Research and scholarship

ISTM Research theme: Therapeutics

Research Interests:

  • Study of how polymorphic genes interact with environmental factors such as ultraviolet radiation to influence susceptibility and outcome in multiple sclerosis, basal cell carcinoma and prostate cancer.
  • Selection of candidate genes, identification of allelic variants and construction of haplotypes. Use of advanced statistics to identify genetic and environmental influences on risk in patient subgroups.
  • Work based on multispeciality teams of biochemists, clinicians and statisticians.

ISTM_Strange_images1+2_650x300  

Research grants:
 

Project Leaders

Funder

Title

Start date

Duration (mths)

Awarded

Monica Spiteri, Richard Strange, Anthony Fryer

 

British Lung Foundation

Is the I1005V polymorphism at the glutathione S-transferase, GSTP1, locus functionally significant in the development of atopic airway inflammation?

01/08/99

36

£89,512

Richard Strange

 

Smith Kline Beecham

Genetic studies in Psoriasis

01/08/1997

65

67,534

Peter Croft

 

Medical Research Council

Establishing North West and Wessex Regional  Biobank

01/04/2004

9

736,154

Richard Strange & Warren Lenney

 

North Staffordshire Respiratory Research Foundation.

Genetics of Asthma

01/10/2000

36

£60,000

Ari Hirvonen (Helsinki)

 

European Union INTAS

Polymorphic genes in lung cancer.

01/08/2000

36

60,000 ECU

Monica Spiteri

 

PPP Healthcare

Genetic epidemiology of chronic obstructive airway disease.

01/09/2001

24

£274,662

Richard Strange & John Lear (Manchester)

3M Healthcare Ltd.

Genetic factors in multiple BCC

01/01/2001

24

£54,413

Clive Hawkins

 

Department of Health Consortium & Serono Pharmaceuticals Ltd.

Host Genotype, response to Ultraviolet light, general immune factors and clinical outcome in Multiple Sclerosis

01/09/2002

36

£

 

Richard Strange & Sudashan Ramachandran

Good Hope Hospital Research and Development Board

Genetics of Coronary Heart Disease.

01/01/2005

24

£32,853

Anthony Fryer, Paul Hoban & Richard Strange

Association for International Cancer Research

Functional analysis of polymorphism in GSTP1

2004

36

£116,769

Selected Publications

  • Ramachandran S, Hackett GI, Strange RC. 2020. Testosterone replacement therapy: Pre-treatment sex hormone-binding globulin levels and age may identify clinical subgroups. Andrology, vol. 8(5), 1222-1232. link> doi> full text>
  • Kalra S, Lowndes C, Durant L, Strange RC, Al-Araji A, Hawkins CP, Curnow SJ. 2020. Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only. Multiple Sclerosis Journal - Experimental, Translational and Clinical, vol. 6(1). link> doi> link> full text>
  • Strange R, Ramachandran S, Livingston M, Hackett GI. 2019. Should laboratory assay quality be described in study publications and clinical guidelines? A focus on testosterone assay performance. Edorium J Biochemistry. doi> full text>
  • Ramachandran S, Bhartia M, Jones A, Strange RC. 2019. PCSK9 Inhibitors in Diabetic Dyslipidemia. In RSSDI Diabetes Update 2018. (87 vols.). J P Medical Publishers. link> doi> link> full text>
  • Ramachandran S, Bhartia M, Jones A, Strange RC. 2019. Use of fibrates in the Metabolic Syndrome and Diabetics: practical tips. In RSSDI Diabetes Update–2018. (87 vols.). J P Medical Publishers. link> doi> link> full text>

