Biography
Professor Alicia El Haj is a leading figure in Regenerative Medicine and has been involved in bringing together interdisciplinary groups within biomedicine, physical sciences and engineering interested in aspects of cell and tissue engineering. She was a founder Director of Keele University's Research Institute of Science & Technology in Medicine (ISTM) which has rated highly; 5A, 5* and 5A through the past 3 RAE assessments. In September 2018 Alicia El Haj moved to the University of Birmingham but remains as a Visiting Professor at Keele University.
Prof El Haj is the Research Director of an EPSRC DTC in Regenerative Medicine, one of the co-directors of the new EPSRC Centre for Innovative Manufacturing Centre in Regenerative Medicine and a collaborator in the new Arthritis Research UK Tissue Engineering Centre. She has published over a 100 publications with an emphasis on engineering solutions for controlling stem cell behaviour and new orthopaedic repair strategies using novel enabling technology approaches with funding from EPSRC, BBSRC, Welcome Trust, AR UK and EU Framework.
Prof El Haj is a Chair elect of the European council for TERMIS, a member of the UK National Stem Cell Advisory Board, the IFMBE Working Group for Cellular Engineering, and the IPEM Academic Advisory board. She is on the editorial board of JTERM and Tissue Engineering and is currently serving as a member of the Medical Research Council’s Developmental Pathway Funding Scheme (DPFS) Panel. Prof El Haj served on the General Engineering UK REF 2014 Panel.
Recent research career:
May 2016 - onwards |
Theme Lead for Regenerative Medicine |
October 2012 - May 2016 |
Director - Institute of Science & Technology in Medicine, Keele University |
November 2009 - September 2012 | Theme Leader, Bioengineering & Therapeutics |
August 2004 - November 2009 | Director - Institute of Science & Technology in Medicine, Keele University |
March 2002 - 2004 | Research Dean for the Faculty of Health, Keele University |
October 1999 - 2004 | Head of Centre, Centre for Science and Technology in Medicine, Keele University |
July 1999 - present | Chair in Cell Engineering, Institute for Science and Technology in Medicine, Keele University |
April 1997 - 1999 | Senior Lecturer, Dept of Biomedical Engineering and Medical Physics, Keele University |
Research and scholarship
ISTM Research themes: Regenerative Medicine
Research Interests:
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Stem cell therapy for orthopaedic applications;
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Bioreactors and in vitro conditioning for tissue growth;
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Magnetic nanoparticle technologies for use in Regenerative Medicine.
Teaching
1997- 2013, Courses/Keele University
I have established an MSc course in Biomedical engineering and an MSc course in Cell and Tissue engineering in 1999 which has now taken its fourteenth year of intake.
- Msc Course in Cell & Tissue Engineering
- Msc Course in Biomedical Engineering
1990-1997, Courses/Birmingham University
1st Year Cell Biology and Molecular Biology:Cell Division and Differentiation
2nd Year Development 5 week option Molecular and Cell Biology; co-option leader:
* Animal Gene Regulation/Drosophila genetics
* Evolutionary Developmental Biology
3rd Year Cell Biology of Development - Option Leader
Biology of Animal Growth - Option Leader
Current Issues in Biomedical Sciences - Option leader
All 3 years involve lectures and practicals. Tutorials were held for all 3 years. Where option leader is noted - this involved design and development of a new course
Further information
Recent Research grants held at Keele awarded by:
- Royal Society
- EPSRC
- BBSRC
- European Commission 7th Framework Programme
- European Commission 6th Framework Programme
- European Commission 5th Framework Programme
- Arthritis Research UK
- Wellcome Trust, UK
- MRC
- ESRC
Recent external appointments:
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Fellow of the Society of Biology (FSB), 2011 to date
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Medical Research Council, Developmental Pathway Funding Scheme Panel Member (DPFS), 2011 to date
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UK HEFCE 2014 Research Excellence Framework (REF), Member of Sub-panel 15: General Engineering, 2011 to date
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EU Chair-Elect for TERMIS, 2011 to date
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EPSRC:
* Strategic Advisory Network Member, 2011 to date
* Healthcare Strategic Advisory Team Member, 2011 to date
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Honorary UHNS Clinical Contract, 2011 to date
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Adjunct Professor, Universiti KebangsaanTissue Engineering Centre, Faculty of Medicine, Malaysia, 2011 to date
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Council Member, European Chapter of the TERMIS (Tissue Engineering and Regenerative Medicine International Society), 2008 to date
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UK HEFCE RAE Panel member, General Engineering – G25, 2005-2008 & 2008 - 2009
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UK Bioengineering Society,Member of Founding Committee, 2008 to date
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UKSCN Stem Cell Advisory Board Member 2008 to 2011
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Deputy Chair / Chair of Engineering and Bioscience Panel (EBS) BBSRC, 2006 - 2009
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BBSRC BioIndustry Panel Member, 2010 to date
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President - UK Cell & Tissue Engineering (TCES), 2003 - 2008
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UK Cell & Tissue Engineering (TCES), Member of committee, 2009 to date
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EPSRC College and Panel Member/Chairman, 1997 to date
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MRC College of Experts, 2003 to date
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BBSRC Member of Engineering and Bioscience Panel (EBS) 2006
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Member Academic Advisory Group – Institute of Physics and Engineering in Medicine – 2006 to date
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Women’s Working Party of the IFMBE – 2004 to date
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Strategic Advisory Team member – Life Sciences interface – 2003
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International Science Committee of ICCE Advisory Board 2003
Patents:
UK/International patents:
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Stem cell conditioning. WO 2005059118 2003
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Culturing tissue using magnetic gen mech stress. WO 2004/00369 2002
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Magnetic nanoparticles as ion channel agonists. WO 02/051985 2002
Details of Awarded Grants:
Engineering & Physical Sciences Research Council (EPSRC), UK
- 2011-2012 £50,000 EPSRC Bridging the gaps sponsorship- for further information, please visit the Bridging the Gaps website.
