Selected Publications

  • Bagga V, Dunnett SB, Fricker RA. 2015. The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions. Behav Brain Res, 107-117, vol. 288. link> doi> full text>
  • Fricker RA, Orme R, Bhangal M. 2013. Calcitriol imparts neuroprotection to midbrain dopaminergic neurons through up-regulation of GDNF. PLoS ONE, vol. 8(4). doi> link> full text>
  • Lukšaitė E, Fricker RA, McKinley RK, Dikomitis L. 2022. Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study. Med Sci Educ, 371-378, vol. 32(2). link> doi> full text>
  • Joseph G, Orme RP, Kyriacou T, Fricker RA, Roach P. 2021. Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses. ACS Omega, 19901-19910, vol. 6(30). link> doi> full text>
  • Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA. 2020. Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells. doi> full text>

Full Publications Listshow

Journal Articles

  • Lukšaitė E, Fricker RA, McKinley RK, Dikomitis L. 2022. Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study. Med Sci Educ, 371-378, vol. 32(2). link> doi> full text>
  • Joseph G, Orme RP, Kyriacou T, Fricker RA, Roach P. 2021. Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses. ACS Omega, 19901-19910, vol. 6(30). link> doi> full text>
  • Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA. 2020. Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells. doi> full text>
  • Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA. 2020. Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells. PLoS One, e0233477, vol. 15(9). link> doi> full text>
  • Kamudzandu M, Köse-Dunn M, Evans MG, Fricker R, Roach P. 2019. A Micro-fabricated in vitro Platform to Model Complex Neuronal Functionality of a Central Nervous System Circuit. Biomedical Physics and Engineering Express. doi> link> full text>
  • Kamudzandu M, Köse-Dunn M, Evans MG, Fricker RA, Roach P. 2019. A micro-fabricated in vitro complex neuronal circuit platform. Biomedical Physics & Engineering Express, 045016, vol. 5(4). doi> full text>
  • Fricker RA, Green EL, Jenkins SI, Griffin SM. 2018. The Influence of Nicotinamide on Health and Disease in the Central Nervous System. Int J Tryptophan Res, 1178646918776658, vol. 11. link> doi> full text>
  • Griffin SM, Pickard MR, Orme RP, Hawkins CP, Williams AC, Fricker RA. 2017. Nicotinamide alone accelerates the conversion of mouse embryonic stem cells into mature neuronal populations. PLoS One, e0183358, vol. 12(8). link> doi> full text>
  • Fricker-Gates RA, Smith R, Muhith J, Dunnett SB. 2003. The role of pretraining on skilled forelimb use in an animal model of Huntington's disease. Cell Transplant, 257-264, vol. 12(3). link> doi>
  • Fricker-Gates RA, Muir JA, Dunnett SB. 2004. Transplanted hNT cells ("LBS neurons") in a rat model of huntington's disease: good survival, incomplete differentiation, and limited functional recovery. Cell Transplant, 123-136, vol. 13(2). link> doi>
  • Gates MA, Fricker-Gates RA, Magavi SS, Macklis JD. 2000. Cellular repair of complex cortical circuitry. NEUROSCIENTIST, 326-337, vol. 6(5). link> doi>
  • Orme RP, Middleditch C, Waite L, Fricker RA. 2015. The Role of Vitamin D₃ in the Development and Neuroprotection of Midbrain Dopamine Neurons. Vitamins and hormones, 273-297, vol. 100. doi>
  • Roach P, Kamudzandu M, Yang Y, Fricker R. 2015. Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 123-131, vol. 2015(3). doi> full text>
  • Bagga V, Dunnett SB, Fricker RA. 2015. The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions. Behav Brain Res, 107-117, vol. 288. link> doi> full text>
  • Kamudzandu M, Yang Y, Roach P, Fricker RA. 2015. Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC ADVANCES, 22053-22059, vol. 5(28). link> doi> full text>
  • Griffin SM, Pickard MR, Orme RP, Hawkins CP, Fricker RA. 2013. Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro. Neuroreport, 1041-1046, vol. 24(18). link> doi> full text>
  • Lane EL, Dunnett SB, Fricker RA. 2013. The 12th International Symposium on Neural Transplantation and Restoration. Neuroreport, 997-999, vol. 24(18). link> doi>
  • Orme RP, Bhangal MS, Fricker RA. 2013. Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PLoS One, e62040, vol. 8(4). link> doi> full text>
  • Fricker RA, Orme R, Bhangal M. 2013. Calcitriol imparts neuroprotection to midbrain dopaminergic neurons through up-regulation of GDNF. PLoS ONE, vol. 8(4). doi> link> full text>
  • Chan A, Orme RP, Fricker RA, Roach P. 2013. Remote and local control of stimuli responsive materials for therapeutic applications. Adv Drug Deliv Rev, 497-514, vol. 65(4). link> doi>