Full Publications List show

Journal Articles

  • Ramachandran S, Hackett GI, Strange RC. 2020. Testosterone replacement therapy: Pre-treatment sex hormone-binding globulin levels and age may identify clinical subgroups. Andrology, vol. 8(5), 1222-1232. link> doi> full text>
  • Kalra S, Lowndes C, Durant L, Strange RC, Al-Araji A, Hawkins CP, Curnow SJ. 2020. Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only. Multiple Sclerosis Journal - Experimental, Translational and Clinical, vol. 6(1). link> doi> link> full text>
  • Strange R, Ramachandran S, Livingston M, Hackett GI. 2019. Should laboratory assay quality be described in study publications and clinical guidelines? A focus on testosterone assay performance. Edorium J Biochemistry. doi> full text>
  • Hackett G, Cole N, Mulay A, Strange RC, Ramachandran S. 2019. Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors. BJU Int, vol. 123(3), 519-529. link> doi> full text>
  • Hackett G, Cole N, Mulay A, Strange RC, Ramachandran S. 2020. Long-Term Testosterone Therapy in Type 2 Diabetes Is Associated with Decreasing Waist Circumference and Improving Erectile Function. World J Mens Health, vol. 38(1), 68-77. link> doi> full text>
  • Strange RC, Ramachandran S, Fryer AA, Saad F, Hackett GI. The association of sex hormone binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes. Andrology. doi> full text>
  • Ramachandran S, Strange RC, Fryer AA, Saad F, Hackett GI. 2018. The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes. Andrology, vol. 6(6), 846-853. link> doi>
  • Ramachandran S, Konig C, Hackett G, Livingston M, Strange RC. 2018. Managing Clinical Heterogeneity: An Argument for Benefit-Based Action Limits. Journal of Engineering in Medical Diagnostics and Therapy, vol. 1(3). doi> link> full text>
  • Hackett G, Cole N, Saghir A, Jones P, Strange RC, Ramachandran S. 2017. Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30-week randomized placebo-controlled study. Andrology. link> doi> link> full text>
  • Ramachandran S, Hackett GI, Strange RC. 2017. Hypogonadism in men with diabetes: Should testosterone replacement therapy be based on evidence based testosterone levels and lifetime risk reduction?. Edorium J Biochem, vol. 2, 1-3.
  • Hackett G, Jones PW, Strange RC, Ramachandran S. 2017. Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes. World J Diabetes, vol. 8(3), 104-111. link> doi>
  • Groves C, Shetty C, Strange RC, Waldron J, Ramachandran S. 2017. A study in high-risk, maximally pretreated patients to determine the potential use of PCSK9 inhibitors at various thresholds of total and LDL cholesterol levels. Postgrad Med J, vol. 93(1098), 205-208. link> doi> full text>
  • Hackett G, Cole N, Saghir A, Jones P, Strange RC, Ramachandran S. 2016. Testosterone undecanoate improves sexual function in men with type 2 diabetes and severe hypogonadism: results from a 30-week randomized placebo-controlled study. BJU Int, vol. 118(5), 804-813. link> doi>
  • Shipman KE, Strange RC, Ramachandran S. 2016. Use of fibrates in the metabolic syndrome: A review. World J Diabetes, vol. 7(5), 74-88. link> doi>
  • Hackett G, Heald AH, Sinclair A, Jones PW, Strange RC, Ramachandran S. 2016. Serum testosterone, testosterone replacement therapy and all-cause mortality in men with type 2 diabetes: retrospective consideration of the impact of PDE5 inhibitors and statins. Int J Clin Pract, vol. 70(3), 244-253. link> doi>
  • Shipman KE, Strange RC, Ramachandran S. 2015. Fibrates: From PPARα activation to clinical use in the metabolic syndrome. Edorium J Biochem, vol. 1, 8-18.
  • Strange RC, Shipman KE, Ramachandran S. 2015. Metabolic syndrome: A review of the role of vitamin D in mediating susceptibility and outcome. World journal of diabetes, vol. 6(7), 896-911. doi>
  • Ramachandran S, Strange RC, Jones PW, Kalra S, Nayak D, Hawkins CP. 2014. Associations between onset age and disability in multiple sclerosis patients studied using MSSS and a progression model. Mult Scler Relat Disord, vol. 3(5), 593-599. link> doi>
  • Ramachandran S, Strange RC, Kalra S, Nayak D, Zeegers MP, Gilford J, Hawkins CP. 2013. Progression of disability in multiple sclerosis: A study of factors influencing median time to reach an EDSS value. Mult Scler Relat Disord, vol. 2(2), 109-116. link> doi>
  • Nayak D, Kalra S, Nayak S, Abraham R, Gilford J, Pherwani A, Jones LD, Ramachandran S, Strange RC, Hawkins CP. 2011. Optico-spinal variant of multiple sclerosis (OSMS) in British patients. Clinical and neuroimaging studies with therapeutic challenges. MULTIPLE SCLEROSIS JOURNAL, vol. 17, S523-S524. link>
  • Sawcer S, Hellenthal G, Pirinen M, Spencer CCA, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Boneschi FM, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox MB, Cozen W, Cree BAC, Cross AH, Cusi D, Daly MJ, Davis E, de Bakker PIW, Debouverie M, D'hooghe MB, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant SFA, Guerini FR, Hakonarson H, Hall P, Hamsten A, Hartung H-P, Heard RN, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode AG, Kilpatrick TJ, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott JS, Leone MA, Leppa V, Liljedahl U, Bomfim IL, Lincoln RR, Link J, Liu J, Lorentzen AR, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley JL, Mentch F, Mero I-L, Mihalova T, Montalban X, Mottershead J, Myhr K-M, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach HL, Ramsay PP, Reunanen M, Reynolds R, Rioux J, Rodegher M, Roesner S, Rubio JP, Rueckert I-M, Salvetti M, Salvi E, Santaniello A, Schaefer CA, Schreiber S, Schulze C, Scott RJ, Sellebjerg F, Selmaj KW, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman PMA, Smestad C, Sorensen PS, Sondergaard HB, Stankovich J, Strange RC, Sulonen A-M, Sundqvist E, Syvaenen A-C, Taddeo F, Taylor B, Blackwell JM, Tienari P, Bramon E, Tourbah A, Brown MA, Tronczynska E, Casas JP, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus HS, Wang K, Mathew CG, Wason J, Palmer CNA, Wichmann H-E, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath RC, Yaouanq J, Viswanathan AC, Zhang H, Wood NW, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg JR, Pericak-Vance MA, Haines JL, Olsson T, Hillert J, Ivinson AJ, De Jager PL, Peltonen L, Stewart GJ, Hafler DA, Hauser SL, McVean G, Donnelly P, Compston A, Co IMSG, Consor WTCC. 2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. NATURE, vol. 476(7359), 214-219. link> doi> full text>
  • Strange RC, Ramachandran S, Zeegers MP, Emes RD, Abraham R, Raveendran V, Boggild M, Gilford J, Hawkins CP. 2010. The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation. Mult Scler, vol. 16(9), 1109-1116. link> doi>
  • Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S, Compston A, WTCCC. 2009. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 17(10), 1309-1313. link> doi>
  • Ramachandran S, Rajaratnam R, Smith AG, Lear JT, Strange RC. 2009. Patients with both basal and squamous cell carcinomas are at a lower risk of further basal cell carcinomas than patients with only a basal cell carcinoma. J Am Acad Dermatol, vol. 61(2), 247-251. link> doi>
  • Booth DR, Heard RN, Stewart GJ, Goris A, Dobosi R, Dubois B, Lorentzen AR, Celius EG, Harbo HF, Spurkland A, Olsson T, Kockum I, Link J, Hillert J, Ban M, Baker A, Sawcer S, Compston A, Mihalova T, Strange R, Hawkins C, Ingram G, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, Pericak-Vance M, Oksenberg JR, Hauser SL, McCauley JL, Sexton D, Haines J, IMSGC. 2009. The expanding genetic overlap between multiple sclerosis and type I diabetes. GENES AND IMMUNITY, vol. 10(1), 11-14. link> doi>
  • Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban PR, Rukin N, Alldersea J, Strange RC, Hawkins CP. 2008. Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis. Mult Scler, vol. 14(9), 1280-1283. link> doi>
  • Varela-Lema L, Taioli E, Ruano-Ravina A, Barros-Dios JM, Anantharaman D, Benhamou S, Boccia S, Bhisey RA, Cadoni G, Capoluongo E, Chen C-J, Foulkes WD, Goloni-Bertollo EM, Hatagima A, Hayes RB, Katoh T, Koifman S, Lazarus P, Manni JJ, Mahimkar M, Morita S, Park J, Park K-K, Pavarino Bertelli EC, de Souza Fonseca Ribeiro EM, Roy B, Spitz MR, Strange RC, Wei Q, Ragin CC. 2008. Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. GENETICS IN MEDICINE, vol. 10(6), 369-384. link> doi>
  • Woolmore J, Stone M, Holley S, Jenkinson P, Ike A, Jones P, Fryer A, Strange R, Stephens R, Langdon D, Hawkins C. 2008. Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. Mult Scler, vol. 14(2), 177-182. link> doi>
  • Holley SL, Fryer AA, Haycock JW, Grubb SEW, Strange RC, Hoban PR. 2007. Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis. Carcinogenesis, vol. 28(11), 2268-2273. link> doi>
  • Vineis P, Anttila S, Benhamou S, Spinola M, Hirvonen A, Kiyohara C, Garte SJ, Puntoni R, Rannug A, Strange RC, Taioli E. 2007. Evidence of gene-gene interactions in lung carcinogenesis in a large pooled analysis. CARCINOGENESIS, vol. 28(9), 1902-1905. link> doi>
  • STRANGE RC, Pye EM, Stone M, Woolmore JA. 2007. Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation. Multiple Sclerosis, vol. 13(3), 369-375. doi>
  • Rukin NJ, Luscombe C, Moon S, Bodiwala D, Liu S, Saxby MF, Fryer AA, Alldersea J, Hoban PR, Strange RC. 2007. Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene. Cancer Lett, vol. 247(2), 328-335. link> doi>
  • Rukin NJ, Zeegers MP, Ramachandran S, Luscombe CJ, Liu S, Saxby M, Lear J, Strange RC. 2007. A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma. Br J Cancer, vol. 96(3), 523-528. link> doi> full text>
  • Rukin N, Blagojevic M, Luscombe CJ, Liu S, Saxby MF, Ramachandran S, Fryer AA, Jones PW, Strange RC. 2007. Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer. Cancer Detect Prev, vol. 31(6), 443-449. link> doi>
  • Kapoor B, Dunlop C, Wynn-Jones C, Fryer AA, Strange RC, Maffulli N. 2007. Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli--a preliminary study. J Negat Results Biomed, vol. 6, 7. link> doi> full text>
  • Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P, Cote ML, Dialyna IA, Dolzan V, Filiberti R, Garte S, Hirvonen A, Husgafvel-Pursiainen K, Imyanitov EN, Kalina I, Kang D, Kiyohara C, Kohno T, Kremers P, Lan Q, London S, Povey AC, Rannug A, Reszka E, Risch A, Romkes M, Schneider J, Seow A, Shields PG, Sobti RC, Sorensen M, Spinola M, Spitz MR, Strange RC, Stucker I, Sugimura H, To-Figueras J, Tokudome S, Yang P, Yuan J-M, Warholm M, Taioli E. 2006. Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. AMERICAN JOURNAL OF EPIDEMIOLOGY, vol. 164(11), 1027-1042. link> doi>
  • Hoban PR, Lear JT, Strange RC. 2006. Basal cell carcinoma: genetic homogeneity in a tumour type displaying phenotypic diversity. Eur J Hum Genet, vol. 14(9), 977-978. link> doi>
  • Madan V, Hoban PR, Strange RC, Fryer AA, Lear JT. 2006. Prognostic factors for a subsequent basal cell carcinoma: implications for follow-up. BRITISH JOURNAL OF DERMATOLOGY, vol. 155(1), 217-218. link> doi>
  • Carroll WD, Lenney W, Child F, Strange RC, Jones PW, Whyte MK, Primhak RA, Fryer AA. 2006. Asthma severity and atopy: how clear is the relationship?. ARCHIVES OF DISEASE IN CHILDHOOD, vol. 91(5), 405-409. link> doi>
  • Moon S, Holley S, Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2006. Associations between G/A1229, A/G3944, T/C30875, C/T48200 and C/T65013 genotypes and haplotypes in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. Ann Hum Genet, vol. 70(Pt 2), 226-236. link> doi>
  • Matthias C, Harreus U, Strange C. 2006. Influential factors on tumour recurrence in head and neck cancer patients. Eur Arch Otorhinolaryngol, vol. 263(1), 37-42. doi>
  • Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2006. Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer. Int J Oncol, vol. 28(1), 231-236. link>
  • Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2005. Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer. Carcinogenesis, vol. 26(12), 2157-2163. link> doi>
  • Moon SJ, Fryer AA, Strange RC. 2005. Ultraviolet radiation, vitamin D and risk of prostate cancer and other diseases. Photochem Photobiol, vol. 81(6), 1252-1260. link> doi>
  • Carroll WD, Lenney W, Jones PW, Strange RC, Child F, Whyte MK, Primhak RA, Fryer AA. 2005. Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. CLINICAL AND EXPERIMENTAL ALLERGY, vol. 35(9), 1155-1161. link> doi>
  • Moon S, Holley S, Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer A, Strange RC. 2006. Associations between G/A(1229), A/G(3944), T/C-30875 C/T-48200 and C/T-65013 genotypes and haplotype in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. ANNALS OF HUMAN GENETICS, vol. 70, 226-236. link> doi>