- 2011-2012 £102,015, Creativity@Home - Designer magnetic particle tagging and activation of mechano-sensitive receptors for remote control of cell signalling and behaviour. (Prof Alicia J. El Haj, Prof Jon Dobson and Dr Paul Roach)
- 2011-2016 £310,000, E-TERM Programme-Collaborative programme between 2 Doctoral Training Centres in Regenerative Medicine including Keele, Loughborough, Sheffield, Leeds and York
- 2010-2015, £620,000, EPSRC Innovative Manufacturing Centre in Regenerative Medicine - Joint award with Loughborough University (Lead PI) and Nottingham University - see website for the EPSRC Centre in Regenerative Medicine
- 2008-2013 £750,000 Doctoral Training Centre in Regenerative Medicine with Nottingham and Loughborough universities - see website for the DTC in Regenerative Medicine.
- 2008-2011 £285,272 3ME - Modelling Methods for Medical Engineering (with Prof Jon Dobson, Prof Peter Styles and Prof Graham Rogerson to foster collaboration between medical engineering, applied mathematics and geophysics - see website for 3ME Initiative.
- 2005-2008 £382,912 Micromechanical analysis of chondrocytes – the role of the pericellular matrix. (Dr Nicola Kuiper (nee Goodstone) and Prof Alicia El Haj). A collaboration with Dr Zhang, Prof Thomas, Chemical Engineering, Birmingham University
- 2004 – 2006 £215,356 Development of a mechano-active scaffold for skeletal tissue. (with Dr Ying Yang).
- 2001 – 2004 £238,156 High resolution optical tomographic imaging of in vivo micro-circulation.
- 2001 - 2003 £62,205 Development of novel magnetic force bioreactor for tissue engineering.
- 1999 - 2002 £258,854 Development of the TSIFT for breath analysis and analysis of headspace above cells in vitro. (with Prof David Smith).
Biotechnology & Biological Sciences Research Council (BBSRC), UK
- 2008-2013 £758,000 of £3m total, LOLA: Combining Stem Cell Science and Tissue Engineering to study the development and repair of human skeletal tissues with Imperial College London (Prof Molly Stevens), Nottingham University (Prof Kevin Shakesheff) and Southampton University (Prof Richard Oreffo)
- 2006 – 2007 £14,600 Masters Level Training for Industry – Bioreactor Development. (Dr Sarah Cartmell and Prof Alicia El Haj).
- 2006 – 2009 £347,381 Nano-optical-mechanical manipulation of bone marrow stem cells in physiological flows: design principles for delivering stem cell therapy. (Dr Isaac Liu, Prof Alicia El Haj, Dr Yibin Fu)
- 2004 – 2007 £335,435 Development of magnetic nanoparticle strategies for manipulation and activation of stem cells in vitro and in vivo. (Prof Alicia El Haj and Prof Jon Dobson), collaboration with Prof Richard Oreffo , Southampton University.
- 2004 – 2006 £170,806 Quantitative on-line assessment of collagen fibre organisation in connective tissues in vivo and during tissue engineering in vitro. (Prof Alicia El Haj, Dr Ying Yang, Prof Nicola Maffulli) Collaboration with Ritchie, Cranfield University.
European Commission 7th Framework Programme
- 2011-2015 £460,000 Rational Bioactive Materials Design for Tissue Regeneration (BIODESIGN) - Coordinated by Upsalla University with 21 partners - see the BIODESIGN website. Grant agreement no: 262948.
