Dr Tess Phillips

Title: Lecturer
Phone: (+44) 01782 7 33038
Email: t.r.phillips@keele.ac.uk
Location: Lennard-Jones 1.46
Role: Study Abroad Tutor
Contacting me: In my office (Tues-Thurs) or by e-mail
Office hours: 11-12 Tues/Weds/Thurs.
Tess Phillips

I graduated from the University of Cambridge with a Masters degree in Natural Sciences, specialising in Chemistry.  I stayed on in Cambridge to complete a PhD under the supervision of Prof. Andrew Holmes, investigating how palladium-catalysed reactions can be conducted using environmentally benign carbon dioxide as an alternative to traditional organic solvents. 

After completing my PhD, I worked as a medicinal chemist at the Cambridge based biotech company Astex Technology, where I was part of drug discovery teams on a number of oncology projects. 

I then moved back into academia, joining The University of Manchester to take up a position as a postdoctoral research associate in Prof. Pat Bailey’s group working on the total synthesis of indole alkaloid natural products.  After moving with Pat to Keele I was appointed to Research Fellow in 2011 and Lecturer in 2013.

My research interests are synthetic organic chemistry, medicinal and natural product chemistry and drug discovery.

Selected Publications

  • Bailey PD, Beard MA, Cresswell M, Dang HPT, Pathak RB, Phillips TR, Price RA. 2013. Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids. TETRAHEDRON LETTERS, vol. 54(13), 1726-1729. link> doi>
  • Horrocks P, Fallon S, Denman L, Devine O, Duffy LJ, Harper A, Meredith E-L, Hasenkamp S, Sidaway A, Monnery D, Phillips TR, Allin SM. 2012. Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads. Bioorg Med Chem Lett, vol. 22(4), 1770-1773. link> doi>
  • Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith D-M, Trewartha G, Vinkovic M, Williams B, Woolford AJ-A. 2010. Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1, 3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, {5956-5969}. doi>
  • Bailey PD, Beard MA, Phillips TR. 2009. Unexpected cis selectivity in the Pictet-Spengler reaction. TETRAHEDRON LETTERS, vol. 50(26), 3645-3647. link> doi>
  • Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O Brien MA, O Reilly M, Reule M, Saxty G, Seavers LCA, Smith D-M, Squires MS, Trewartha G, Walker MT, Woolford AJ-A. 2008. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, {4986-4999}. doi>

Full Publications List show

Journal Articles

  • Brown N, Howe C, Jones GR, Phillips TR. 2018. Active Learning Techniques to Build Problem Solving Skills in Chemistry Students. Journal of Academic Development and Education. full text>
  • Bailey PD, Beard MA, Cresswell M, Dang HPT, Pathak RB, Phillips TR, Price RA. 2013. Stereoselectivity and conformational control in the synthesis of ajmaline and epi-ajmaline alkaloids. TETRAHEDRON LETTERS, vol. 54(13), 1726-1729. link> doi>
  • Horrocks P, Fallon S, Denman L, Devine O, Duffy LJ, Harper A, Meredith E-L, Hasenkamp S, Sidaway A, Monnery D, Phillips TR, Allin SM. 2012. Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads. Bioorg Med Chem Lett, vol. 22(4), 1770-1773. link> doi>
  • Murray CW, Carr MG, Callaghan O, Chessari G, Congreve M, Cowan S, Coyle JE, Downham R, Figueroa E, Frederickson M, Graham B, McMenamin R, O Brien MA, Patel S, Phillips TR, Williams G, Woodhead AJ, Woolford AJ-A. 2010. Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, {5942-5955}. doi>
  • Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith D-M, Trewartha G, Vinkovic M, Williams B, Woolford AJ-A. 2010. Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1, 3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, {5956-5969}. doi>
  • Bailey PD, Beard MA, Phillips TR. 2009. Unexpected cis selectivity in the Pictet-Spengler reaction. TETRAHEDRON LETTERS, vol. 50(26), 3645-3647. link> doi>
  • Howard S, Berdini V, Boulstridge JA, Carr MG, Cross DM, Curry J, Devine LA, Early TR, Fazal L, Gill AL, Heathcote M, Maman S, Matthews JE, McMenamin RL, Navarro EF, O Brien MA, O Reilly M, Rees DC, Reule M, Tisi D, Williams G, Vinkovic M, Wyatt PG. 2009. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, {379-388}. doi>
  • Bailey PD, Beard MA, Dang HPT, Phillips TR, Price RA, Whittaker JH. 2008. Debenzylation using catalytic hydrogenolysis in trifluoroethanol, and the total synthesis of (-)-raumacline. Tetrahedron letters, vol. 49, 2150-2153. doi>
  • Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O Brien MA, O Reilly M, Reule M, Saxty G, Seavers LCA, Smith D-M, Squires MS, Trewartha G, Walker MT, Woolford AJ-A. 2008. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, {4986-4999}. doi>
  • Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early T, Feltell RE, Figueroa E, Lewis J, Brien AO, Reilly MO, Squires MS, Saxty G, Seavers L, Smith DM, Trewartha G, Walker MT, Woodhead AJ, Woolford AJ, Wyatt PG. 2006. From fragment to lead: High throughput crystallography and rational design to identify CDKs inhibitors as anticancer drugs. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006, COMP-405.
  • Smith CJ, Early TR, Holmes AB, Shute RE. 2004. Palladium catalysed cross-coupling reactions of silylamines. CHEMICAL COMMUNICATIONS, 1976-1977. doi>
  • Early TR, Holmes AB, Lee JK, Quaranta E, Stamp LM. 2003. Homogeneous catalysis in supercritical carbon dioxide. Carbon Dioxide Recovery and Utilization, 149-168.
  • Holmes AB, Early TR, Gordon RS, Stamp LM, Shute RE, McConvey IF. 2002. Carbon dioxide as a solvent for polymerization and cross coupling reactions. Preprints of Symposia - American Chemical Society, Division of Fuel Chemistry, vol. 47, 282-283.
  • Early TR, Holmes AB, Gordon RS, Shute RE, McConvey IF. 2002. Palladium-catalyzed cross-coupling reactions in supercritical carbon dioxide. Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002, ORGN-464.
  • Early TR, Gordon RS, Carroll MA, Holmes AB, Shute RE, McConvey IF. 2001. Palladium-catalysed cross-coupling reactions in supercritical carbon dioxide. CHEMICAL COMMUNICATIONS, 1966-1967. doi>