  • STRANGE RC, Hoban PR, Lovatt T, Ramachandran. 2005. Polymorphism in the nuclear excision repair geneERCC2/XPD: association between an exon 6-exon 10 haplotype and susceptibility to cutaneous basal cell carcinoma. Human Mutation, vol. 25(4), 353-359. doi>
  • Carroll WD, Lenney W, Proctor A, Whyte MC, Primhak RA, Cliffe I, Jones PW, Strange RC, Fryer AA, Child F. 2005. Regional variation of airway hyperresponsiveness in children with asthma. RESPIRATORY MEDICINE, vol. 99(4), 403-407. link> doi>
  • Moon SJ, Fryer AA, Strange RC. 2005. Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers. Mutat Res, vol. 571(1-2), 207-219. link> doi>
  • Lovatt TJ, Lear JT, Bastrilles J, Wong C, Griffiths CEM, Samarasinghe V, Roebuck J, Ramachandran S, Smith AG, Jones PW, Fryer AA, Strange RC. 2005. Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors. J Am Acad Dermatol, vol. 52(3 Pt 1), 468-473. link> doi>
  • Carroll WD, Lenney W, Child F, Strange RC, Jones PW, Fryer AA. 2005. Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. PEDIATRIC ALLERGY AND IMMUNOLOGY, vol. 16(1), 32-39. link> doi>
  • Holley SL, Matthias C, Jahnke V, Fryer AA, Strange RC, Hoban PR. 2005. Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma. Oral Oncol, vol. 41(2), 156-160. link> doi>
  • Lear JT, Hoban P, Strange RC, Fryer AA. 2005. Basal cell carcinoma: from host response and polymorphic variants to tumour suppressor genes. CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 30(1), 49-55. link> doi>
  • Fryer AA, Ramsay HM, Lovatt TJ, Jones PW, Hawley CM, Nicol DL, Strange RC, Harden PN. 2005. Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis, vol. 26(1), 185-191. link> doi>
  • Rukin NJ, Luscombe C, Strange RC. 2005. Vitamin D: new insights into its broader role in disease pathogogenesis. Retinoids & other treatments in Clinical Dermatology, vol. 21(4), 50-54.
  • STRANGE RC, EL-GENIDY N, RAMACHANDRAN S, LOVATT TJ, FRYER AA, SMITH AG, LEAR JT, WONG C, JONES PW, ICHII-JONES F, HOBAN PR. 2004. Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms. Annals of Human Genetics, vol. 68(6), 536-545. doi>
  • BARTON A, WOOLMORE JA, WARD D, EYRE S, HINKS A, OLLIER WE, STRANGE RC, FRYER AA, JOHN S, HAWKINS CP, WORTHINGTON J. 2004. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. Brain, vol. 127(8), 1717-1722. doi>
  • SMITS KM, BENHAMOU S, GARTE S, WEIJENBERG MP, ALAMANOS Y, AMBROSONE C, AUTRUP H, AUTROP JL, BARANOVA H, BATHUM L, BOFFETTA P, BOUCHARDY C, BROCKMOLLER J, BUTKIEWICZ D, CASCORBI I, CLAPPER ML, COUTELLE C, DALY AK, MUZI G, DOLZAN V, DUZHAK TG, FARKER K, GOLKA K, STRANGE RC. 2004. Association of metabolic gene polymorphisms with tobacco consumption healthy controls. Int J Cancer, vol. 110(2), 266-270. doi>
  • Vineis P, Veglia F, Anttila S, Benhamou S, Clapper ML, Dolzan V, Ryberg D, Hirvonen A, Kremers P, Le Marchand L, Pastorelli R, Rannug A, Romkes M, Schoket B, Strange RC, Garte S, Taioli E. 2004. CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions. BIOMARKERS, vol. 9(3), 298-305. link> doi>
  • FLAMANT C, HENRION-CAUDE A, BOELLE PY, BREMONT F, BROUARD J, DELAISI B, DUHAMEL JF, MARGUET C, ROUSSEY M, MIESCH MC, BOULE M, STRANGE RC, CLEMENT A. 2004. Glutathione-s-transferase M1, M3, P1 and T1 polymorphisms and severity of lung disease in children with cystic fibrosis. Pharmacogenetics, vol. 14(5), 295-301. doi>
  • Howells REJ, Dhar KK, Hoban PR, Jones PW, Fryer AA, Redman CWE, Strange RC. 2004. Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer. Int J Gynecol Cancer, vol. 14(2), 242-250. link> doi>
  • LOVATT TJ, LEAR JT, BASTRILLES J, WONG C, GRIFFITHS CEM, RAMACHANDRAN S, SMITH AG, SALIM A, FRYER AA, JONES PW, STRANGE RC. 2004. Association between UVR exposure and basal cell carcinoma site and histology. Cancer Letters, vol. 216(2), 191-197. doi>
  • BYROM J, MUDALIAR V, HOBAN PR, REDMAN CW, JONES P, STRANGE RC. 2004. Loss of heterozygosity at chromosome 9q22-31is a frequent and early even in ovarian tumours. Int J Oncol, vol. 24(5), 1271-1277.
  • FRYER AA, RAMSAY HM, LOVATT TJ, JONES PW, HAWLEY CM, NICOL DL, STRANGE RC, HARDEN P. 2004. Polymorphisms in glutathione S-transferase and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcenogenesis, vol. 25(11), 1-7.
  • RAMSAY HM, HARDEN P, HAWLEY CM, NICOL DL, LOVATT TJ, SMITH AG, STRANGE RC, FRYER AA. 2004. Polymorphisms in glutathione S-transferase and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis, vol. 26(1), 536-545.
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2004. Polymorphisms in the vitamin D receptor gene, ultraviolet radiation, and susceptibility to prostate cancer. Environ Mol Mutagen, vol. 43(2), 121-127. link> doi>
  • Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Lear JT, Ichii-Jones F, Jones PW, Hoban PR. 2004. PTCH polymorphism is associated with the rate of increase in basal cell carcinoma numbers during follow-up: preliminary data on the influence of an exon 12-exon 23 haplotype. Environ Mol Mutagen, vol. 44(5), 469-476. link> doi>
  • HODGSON R, SMITH SE, STRANGE RC, FRYER AA. 2004. Service innovations. Pharmacogenetic clinics in psychiatry: a clinical reality?. Psychiatric Bulletin.
  • GRANT WB, STRANGE RC, FRYER AA. 2004. Sunshine is good medicine. The health benefits of ultraviolet-B induced vitamin D production. Journal of Cosmetic Dermatology.
  • PARTRIDGE JM, WEATHERBY SJ, WOOLMORE JA, HIGHLAND DJ, FYER AA, MANN CL, BOGGILD MD, OLLIER WE, STRANGE RC, HAWKINS CP. 2004. Susceptibility and outcome in MS; associations with polymorphisms in pigmentation-related genes. Neurology, vol. 62(12), 2323-2325. doi>
  • BRIND AM, HURLSTONE A, EDRISINGHE, STRANGE RC, GILMORE I, FISHER N, PIRMOHAMED M, FRYER AA. 2004. The role of polymorphisms of glutathione S-transferase GSTM1, M3, P1, T1 and A1 in susceptibility to alcohol liver disease. Alcohol and Alcoholism, vol. 39(6), 478-483.
  • Strange R, Hashibe, Brennan, Taioli, Bhisey, Cascorbi, Romkes, Lazarus, Ophuis, Gaspari, Benhamou, Boffetta, Foulkes, Katoh, Coutelle. 2003. Meta-and Pooled Analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 Genotypes and risk of Head and neck Cancer. Cancer Epidemiol Biomarkers Prev., vol. 12(12), 1509-1517.
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Alldersea J, Strange RC, Fryer AA. 2003. The Association of material but not paternal genetic variation in GSTP1 with asthma phenotypes in children. Respiratory Medicine, vol. 97(12), 1247-1256. doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Strange RC, Fryer AA. 2003. Correction of bronchial challenge data for age and size may affect the results of genetic association studies in children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology., vol. 14(3), 193-200. doi> link>
  • Strange RC and et A. 2003. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years. International Journal of Epidemiology, 60-63. doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2003. Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation. Cancer Lett, vol. 200(2), 141-148. link> doi>
  • Wong CS, Strange RC, Lear JT. 2003. Basal cell carcinoma. British Medical Journal, vol. 327(7418), 794-798. doi>
  • Ramachandran MS, Fryer AA, Lovatt T, Smith AG, Lear JT, Jones PW, Strange RC. 2003. Combined effects of gender, skin type and polymorphic genes in clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system. Cancer Letters, vol. 189(2), 175-181. doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Strange RC, Fryer AA. 2003. Correction of bronchial challenge data for age and size may affect the results of genetic association studies in children. Paediatric Allergy and Immunology.
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Strange RC, Fryer AA. 2003. Correction of bronchial challenge data for age and size may affect the results of genetic association studies in children. Pediatr Allergy Immunol, vol. 14(3), 193-200. link> doi>
  • Vineis P, Veglia F, Benhamou S, Butkiewicz D, Cascorbi I, Clapper ML, Dolzan V, Haugen A, Hirvonen A, Ingelman-Sundberg M, Kihara M, Kiyohara C, Kremers P, Le Marchand L, Ohshima S, Pastorelli R, Strange RC, et A. 2003. CYP1A1 T3801 Polymorphism and lung cancer: A pooled analysis of 2,451 cases and 3,358 controls. International Journal of Cancer, vol. 104(5), 650-657. doi>
  • Matthias C, Jahnke V, Fryer AA, Strange AA. 2003. First results on the influence of polymorphisms at glutahione s-tranferase, cytochrome p450, and tumer necrosis factor gene Loci on the development of multiple head and neck cancer. Laryngo-rhino-otologie, vol. 82(1), 25-30. doi>
  • Smits KM, Gaspari L, Weijenberg MP, Dolzan V, Golka K, Roemer HC, Nedelcheva Kristensen V, Lechner MC, Mehling GI, Seidegard J, Strange RC, Taioli E. 2003. Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study. Biomarkers, vol. 8(3-4), 299-310. doi>
  • Bodiwala D, Luscombe CJ, Liu S, Saxby M, French M, Jones PW, Fryer AA, Strange RC. 2003. Prostate cancer risk and exposure to ultraviolet radiation: further support for the protective effect of sunlight. Cancer Lett, vol. 192(2), 145-149. link> doi>
  • Carroll W, Child F, Kwong G, Proctor A, Pimhak R, Clayton S, Davies S, Strange RC, Whyte MC, Fryer AA, Lenney W. 2003. Regional variations in phenotype between cohorts of asthmatic children and their families. Thorax, vol. 58(3).
  • Strange RC, Hoban P, Salim A. 2003. Skin Cancer and Exposure to sunlight, polycylic aromatic hydrocarbons and arsenic. Clinics in Occupational and Enviromental Medicine, vol. 2(4), 803-828. doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Ramachandran S, Fryer AA, Strange RC. 2003. Susceptibility to prostate cancer: studies on interactions between UVR exposure and skin type. Carcinogenesis, vol. 24(4), 711-717. link> doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones P, Aldersea J, Strange RC, Fryer AA. 2003. The association of maternal but not paternal genetic variation in GDPT1 with asthma genetic phenotypes in children. Respiratory Medicine.
  • Ramachandran MS, Fryer AA, Lovatt T, Smith AG, Lear JT, Jones PW, Strange RC. 2003. The rate of increase in the numbers of primary sporadic basal cell carcinomas during follow up with age at first presentation. Carcenogenesis.
  • McGinnis R, Child F, Clayton S, Davies S, Lenney W, Illig T, Wjst M, Spurr N, Debouck C, Hajeer AH, Ollier WER, Strange R, Fryer AA. 2002. Further support for the association of CCR5 allelic variants with asthma susceptibility. EUROPEAN JOURNAL OF IMMUNOGENETICS, vol. 29(6), 525-528. link> doi>
  • Ramachandran MS, Fryer AA, Lovatt T, Smith AG, Lear JT, Jones PW, Strange RC. 2003. The rate of increase in the numbers of primary sporadic basal cell carcinomas during follow up with age at first presentation. Carcenogenesis. doi>
  • Hoban PR, Ramachandran S, Strange RC. 2002. Environment, phenotype and genetics: risk factors associated with BCC of the skin. Expert Rev Anticancer Ther, vol. 2(5), 570-579. link> doi>
  • Henrion-Caude A, Flamant C, Roussey M, Housset C, Flahault A, Fryer AA, Chadelat K, Strange RC, Clement A. 2002. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. HEPATOLOGY, vol. 36(4), 913-917. link> doi>
  • Mann CLA, Davies MB, Stevenson VL, Leary SM, Boggild MD, Ko Ko C, Jones PW, Fryer AA, Strange RC, Thompson AJ, Hawkins CP. 2002. Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity. J Neuroimmunol, vol. 129(1-2), 197-204. link> doi>
  • Mansur AH, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2002. An association study between the Clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes. Clin Exp Allergy, vol. 32(7), 994-999. link> doi>
  • Matthias C, Jahnke V, Fryer AA, Strange RC. 2002. Influence of glutathione S-transferase and cytochrome P450 polymorphisms on prognosis of head and neck cancer. LARYNGO-RHINO-OTOLOGIE, vol. 81(6), 406-412. link> doi>
  • Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osborne JE, Lear JT, Smith AG, Hutchinson IV. 2002. Association between functional polymorphism in EGF gene and malignant melanoma. LANCET, vol. 359(9304), 397-401. link> doi>
  • Shahbazi M, Pravica V, Nareen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osbourne JE, Lear JT, Smith AG, Hutchinson IV. 2002. A functional polymorphism in the human EGF gene associated with malignant melanoma. Lancet.
  • Mansur AH, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2002. An association study between the clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes. Clinical and experimental allergy: Journal of the British Society for Allergy and Clinical Immunology, vol. 32(7), 994/999.
  • Partridge J, Fryer AA, Strange RC, Boggild MD, Hawkins CP. 2002. Chemokine receptors 5 delta 32 polymorphism: suspectibility to and outcome from multiple sclerosis. Journal of Neurology.