  • Balami JS, Fricker RA, Chen R. 2013. Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment. CNS Neurol Disord Drug Targets, 209-219, vol. 12(2). link> doi> full text>
  • Shin E, Forsyth N, Fricker RA. Physiologic oxygen levels increase the differentiation and maturation of GABAergic neurons derived from mouse embryonic stem cells. Stem Cells Studies.
  • Shin E, Forsyth NR, Fricker RA. The effect of physiological oxygen levels on GABAergic neuronal differentiation from mouse embryonic stem cells. Stem Cell Studies, 3, vol. 2(1). doi> link>
  • Fricker RA, Kuiper JH, Gates MA. 2012. Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PLoS One, e47169, vol. 7(10). link> doi> full text>
  • Shin E, Palmer MJ, Li M, Fricker RA. 2012. GABAergic neurons from mouse embryonic stem cells possess functional properties of striatal neurons in vitro, and develop into striatal neurons in vivo in a mouse model of Huntington's disease. Stem Cell Rev Rep, 513-531, vol. 8(2). link> doi>
  • Fricker RA. Models in Parkinson’s research: Are we addressing the right questions?. Advances in Clinical Neuroscience and Rehabilitation. full text>
  • Orme RP, Gates MA, Fricker-Gates RA. 2010. A multiplexed quantitative proteomics approach for investigating protein expression in the developing central nervous system. J Neurosci Methods, 75-82, vol. 191(1). link> doi>
  • Fricker-Gates RA and Gates MA. 2010. Stem cell-derived dopamine neurons for brain repair in Parkinson's disease. Regen Med, 267-278, vol. 5(2). link> doi>
  • Orme R, Fricker-Gates RA, Gates MA. 2009. Ontogeny of substantia nigra dopamine neurons. J Neural Transm Suppl, 3-18. link> doi>
  • Bagga V, Dunnett SB, Fricker-Gates RA. 2008. Ascorbic acid increases the number of dopamine neurons in vitro and in transplants to the 6-OHDA-lesioned rat brain. Cell Transplant, 763-773, vol. 17(7). link> doi>
  • Fricker-Gates RA. 2006. Radial glia: a changing role in the central nervous system. Neuroreport, 1081-1084, vol. 17(11). link> doi>
  • Gates MA, Torres EM, White A, Fricker-Gates RA, Dunnett SB. 2006. Re-examining the ontogeny of substantia nigra dopamine neurons. Eur J Neurosci, 1384-1390, vol. 23(5). link> doi>
  • Hughes AC, Errington RJ, Fricker-Gates RA, Jones L. 2004. Endophilin A3 forms filamentous structures which colocalise with microtubules but not actin filaments. Molecular Brain Research, 182-192, vol. 128(2). doi>
  • Gates MA, Coupe VM, Torres EM, Fricker-Gates RA, Dunnett SB. 2004. Spatially and temporally restricted chemoattractive and chemorepulsive cues direct the formation of the nigro-striatal circuit. Eur J Neurosci, 831-844, vol. 19(4). link> doi>
  • Fricker-Gates RA, White A, Gates MA, Dunnett SB. 2004. Striatal neurons in striatal grafts are derived from both post-mitotic cells and dividing progenitors. Eur J Neurosci, 513-520, vol. 19(3). link> doi>
  • Smith R, Bagga V, Fricker-Gates RA. 2003. Embryonic neural progenitor cells: the effects of species, region, and culture conditions on long-term proliferation and neuronal differentiation. J Hematother Stem Cell Res, 713-725, vol. 12(6). link> doi>
  • Fricker-Gates RA, Lewis J, Baird AL, Dunnett SB. 2002. Survival and differentiation of LBS neurons after transplantation in a rat model of Huntington's disease. EXPERIMENTAL NEUROLOGY, 431, vol. 175(2). link>
  • Smith R, Fricker-Gates RA, Muhith J, Dunnett SB. 2002. The role of pretraining on skilled forelimb use after striatal neuron loss. EXPERIMENTAL NEUROLOGY, 444, vol. 175(2). link>
  • FRICKER-GATES RA, Macklis JD, Shin JJ, Tai CC. 2002. Late-Stage Immature Neocortical Neurons Reconstruct Interhemispheric Connections and Form Synaptic Contacts with Increased Efficiency in Adult Mouse Cortex Undergoing Targeted Neurodegeneration. Journal of Neuroscience, 4045-4056, vol. 22(10). link> doi>
  • Fricker-Gates RA, Shin JJ, Tai CC, Catapano LA, Macklis JD. 2002. Late-stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing targeted neurodegeneration. J Neurosci, 4045-4056, vol. 22(10). link> doi>
  • Fricker-Gates RA and Dunnett SB. 2002. Rewiring the Parkinsonian brain. Nat Med, 105-106, vol. 8(2). link> doi>
  • Englund U, Fricker-Gates RA, Lundberg C, Björklund A, Wictorin K. 2002. Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections. Exp Neurol, 1-21, vol. 173(1). link> doi>
  • Fricker-Gates R. 2001. New steps in combating the prions. NEUROREPORT, A85-A86, vol. 12(14). link>
  • Fricker-Gates R. 2001. Rival vaccines for Alzheimer's disease. NEUROREPORT, A85, vol. 12(14). link>
  • Fricker-Gates R. 2001. Food dependence - It's all in the mind!. NEUROREPORT, A72, vol. 12(12). link> doi>
  • Fricker-Gates RA, Lundberg C, Dunnett SB. 2001. Neural transplantation: restoring complex circuitry in the striatum. Restor Neurol Neurosci, 119-138, vol. 19(1-2). link>
