke Journal, vol. 1(2), 76-84. doi> link>
  • Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarria VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Ricci S, Roffe C, Pandian J, Billot L, Woodward M, Li Q, Wang X, Wang J, Chalmers J. 2016. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. The New England Journal of Medicine. doi> link>

Full Publications List show

Journal Articles

  • Shi Y, Cheshire D, Lally F, Roffe C. 2017. Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study. Physics in Medicine, vol. 3, 1-8. doi> link>
  • Ferdinand P and Roffe C. 2016. Hypoxia after stroke: a review of experimental and clinical evidence. Experimental and Translational Stroke Medicine, vol. 8(9). doi> link>
  • Netzer N, Ancoli-Israel S, Bliwise D, Fulda S, Roffe C, Almeida F, Onen H, Onen F, Raschke F, Garcia M, Frohnhofen H. 2016. Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force. European Respiratory Journal, vol. 48(2). doi> link>
  • Kishore A, Vail A, Bray B, Chamorro A, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd A, Tyrrell A, Van de Beek D, Woodhead M, Meisel A, Smith C. 2016. Clinical risk scores for predicting stroke-associated pneumonia: A systematic review. European Stroke Journal, vol. 1(2), 76-84. doi> link>
  • Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarria VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Ricci S, Roffe C, Pandian J, Billot L, Woodward M, Li Q, Wang X, Wang J, Chalmers J. 2016. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. The New England Journal of Medicine. doi> link>
  • Myint PK, Kwok CS, Roffe C, Kontopantelis E, Zaman A, Berry C, Ludman PF, de Belder MA, Mamas MA, British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research. 2016. Determinants and Outcomes of Stroke Following Percutaneous Coronary Intervention by Indication. Stroke, vol. 47(6), 1500-1507. link> doi>
  • Sprigg N, Robson K, Bath P, Dineen R, Roberts I, Robinson T, Roffe C, Werring D, Al-Shahi Salman R, Pocock S, Duley L, England T, Whynes D, Ciccone A, Laska AC, Christensen H, Ozturk S, Collins R, Bereczki D, Egea-Guerrero JJ, Law ZK, Czlonkowska A, Seiffge D, Beredzie M. 2016. Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial. International Journal of Stroke. doi> link>
  • Sim J, Teece L, Dennis MS, Roffe C, SOࠢS Study Team. 2016. Validation and Recalibration of Two Multivariable Prognostic Models for Survival and Independence in Acute Stroke. PLoS One, vol. 11(5), e0153527. link> doi>
  • Warusevitane A, Karunatilake D, Sim J, Smith C, Roffe C. 2016. Early Diagnosis of Pneumonia in Severe Stroke: Clinical Features and the Diagnostic Role of C-Reactive Protein. PLoS One, vol. 11(3), e0150269. link> doi>
  • Cohen DL, Roffe C, Beavan J, Blackett B, Fairfield CA, Hamdy S, Havard D, McFarlane M, McLauglin C, Randall M, Robson K, Scutt P, Smith C, Smithard D, Sprigg N, Warusevitane A, Watkins C, Woodhouse L, Bath PM. 2016. Post-stroke dysphagia: A review and design considerations for future trials. Int J Stroke, vol. 11(4), 399-411. link> doi>
  • Lally F, Soorani M, Woo T, Nayak S, Jadun C, Yang Y, McCrudden J, Naire S, Grunwald I, Roffe C. 2015. In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow. Journal of NeuroInterventional Surgery, vol. 8, 969-972. doi> link>