  • Hoban P, Ramachandran S, Strange R. 2002. Environment, phenotype and genetics: risk factors associated with BCC of the skin. Expert Review of Anticancer Therapy, vol. 2(5), 570/581.
  • Luscombe CJ, French ME, Saxby MF, Farrell WE, Jones PW, Fryer AA, Strange RC. 2003. Glutathione S-fransferase GSTP1 genotype are associated with response to androgen ablation therapy advanced prostate cancer. Cancer Detection and Prevention, vol. 26(5), 376-380. doi>
  • Mapp CE, Fryer AA, De Marzo N, Pozzato V, Padoan M, Boschetto P, Strange RC, Hemmingsem A, Spiteri M. 2002. Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by Isocyanates. The Journal of Clinical Immunology. doi>
  • Mapp CE, De Marzo N, Pozzato V, Boschetto P, Fryer AA, Strange RC, Hemmingsen A, Spiteri MA. 2002. Gluththione S-transferase, GSTP1 is a susceptibility gene for occupational asthma induced by Isocyanates. Journal of Allergy and Clinical Immunology.
  • Matthias C, Jahnke V, Fryer AA, Strange RC. 2002. Influence of glutathione S-transferase and cytochrome p450 polymorphisms on prognosis of head and neck cancer. Laryngo-rhino-otologie, vol. 81(6), 406/412.
  • Mann CL, Davies MB, Steveson VL, Leary SM, Boggild MD, Jones PW, Fryer AA, Strange RC, Thompson AJ, Hawkins CP. 2002. Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity. Journal of Neuroimmunology.
  • Henrion-Caude A, Flamant C, Roussey M, Housset C, Flahaoult A, Fryer AA, Chadelat K, Strange RC, Clement A. 2002. Liver disease in pediatric with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. Hepatology, vol. 36(4), 319/917.
  • Benhamou S, Lee WJ, Strange RC, et A. 2002. Meta- and pooled analyses of the effects of glutathione S-transferease M1 polymorphisms and smoking on lung cancer risk. Carcinogenesis. doi>
  • Partridge J, Fryer AA, Boggild MD, Strange RC, Hawkins CP. 2002. Polymorphisms in the glutathione-S-Transferases, GSTA1 and GSTA2, in Multiple Sclerosis. Multiple Sclerosis.
  • Partridge J, Fryer AA, Strange RC, Boggild MD, Hawkins CP. 2002. Rantes and Chemokine Recptor 5 polymorphism: susceptibility to outcome in multiple sclerosis. Multiple Sclerosis.
  • Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Jones PW, Clarke S, Fisher J, Brownfield A, Alldersea J, Fryer AA, Strange RC. 2002. Smoking and disease severity in rheumatoid arthritis. Association with polymorphism at the gluatathione S-transferase (GST) M1 locus. Arthritis Rheum. doi>
  • Partridge J, Fryer AA, Strange RC, Boggild MD, Hawkins CP. 2002. Vascular endothelial growth factor gene polymorphism and its association with multiple sclerosis. Journal of Neurology.
  • Fryer AA and Strange RC (Plus 64 non keele authors). 2001. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology, Biomarkers & Prevention.
  • Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. British Journal of Cancer. doi> full text>
  • Bamber DE, Fryer AA, Strange RC, Elder JB, Deakin M, Rajagopal R, Fawole S, Gilissen R, Campbell FC, Coughtrie MWH. 2001. Phenol sulfotransferase SULT1a1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics. doi>
  • Smith AG, Ramsay HM, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Outcome in prostate cancer: Associations with skin type and polymorphism in pigmentation-related genes. Carcinogensis. doi>
  • STRANGE RC, French ME, Liu S, Luscombe CJ. 2001. Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer. The Lancet, vol. 358(9282), 641-642. doi>
  • Luscombe CJ, Fryer AA, French ME, Liu S, Saxby MF, Jones PW, Strange RC. 2001. Exposure to ultraviolet radiation: Association with susceptibility and age at presentation with prostate cancer. Lancet. doi>
  • Ramsay HM, Harden PN, Reece S, Smith AG, Jones PW, Strange RC, Fryer AA. 2001. Polymorphisms in glutathione S-transferases are associated with altered risk of nonmelanoma skin cancer in renal transplant recipients: a preliminary analysis. J Invest Dermatol, vol. 117(2), 251-255. link> doi>
  • Ramachandran S, Fryer AA, Smith A, Lear J, Bowers B, Jones PW, Strange RC. 2001. Cutaneous basal cell carcinomas: distinct host factors are associated with the development of tumors on the trunk and on the head and neck. Cancer, vol. 92(2), 354-358. link> doi>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Hartland AJ, Whiteside JR, Jones PW, Strange RC. 2001. Basal cell carcinomas: Associatio of allelic variants with a high risk subgroup of patients with the mutiple presentation phenotype. Pharmacogenetics. doi>
  • Strange RC, Lear JT, Fryer AA. 2001. How important are GST polymorphisms in defining clinical phenotypes: some answers from studies in high risk groups. Chemico-Biological Interactions.
  • Weatherby SJM, Fryer AA, Mann C, Ollier W, Strange R, Hawkins CP. 2001. Epistasis: a potentially important concept in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 70(2), 283. link>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Hartland AJ, Whiteside JR, Jones PW, Strange RC. 2001. Basal cell carcinomas: Associatio of allelic variants with a high risk subgroup of patients with the mutiple presentation phenotype. Pharmacogenetics.
  • Holley S, Parkes G, Matthias C, Brockmuhle, Leder K, Jahnke, Strange RC, Fryer AA, Hoban PR. 2001. Cyclin D1 polymorphism and expression in squamous cell carcinoma of the head and neck. American Journal of Pathology, vol. 159(5), 1917-1924.
  • Ramachandran S, Fryer AA, Strange RC. 2001. Genetic factors determining cutaneous basal cell. Medical Pediatric oncology.
  • Partridge J, Weatherby SJM, Fryer AA, Strange R, Hawkins C. 2001. Genetic polymorphisms of MSH receptor: Susceptibility and outcome in multiple sclerosis. journal of Neurology.
  • Howells RE, Holland T, Dhar KK, Redman CW, Hand P, Hoban PR, Jones PW, Fryer AA, Strange RC. 2001. Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 expression and survival. Int J Gynecol Cancer, vol. 11(2), 107-112. link> doi>
  • Howells REJ, Holland T, Dhar KK, Redman CWE, Hand P, Hoban PR, Jones PW, Fryer AA, Strange R. 2001. Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer:association with p53 expression and survival. International Journal of Gynaecological Cancer.
  • Hemmingsen A, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2001. Glutathione S-transferase GSTP1 genotypes are associated with asthma risk: development of an ARMS-PCR assay for the simultaneous identification of the I105-V105 and A114-V114 substitutions. Respiratory Research.
  • Strange RC, Spiteri MA, Ramachandran S, Fryer AA. 2001. Glutathione-S-transferase family of enzymes. Mutat Res, vol. 482(1-2), 21-26. link> doi>
  • Weatherby SJM, Thompson W, Pepper L, Donn R, Worthington J, Mann CLA, Davies MB, Fryer AA, Bogggild MD, STrange RC, Jones PW, Ollier W, Hawkins CP. 2001. HLA-DRB1 and disease outcome in multiple sclerosis. Journal of Neurology. doi>
  • Weatherby SJM, Thompson W, Pepper L, Donn R, Worthington J, Mann CLA, Davies MB, Fryer AA, Bogggild MD, STrange RC, Jones PW, Ollier W, Hawkins CP. 2001. HLA-DRB1 and disease outcome in multiple sclerosis. Journal of Neurology.
  • Jones PW, Strange RC, Ramachandran S, Fryer A. 2002. Models for determining genetic susceptibility and predicting outcome. Methods Mol Biol, vol. 184, 131-142. link> doi>
  • Smith AG, Ramsay HM, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Outcome in prostate cancer: Associations with skin type and polymorphism in pigmentation-related genes. Carcinogensis.
  • Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. 2001. Polymorphism at the glutathione S-transferase, GSTP1, Locus: A new marker for bronchial hyperresponsiveness and asthma. Allergy Review Journal.
  • Ramsay HM, Harden PN, Reece S, Smith AG, Jones PW, Strange RC, Fryer AA. 2001. Polymorphisms in glutathione S-transferases are associated with altered risk of non-melanoma skin cancer in renel transplant recipients: A preliminary analysis. Journal of Investigate Dermatology.
  • Partridge J, Weatherby SJM, Fryer AA, Strange R, Hawkins C. 2001. Preliminary Study of genetic polymorphisms of MSH receptor related to susceptibility and outcome in multiple sclerosis. International Journal of Multiple Sclerosis.
  • Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. British Journal of Cancer.
  • Hemmingsen A, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2001. Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respir Res, vol. 2(4), 255-260. link> doi> full text>
  • Ramachandran S, Fryer AA, Lovatt T, Lear J, Smith AG, Strange RC. 2001. Susceptibility and modifier genes in cutaneous basal cell carcinomas and their associations with clinical phenotype. J Photochem Photobiol B, vol. 63(1-3), 1-7. link> doi>
  • Hemmingsen A, Fryer AA, Allen JT, Strange RC, Spiteri MA. 2000. Measurement of glutathione S-transferease, GSTP1 expression in human bronchial epithelial cells following oxidative stress. THORAX, vol. 55, A59. link>
  • Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC, Makki R, Tavernier G, Smilie FI, Custovic A, Woodcock AA, Ollier WE, Hajeer AH. 2000. The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun, vol. 1(8), 509-514. link> doi>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Griffiths CE, Jones PW, Strange RC. 2000. Basal cell carcinoma. Cancer, vol. 89(5), 1012-1018. link> doi>
  • Boissy RJ, Watson MA, Umbach DM, Deakin M, Elder J, Strange RC, Bell DA. 2000. A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma. INTERNATIONAL JOURNAL OF CANCER, vol. 87(4), 507-511. link> doi>
  • Ramachandran S, Hoban PR, Ichii-Jones F, Pleasants L, Ali-Osman F, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. 2000. Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours. Pharmacogenetics, vol. 10(6), 545-556. link> doi>
  • Beswick SJ, Garrido MC, Fryer AA, Strange RC, Smith AG. 2000. Multiple basal cell carcinomas and malignant melanoma following radiotherapy for ankylosing spondylitis. Clin Exp Dermatol, vol. 25(5), 381-383. link> doi>
  • Weatherby SJM, Mann CLA, Davies MB, Fryer AA, Haq N, Strange RC, Hawkins CP. 2000. A pilot study of the relationship between gadolinium-enhancing lesions, gender effect and polymorphisms of antioxidant enzymes in multiple sclerosis. JOURNAL OF NEUROLOGY, vol. 247(6), 467-470. link> doi>
  • Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. 2000. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med, vol. 161(5), 1437-1442. link> doi>
  • Mattey DL, Hassell AB, Dawes PT, Jones PW, Yengi L, Alldersea J, Strange RC, Fryer AA. 2000. Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: evidence for interaction with glutathione S-transferase genes. Arthritis Rheum, vol. 43(4), 859-864. link> doi>
  • Weatherby SJM, Mann CLA, Fryer AA, Strange RC, Hawkins CP, Stevenson VL, Leary SM, Thompson AJ. 2000. No association between the APOE epsilon 4 allele and outcome and susceptibility in primary progressive multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 68(4), 532. link> doi>
  • Hajeer AH, Lear JT, Ollier WER, Naves M, Worthington J, Bell DA, Smith AG, Bowers WP, Jones PW, Strange RC, Fryer AA. 2000. Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas. BRITISH JOURNAL OF DERMATOLOGY, vol. 142(3), 441-445. link> doi>
  • Mann CLA, Davies MB, Boggild MD, Alldersea J, Fryer AA, Jones PW, Ko CK, Young C, Strange RC, Hawkins CP. 2000. Glutathione S-transferase polymorphisms in MS - Their relationship to disability. NEUROLOGY, vol. 54(3), 552-557. link> doi>
  • Weatherby SJ, Mann CL, Davies MB, Carthy D, Fryer AA, Boggild MD, Young C, Strange RC, Ollier W, Hawkins CP. 2000. Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis. Mult Scler, vol. 6(1), 32-36. link> doi>
  • Hutchinson PE, Osborne JE, Lear JT, Smith AG, Bowers PW, Morris PN, Jones PW, York C, Strange RC, Fryer AA. 2000. Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. CLINICAL CANCER RESEARCH, vol. 6(2), 498-504. link>
  • Lear JT, Smith AG, Strange RC, Fryer AA. 2000. Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy. BRITISH JOURNAL OF DERMATOLOGY, vol. 142(1), 8-15. link> doi>
  • Hayes JD and Strange RC. 2000. Glutathione S-transferase polymorphisms and their biological consequences. PHARMACOLOGY, vol. 61(3), 154-166. link> doi>
  • Dhar KK, Branigan K, Parkes J, Howells RE, Hand P, Musgrove C, Strange RC, Fryer AA, Redman CW, Hoban PR. 1999. Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells. Br J Cancer, vol. 81(7), 1174-1181. link> doi> full text>
  • Anwar S, Fryer AA, Gilissen RAHJ, Holland T, Bamber DE, Elder JB, Elder J, White J, Bicknell EJ, Strange RC, Coughtrie MWH. 1999. p53 protein overexpression correlates with phenol sulphotransferase (SULTIA1) genotype in colorectal cancer. BRITISH JOURNAL OF CANCER, vol. 81(4), 571-572. link>
