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    •
    Dr Gordon Dent

    Dr Gordon Dent

    Title
    Senior Lecturer (E & S) in Pharmacology
    Location
    Keele University School of Medicine, David Weatherall building, ST5 5BG
    Role

    Director of Admissions
    Contact me
    Via tel or email
    Phone
    +44 (0) 1782 734652
    Email
    g.dent@keele.ac.uk

    Biography

    Gordon Dent is a pharmacologist with interests in medical student selection, pharmacology, therapeutics & prescribing education, and pathophysiology of inflammatory diseases.
    He studied at the University of London, gaining a BSc (Hons) in Pharmacology at King’s College in 1985 and a PhD in Immunopharmacology at the National Heart & Lung Institute in 1991. He subsequently worked at the Großhansdorf Institute for Pneumology and Thoracic Surgery, Germany, and the University of Southampton before joining the new School of Medicine at Keele in 2003.
    Dr Dent is a board member of the Medical Schools Council Selection Alliance, a question author and peer-reviewer for the Prescribing Safety Assessment and an associate editor of the American Journal of Immunology. He is a member of the British Pharmacological Society and the Association for the Study of Medical Education.

    Research and scholarship

    Research theme: Therapeutics

    Dr Dent’s research has focused on the roles of leukocytes and epithelium in inflammatory diseases of the lungs (asthma and COPD) and intestine (ulcerative colitis). He has a particular interest in intracellular signalling pathways in leukocytes and the mechanisms of cell-cell interactions between epithelial cells and leukocytes.
    He is also active in the field of undergraduate medicine admissions, engaging in regional and national groups exploring policies and procedures.

    Teaching

    MBChB: Unit lead – Mechanisms of Disease (year 2); pharmacology, physiology and pathophysiology teaching across years 1, 2 & 3
    V100/V300 supplementary prescribing: general pharmacology
    Physiology & Pharmacology of Pain: pharmacology of inflammation and pain

    Further information

    Dr Dent has contributed to the development and implementation of curriculums for medicine, pharmacy and veterinary medicine. He is currently a member of the joint academic board and curriculum, programme and admissions groups for Harper Keele Veterinary School.
    Along with the Access to HE team at the QAA, he has led the development of a national subject descriptor for Access to Medicine diplomas.

    He engages in extensive outreach and widening participation work across the north and west midlands, as well as national events co-ordinated by the Medical Schools Council and UCAS.

     

     

    Selected Publications

    • Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Koesling D, Ostrom R, Pyne NJ, Pyne S, Russwurm M, Seifert R, Stasch J-P, van der Stelt M, van der Vliet A, Watts V, Wong SS. 2021. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British Journal of Pharmacology, S313-S411, vol. 178(Suppl 1). link> doi> link> full text>
    • Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu J-M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo MD, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp H-J, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon J-L, Ngo T, Norel X, Nyimanu D, O'Carroll A-M, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin J-P, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga J-P, Walker CS, Wang JM, Ward DT, Wester H-J, Willars GB, Woodruff TM, Yao C, Ye RD. 2021. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol, S27-S156, vol. 178 Suppl 1. link> doi> full text>
    • Hasan AM and Dent G. 2017. Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, 209-215, vol. 13(4). doi> full text>
    • Rees EL, Hawarden AW, Dent G, Hays R, Bates J, Hassell AB. 2016. Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37. Med Teach, 443-455, vol. 38(5). link> doi> full text>
    • Dent G, Loweth SC, Hasan AM, Leslie FM. 2014. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology, 793-797, vol. 219(10). link> doi>