  • Fricker-Gates RA. 2000. Axonal growth - from outside or within?. NEUROREPORT, F19-F20, vol. 11(18). link> doi>
  • Fricker-Gates R. 2000. Three neuroscientists to share Nobel Prize in physiology and medicine. Neuroreport, A13, vol. 11(17). link> doi>
  • Fricker-Gates RA, Winkler C, Kirik D, Rosenblad C, Carpenter MK, Björklund A. 2000. EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum. Exp Neurol, 237-247, vol. 165(2). link> doi>
  • Shin JJ, Fricker-Gates RA, Perez FA, Leavitt BR, Zurakowski D, Macklis JD. 2000. Transplanted neuroblasts differentiate appropriately into projection neurons with correct neurotransmitter and receptor phenotype in neocortex undergoing targeted projection neuron degeneration. J Neurosci, 7404-7416, vol. 20(19). link> doi>
  • Englund U, Fricker RA, Lundberg C, Bjorklund A, Wictorin K. 2000. Comparison of the integration, migration and differentiation of human neural progenitor cells after transplantation into either the embryonic, neonatal or adult rat brain. EUROPEAN JOURNAL OF NEUROSCIENCE, 292, vol. 12. link>
  • Gates MA, Fricker-Gates RA, Macklis JD. 2000. Reconstruction of cortical circuitry. Prog Brain Res, 115-156, vol. 127. link> doi>
  • Fricker RA, Carpenter MK, Winkler C, Greco C, Gates MA, Björklund A. 1999. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J Neurosci, 5990-6005, vol. 19(14). link> doi>
  • Winkler C, Fricker RA, Gates MA, Olsson M, Hammang JP, Carpenter MK, Björklund A. 1998. Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain. Mol Cell Neurosci, 99-116, vol. 11(3). link> doi>
  • Englund U, Fricker RA, Eyes EM, Rosner MR, Victorin K. 1998. Transplantation of the conditionally immortalized hippocampal cell line H19-7 into the adult and neonatal rat striatum and hippocampus. EUROPEAN JOURNAL OF NEUROSCIENCE, 334, vol. 10. link>
  • Carpenter MK, Winkler C, Fricker R, Emerich DF, Wong SC, Greco C, Chen EY, Chu Y, Kordower JH, Messing A, Björklund A, Hammang JP. 1997. Generation and transplantation of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice. Exp Neurol, 187-204, vol. 148(1). link> doi>
  • Kordower JH, Chen EY, Winkler C, Fricker R, Charles V, Messing A, Mufson EJ, Wong SC, Rosenstein JM, Björklund A, Emerich DF, Hammang J, Carpenter MK. 1997. Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: trophic and tropic effects in a rodent model of Huntington's disease. J Comp Neurol, 96-113, vol. 387(1). link> doi>
  • Fricker RA, Torres EM, Dunnett SB. 1997. The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain. I. Morphological characteristics. Neuroscience, 695-710, vol. 79(3). link> doi>
  • Fricker RA, Torres EM, Hume SP, Myers R, Opacka-Juffrey J, Ashworth S, Brooks DJ, Dunnett SB. 1997. The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain. II. Correlation between positron emission tomography and reaching behaviour. Neuroscience, 711-721, vol. 79(3). link> doi>
  • Fricker RA, Barker RA, Fawcett JW, Dunnett SB. 1996. A comparative study of preparation techniques for improving the viability of striatal grafts using vital stains, in vitro cultures, and in vivo grafts. Cell Transplant, 599-611, vol. 5(6). link> doi>
  • Hume SP, Lammertsma AA, Myers R, Rajeswaran S, Bloomfield PM, Ashworth S, Fricker RA, Torres EM, Watson I, Jones T. 1996. The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease. J Neurosci Methods, 103-112, vol. 67(2). link> doi>
  • Brundin P, Fricker RA, Nakao N. 1996. Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease. Neuroscience, 895-897, vol. 71(3). link> doi>
  • Fricker RA, Annett LE, Torres EM, Dunnett SB. 1996. The placement of a striatal ibotenic acid lesion affects skilled forelimb use and the direction of drug-induced rotation. Brain Res Bull, 409-416, vol. 41(6). link> doi>
  • Torres EM, Fricker RA, Hume SP, Myers R, Opacka-Juffry J, Ashworth S, Brooks DJ, Dunnett SB. 1995. Assessment of striatal graft viability in the rat in vivo using a small diameter PET scanner. Neuroreport, 2017-2021, vol. 6(15). link> doi>
  • FRICKER RA, TORRES EM, LOMBROSO PJ, DUNNETT SB. 1995. THE LOCALIZATION OF AN ANTIBODY TO STEP IN STRIATAL TISSUE GRAFTS (VOL 5, PG 2638, 1994). NEUROREPORT, 1072, vol. 6(7). link> doi>
  • Barker RA, Fricker RA, Abrous DN, Fawcett J, Dunnett SB. 1995. A comparative study of preparation techniques for improving the viability of nigral grafts using vital stains, in vitro cultures, and in vivo grafts. Cell Transplant, 173-200, vol. 4(2). link> doi>
  • Fricker RA, Torres EM, Lombroso PJ, Dunnett SB. 1994. The localization of an antibody to STEP in embryonic striatal tissue grafts. Neuroreport, 2638-2640, vol. 5(18). link> doi>