  • Lear J, Sies H, Clairmont A, Ramachandran S, Smith A, Bowers B, Jones P, Fryer A, Strange R. 1999. Association of quinone oxidoreductase genotypes with basal cell carcinomas. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 113(3), 462. link>
  • Matthias C, Jahnke V, Jones PW, Hoban PR, Alldersea JE, Worrall SF, Fryer AA, Strange RC. 1999. Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: Assessment of the importance of individual genes using multivariate analysis. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, vol. 8(9), 815-823. link>
  • Clairmont A, Sies H, Ramachandran S, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. 1999. Association of NAD(P)H : quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci. CARCINOGENESIS, vol. 20(7), 1235-1240. link> doi>
  • Dhar KK, Branigan K, Howells R, Musgrove C, Strange RC, Fryer AA, Redman CWE, Hoban PR. 1999. Expression and subcellular localisation of cyclin DI protein in epithelial ovarian tumour cells. BRITISH JOURNAL OF CANCER, vol. 80, 74. link>
  • Ramsay HM, Fryer A, Strange RC, Smith AG. 1999. Multiple basal cell carcinomas in a patient with acute myeloid leukaemia and chronic lymphocytic leukaemia. Clin Exp Dermatol, vol. 24(4), 281-282. link> doi>
  • Dhar KK, Branigan K, Howells REJ, Musgrove C, Jones PW, Strange RC, Fryer AA, Redman CWE, Hoban PR. 1999. Prognostic significance of cyclin D1 gene (CCND1) polymorphism in epithelial ovarian cancer. Int J Gynecol Cancer, vol. 9(4), 342-347. link> doi>
  • Strange RC, Ellison T, Ichii-Jones F, Bath J, Hoban P, Lear JT, Smith AG, Hutchinson PE, Osborne J, Bowers B, Jones PW, Fryer AA. 1999. Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma. Pharmacogenetics, vol. 9(3), 269-276. link> doi>
  • Matthias C, Jahnke V, Hand P, Fryer AA, Strange RC. 1999. [Immunohistologic and molecular genetic studies of the effect of glutathione-S-transferases on the development of squamous epithelial carcinomas in the area of the head-neck]. Laryngorhinootologie, vol. 78(4), 182-188. link> doi>
  • Holland TA, Elder J, Deakin M, Hall C, Strange RC, Fryer AA, Hoban PR, Elder JB. 1999. Cyclin D1 protein expression in human colorectal carcinoma. GUT, vol. 44, A141. link>
  • Strange RC, Ichii-Jones F, Lear JT, Hutchinson PE, Fryer AA. 1999. Skin type, melanoma, and melanocortin 1 receptor variants - Reply. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 112(4), 513. link> doi>
  • Jones FI, Ramachandran S, Lear J, Smith A, Bowers B, Ollier WE, Jones P, Fryer AA, Strange RC. 1999. The melanocyte stimulating hormone receptor polymorphism: association of the V92M and A294H alleles with basal cell carcinoma. Clin Chim Acta, vol. 282(1-2), 125-134. link> doi>
  • Mattey DL, Hassell AB, Plant M, Dawes PT, Ollier WR, Jones PW, Fryer AA, Alldersea JE, Strange RC. 1999. Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. Ann Rheum Dis, vol. 58(3), 164-168. link> doi>
  • Bianco A, Fryer AA, Hepple M, Alldersea J, Strange RC, Spiteri MA. 1999. Polymorphism at the glutathione S-transferase, GSTP1, locus is associated with atopy/airway responsiveness. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 159(3), A649. link>
  • Matthias C, Jahnke V, Hand P, Fryer AA, Strange RC. 1999. Immunohistochemical and molecular genetic studies of the influence of glutathione-S-transferase as risk factors for the development of head and neck carcinomas. LARYNGO-RHINO-OTOLOGIE, vol. 78(4), 182-188. link> doi>
  • Coughtrie MWH, Gilissen RAHJ, Shek B, Strange RC, Fryer AA, Jones PW, Bamber DE. 1999. Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. BIOCHEMICAL JOURNAL, vol. 337, 45-49. link> doi>
  • Ramachandran S, Lear JT, Ramsay H, Smith AG, Bowers B, Hutchinson PE, Jones PW, Fryer AA, Strange RC. 1999. Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. Cancer Epidemiol Biomarkers Prev, vol. 8(1), 61-67. link>
  • Strange RC and Fryer AA. 1999. The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ, 231-249. link>
  • Layton MA, Jones PW, Alldersea JE, Strange RC, Fryer AA, Dawes PT, Mattey DL. 1999. The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumatology (Oxford), vol. 38(1), 43-47. link> doi> full text>
  • Lear JT, Harvey I, de Berker D, Strange RC, Fryer AA. 1998. Basal cell carcinoma. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, vol. 91(11), 585-588. link> doi>
  • Howells RE, Redman CW, Dhar KK, Sarhanis P, Musgrove C, Jones PW, Alldersea J, Fryer AA, Hoban PR, Strange RC. 1998. Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. Clin Cancer Res, vol. 4(10), 2439-2445. link>
  • Matthias C, Branigan K, Jahnke V, Leder K, Haas J, Heighway J, Jones PW, Strange RC, Fryer AA, Hoban PR. 1998. Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. CLINICAL CANCER RESEARCH, vol. 4(10), 2411-2418. link>
  • Worrall SF, Corrigan M, High A, Starr D, Matthias C, Wolf CR, Jones PW, Hand P, Gilford J, Farrell WE, Hoban P, Fryer AA, Strange RC. 1998. Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6. Pharmacogenetics, vol. 8(5), 433-439. link> doi>
  • Ichii-Jones F, Lear JT, Heagerty AH, Smith AG, Hutchinson PE, Osborne J, Bowers B, Jones PW, Davies E, Ollier WE, Thomson W, Yengi L, Bath J, Fryer AA, Strange RC. 1998. Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene. J Invest Dermatol, vol. 111(2), 218-221. link> doi>
  • Lear JT, Tan BB, Smith AG, Jones PW, Heagerty AH, Strange RC, Fryer AA. 1998. A comparison of risk factors for malignant melanoma, squamous cell carcinoma and basal cell carcinoma in the UK. Int J Clin Pract, vol. 52(3), 145-149. link>
  • Matthias C, Bockmuhl U, Jahnke V, Jones PW, Hayes JD, Alldersea J, Gilford J, Bailey L, Bath J, Worrall SF, Hand P, Fryer AA, Strange RC. 1998. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. PHARMACOGENETICS, vol. 8(2), 91-100. link>
  • Matthias C, Bockmuhl U, Jahnke V, Harries LW, Wolf CR, Jones PW, Alldersea J, Worrall SF, Hand P, Fryer AA, Strange RC. 1998. The glutathione S-transferase GSTP1 polymorphism: Effects on susceptibility to oral/pharyngeal and laryngeal carcinomas. PHARMACOGENETICS, vol. 8(1), 1-6. link> doi>
  • Matthias C, Bockmühl U, Jahnke V, Petersen I, Dietel M, Fryer A, Strange RC. 1998. [Effect of gene polymorphism on detoxifying glutathione-S-transferase enzymes on chromosomal stability of squamous epithelial carcinomas in the area of the head-neck]. Laryngorhinootologie, vol. 77(4), 201-206. link> doi>
  • MATTHIAS C, JAHNKE V, FRYER AA, STRANGE R, OLLIER W, HAJEER A. 1998. Influence of tumour necrosis factor microsatellite polymorphisms on susceptibility to head and neck cancer. Acta Otolaryngol, vol. 118, 284-288. doi>
  • Lear JT, Smith AG, Strange RC, Fryer AA. 1998. Patients with truncal basal cell carcinoma represent a high-risk group. Arch Dermatol, vol. 134(3), 373. link> doi>
  • Strange RC, Lear JT, Fryer AA. 1998. Polymorphism in glutathione S-transferase loci as a risk factor for common cancers. Arch Toxicol Suppl, vol. 20, 419-428. link> doi>
  • Mattey DL, Hassell AB, Plant MJ, Davis MJ, Dawes PT, Ollier WER, Jones PW, Fryer AA, Alldersea J, Strange RC. 1997. Association of radiological outcome in RA with polymorphisms in the glutathione S-transferase supergene family. ARTHRITIS AND RHEUMATISM, vol. 40(9), 1790. link>
  • Matthias C, Jahnke V, Hand P, Fryer AA, Strange RC. 1997. Influence of allelism at GSTM1, GSTM3 and GSTP1 gene loci and enzyme expression on site-specific susceptibility to head and neck cancer. EUROPEAN JOURNAL OF CANCER, vol. 33, 822. link>
  • Lear JT, Smith A, Bowers W, Heagerty A, Jones P, Gilford J, Alldersea J, Strange R, Fryer A. 1997. Truncal site, detoxifying enzyme genotypes and time to presentation of next basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 109(3), 435. link>
  • Lear JT, Smith AG, Heagerty AH, Bowers B, Jones PW, Gilford J, Alldersea J, Strange RC, Fryer AA. 1997. Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of further primary cutaneous basal cell carcinoma. Carcinogenesis, vol. 18(8), 1499-1503. link> doi>
  • Lear JT, Tan BB, Smith AG, Bowers W, Jones PW, Heagerty AH, Strange RC, Fryer AA. 1997. Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. J R Soc Med, vol. 90(7), 371-374. link> doi>
  • Lear JT, Smith AG, Bowers B, Heagearty AH, Jones PW, Gilford J, Alldersea J, Strange RC, Fryer AA. 1997. Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. J Invest Dermatol, vol. 108(4), 519-522. link> doi>
  • D'Souza RJ, Phillips HM, Strange RC, Aber GM. 1997. Modifying influence of enalaprilat on mesangial cell DNA synthesis induced by hydrogen peroxide. Clin Chim Acta, vol. 259(1-2), 137-146. link> doi>
  • JAHNKE V, STRANGE R, MATTHIAS C, FRYER AA. 1997. Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. European Archives of Otorhinolayngology, vol. 254(1), S147-S149. doi>
  • Lear JT, Strange RC, Fryer AA. 1997. Re: relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Inst, vol. 89(6), 454-455. link> doi>
  • HAJEER A, JOHN S, OLLIER WE, SILMAN AJ, DAWES P, HASSALL A, MATTEY D, FRYER AA, STRANGE R, WORTHINGTON J. 1997. Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. Journal of Rheumatology, vol. 24, 217-219.
  • Sarhanis P, Redman C, Perrett C, Brannigan K, Clayton RN, Hand P, Musgrove C, Suarez V, Jones P, Fryer AA, Farrell WE, Strange RC. 1996. Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. Br J Cancer, vol. 74(11), 1757-1761. link> doi>
  • Hand PA, Inskip A, Gilford J, Alldersea J, Elexpuru-Camiruaga J, Hayes JD, Jones PW, Strange RC, Fryer AA. 1996. Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis, vol. 17(9), 1919-1922. link> doi>
  • Lear JT, Heagerty AH, Smith A, Bowers B, Payne CR, Smith CA, Jones PW, Gilford J, Yengi L, Alldersea J, Fryer AA, Strange RC. 1996. Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis, vol. 17(9), 1891-1896. link> doi>
  • Lear JT, Tan BB, Smith AG, Fryer AA, Strange RC, Jones PW. 1996. Non-Hodgkin's lymphoma and solar ultraviolet radiation - Basal cell carcinoma may be linked to haematological malignancy. BRITISH MEDICAL JOURNAL, vol. 313(7052), 298-299. link> doi>
  • Yengi L, Inskip A, Gilford J, Alldersea J, Bailey L, Smith A, Lear JT, Heagerty AH, Bowers B, Hand P, Hayes JD, Jones PW, Strange RC, Fryer AA. 1996. Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Res, vol. 56(9), 1974-1977. link>
  • Deakin M, Elder J, Hendrickse C, Peckham D, Baldwin D, Pantin C, Wild N, Leopard P, Bell DA, Jones P, Duncan H, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1996. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, vol. 17(4), 881-884. link> doi>
  • Lear J, Heagerty A, Smith A, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange R. 1996. Polymorphism in detoxifying enzymes and susceptibility to skin cancer. Photochem Photobiol, vol. 63(4), 424-428. link> doi>
  • Ollier W, Davies E, Snowden N, Alldersea J, Fryer A, Jones P, Strange R. 1996. Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. Arthritis Rheum, vol. 39(10), 1763-1764. link> doi>
  • JAHNKE V, MATTHIAS C, FRYER AA, STRANGE R. 1996. Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. American Journal of Surgery, vol. 172, 671-673. doi>
  • D'Souza RJ, Phillips HM, Radeke HH, Aber GM, Strange RC. 1996. Mesangial cell DNA synthesis induced by hydrogen peroxide, interleukin-6, and platelet-derived growth factor: effects of indomethacin and dazmegrel. Nephron, vol. 72(2), 263-268. link> doi>
  • Heagerty A, Smith A, English J, Lear J, Perkins W, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange RC. 1996. Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. Br J Cancer, vol. 73(1), 44-48. link> doi>
  • Inskip A, Elexperu-Camiruaga J, Buxton N, Dias PS, MacIntosh J, Campbell D, Jones PW, Yengi L, Talbot JA, Strange RC. 1995. Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A. Biochem J, vol. 312 ( Pt 3), 713-716. link> doi>
  • Strange RC. 1995. More on genetic predisposition. Hum Exp Toxicol, vol. 14(12), 992-993. link> doi>
  • Strange RC. 1995. Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes - Comment. HUMAN & EXPERIMENTAL TOXICOLOGY, vol. 14(12), 992-993. link> doi>
  • Jahnke V, Strange R, Matthias C, Fryer AA. 1995. [Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]. Laryngorhinootologie, vol. 74(11), 691-694. link> doi>
  • Elexpuru-Camiruaga J, Buxton N, Kandula V, Dias PS, Campbell D, McIntosh J, Broome J, Jones P, Inskip A, Alldersea J. 1995. Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res, vol. 55(19), 4237-4239. link>
  • Ollier WER, Davies E, Snowden N, Alldersea J, Fryer A, Strange R, Jones P. 1995. Homozygosity for glutathione-transferase GSTM1 and GSTT1 null alleles may confer risk for anti-Ro antibodies in systemic lupus-erythematosus (SLE). Arthritis and Rheumatism, vol. 38, 183.