- 2008-2012 374,400 Euro Hyaluronan-based injectable material for tissue engineering (HYANJI-SCAFFOLD) - Prof Alicia El Haj and Dr Nicholas R. Forsyth: Project Co-ordinators. An IRSES exchange programme with Italian and Chinese partners, for details see the HYANJI SCAFFOLD website.
European Commission 6th Framework Programme
- 2005 - 2009 £250,000 EXPERTISSUES, Network of Excellence –(Prof Alicia El Haj lead for WP8) Total value of grant 7 million Euro
- 2007-2010 £650,000 NEST project – MYJOINT,Lead by Keil Germany and Keele UK with 6 partners.
- 2005 – 2007 €346,436 Marie Curie Multicentre Training Grant (ALEA JACTA) in regenerative medicine.
European Commission 5th Framework Programme
- 2001 - 2004 £165,145 European Partnership for Autologous Chrondrocye Implantation (EUROCELL). (Prof Alicia El Haj, Prof James Richardson et al, 8 lead investigators in total)
- 2000 - 2002 £254,706 Biomedical interactions in tissue engineering and tissue engineering in surgical repair (BITES) - Prof Alicia El Haj: Project Co-ordinator. Total value of grant 2,104,999 Euro
Arthritis Research UK
- 2011-2016 £713,417 ARUK Tissue Engineering Centre - Collaborative bid with Newcastle, Keele, York, Aberdeen,for details please see the Arthritis Research UK Tissue Engineering Centre website.
Wellcome Trust, UK
- 2011 £1440 Vacation Scholarship 2011: Tendon Tissue Engineering.
- 2002 – 2004 £125,000 Sir Henry Wellcome Showcase Award - Biomagnetic strategies for therapeutics in bone. (Prof Alicia El Haj and Prof Jon Dobson)
MRC
- 2012-2013 £30,000 MRC Centenary AWARD
2013-2017 £326,095 Acellular Approaches for Therapeutic Delivery:UK Regenerative Medicine Platform Hub Application
2013-2017 £23,833 A hub for Engineering and exploiting the stem cell niche: UK Regenerative Medicine Platform Hub Application
Royal Society
- 2013-2018 £50,000 Wolfson Research Merit Awards- Engineering cells and tissues for regenerative medicine and stem cell therapies
ESRC
- 2015-2017 ESRC Seminar Series grant: ‘Liability versus Innovation: Unpacking Key connections’
Selected Publications
- 2016.
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Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering. Stem Cell Reports, vol. 7(1), 126-137. link> doi> full text>2016.
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In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors. PLoS One, vol. 10(12), e0145080. link> doi> full text>2015.
- 2011.
- 2010.
Full Publications List show
Books
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Biomechanics and Cells. Cambridge Univ Pr.2009.
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Ashammaki N and Waris T (Eds.). 2004. Enhancement of mechanical signals for tissue engineering bone. e-book, ..
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Molecular biology of muscle. Company of Biologists.1992.
Journal Articles
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Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model. Sci Rep, vol. 10(1), 8451. link> doi> full text>2020.
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Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction. Tissue Eng Part A, vol. 25(3-4), 214-223. link> doi> full text>2019.
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A Perfusion Culture System for Assessing Bone Marrow Stromal Cell Differentiation on PLGA Scaffolds for Bone Repair. Front Bioeng Biotechnol, vol. 6, 161. link> doi> full text>2018.
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Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing. Stem Cell Res Ther, vol. 9(1), 248. link> doi> full text>2018.
- 2018.
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Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation. Nanomedicine, vol. 14(4), 1149-1159. link> doi> full text>2018.
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Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. J Biomed Mater Res A, vol. 106(3), 629-640. link> doi> full text>2018.
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Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. Stem Cells Int, vol. 2017, 2905104. link> doi> full text>2017.
- 2017.
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Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods, vol. 136, 126-133. link> doi> full text>2018.
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Remote regulation of magnetic particle targeted Wnt signaling for bone tissue engineering. Nanomedicine, vol. 14(1), 173-184. link> doi> full text>2018.
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Tenogenic Differentiation of Human Embryonic Stem Cells. Tissue Eng Part A, vol. 24(5-6), 361-368. link> doi> full text>2018.
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Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. Tissue Eng Part C Methods, vol. 23(4), 228-236. link> doi> full text>2017.
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Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications. J Biomed Mater Res A, vol. 105(6), 1775-1785. link> doi> full text>2017.
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The cellular magnetic response and biocompatibility of biogenic zinc- and cobalt-doped magnetite nanoparticles. Sci Rep, vol. 7, 39922. link> doi> full text>2017.
- 2017.
- 2016.
- 2016.
- 2016.
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Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering. Stem Cell Reports, vol. 7(1), 126-137. link> doi> full text>2016.