  • Warusevitane A, Karunatilake D, Sim J, Lally F, Roffe C. 2015. Safety and effect of metoclopramide to prevent pneumonia in patients with stroke fed via nasogastric tubes trial. Stroke, vol. 46(2), 454-460. link> doi>
  • Roffe C, Nevatte T, Crome P, Gray R, Sim J, Pountain S, Handy L, Handy P. 2014. The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. Trials, vol. 15, 99. link> doi>
  • Sim J, Gray R, Nevatte T, Howman A, Ives N, Roffe C. 2014. Statistical analysis plan for the Stroke Oxygen Study (SO₂S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome. Trials, vol. 15, 229. link> doi>
  • Pountain SJ and Roffe C. 2013. [Does routine oxygen administration in acute stroke patients improve treatment outcome]. Praxis (Bern 1994), vol. 102(8), 481-485. link> doi>
  • Lally F, Grunwald IQ, Sanyal R, Natarajan I, Roffe C. 2013. Mechanical thrombectomy in acute ischaemic stroke: a review of the literature, clinical effectiveness and future use. CNS Neurol Disord Drug Targets, vol. 12(2), 170-190. link> doi>
  • Sanyal R, Barrick J, Bhalla A, Cassidy T, Collas D, Cloud G, Fearon P, Gompertz P, Keir S, Khanna P, Power M, White P, Roffe C. 2013. The 2010 British Association of Stroke Physicians Survey of interventional treatments for stroke in the United Kingdom. Int J Stroke, vol. 8 Suppl A100, 62-68. link> doi>
  • Ali K, Warusevitane A, Lally F, Sim J, Sills S, Pountain S, Nevatte T, Allen M, Roffe C. 2013. The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke-effect on key outcomes at six months. PLoS One, vol. 8(6), e59274. link> doi>
  • Warusevitane AB, Karunatilake DS, Lally F, Roffe C. 2012. Does metoclopramide reduce pneumonia in acute stroke patients on nasogastric feeds?. INTERNATIONAL JOURNAL OF STROKE, vol. 7, 10. link>
  • Leathley MJ, Fitzgerald J, Fletcher M, Golton I, Jenkinson D, Price C, Quinn T, Roffe C, Williams J, Watkins C. 2012. Developing an education framework for stroke. Nurs Times, vol. 108(47), 20-21. link>
  • Malhotra S, Rosewilliam S, Hermens H, Roffe C, Jones P, Pandyan AD. 2013. A randomized controlled trial of surface neuromuscular electrical stimulation applied early after acute stroke: effects on wrist pain, spasticity and contractures. Clin Rehabil, vol. 27(7), 579-590. link> doi>
  • Frohnhofen H and Roffe C. 2012. Intermittent nocturnal hypoxemia in individuals with dementia: prevalence and relationship with functional status. J Am Geriatr Soc, vol. 60(10), 1997-1999. link> doi>
  • Rosewilliam S, Malhotra S, Roffe C, Jones P, Pandyan AD. 2012. Can surface neuromuscular electrical stimulation of the wrist and hand combined with routine therapy facilitate recovery of arm function in patients with stroke?. Arch Phys Med Rehabil, vol. 93(10), 1715-21.e1. link> doi>
  • Chembala J, Natarajan I, Roffe C. 2012. Thrombolysis in a stroke patient with Marfan syndrome. JRSM Short Rep, vol. 3(4), 22. link> doi>
  • Ali K, Tanner S, Whatley B, Rajkumar C, Roffe C. 2012. DOES OXYGEN SATURATION AFFECT VASCULAR COMPLIANCE IN ACUTE ISCHAEMIC STROKE?. AGE AND AGEING, vol. 41, 80. link>