Chapters

  • FRICKER-GATES RA. 2006. Neural Transplantation. In Handbook of Experimental Neurology: Methods and Techniques in Animal Research. Tatlisumak T and Fisher M (Eds.). Cambridge University Press.
  • FRICKER-GATES RA. 2006. Neural Transplantation. In Handbook of Experimental Neurology: Methods and Techniques in Animal Research. Tatlisumak T and Fisher M (Eds.). Cambridge University Press.
  • FRICKER-GATES RA, Dunnett SB, Torres EM, Gates MA. 2006. Neural Transplantation. In Handbook of Experimental Neurology: Methods and Techniques in Animal Research. Tatlisumak T and Fisher M (Eds.). Cambridge University Press.
  • FRICKER-GATES RA, Wictorin K, Campbell K, Olsson M. 1999. Cell and tissue transplantation. In Modern Techniques in Neuroscience Research. Windhorst U and Johansson H (Eds.). Springer.
  • FRICKER-GATES RA, Barker RA, Dunnett SB. 1994. Factors important in the survival of dopaminergic neurons in intracerebal grafts of substantia nigra. In Providing Pharmacological Access to the Brain. Flanagan TR, Emerich DF, Winn SR (Eds.). Academic Press, Orlando, Florida.
  • FRICKER-GATES RA, Bjorklund A, Campbell K, Sirinathsinghji DJS, Dunnett SB. 1994. Functional capacity of striatal transplants in the rat Huntington model. In Functional Neural Transplantation. Dunnett SB and Bjorklund A (Eds.). Lippincott Williams and Wilkins.

Other

  • Williams A, Griffin S, Fricker R. 2018. Vitamin B3 and Neurodevelopment in Parkinson's Disease. MOVEMENT DISORDERS (p. S274, vol. 33). link> full text>
  • Williams A, Griffin S, Pickard M, Fricker R. 2016. Nicotinamide: A Key Player in the Developmental Origins of Parkinson's Disease?. NEUROLOGY (vol. 86). link> full text>
  • Griffin S, Pickard M, Orme R, Hawkins C, Williams A, Chari D, Fricker R. 2014. THE INFLUENCE OF NICOTINAMIDE ON THE DEVELOPMENT OF NEURONS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 85). link> doi>
  • Griffin SM, Pickard MR, Orme RP, Hawkins CP, Williams AC, Chari DM, Fricker RA. 2014. Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro. MOVEMENT DISORDERS (p. S13, vol. 29). link>
  • Griffin SM, Pickard MR, Orme RP, Hawkins CP, Fricker RA. 2014. The influence of nicotinamide on directed differentiation of neurons from embryonic stem cells in vitro. NEUROREPORT (p. 154, vol. 25). link>
  • Orme RP, Bhangal M, Fricker RA. 2014. Vitamin D3 promotes dopamine neuron survival through upregulation of GDNF. NEUROREPORT (pp. 153-154, vol. 25). link>
  • Fricker-Gates RA, Muir JA, Dunnett SB. 2003. Transplanted hNT cells ('LBS neurons') in a rat model of Huntington's disease: Good survival, incomplete differentiation, and no functional recovery. CELL TRANSPLANTATION (pp. 317-318, vol. 12). link>

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