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A comparative study of skin cell activities in collagen and fibrin constructs. Med Eng Phys, vol. 38(9), 854-861. link> doi> full text>2016.
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Fluorescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC ADVANCES, vol. 6(50), 44364-44370. link> doi> full text>2016.
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Liquid Crystalline Ordered Collagen Substrates for Applications in Tissue Engineering. ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 2(4), 625-633. link> doi> full text>2016.
- 2016.
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The influence of hydrostatic pressure on tissue engineered bone development. Journal of Theoretical Biology, vol. 394, 149-159. doi> link> full text>2016.
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In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors. PLoS One, vol. 10(12), e0145080. link> doi> full text>2015.
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Autonomous magnetic labelling of functional mesenchymal stem cells for improved traceability and spatial control in cell therapy applications. J Tissue Eng Regen Med, vol. 11(8), 2333-2348. link> doi> full text>2017.
- 2015.
- 2015.
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Nano-colloid printing of functionalized PLA-b-PEO copolymers: tailoring the surface pattern of adhesive motif and its effect on cell attachment. Physiol Res, vol. 64(Suppl 1), S61-S73. link> doi> full text>2015.
- 2015.
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BMP2 repression and optimized culture conditions promote human bone marrow-derived mesenchymal stem cell isolation. Regen Med, vol. 10(2), 109-125. link> doi> full text>2015.
- 2015.
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Remote Activation of the Wnt/beta-Catenin Signalling Pathway Using Functionalised Magnetic Particles. PLOS ONE, vol. 10(3), Article ARTN e0121761. link> doi> full text>2015.
- 2014.
- 2014.
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Counting cell number in situ by quantification of dimethyl sulphide in culture headspace. Analyst, vol. 139(19), 4903-4907. link> doi> full text>2014.
- 2015.
- 2014.
- 2014.
- 2014.
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An ex vivo chick femur as a model to study the effect of soluble growth factors and small molecules on chondroprogenitors. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, 499-500. link>2014.
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Correlating mesenchymal stem cell delivery with pain in an OA rat model. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, 146. link>2014.
- 2014.
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Physico-chemical properties and in vitro biological assessment of multi-substituted hydroxyapatite powders. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, 411. link>2014.
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The magnetic-induced migration of adipose-derived stromal cells and its applicability in tendon tissue engineering. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, 505-506. link>2014.
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Gelatin-Based Materials in Ocular Tissue Engineering. Materials (Basel), vol. 7(4), 3106-3135. link> doi> full text>2014.
- 2014.
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Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model. J Biomed Mater Res A, vol. 103(1), 282-288. link> doi> full text>2015.
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Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis. J Transl Med, vol. 12, 157. link> doi> full text>2014.
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STEM CELL THERAPY: CHALLENGES FOR CONTROL AND DELIVERY. WOUND REPAIR AND REGENERATION, vol. 22(5), A79. link>2014.
- 2014.
- 2013.
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Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model. Stem Cell Res Ther, vol. 4(5), 126. link> doi> full text>2013.
- 2014.
- 2014.
- 2013.
- 2013.
- 2013.
- 2013.
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Control of smooth muscle α-actin (SMA) up-regulation in HBMSCs using remote magnetic particle mechano-activation. Nanomedicine. doi>2013.
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Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro. Bone. doi>2013.
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Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Int J Mol Sci, vol. 14(9), 19276-19293. link> doi> full text>2013.
- 2012.
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Assessment of the performance of a novel hydrostatic force bioreactor- changes of pH and oxygen tension during cell culture. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 337. link>2012.
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Cyclic hydrostatic pressure enhances osteogenesis in cell-seeded scaffolds. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 338. link>2012.
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Effects of components of the blood on magnetic targeting of stem cells for therapy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 362-363. link>2012.
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Ingrowth of bone cells within cryogels under compression and perfusion. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 241. link>2012.
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Keynote: Controlled stem cell receptor activation using magnetic particle based approches. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 321. link>2012.
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Mechanostimulation of human mesenchymal stem cells in PHBHHx/collagen hybrid scaffolds for tendon tissue engineering applications. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 46. link>2012.
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Regulation of genotype and phenotype of corneal stromal cells. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 137-138. link>2012.
- 2012.
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Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine. JOURNAL OF NANOMATERIALS, Article ARTN 614094. link> doi> full text>2012.
- 2012.
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Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Res Ther, vol. 3(2), 13. link> doi> full text>2012.
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Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering. J Funct Biomater, vol. 3(3), 642-687. link> doi> full text>2012.
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Engineering cells to grow tissue. Ingenia. link>2011.
- 2013.
- 2011.
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REGULATION AND CHARACTERISATION OF CORNEAL STROMAL CELL CONTRACTION. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol. 34(8), 694. link>2011.
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Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, vol. 4, 775-780. doi>2011.