    Full Publications Listshow

    Journal Articles

    • Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Koesling D, Ostrom R, Pyne NJ, Pyne S, Russwurm M, Seifert R, Stasch J-P, van der Stelt M, van der Vliet A, Watts V, Wong SS. 2021. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British Journal of Pharmacology, S313-S411, vol. 178(Suppl 1). link> doi> link> full text>
    • Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu J-M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo MD, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp H-J, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon J-L, Ngo T, Norel X, Nyimanu D, O'Carroll A-M, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin J-P, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga J-P, Walker CS, Wang JM, Ward DT, Wester H-J, Willars GB, Woodruff TM, Yao C, Ye RD. 2021. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol, S27-S156, vol. 178 Suppl 1. link> doi> full text>
    • Hasan AM and Dent G. 2017. Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, 209-215, vol. 13(4). doi> full text>
    • Rees EL, Hawarden AW, Dent G, Hays R, Bates J, Hassell AB. 2016. Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37. Med Teach, 443-455, vol. 38(5). link> doi> full text>
    • Dent G, Loweth SC, Hasan AM, Leslie FM. 2014. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology, 793-797, vol. 219(10). link> doi>
    • Dent G. 2014. Eosinophil chemotaxis. Methods Mol Biol, 101-110, vol. 1178. link> doi>
    • Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. 2010. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol, 1017-1021, vol. 10(9). link> doi>
    • Yoshikawa T, Dent G, Ward J, Angco G, Nong G, Nomura N, Hirata K, Djukanovic R. 2007. Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 473-479, vol. 175(5). link> doi>
    • Mishra RK, Scaife JE, Harb Z, Gray BC, Djukanovic R, Dent G. 2005. Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K). ALLERGY, 1204-1207, vol. 60(9). link> doi>
    • Dent G. 2003. IgE modulation in asthma. Expert Opinion on Therapeutic Patents, 1607-1617, vol. 13(10). doi>
    • Dent G, Hadjicharalambous C, Yoshikawa T, Handy R L C, Powell J, Anderson I K, Louis R, Davies D E, Djukanovic R. 2004. Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum. Amercian Journal of Respiratory & Crictical Care Medicine. doi>
    • Hadjicharalambous C, Dent G, May RD, Handy RLC, Anderson IK, Davies DE, Djukanovic R. 2004. Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma. Journal of Allergy & Clinical Immunology.
    • Dent G. 2002. Ciclesonide. Curr Opin Invest Drugs, 78-83, vol. 3.
    • Dent G, Hosking LA, Lordan JL, Steel MD, Cruikshank WW, Center DM, Ellis JH, Holgate ST, Davies DE, Djukanovic R. 2002. Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthamatic individuals. J Allergy Clin Immunol, 906-914, vol. 110.
    • Schmidt DT, Dent G, Ruhlmann E, Munoz NM, Leff AR, Rabe KF. 2002. Studying human airway pharmacology in microsections: application of videomicrometry. Eur Respir, 991-996, vol. 19.
    • Dent G. 2001. Protein Kinase A-independent responses to beta-adrenoceptor agonists. Br J Pharmacol, 1199-1200, vol. 133.
    • Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, Davies DE. 2001. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol, 385-391, vol. 25.
    • Lordan JL, Davies DE, Wilson SJ, Dent G, Corkhill A, Jaffar Z, Roberts K, Djukanovic R, Holgate ST. 2001. The role of CD28-B7 costimulation in allergen-induced cytokine release in bronchial mucosa from patients with moderately severe asthma. J Allergy Clin Immunol, 976-981, vol. 108.

    Chapters

    • Dent G and Cowling MG. Drugs used in vascular interventional radiology. In Vascular Interventional Radiology. Springer. doi>
    • DENT G. 2006. Airway Inflammation. In The Year in Allergy. (vol. 3). Clinical Publishing, Oxford.
    • DENT G, Holgate ST, Buckley MG. 2006. Asthma. In Principles of Molecular Medicine. Runge MS and Patterson C (Eds.). Humana Press.
    • Haitchi H M, Krishna M T, Holloway J H, Dent G, Buckley M G, Holgate S T. 2004. Asthma: clinical aspects and mucosal immunity. In Mucosal Immunology (3rd Edition). Mestecky J, Beinenstock J, Lamm M, Strober W, McGhee J, Mayer L (Eds.). Academic Press, San Diego.

    Other

    • Dent G. 2004. BLT-1 leukotriene receptor.
    • Dent G. 2004. BLT-2 leukotriene receptor.
    • Dent G. 2004. CysLT-1 leukotriene receptor.
    • Dent G. 2004. CysLT-2 leukotriene receptor.
    • Dent G, Uddin M, Puddicombe SM, Davies E D, Djukanovic R. 2004. Eosinophils stimulate the secretion of neutrophil chemoattracants by bronichal epithelial cells. European Respiratory Journal.
    • Uddin M, Rytila P, Dent G, Davies D E, Djukanovic R. 2004. Modulation of neutrophil activation and survival by bronchial epithelial cells. European Respiratory Journal.

    School of Medicine
    David Weatherall building
    University Road
    Keele University
    Staffordshire
    ST5 5BG