  • Duncan H, Swan C, Green J, Jones P, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1995. Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. Clin Chim Acta, vol. 240(1), 53-61. link> doi>
  • BELL DA, STEPHENS EA, CASTRANIO T, UMBACH DM, WATSON M, DEAKIN M, ELDER J, HENDRICKSE C, DUNCAN H, STRANGE RC. 1995. POLYADENYLATION POLYMORPHISM IN THE ACETYLTRANSFERASE-1 GENE (NAT1) INCREASES RISK OF COLORECTAL-CANCER. CANCER RESEARCH, vol. 55(16), 3537-3542. link>
  • Perrett CW, Clayton RN, Pistorello M, Boscaro M, Scanarini M, Bates AS, Buckley N, Jones P, Fryer AA, Gilford J. 1995. GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp. Carcinogenesis, vol. 16(7), 1643-1645. link> doi>
  • Buckley N, Bates AS, Broome JC, Strange RC, Perrett CW, Burke CW, Clayton RN. 1995. P53 protein accumulates in Cushings adenomas and invasive non-functional adenomas. J Clin Endocrinol Metab, vol. 80(2), 4 p following 692. link> doi>
  • HAYES JD and STRANGE RC. 1995. INVITED COMMENTARY POTENTIAL CONTRIBUTION OF THE GLUTATHIONE-S-TRANSFERASE SUPERGENE FAMILY TO RESISTANCE TO OXIDATIVE STRESS. FREE RADICAL RESEARCH, vol. 22(3), 193-207. link> doi>
  • Abukhalil I, Redman C, Strange R. 1995. Serum squamous cell carcinoma antigen: a potential marker for benign vulval disease?. Clin Exp Obstet Gynecol, vol. 22(4), 265-267. link>
  • JAHNKE V, STRANGE R, MATTHIAS C, FRYER AA. 1995. STUDIES ON GLUTATHIONE-S-TRANSFERASE GSTM1 AND GSTT1 GENOTYPES AND SUSCEPTIBILITY TO LARYNGEAL-CANCER. LARYNGO-RHINO-OTOLOGIE, vol. 74(11), 691-694. link> doi>
  • Warwick A, Sarhanis P, Redman C, Pemble S, Taylor JB, Ketterer B, Jones P, Alldersea J, Gilford J, Yengi L. 1994. Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking. Carcinogenesis, vol. 15(12), 2841-2845. link> doi>
  • Buckley N, Bates AS, Broome JC, Strange RC, Perrett CW, Burke CW, Clayton RN. 1994. p53 Protein accumulates in Cushings adenomas and invasive non-functional adenomas. J Clin Endocrinol Metab, vol. 79(5), 1513-1516. link> doi>
  • Warwick AP, Redman CW, Jones PW, Fryer AA, Gilford J, Alldersea J, Strange RC. 1994. Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. Br J Cancer, vol. 70(4), 704-708. link> doi>
  • Pinkham JM, Strange RC, Pantin C. 1994. Examination of bronchoalveolar wash fluid for ras, myc and fos oncoproteins and glutathione S-transferase isoenzymes: an attempt to improve the accuracy of lung cancer diagnosis. Clin Chim Acta, vol. 227(1-2), 211-215. link> doi>
  • Hiley CG, Otter M, Bell J, Strange RC, Keeling JW. 1994. Immunocytochemical studies of the distribution of alpha and pi isoforms of glutathione S-transferase in cystic renal diseases. Pediatr Pathol, vol. 14(3), 497-504. link> doi>
  • ZHAO L, ALLDERSEA J, FRYER AA, TIGHE A, OLLIER B, THOMSON W, JONES P, STRANGE RC. 1994. Polymorphism at the glutathione S-transferase GSTM1 locus: a study of the frequencies of the GSTM1 A, B, A/B and null phenotypes in Nigerians. Clinica Chimica Acta, vol. 225, 85-88. doi>
  • Heagerty AH, Fitzgerald D, Smith A, Bowers B, Jones P, Fryer AA, Zhao L, Alldersea J, Strange RC. 1994. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Lancet, vol. 343(8892), 266-268. link> doi>
  • D'Souza RJ, Phillips HM, Jones PW, Strange RC, Aber GM. 1993. Interactions of hydrogen peroxide with interleukin-6 and platelet-derived growth factor in determining mesangial cell growth: effect of repeated oxidant stress. Clin Sci (Lond), vol. 85(6), 747-751. link> doi>
  • Fryer AA, Zhao L, Alldersea J, Pearson WR, Strange RC. 1993. Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus. Biochem J, vol. 295 ( Pt 1), 313-315. link> doi>
  • Fryer AA, Jones P, Strange R, Hume R, Bell JE. 1993. Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation. Br J Obstet Gynaecol, vol. 100(9), 850-855. link> doi>
  • Davies SJ, D'Sousa R, Philips H, Mattey D, Hiley C, Hayes JD, Aber GM, Strange RC. 1993. Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase. Biochim Biophys Acta, vol. 1157(2), 204-208. link> doi>
  • HILEY CG, STRANGE RC, DAVIES MH, ELIAS E, HUBSCHER SG. 1993. GLUTATHIONE-S-TRANSFERASE EXPRESSION IN PRIMARY BILIARY-CIRRHOSIS SUPPORTS CONCEPT OF DUCTULAR METAPLASIA OF HEPATOCYTES. JOURNAL OF CLINICAL PATHOLOGY, vol. 46(4), 381. link> doi>
  • DAVIES MH, ELIAS E, ACHARYA S, COTTON W, FAULDER GC, FRYER AA, STRANGE RC. 1993. GSTM1 NULL POLYMORPHISM AT THE GLUTATHIONE-S-TRANSFERASE M1 LOCUS - PHENOTYPE AND GENOTYPE STUDIES IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS. GUT, vol. 34(4), 549-553. link> doi>
  • Fryer AA, Zhao L, Alldersea J, Boggild MD, Perrett CW, Clayton RN, Jones PW, Strange RC. 1993. The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. Carcinogenesis, vol. 14(4), 563-566. link> doi>
  • Mattey DL, Nixon N, Alldersea JE, Cotton W, Fryer AA, Zhao L, Jones P, Strange RC. 1993. Alpha, mu and pi class glutathione S-transferases in human synovium and cultured synovial fibroblasts: effects of interleukin-1 alpha, hydrogen peroxide and inhibition of eicosanoid synthesis. Free Radic Res Commun, vol. 19(3), 159-171. link> doi>
  • Clayton L, Hiley C, D'Souza RJ, Jones PW, Davies SJ, Strange RC, Aber GM. 1993. Oxidant stress and glomerular prostanoid production: influence of angiotensin converting enzyme inhibition. Free Radic Res Commun, vol. 18(2), 107-113. link> doi>
  • Strange RC, Fryer AA, Matharoo B, Zhao L, Broome J, Campbell DA, Jones P, Pastor IC, Singh RV. 1992. The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain. Biochim Biophys Acta, vol. 1139(3), 222-228. link> doi>
  • STRANGE RC, JONES P, BICKNELL J, SCARPELLO J. 1992. EXPRESSION OF CUZN-SUPEROXIDE DISMUTASE AND GLUTATHIONE-PEROXIDASE IN ERYTHROCYTES FROM DIABETIC AND NONDIABETIC SUBJECTS. CLINICA CHIMICA ACTA, vol. 207(3), 261-263. link> doi>
  • Clayton L, Hiley C, Davies S, D'Souza R, Jones P, Strange R, Aber G. 1992. Glomerular injury induced by hydrogen peroxide: modifying influence of ACE inhibitors. Free Radic Res Commun, vol. 17(4), 271-278. link> doi>
  • DAVIES MH, ACHARYA SK, ELIAS E, COTTON W, FRYER AA, FAULDER GC, STRANGE RC. 1992. THE GST1-0 POLYMORPHISM AT THE GLUTATHIONE S-TRANSFERASE-1 LOCUS - PHENOTYPE AND GENOTYPE STUDIES IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS. GUT, vol. 33(2), S8. link>
  • BELL JE, FRYER AA, COLLINS M, MARSHALL T, JONES PW, STRANGE R, HUME R. 1991. DEVELOPMENTAL PROFILE OF PLASMA-PROTEINS IN HUMAN FETAL CEREBROSPINAL-FLUID AND BLOOD. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, vol. 17(6), 441-456. link> doi>
  • Strange RC, Matharoo B, Faulder GC, Jones P, Cotton W, Elder JB, Deakin M. 1991. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Carcinogenesis, vol. 12(1), 25-28. link> doi>
  • BECKETT GJ, HOWIE AF, HUME R, MATHAROO B, HILEY C, JONES P, STRANGE RC. 1990. HUMAN GLUTATHIONE S-TRANSFERASES - RADIOIMMUNOASSAY STUDIES ON THE EXPRESSION OF ALPHA-CLASS, MU-CLASS AND PI-CLASS ISOENZYMES IN DEVELOPING LUNG AND KIDNEY. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1036(3), 176-182. link> doi>
  • Strange RC, Cotton W, Fryer AA, Jones P, Bell J, Hume R. 1990. Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. J Lab Clin Med, vol. 116(5), 666-673. link>
  • CARDER PJ, HUME R, FRYER AA, STRANGE RC, LAUDER J, BELL JE. 1990. GLUTATHIONE-S-TRANSFERASE IN HUMAN BRAIN. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, vol. 16(4), 293-303. link> doi>
  • WILKINSON M, HUME R, STRANGE R, BELL JE. 1990. GLIAL AND NEURONAL DIFFERENTIATION IN THE HUMAN FETAL BRAIN 9-23 WEEKS OF GESTATION. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, vol. 16(3), 193-204. link> doi>
  • STRANGE RC, FRYER A, BELL J, HUME R. 1990. STUDIES INTO THE ROLE OF REACTIVE OXYGEN SPECIES IN THE PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA. CLINICAL CHEMISTRY, vol. 36(6), 981. link>
  • COSSAR D, BELL J, STRANGE R, JONES M, SANDISON A, HUME R. 1990. THE ALPHA-ISOENZYME AND PI-ISOENZYME OF GLUTATHIONE S-TRANSFERASE IN HUMAN FETAL LUNG - INUTERO ONTOGENY COMPARED WITH DIFFERENTIATION IN LUNG ORGAN-CULTURE. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1037(2), 221-226. link> doi>
  • Carter ND, Fryer A, Grant AG, Hume R, Strange RG, Wistrand PJ. 1990. Membrane specific carbonic anhydrase (CAIV) expression in human tissues. Biochim Biophys Acta, vol. 1026(1), 113-116. link> doi>
  • Strange RC, Howie AF, Hume R, Matharoo B, Bell J, Hiley C, Jones P, Beckett GJ. 1989. The development expression of alpha-, mu- and pi-class glutathione S-transferases in human liver. Biochim Biophys Acta, vol. 993(2-3), 186-190. link> doi>
  • CARTER N, FRYER A, HUME R, STRANGE R, WISTRAND P. 1989. EXPRESSION OF MEMBRANE-BOUND CARBONIC-ANHYDRASE IN DEVELOPING HUMAN-LUNG AND KIDNEY. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 17(6), 1122-1123. link> doi>
  • FRYER AA, COTTON W, BELL J, HUME R, STRANGE RC. 1989. STUDIES ON THE DEVELOPMENTAL EXPRESSION OF SUPEROXIDE-DISMUTASE IN HUMAN-TISSUES. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 17(4), 794. link> doi>
  • BECKETT GJ, HUSSEY AJ, LAING I, HOWIE AF, HAYES JD, STRANGE RC, FAULDER CG, HUME R. 1989. MEASUREMENTS OF GLUTATHIONE S-TRANSFERASE-B1 IN PLASMA AFTER BIRTH ASPHYXIA - AN EARLY INDICATION OF HEPATOCELLULAR DAMAGE. CLINICAL CHEMISTRY, vol. 35(6), 995-999. link>
  • Hiley C, Bell J, Hume R, Strange R. 1989. Differential expression of alpha and pi isoenzymes of glutathione S-transferase in developing human kidney. Biochim Biophys Acta, vol. 990(3), 321-324. link> doi>
  • Matharoo B, Faulder GC, Strange RC. 1989. Alpha, mu and pi glutathione S-transferases: species (Talpa europaea) differences in their expression. Comp Biochem Physiol B, vol. 94(2), 343-347. link> doi>
  • MATHAROO B, FAULDER GC, STRANGE RC. 1989. ALPHA-GLUTATHIONE, MU-GLUTATHIONE AND PI-GLUTATHIONE S-TRANSFERASES - SPECIES (TALPA-EUROPAEA) DIFFERENCES IN THEIR EXPRESSION. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 94(2), 343-347. link> doi>
  • Strange RC, Hiley C, Roberts C, Jones PW, Bell J, Hume R. 1989. Studies on copper-zinc superoxide dismutase expression in developing human liver and kidney. Free Radic Res Commun, vol. 7(2), 105-112. link> doi>
  • STRANGE RC, HILEY C, ROBERTS C, JONES PW, BELL J, HUME R. 1989. STUDIES ON COPPER-ZINC SUPEROXIDE-DISMUTASE EXPRESSION IN DEVELOPING HUMAN-LIVER AND KIDNEY. FREE RADICAL RESEARCH COMMUNICATIONS, vol. 7(2), 105-&. link> doi>
  • Paramsothy J, Strange R, Sharif H, Collins M, Shaw P, Lawrence CM. 1988. The use of antipyrine clearance to measure liver damage in psoriatic patients receiving methotrexate. Br J Dermatol, vol. 119(6), 761-765. link> doi>
  • Hiley C, Fryer A, Bell J, Hume R, Strange RC. 1988. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochem J, vol. 254(1), 255-259. link> doi>
  • Strange RC, Cotton W, Fryer AA, Drew R, Bradwell AR, Marshall T, Collins MF, Bell J, Hume R. 1988. Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development. Biochim Biophys Acta, vol. 964(2), 260-265. link> doi>
  • Hirrell PA, Hume R, Fryer AA, Collins MF, Drew R, Bradwell AR, Strange RC. 1987. Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm. Biochim Biophys Acta, vol. 915(3), 371-377. link> doi>
  • HIRRELL PA, COLLINS MF, NIMMO IA, STRANGE RC. 1987. THE HUMAN GLUTATHIONE S-TRANSFERASES - STUDIES ON THE KINETIC, STABILITY AND INHIBITION CHARACTERISTICS OF THE ERYTHROCYTE ENZYME. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 913(1), 92-96. link> doi>
  • FAULDER CG, HIRRELL PA, HUME R, STRANGE RC. 1987. STUDIES OF THE DEVELOPMENT OF BASIC, NEUTRAL AND ACIDIC ISOENZYMES OF GLUTATHIONE-S-TRANSFERASE IN HUMAN-LIVER, ADRENAL, KIDNEY AND SPLEEN. BIOCHEMICAL JOURNAL, vol. 241(1), 221-228. link> doi>
  • FRYER AA, HUME R, STRANGE RC. 1986. THE DEVELOPMENT OF GLUTATHIONE-S-TRANSFERASE AND GLUTATHIONE-PEROXIDASE ACTIVITIES IN HUMAN-LUNG. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 883(3), 448-453. link> doi>
  • McGinnis R, Child F, Clayton S, Davies S, Lenney W, Immervoll T, Wjst M, Spurr N, Debouck C, Hajeer AH, Ollier WER, Strange RC, Fryer AA. Further support for the association of CCR5 allelic variants with asthma susceptibility. European Journal of Immunogenetics, vol. 29, 525-528. doi>
  • Ramachandran S, Hackett GI, Strange RC. 2019. Sex Hormone Binding Globulin: A Review of its Interactions With Testosterone and Age, and its Impact on Mortality in Men With Type 2 Diabetes. Sex Med Rev, vol. 7(4), 669-678. link> doi> full text>
  • König CS, Balabani S, Hackett GI, Strange RC, Ramachandran S. 2019. Testosterone Therapy: An Assessment of the Clinical Consequences of Changes in Hematocrit and Blood Flow Characteristics. Sex Med Rev, vol. 7(4), 650-660. link> doi> full text>