- 2011.
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An in Vitro model of mesenchymal stem cell targeting using magnetic particle labelling. Journal of Tissue Engineering and Regenerative Medicine. doi>2011.
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3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med. doi>2010.
- 2011.
- 2010.
- 2010.
- 2010.
- 2010.
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In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography. Phys Med Biol. 2010 Jul 7;55(13):3777-87. Epub 2010 Jun 15., vol. 13(55), 3777-3787.2010.
- 2010.
- 2010.
- 2010.
- 2010.
- 2010.
- 2010.
- 2010.
- 2009.
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An optical-manipulation technique for cells in physiological flows. Journal of Biological Physics: an international journal for the formulation and application of physi, vol. 36, 135-143. doi>2009.
- 2010.
- 2009.
- 2009.
- 2010.
- 2009.
- 2009.
- 2009.
- 2009.
- 2009.
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Natural variations in myosin heavy chain genotype in gammarid amphipods. Comparative Biochemistry and physiology, Part A: molecular & Interactive Physiology, vol. 2(153), S72. doi>2009.
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Opto-Mechanical Manipulation of Stem Cells. The Open Nanomedicine Journal, vol. 2, 10-14. doi>2009.
- 2008.
- 2008.
- 2008.
- 2008.
- 2008.
- 2008.
- 2010.
- 2008.
- 2007.
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Determination of drug permeability in Caco-2 monolayers using mica technology. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, 222-223. link>2007.
- 2007.
- 2007.
- 2007.
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DNA delivery using polyethyleneimine (PEI) coated iron oxide-silica mesostructured particles. Studies in Surface Science and Catalysis, vol. 165, 869-872. doi>2007.
- 2007.
- 2007.
- 2006.
- 2006.
- 2006.
- 2006.
- 2006.
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Investigation of optical coherence tomography as an imaging modality in tissue engineering. Physics in Medicine and Biology, vol. 51(7), 1-11. doi>2006.
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Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. Journal of Cellular Physiology, vol. 206(3), 738-748. doi>2006.
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Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. Journal of cellular physiology, vol. 206(3), 738-748.2006.
- 2005.
- 2005.
- 2005.
- 2005.
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Sensitivity of single, in vitro growing lung cancer cells to gemcitabine measured with synchrotron based fourier transform infrared microspectroscopy. EJC SUPPLEMENTS, vol. 3(2), 51. link>2005.
- 2005.
- 2005.
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FT-IR microspectroscopy as a tool to assess lung cancer cells response to chemotherapy. Vibrational Spectroscopy, vol. 38, 179-184.2005.
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Growing muscles in the fridge: the crustacean way. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, vol. 141(3), S99-S100. link>2005.
- 2005.
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The plasticity of myosin heavy chain genes in gammarid amphipods distributed along a latitudinal thermal gradient. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, vol. 141(3), S353. link>2005.
- 2005.
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Use of magnetic particles to apply mechanical forces for bone tissue engineering purposes. Journal of Physics: Conference Series, vol. 17(1), 77-80.2005.
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Monitoring of lung tumour cell growth in artificial membranes. Biosens Bioelectron, vol. 20(3), 442-447. doi>2004.
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Biomechanical interactions in tissue engineering and surgical repair (BITES). Med Biol Eng Comput, vol. 42(1), 2. doi>2004.
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Bone tissue engineering. Scope, vol. 13(3), 33-35.2004.
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Effects of CaCl2 and MgCl2 on Fourier transform infrared spectra of lung cancer cells. Applied Spectroscopy, vol. 1(58), 61-67.2004.
- 2004.
- 2004.
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Mechanotransduction of bone cells in vitro; mechanobiology of bone tissue. Med Biol Eng Comput, vol. 42(1), 14-21. doi>2004.
- 2004.
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Scaffold design and synthesis for bone tissue engineering. CME Orthopaedics, vol. 3(3), 71-76.2004.
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Use of OCT to study tumor cell growth in 3D membranes. Proceedings of SPIE.2004.
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Use of OCT to study tumor cell growth in 3D membranes. Proceedings of SPIE. doi>2004.
- 2003.
- 2003.
- 2003.
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Effects of mechanical force application on 3D bone tissue engineered constructs using magnetic microparticles. European Cells & Materials, vol. 6(2), 7.2003.
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Effects of media perfusion rate on cell seeded 3D bone constructs in vitro. Tissue Engineering, vol. 9(6), 1197-1203.2003.
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Investigation of changes in optical attenuation of bone and neuronal cells in organ culture or 3D constructs in vitro with OCT; relevance to cytochrome oxidase monitoring. Biophysics Journal with Biophysics Letters, vol. 32(4), 355-362.2003.
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Ion channel expression in intervertebral disc cells. European Cells and Materials.2003.