  • Pountain SJ and Roffe C. 2012. Does routine oxygen supplementation in patients with acute stroke improve outcome?. BMJ, vol. 345, e6976. link> doi>
  • Saleh M, Spence JN, Nayak S, Pearce G, Tennuci C, Roffe C. 2012. Safety and efficacy of the Aperio thrombectomy device when compared to the Solitaire AB/FR and the Revive devices in a pulsatile flow system. Am J Cardiovasc Dis, vol. 2(4), 301-308. link>
  • Tennuci C, Pearce G, Wong J, Nayak S, Jones T, Lally F, Roffe C. 2011. Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device. Stroke Res Treat, vol. 2011, 186424. link> doi>
  • Roffe C, Ali K, Warusevitane A, Sills S, Pountain S, Allen M, Hodsoll J, Lally F, Jones P, Crome P. 2011. The SOS pilot study: a RCT of routine oxygen supplementation early after acute stroke--effect on recovery of neurological function at one week. PLoS One, vol. 6(5), e19113. link> doi>
  • Frohnhofen H and Roffe C. 2010. Successful treatment of Charles Bonnet syndrome with nocturnal oxygen supplementation. J Am Geriatr Soc, vol. 58(11), 2241-2242. link> doi>
  • Malhotra S, Pandyan AD, Rosewilliam S, Roffe C, Hermens H. 2011. Spasticity and contractures at the wrist after stroke: time course of development and their association with functional recovery of the upper limb. Clin Rehabil, vol. 25(2), 184-191. link> doi>
  • Cousins E, Ward A, Roffe C, Rimington L, Pandyan A. 2010. Does low-dose botulinum toxin help the recovery of arm function when given early after stroke? A phase II randomized controlled pilot study to estimate effect size. Clin Rehabil, vol. 24(6), 501-513. link> doi>
  • Pearce G, Perkinson ND, Wong J, Roffe C, Brooker L, Jones K, Dodd M, Spence J, Rai M, Brookfield P. 2010. In vitro testing of a new aspiration thrombus device. J Stroke Cerebrovasc Dis, vol. 19(2), 121-129. link> doi>
  • Roffe C, Frohnhofen H, Sills S, Hodsoll J, Allen MB, Jones PW. 2010. Frequency of nocturnal hypoxia in clinically stable patients during stroke rehabilitation. Clin Rehabil, vol. 24(3), 267-275. link> doi>
  • Roffe C, Sills S, Pountain SJ, Allen M. 2010. A randomized controlled trial of the effect of fixed-dose routine nocturnal oxygen supplementation on oxygen saturation in patients with acute stroke. J Stroke Cerebrovasc Dis, vol. 19(1), 29-35. link> doi>
  • Romero G, Higuera I, Martinez ML, Pearce G, Perkinson N, Roffe C, Wong J. 2010. Computational modeling of a new thrombectomy device for the extraction of blood clots. Adv Exp Med Biol, vol. 680, 627-633. link> doi>
  • Jenkinson PM, Edelstyn NMJ, Drakeford JL, Roffe C, Ellis SJ. 2010. The role of reality monitoring in anosognosia for hemiplegia. Behav Neurol, vol. 23(4), 241-243. link> doi>
  • Cousins E, Ward AB, Roffe C, Rimington LD, Pandyan AD. 2009. Quantitative measurement of poststroke spasticity and response to treatment with botulinum toxin: a 2-patient case report. Phys Ther, vol. 89(7), 688-697. link> doi>
  • Malhotra S, Cousins E, Ward A, Day C, Jones P, Roffe C, Pandyan A. 2008. An investigation into the agreement between clinical, biomechanical and neurophysiological measures of spasticity. Clin Rehabil, vol. 22(12), 1105-1115. link> doi>
  • Srinivasan M and Roffe C. 2008. Nutritional status after acute stroke: is a stroke unit better than a general geriatric ward?. J Nutr Health Aging, vol. 12(5), 323-325. link> doi>