Chapters

  • Ramachandran S, Bhartia M, Jones A, Strange RC. 2019. PCSK9 Inhibitors in Diabetic Dyslipidemia. In RSSDI Diabetes Update 2018. (87 vols.). J P Medical Publishers. link> doi> link> full text>
  • Ramachandran S, Bhartia M, Jones A, Strange RC. 2019. Use of fibrates in the Metabolic Syndrome and Diabetics: practical tips. In RSSDI Diabetes Update–2018. (87 vols.). J P Medical Publishers. link> doi> link> full text>
  • STRANGE RC and FRYER AA. 2004. Glutathione S-transferase genotype - clinical implications. In Encyclopedia of Medical Genomics and Proteomics. Fuchs J and Podda M (Eds.). Marcel Dekker Inc, New York.
  • Jones PW, Strange RC, Fryer AA. 2002. Models of determining genetic suspectibility and predicting outcome. In Methods of Molecular Biology/Biostatistical Methods. Looney SW (Ed.). Humana Press, Totowa, New Jersey.
  • Jones PW, Strange RC, Ramachandran S, Fryer AA. 2001. Models for determining genetic susceptibility and outcome. In Methods in Molecular Biology Vol. 184. Humana Press, Totowa, New Jersey, USA.
  • Jones PW, Strange RC, Ramachandran S, Fryer AA. 2001. Models for determining genetic susceptibility and predicting outcome. In Biostatistical Methods. Looney SW (Ed.). Humana Press, Totowa, New Jersey.