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Mechanical stimulation of calcium signalling pathways in human bone cells using ferromagnetic microparticles: Implications for tissue engineering. European Cells & Materials, vol. 6(2), 43.2003.
- 2003.
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Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Communcations Mass Spectometry, vol. 17(8), 845-850. doi>2003.
- 2002.
- 2002.
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Characterisation of the mechanoresponsive regions of the c-fos promoter in osteoblasts. BONE, vol. 30(3), 9S. link>2002.
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Advances in tissue engineering and regenerative medicine. Eye News, vol. 8(5), 14-20.2002.
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Comparsion of the variable loop regions of myosin heavy chain genes from Antarctic and temperate isopods. Comparative Biochemistry and Physiology B-Biochemistry and Molecular Biology, vol. 131, 349-359. doi>2002.
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Does light scattering affect the OCT quantitation of redox state of cytochrome oxidase in bone tissue?. Proceedings of SPIE, vol. 4619, 219-222.2002.
- 2001.
- 2001.
- 2001.
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Nicotinic regulation of C-Fos and osteopontin expression in human-derived osteoblast like cells and human trabecular bone organ culture. Bone, vol. 28(6), 603-608. doi>2001.
- 2001.
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High resolution optical tomographic imaging of biological tissues. Scope, vol. 10, 12-14.2001.
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Immuno histochemical detection of schwann cells and vascularisation in the degenerating human intervertebral discs. Spine, vol. 26, 2550-2557.2001.
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In vitro monitoring of redox state of cytochrome oxidase in bone by optical coherence quantitation based on low-coherence interferometry. Proceddings of SPIE, vol. 4251, 117-122. doi>2001.
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In-vitro imaging of bone tissue and monitoring of tissue viability by optical coherence tomography. Proceedings of SPIE, vol. 4257, 442-447. doi>2001.
- 2001.
- 2000.
- 2000.
- 2000.
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Study of lung cancer cells by Fourier Transform Infrared spectroscopy. THORAX, vol. 54, A83. link>1999.
- 1999.
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Nicotine promotes proliferation and cfos induction in bone cells - The effects of smoking on skeletal repair and remodeling. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, S477. link>1999.
- 1999.
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Upregulation of calcium channel expression in the mouse osteocyte cell line, MLO-Y4, by bone regulating factors. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, S472. link>1999.
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Effects of smoking on fracture repair; A study of the possible direct effects on bone cell activity. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14(6), 1045. link>1999.
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Expression of voltage operated calcium channels in the mouse osteocyte cell line MLO-Y4. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14(6), 1047. link>1999.
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Interaction between substrates and mechanical loading of human bone cells, responses in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14(6), 1050. link>1999.
- 1999.
- 1998.
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Hormonal regulation of [Ca2+]i in periosteal, derived osteoblasts; Effects of PTH, vitamin D and PGE(2). JOURNAL OF BONE AND MINERAL RESEARCH, vol. 13(9), 1512. link>1998.
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Mechanical manipulation of human osteoblast and chondrocyte cells with 'optical tweezers'. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 13(9), 1506. link>1998.
- 1998.
- 1997.
- 1997.
- 1996.
- 1996.
- 1996.
- 1995.
- 1995.
- 1994.
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Actin mRNA levels and myofibrillar growth in leg muscles of the European lobster (Homarus gammarus) in response to passive stretch. Mol Mar Biol Biotechnol, vol. 3(1), 35-41. link>1994.
- 1994.
- 1992.
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Regulation of muscle gene expression in Crustacea over the moult cycle. Symp Soc Exp Biol, vol. 46, 151-165. link>1992.
- 1991.
- 1990.
- 1990.
- 1988.
- 1987.
- 1986.
-
Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells. Journal of Tissue Engineering, vol. 9, 2041731418808695. link> doi> full text>
Chapters
- 2016.
-
Biomechanics and Cells. In Biomechanics and Cells. Lyall F and El Haj AJ (Eds.). Cambridge Univ Pr.2009.
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Bioreactors for Connective Tissue engineering: Design and Monitoring Innovations. In Advances in biochemical engineering/biotechnology. Kasper C, Griensven MV, Pörtner R, Al-Rubeai M (Eds.). doi>2008.
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Bone regeneration and repair using tissue engineering. In Tissue Engineering using Ceramics and Polymers. BOCCACCINI AR and GOUGH JE (Eds.). North America by CRC Press LLC, 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, USA: Woodhead Publishing Limited. link>2007.
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Nanomaterials for Controlled Release of Anticancer Agents. Wiley-VCH. doi>2007.
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Mechanical Bioreactors for Bone Tissue Engineering. In Bioreactors for Tissue Engineering: Principles, Design and Operation. Chaudhuri J and Al-Rubeai M (Eds.). Springer.2005.