  • Ali K, Cheek E, Sills S, Crome P, Roffe C. 2007. Day-night differences in oxygen saturation and the frequency of desaturations in the first 24 hours in patients with acute stroke. J Stroke Cerebrovasc Dis, vol. 16(6), 239-244. link> doi>
  • Ali K, Cheek E, Sills S, Crome P, Roffe C. 2007. Development of a conversion factor to facilitate comparison of National Institute of Health Stroke Scale scores with Scandinavian Stroke Scale scores. Cerebrovasc Dis, vol. 24(6), 509-515. link> doi>
  • CROME P, Ali, K, Roffe, C.. 2006. What Patients Want: Consumer Involvement in the Design of a Randomized Controlled Trial of a Routine Oxygen Supplementation After Acute Stroke. Stroke, vol. 37(3), 865-871. doi>
  • Arora A, Arora M, Roffe C. 2005. Mystery of the missing denture: an unusual cause of respiratory arrest in a nonagenarian. Age Ageing, vol. 34(5), 519-520. link> doi>
  • Arora A, Roffe C, Crome P. 2005. Methods to check correct placement of a nasogastric tube: beware of the pitfalls - Reply. AGE AND AGEING, vol. 34(4), 415-416. link> doi>
  • Arora A, Roffe C, Crome P. 2005. An unusual and overlooked complication of nasogastric tube feeding. Age Ageing, vol. 34(1), 84-85. link> doi>
  • Scott F, BEECH R, Smedley F, Timmis L, Stokes E, Jones P, Roffe C, Bowling T. 2005. Prospective randomised controlled single-blind trial of the costs and consequences of systematic nutrition team follow-up over 12 months after percutaneous endoscopic gastrostomy. Nutrition, vol. 21, 1071-1077. doi>
  • Ali K, Sills S, Roffe C. 2005. The effect of different doses of oxygen administration on oxygen saturation in patients with stroke. NEUROCRITICAL CARE, vol. 3(1), 24-26. link> doi>
  • Ali K, Sills S, Roffe C. 2005. The effect of different doses of oxygen administration on oxygen saturation in patients with stroke. Neurocrit Care, vol. 3(1), 24-26. link> doi>
  • Roffe C, Sills S, Halim M, Wilde K, Jones PW, Allen MB, Crome P. 2004. Nocturnal hypoxia after stroke - Response. STROKE, vol. 35(6), E138-E139. link>
  • Lees KR, Muir KW, Ford I, Reid JL, Mendelow AD, Sandercock PAG, Bath PMW, Lees KR, Ford I, Muir KW, Lees KR, Bath PMW, Chen C, Davis SM, Muir KW, Phillips SJ, Saver J, Vanhooren G, Forbes C, Murray G, Bone I, Ford I, Norrie J, Kean S, Robertson M, Murray H, McIlvenna Y, Gardner A, Bradford A, Fenton J, Sakhri A, Rodger M, Sanmuganathan P, Milia P, Chong V, Teasdale E, Muir KW, Lees KR, Ford I, Davis S, Donnan G, Crimmins D, Hankey G, Vanhooren G, Phillips S, Shuaib A, Bailey P, Jaramillo A, Lisheng L, Li KB, Jiang XD, Gao B, Jia QS, Cai ZL, Zhang JP, Feng HL, Xu CL, Zhang Q, Ma C, Zhang HY, Wang AH, Yu SL, Cao YB, Wang XH, Li YW, Yuan XD, Meng LH, Li L, Zhang LH, He YJ, Zhang XJ, Ji H, Wang JL, Li YH, Cenek M, Vlachova I, Cheung R, Gallai V, Parnetti L, Chen C, Haur LS, Alvaro LC, Ozdemir G, Lees KR, Nandi K, Muir KW, Barrett J, Sangster G, Ford G, McLeod MJ, Dijkhuizen R, Grant R, Adams K, Wani M, Steven M, Srivastava PK, Bland R, Curless R, Evans M, Murphy P, Bruce D, Jenkinson D, Sharma A, Power M, Scane A, Bishop-Miller J, Roffe C, Sleight P, Deering A, Kalra L, Bath P, Fulcher RA, Chaudhury MD, Bath P, Ardron M, Lindley R, Chadha DK, Hussain R, Kelly J, Villar T, Athulathmudali C, Seddon D, Dewar RI, Watt M, Kemp T, Robinson T, Sharma J, Hudson C, Erwin L, Ali MS, Forsyth D, Farag R, Ross I, Tsang P, Kafetz K, Tyrell P, Ghosh SK, Patterson J, Fricker R, Kidwell C, Neff S, Saver J, Friday G, Mattio T, Hwang TL, Simon L, Burke J, Investigators IMAGESS. 2004. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. LANCET, vol. 363(9407), 439-445. link> doi>