Other

  • Ramachandran S, Strange RC, Fryer AA, Hackett GI. 2018. THE ASSOCIATION OF SEX HORMONE BINDING GLOBULIN WITH MORTALITY IS MEDIATED BY AGE IN MEN WITH TYPE 2 DIABETES. JOURNAL OF SEXUAL MEDICINE (vol. 15, pp. S218-S219). link> doi>
  • Koenig C, Atherton M, Cavazzuti M, Ramamchandran S, Gomm C, Strange RC, Halliday I, Schenkel T. 2017. A pilot study to assess peak systolic velocity as a possible marker of atherosclerotic burden using ultrasound. Artery Research (vol. 20, p. 76). Elsevier BV. doi> link>
  • Hackett G, Ramachandran S, Strange R, Jones P. 2017. LONG TERM THERAPY WITH TESTOSTERONE UNDECANOATE IN TYPE 2 DIABETES WAS ASSOCIATED WITH REDUCED ALL-CAUSE MORTALITY BUT NO SIGNIFICANT IMPROVEMENT IN CONVENTIONAL RISK FACTORS FOR CVD. JOURNAL OF SEXUAL MEDICINE (vol. 14, pp. S2-S3). link>
  • Mihalova T, Ban M, Baker A, Abraham R, Strange R, Hawkins CP. 2010. IL2RA AND CD226 GENOTYPES INFLUENCE MULTIPLE SCLEROSIS DISEASE OUTCOME. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 81, p. E27). link> doi>
  • Rukin NJ, Patel P, Blagojevic M, Luscombe CJ, Liu S, Ramachandran S, Strange RC. 2010. Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer. BJU INTERNATIONAL (vol. 105, p. 16). link>
  • Stone MJ, Woolmore J, Jenkinson P, Mihalova T, Stevenson R, Strange R, Langdon D, Hawkins CP. 2007. Cathepsin D polymorphisms and cognitive impairment in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 78, p. 1037). link>
  • Rukin NJ and Strange RC. 2007. What are the frequency, distribution, and functional effects of vitamin D receptor Polymorphisms as related to cancer risk?. NUTRITION REVIEWS (vol. 65, pp. S96-S101). link> doi>
  • Stone MJ, Woolmore JA, Jenkinson P, Stephens R, Mihalova T, Langdon D, Fryer AA, Strange R, Hawkins CP. 2007. Cognitive impairment and polymorphisms of cathepsin D in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 254, p. 163). link>
  • Mihalova T, Eyre S, Barton A, Bowes J, Rukin N, Stone M, Boggild M, Young CA, Fryer A, Hoban P, Worthington J, Strange R, Hawkins CP. 2006. Genetic polymorphism in type III promoter of the major histocompatibility complex class II transactivator gene is associated with susceptibility to multiple sclerosis. MULTIPLE SCLEROSIS (vol. 12, pp. S73-S74). link>
  • Madan V, Hoban P, Strange RC, Fryer AA, Lear JT. 2006. Genetics and risk factors for basal cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY (vol. 154, pp. 5-7). link> doi>
  • Holley S, Fryer A, Carroll W, Strange R, Hoban P, Lenney W. 2005. Functional analysis of GSTP1 haplotypes on cell growth and apoptosis in NIH3T3 fibroblasts. THORAX (vol. 60, pp. II22-II23). link>
  • Woolmore JA, Jenkinson PM, Stephens R, Weatherby SJ, Fryer AA, Strange RC, Payton A, Ollier W, Jones P, Langdon D, Hawkins CP, Keele MS. 2005. Neuropsychological outcome and APOE polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 76, p. 158). link>
  • CARROLL W, FRYER AA, CLIFF, STRANGE RC, SILVERMAN, WHYTE, LENNEY W. 2004. Familial segregation of lung function in asthmatic families: both parents are important but mother's influence may predominate earlier. Thorax.
  • CARROLL W, CHILD F, STRANGE RC, LENNEY W, FRYER AA. 2004. Glutathione s-transferase, oxidative stress and seasonal allergic responses. Thorax.
  • CARROLL W, CHILD F, FRYER AA, STRANGE RC, LENNEY W. 2004. Maternal Clasa Cell Secretory Protein (CC16) genotype is associated with fev in asthmatic children. Thorax.
  • CARROLL W, CHILD F, FRYER AA, STRANGE RC, WHYTE, PRIMHAK, LENNEY W. 2004. Relation of total immunoglobulin E, allergic sensitisation and asthma severity on children with asthma. Thorax.
  • Woolmore JA, Jenkinson P, Stephens R, Payton A, Weatherby SJ, Strange RC, Fryer AA, Ollier W, Jones PW, Langdon DW, Hawkins CR. 2004. Neuropsychological outcome and APOE polymorphism in multiple sclerosis. MULTIPLE SCLEROSIS (vol. 10, pp. S207-S208). link>
  • Lear JT, Lovatt TJ, Bastrilles J, Wong C, Griffiths CEM, Ramachandran S, Smith AG, Fryer AA, Jones PW, Strange RC. 2004. Associations between exposure to ultraviolet radiation and site and histology of basal cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY (vol. 151, p. 28). link>
  • Lear JT, Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Wong C, Jones PW, Ichii-Jones F, Hoban PR. 2004. Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms. BRITISH JOURNAL OF DERMATOLOGY (vol. 151, p. 28). link>
  • Woolmore JA, Barton A, John S, Fryer AA, Strange RC, Worthington J, Hawkins CR. 2004. High-density single nucleotide polymorphism mapping of protein kinase C alpha gene in a UK population of multiple sclerosis patients. JOURNAL OF NEUROLOGY (vol. 251, p. 61). link>
  • Woolmore JA, Barton A, John S, Worthington J, Fryer AA, Strange RC, Hawkins CP. 2004. High density single nucleotide polymorphism mapping of protein kinase C alpha gene in a UK population of multiple sclerosis patients. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 75, p. 517). link>
  • CARROLL W, LENNEY W, STRANGE RC, CHILD F, WHITE, PRIMHAK, KWONG, PROCTOR, CLAYTON S, DAVIS S, FRYER AA. 2004. Effects of glutathione s-transferase P1 on childhood lung function in asthmatic children and their families. American Journal of Respiratory and Critical Care Medicine.
  • CARROLL W, FRYER AA, STRANGE RC, WHYTE, CHILD F, CLAYTON S, DAVIES S, PROCTOR, PRIMHAK, KWONG, LENNEY W. 2004. Glutathione s-transferase PI (GSTP) genotype exerts a complex effect on asthma phenotype in asthmatic children and their families. American Journal of Respiratory and Critical Care Medicine.
  • CARROLL W, FRYER AA, STRANGE RC, CHILD F, LENNEY W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma. European Respiratory Journal.
  • Carroll WD, Fryer AA, Child F, Clayton S, Davies S, Strange RC, Lenney W. 2003. Further evidence supporting an in utero effect of maternal GSTP 1 on asthma phenotype. THORAX (vol. 58, pp. 1-2). link>
  • Carroll WD, Child F, Kwong GNM, Proctor A, Primhak R, Clayton S, Davies S, Strange RC, Whyte M, Fryer A, Lenney W. 2003. Regional variations in phenotype between cohorts 0f asthmatic children and their families. THORAX (vol. 58, pp. 69-70). link>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby F, Jones PW, Ramachandran S, Fryer AA, Strange RC. 2003. Susceptibility to prostate cancer: studies on interactions between ultraviolet exposure and skin type. BJU INTERNATIONAL (vol. 92, p. 832). link>
  • Lear JT, Ramachandran S, Fryer AA, Lovatt T, Smith AG, Jones PW, Strange RC. 2003. Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system. BRITISH JOURNAL OF DERMATOLOGY (vol. 148, p. 858). link>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Alldersea J, Strange RC, Fryer AA. 2002. Maternal but not paternal genetic variation in GSTP1 is associated with asthma phenotypes in children. THORAX (vol. 57). link>
  • Matthias C, Jahnke V, Hajeer A, Ollier W, Fryer AA, Strange RC. 2001. Influence of genetic variation in the major histocompatibility complex on head and neck cancer susceptibility. Laryngorhinootolgie. doi>
  • Ramachandran S, Fryer AA, Strange RC. 2001. Genetic factors determining cutaneous basal cell carcinoma phenotype. Med Pediatr Oncol (vol. 36, pp. 559-563). link> doi>
  • Bamber DE, Board PG, Coggan M, Elder JB, Deakin M, Rajagopal R, Fawole AS, Strange RC, Fryer AA. 2001. Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 95-97). link>
  • Rajagopal R, Fawole AS, White J, Holland TA, Deakin M, Elder JB, Strange RC, Fryer AA. 2001. Glutathione S-transferase M1, M3, P1 and T1 in susceptibility to and outcome in patients with colorectal adenocarcinoma. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 109-112). link>
  • Hemmingsen A, Fryer AA, Strange RC, De Marzo N, Pozzato V, Jovine L, Spiteri MA, Mapp CE. 2001. Polymorphism at the glutathione S-transferase: GSTP1 locus is associated with isocyanate-induced asthma: use of an ARMS-PCR assay for the simultaneous determination of (I105-V105) and A(114)-V-114 alleles. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 120-122). link>
  • Holley S, Parkes G, Bockmuehl U, Matthias C, Jahnke V, Strange RC, Hoban PR. 2001. Cyclin D1 polymorphism and expression in squamous cell carcinoma of the head and neck. Proceedings of the American Association of Cancer Research. doi>
  • Hemmingsen A, Fryer AA, Allen JT, Strange RC, Spiteri MA. 2001. Examination of glutathione S-transferase GSTP1 expression in human bronchial epithelial cells following acute ozone exposure. American Journal of Respiratory and Critical Care Medicine.
  • Byrom J, Mudaliar V, Redman C, Strange RC, Hoban PR. 2001. LOH at 9q22-31 is a frequent and early event in ovarian tumourigenesis. Proceedings of the American Association of Cancer Research.
  • Strange RC, Jones PW, Fryer AA. 2000. Glutathione S-transferase: genetics and role in toxicology. Toxicol Lett (vols. 112-113, pp. 357-363). link> doi>
  • Strange RC, Alldersea J, Hoban PR, Fryer AA, Matthias C, Jahnke V, Jones PW. 2000. Genetic polymorphism and clinical outcome: identification of individuals at risk of a poor clinical outcome. Allergy (vol. 55 Suppl 61, pp. 10-14). link> doi>
  • Spiteri MA, Bianco A, Strange RC, Fryer AA. 2000. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy (vol. 55 Suppl 61, pp. 15-20). link> doi>
  • Weatherby SJM, Carthy D, Mann C, Davies M, Aldersea J, Boggild M, Young C, Fryer A, Ollier W, Strange R, Hawkins CP. 1999. SEVERITY AND SUSCEPTIBILITY OF MULTIPLE SCLEROSIS RELATED TO POLYMORPHISMS OF APOLIPOPROTEIN E. JOURNAL OF NEUROLOGY (vol. 246, p. I21). link>
  • Mann CLA, Stevenson VL, Leary SM, Weatherby SJM, Fryer AA, Strange RC, Thompson AJ, Hawkins CP. 1999. THE ASSOCIATION OF POLYMORPHISMS AT THE IL-1 GENE CLUSTER; TNF; APOE; AND GST WITH PROGNOSIS IN A COHORT OF PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS PATIENTS. JOURNAL OF NEUROLOGY (vol. 246, p. I18). link>
  • Ramsay HM, Fryer A, Strange RC, Smith AG. 1999. Multiple basal cell carcinomas in a patient with acute myeloid leukaemia and chronic lymphocytic leukaemia. link>
  • Strange RC, Lear JT, Fryer AA. 1998. Glutathione S-transferase polymorphisms: influence on susceptibility to cancer. Chem Biol Interact (vols. 111-112, pp. 351-364). link> doi>
  • Hackett G, Ramachandran S, Strange R, Jones PW. 004 Long Term Therapy With Testosterone Undecanoate in Type 2 Diabetes was Associated With Reduced All-Cause Mortality but no Significant Improvement in Conventional Risk Factors for CVD. The Journal of Sexual Medicine (vol. 14, pp. S2-S3). Blackwell Publishing Inc.. doi> full text>
  • Kalra S, Durant L, Strange RC, Douglas MR, Hawkins CP, Curnow SJ. 2015. Role of Th17 and CCR6 cell lineage in multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL (vol. 21, pp. 796-797). link>
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