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Tissue Engineering. In Applications of Cell Immobilisation Biotechnology. Nedovic V and Willaert R (Eds.). (vol. 8B). Kluwer Academic Publishers.2005.
Other
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Multicentre study reveals poor correlation between in vitro and in vivo assessments of biomaterials for bone-regeneration. Bone Abstracts. Bioscientifica. doi>2016.
- 2016.
- 2016.
-
Fluorescent Monitoring of Poly(lactic-co-glycolic Acid) Degradation and Extracellular Matrix Turnover of Engineered Tissue Constructs. TISSUE ENGINEERING PART A (vol. 21, p. S99). link>2015.
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Remote Cell Activation for Bone Regeneration - a Pre Clinical Animal Study. TISSUE ENGINEERING PART A (vol. 21, pp. S7-S8). link>2015.
- 2014.
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Targeted magnetic nanoparticles - remotely controlled mechanotransduction for injectable cell therapy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 8, p. 50). link>2014.
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INTRA-ARTICULAR INJECTION OF MESENCHYMAL STEM CELLS LEADS TO REDUCED INFLAMMATION IN ANTIGEN-INDUCED ARTHRITIS. RHEUMATOLOGY (vol. 52, p. 78). link>2013.
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A Morphological Study of Cell Aggregations on Mineralization. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (vol. 30, pp. 9-12). link>2011.
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Mechanical Conditioning Using Magnetic Nanoparticles Bound to PDGF Receptors on HBMSCs Promotes the Smooth Muscle Alpha Actin (SMA) Expression. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (vol. 30, pp. 23-25). link>2011.
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Online Monitoring the Mechanical Remodeling of Hydrogels by Corneal Fibroblasts. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (vol. 30, pp. 1-+). link>2011.
- 2010.
- 2009.
- 2009.
- 2008.
- 2008.
- 2008.
-
Characterisation of the glycosaminoglycans in the pericellular matrix of chondrons and chondrocytes following enzymatic isolation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A6-A7). link>2008.
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Low intensity pulsed ultrasound (LIPUS) increases extracellular matrix synthesis by chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A17-A18). link>2008.
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Tendon collagen orientation and crimp pattern characterized by PSOCT. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A28-A29). link>2008.
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Dynamic studies of biomimetic coated polycaprolactone nanofiber meshes as bone extracellular matrix analogues. TISSUE ENGINEERING PART A (vol. 14, pp. 723-724). link>2008.
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Linking the physical environment to cell behaviour - Applications for tissue engineering and regenerative medicine. TISSUE ENGINEERING PART A (vol. 14, p. 752). link>2008.
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Real time monitoring of scaffold degradation under culture conditions. TISSUE ENGINEERING PART A (vol. 14, p. 903). link>2008.
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The validation of a novel compression bioreactor to ensure the accurate application of loading regimes. TISSUE ENGINEERING PART A (vol. 14, p. 919). link>2008.
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Visualization of structural evolution in tissue engineering tendon. TISSUE ENGINEERING PART A (vol. 14, p. 795). link>2008.
- 2008.
- 2008.
-
Electrophysiological responses of HMSCs and bone cells to magnetic particle tagging. TISSUE ENGINEERING (vol. 13, p. 1684). link>2007.
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Exploring fluorescence as a tool for real-time monitoring of scaffolds degradation. TISSUE ENGINEERING (vol. 13, p. 1694). link>2007.
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Gene expression in stem cells following stimulation using magnetic particle technology. TISSUE ENGINEERING (vol. 13, p. 1699). link>2007.
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Interaction of cells with novel biodegradable cryogels in bioreactors. TISSUE ENGINEERING (vol. 13, p. 1718). link>2007.
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Targeting stem cells transfected with magnetic nanoparticles in a flow system. TISSUE ENGINEERING (vol. 13, p. 1760). link>2007.
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The use of osteoblast/osteoclast co-cultures on PLLA, silk and dentine scaffolds. TISSUE ENGINEERING (vol. 13, pp. 1765-1766). link>2007.
- 2007.
- 2007.
- 2007.
- 2007.
- 2006.
- 2006.
-
Mechanically characterizing and stimulating tissue-engineered corneal stromal equivalent. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 86, pp. A29-A30). link>2005.
- 2005.
- 2005.
-
Use of magnetic particles to apply forces for bone tissue engineering purposes. Proceedings of the 5th International Conference on Fine Particle Magnetism. doi>2004.
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A novel mechanical conditioning regime for tissue engineered constructs. International Journal of Experimental Pathology.2004.
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A novel mechanical conditioning regime for tissue-engineered constructs. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 86, p. A38). link>2005.
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A study of the effects of seeding density, media flow and biochemical stimuli on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of the Combined Meeting of the Tissue Engineering Society International ? European Tissue Engineering Society Meeting.2004.