  • Roffe C, Sills S, Halim M, Wilde K, Allen MB, Jones PW, Crome P. 2003. Unexpected nocturnal hypoxia in patients with acute stroke. Stroke, vol. 34(11), 2641-2645. link> doi>
  • Roffe C, Sills S, Crome P, Jones P. 2002. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit, vol. 8(5), CR326-CR330. link>
  • Roffe C, Sills S, Wilde K, Crome P. 2001. Effect of hemiparetic stroke on pulse oximtery readings on the affected side. Stroke. doi>
  • Roffe C. 2001. Nonconvulsive status epilepticus causing acute confusion. Age Ageing, vol. 30(2), 176-177. link> doi>
  • Roffe C. 2000. Carbaril for head lice - Reply. LANCET, vol. 356(9232), 855. link> doi>
  • Roffe C. 2000. Treatment of pediculosis capitis by dry combing. Lancet, vol. 355(9216), 1724. link> doi>
  • Roffe C. 1998. Ageing of the heart. Br J Biomed Sci, vol. 55(2), 136-148. link>
  • Roffe C, Sills S, Crome P. 1997. Randomised controlled trial of hydroquinine in muscle cramps. Lancet, vol. 349(9061), 1325. link> doi>
  • Roffe C, MacDiarmaid-Gordon A, Ohanian V, Hollis S, Heagerty AM. 1996. The effect of afterload and angiotensin II on proto-oncogene mRNA levels in the isolated working rat heart. Cardiovasc Res, vol. 31(6), 907-916. link> doi>
  • Roffe C. 1996. Biotherapy for antibiotic-associated and other diarrhoeas. J Infect, vol. 32(1), 1-10. link> doi>
  • Roffe D and Roffe C. 1995. Madness and care in the community: a medieval perspective. BMJ, vol. 311(7021), 1708-1712. link> doi>
  • Roffe C, Smith MJ, Basran GS. 1994. Anticholinergic premedication for fibreoptic bronchoscopy. Monaldi Arch Chest Dis, vol. 49(2), 101-106. link>
  • Roffe C, Fletcher S, Woods KL. 1994. Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm in acute myocardial infarction. Br Heart J, vol. 71(2), 141-145. link> doi>
  • Woods KL, Fletcher S, Roffe C, Haider Y. 1992. Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet, vol. 339(8809), 1553-1558. link> doi>
  • Roffe C, Tidmarsh M, Howlett TA. 1991. Ketanserin overdose: a case report. Postgrad Med J, vol. 67(791), 857. link> doi>
  • Roffe C, Cahill MR, Samanta A, Bricknell S, Durrant ST. 1991. Aplastic anaemia in systemic lupus erythematosus: a cellular immune mechanism?. Br J Rheumatol, vol. 30(4), 301-304. link> doi>
  • Roffe C, Patel V, Abbott RJ, Czapla K. 1991. Peripheral neuropathy as a complication of neuroleptic malignant syndrome. J Neurol Neurosurg Psychiatry, vol. 54(4), 378-379. link> doi>
  • Samanta A, Haider Y, Roffe C. 1991. An audit of patients attending a general medical follow-up clinic. J R Coll Physicians Lond, vol. 25(1), 33-35. link>
  • Samanta A, Roffe C, Woods KL. 1990. Accidental self administration of xylazine in a veterinary nurse. Postgrad Med J, vol. 66(773), 244-245. link> doi>