Other

  • Holmes AB, Smith CJ, Tsang MW-S, Early TR, Shute RE. 2005. Amination of aromatic compounds using transition metal catalysts.
  • Holmes AB, Gordon RS, Early TR. 2003. Chemical reactions in compressed carbon dioxide using palladium catalysts.
  • Holmes AB, Ley SV, Gordon RS, Ramarao C, Early TR. 2003. Microencapsulated transition metal reagents for reactions in supercritical fluids.
  • Berdini V, Early TR, Brien MAO, Woodhead AJ, Wyatt PG. 2006. Pharmaceutical compounds such as substituted thiazole and isothiazole derivatives and their preparation, pharmaceutical compositions, formulations, and use in prophylaxis or treatment of disease states or conditions mediated by cyclin dependent kinase such as cancers, fungal infections or agricultural use.
  • Berdini V, Brien MAO, Carr MG, Early TR, Navarro EF, Gill AL, Trewartha G, Woolford AJ-A, Woodhead AJ, Wyatt PG. 2005. Preparation of 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators.
  • Wyatt PG, Berdini V, Gill AL, Trewartha G, Woodhead AJ, Navarro EF, Brien MAO, Phillips TR. 2006. Preparation of 4-amino-3-pyrazolecarboxamides as CDK2 kinase inhibitors.
  • Chessari G, Congreve MS, Navarro EF, Frederickson M, Murray C, Woolford AJ-A, Carr MG, Downham R, Brien MAO, Phillips TR, Woodhead AJ. 2006. Preparation of hydroxybenzamides as Hsp90 inhibitors.
  • Wyatt PG, Berdini V, Gill AL, Trewartha G, Woodhead AJ, Navarro EF, Brien MAO, Phillips TR. 2006. Preparation of pyrazole derivatives for use in pharmaceutical compositions for the inhibition of cyclin dependent kinases and glycogen synthase kinases.
  • Berdini V, Brien MAO, Carr MG, Early TR, Navarro EF, Gill AL, Howard S, Trewartha G, Woolford AJ-A, Woodhead AJ, Wyatt P. 2005. Preparation of pyrazoles as inhibitors of cyclin dependent kinases, glycogen synthase kinase-3 and Aurora kinase.
  • Berdini V, Brien MAO, Phillips TR, Wyatt PG. 2006. Preparation of thiazole and isothiazole derivatives that modulate the activity of cdk, gsk and aurora kinases.

CHE-00027: General and Organic Chemistry

CHE-00029: General and Organic Chemistry for Health

CHE-20001: Organic Synthesis and Chirality (tutorials)

CHE-20027: Medicinal and Biological Chemistry 1 (Module Leader)

CHE-30047: Medicinal and Biological Chemistry 2 (Module Leader)

CHE-30044: Topics in Medicinal Chemistry 

CHE-40023: Applied Chemistry Topics (Module Leader)


CHE-30002: Dual Honours Research Project

CHE-30040: Chemistry Research Project

CHE-30041: Medicinal Chemistry Research Project

CHE-40021: MChem Research Project

I enjoy promoting the understanding of what molecules are through hands-on outreach activities.  I created the Molecules Network - a group of schools committed to molecules based science outreach in their communities. 

See the Make-it-Molecular website for more information.