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FTIR microspectrosocopy as a tool to assess tumour response to chemotherapy in lung cancer cells. Spec2004. Shedding new light on disease: optical diagnosis for the new millennium. Newark, USA. July 2004.2004.
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Microarray analysis of mechanically and chemically induced primary human stem cell differentiation. Proceedings of the European Tissue Engineering Society Conference.2004.
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Novel mechanical conditioning of 3D bone tissue engineered constructs. Proceedings of the European Tissue Engineering Society Conference.2004.
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The effects of a 3D environment on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of Tissue and Cell Engineering Society Spring Meeting.2004.
-
The effects of a 3D environment on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of Tissue and Cell Engineering Society Spring Meeting.2004.
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Use of magnetic particles to apply forces for bone tissue engineering purposes. Proceedings of the 5th International Conference on Fine Particle Magnetism.2004.
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Effect of microtopographical cue on human corneal keratocytes orientation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (vol. 44, p. U254). link>2003.
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Mechanical conditioning of bone cells for tissue engineering strategies. Proceedings of the International Conference on Cellular Engineering, Sydney, Australia - 20th - 22nd August 2003.2003.
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Mechanical conditioning of bone cells for tissue engineering strategies. Proceedings of the International Conference on Cellular Engineering, Sydney, Australia - 20th - 22nd August 2003.2003.
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Reconstruction of 3D human cornea using processed porcine cornea as a biological scaffold. SOE 2003: XIV CONGRESS OF THE EUROPEAN SOCIETY OF OPHTHALMOLOGY (pp. 275-280). link>2003.
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Use of Magnetic Microparticles to Apply Mechanical Forces to 3D Bone Tissue Engineered Constructs. Proceedings of the World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia.2003.
-
Preliminary analysis of magnetic particle techniques for activating mechanotransduction in bone cell. Proceedings of the IEEE-EMBS Conference on Molecular, Cellular & Tissue Engineering, Genoa, Italy.2002.
- 2001.
- 1999.
-
In vitro monitoring of cytochrome oxidase activity in neuronal cells. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2939-2940). link>1998.
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Mechanical manipulation of human osteoblast and chondrocyte cells with 'optical tweezers'. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2957-2959). link>1998.
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Patterning of populations of spinal cord neurons on silicon micromachined substrates by means of a microfluidic system. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2945-2948). link>1998.
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Quantitation of brain oxygenation and blood volume using a new intensity modulated NIR instrument. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 1851-1854). link>1998.
- 2005.
- 2016.
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In The Same Room - practical methods to encourage collaboration across scientific disciplines. link> full text>
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Magnetic Targeting for Enhanced Stem Cell Therapies. TISSUE ENGINEERING PART A (vol. 20, p. S11). link>2014.
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Magnetic Targeting of Stem Cell Therapies. TISSUE ENGINEERING PART A (vol. 21, p. S207). link>2015.
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Remote activation of wnt signalling pathways in human mesenchymal stem cells using magnetic nanoparticle technology. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 8, pp. 51-52). link>2014.
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Remote activation of Wnt signalling pathways in human mesenchymal stem cells using magnetic nanoparticle technology. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6, p. 242). link>2012.
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Spatial Control of Wnt signalling for Orthopaedic Tissue Engineering. TISSUE ENGINEERING PART A (vol. 21, p. S132). link>2015.
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The effects of a supraphysiological strain magnitude, combined with a low cycle number on the osteogenic differentiation of mesenchymal stem cells (MSCs). TISSUE ENGINEERING (vol. 13, p. 1764). link>2007.
-
The response of cells from mesenchymal origins to osteogenic stimuli after sub-culture in vitro. TISSUE ENGINEERING (vol. 13, p. 1765). link>2007.
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Translation of Novel Strategies for Mechanical Conditioning for Functional Bone Tissue Engineering. TISSUE ENGINEERING PART A (vol. 21, p. S179). link>2015.
Research Group
Professor Alicia J. El Haj's Research Group:
Postdoctoral Researchers and Fellows:
Katie Bardsley
Hareklea Markides
Michael Rotherham
Yvonne Reinwald
Evangelia Vezouviou
Timothy Hopkins
Current Students:
Nicola Foster
Graziana Monaco
Eatelaf Muhammad
Rachel Gater
Jessica Bratt
Tom Bateman-Price
Visiting Researchers:
Ana Gonçalves
Kaveh Roshanbinfar
Visiting professor- Sue Kimber
Publicity and links
Growing bones using stem cell research. YouTube excerpt from USA' CNBC International "The Edge" programme focussing on Prof Alicia El Haj's team.
Human Bones grown from fat Article in UK The Telegraph by Richard Gray on growing human bones from stem cells.