Other

  • Roffe C and Grp IC. 2013. THE EFFECT OF INTRAVENOUS THROMBOLYSIS WITHIN 6 HOURS OF STROKE ONSET ON DISCHARGE DESTINATION, THE ABILITY TO WALK AND TALK, AND QUALITY OF LIFE IN PATIENTS OVER THE AGE OF 80 YEARS IN THE THIRD INTERNATIONAL STROKE TRIAL (IST-3). AGE AND AGEING (vol. 42, p. 31). link>
  • Gardner MJ, Roffe CM, Fox CJ, Seres Z, Middlemist S, Laurie D, Garrity ML. 2011. A semi-automated 1,25-dihydroxy vitamin D assay on the IDS-iSYS automated analyser. BONE (vol. 48, p. S151). link> doi>
  • Mudford LA, Tang AA, Middlemisi S, Fox CJ, Roffe CM, Gardner MJ, Laurie D, Barnes AK, Garrity ML. 2008. A New 25-Hydroxy Vitamin D Assay on the IDS Automated Analyser 3x3 (TM). JOURNAL OF BONE AND MINERAL RESEARCH (vol. 23, p. S290). link>
  • Halim M, Sills SA, Roffe C. 2002. Changes in arterial oxygen saturation with time after acute stroke. STROKE (vol. 33, p. 416). link>
  • Roffe C, Sills S, Jones P, Crome P. 1999. A double blind placebo controlled cross over study of magnesium citrate in patients with leg cramps. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE (vol. 32, p. 160). link>
  • Obiechina N and Roffe C. 1999. Screening for depression in patients recovering from acute stroke. ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE (vol. 32, p. 283). link>
  • WOODS KL, FLETCHER S, ROFFE C, HAIDER Y. 1994. INTRAVENOUS MAGNESIUM-SULFATE IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION - RESULTS OF THE 2ND-LEICESTER-INTRAVENOUS-MAGNESIUM-INTERVENTION-TRIAL (LIMIT-2). HERZ KREISLAUF (vol. 26, p. 112). link>
  • ROFFE C, WOODS KL, FLETCHER S. 1992. THE EFFECT OF INTRAVENOUS MAGNESIUM-SULFATE ON ARRHYTHMIAS WITHIN 24 HOURS OF ACUTE MYOCARDIAL-INFARCTION. CIRCULATION (vol. 86, p. 315). link>
  • WOODS KL, FLETCHER S, ROFFE C, HAIDER Y. 1992. THE EFFECT OF INTRAVENOUS MAGNESIUM-SULFATE ON MORTALITY AND MORBIDITY OF SUSPECTED ACUTE MYOCARDIAL-INFARCTION - RESULTS OF THE 2ND LEICESTER INTRAVENOUS MAGNESIUM INTERVENTION TRIAL (LIMIT-2). CIRCULATION (vol. 86, p. 641). link>

Contributions to Textbooks

Confusion: mental illness in older people. In: Clinical Guidelines 1999, West Mercia Clinical Guidelines Partnership (annual revised reprints to 2005).

Stroke. In: Clinical Guidelines 1999, West Mercia Clinical Guidelines Partnership (Annual revised reprints to 2005).

Roffe C. Drugs in Stroke. In: Drugs and the Older Population, eds Crome P, Ford G. Imperial College Press 2000.

Borriello SP, Roffe C. The normal microflora and antibiotic-associated diarrhoea and colitis. In: Medical importance of the normal microflora. Ed: Tannock GW. Kluwer Academic Publishers, Dordrecht, The Netherlands 1999, pp 371-387.

Review Articles

Roffe C. Hypoxia and stroke. Age and Ageing 2002;3I-S2:1-3.

Roffe C. Hypoxaemia and stroke. Reviews in Clinical Gerontology 2001;11(4):323-335.

Roffe C. Ageing of the heart. Br J Biomed Sci 1998;55:136-148.

Roffe C, Christie L. After the stroke. Midlands Medicine 1998;20(6)108-115.

Roffe C . Biotherapy for antibiotic-associated and other diarrhoeas. Journal of Infection

1996;32(1): 1-10.

MD thesis

The role of afterload and angiotensin II in the generation of early molecular signals of left ventricular hypertrophy, University of Leicester 1999.