Dr David Thompson

Title: Course Director Forensic Science
Lecturer
Phone: +44 (0) 1782 7 34954
Email: d.f.thompson@keele.ac.uk
Location: Lennard-Jones 0.17A
Role:
Contacting me:
David Thomson

I was appointed as a lecturer at Keele in August 2012. Prior to this I had completed a PhD in analytical chemistry in a collaborative project between Keele University and  AstraZeneca. This focused on developing novel analytical methods, using inductively coupled plasma-mass spectrometry (ICP-MS), for the early stage detection of cancer biomarkers. My first degree was in chemistry and forensic science which was obtained in 2007 from Keele University. My current research interests focus on the forensic applications of global metabolic profiling techniques, particularly applications associated with the putrefaction of organic material.

My previous research has focused on the development of novel analytical techniques for the detection of blood-borne biomarkers related to early stage tumour formation. Mainly this involved using inductively coupled plasma-mass spectrometry (ICP-MS) but also included some time of flight-mass spectrometry. This research led to the development of both single and multi-analyte immunoassay systems that incorporated novel metal labels and were detected by ICP-MS. One of these systems has also been validated for clinical use. Other research focused on the application of metabonomics to aid biomarker discovery for a range of conditions. This work included the development of phosphorus specific metabonomics using ultra performance liquid chromatography (UPLC) ICP-MS.

My current research interests include the application of metabonomics to forensic analysis, particularly in the discovery of buried remains and determination of post-mortem interval.

Selected Publications

  • Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. ANALYTICAL CHEMISTRY, vol. 89(22), 12131-12136. link> doi>
  • Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. Anal Chem, vol. 89(22), 12131-12136. link> doi> full text>
  • Mendecki L, Chen X, Callan N, Thompson DF, Schazmann B, Granados-Focil S, Radu A. 2016. Simple, Robust, and Plasticizer-Free Iodide-Selective Sensor Based on Copolymerized Triazole-Based Ionic Liquid. Anal Chem, vol. 88(8), 4311-4317. link> doi> full text>
  • Thompson DF. 2014. Rapid production of cyclonic spray chambers for inductively coupled plasma applications using low cost 3D printer technology. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, vol. 29(12), 2262-2266. link> doi> link>
  • Thompson DF, Michopoulos F, Smith CJ, Duckett CJ, Wilkinson RW, Jarvis P, Wilson ID. 2013. Phosphorus and sulfur metabonomic profiling of tissue and plasma obtained from tumour-bearing mice using ultra-performance liquid chromatography/inductively coupled plasma mass spectrometry. Rapid Commun Mass Spectrom, vol. 27(22), 2539-2545. link> doi>

Full Publications List show

Journal Articles

  • Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. ANALYTICAL CHEMISTRY, vol. 89(22), 12131-12136. link> doi>
  • Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. Anal Chem, vol. 89(22), 12131-12136. link> doi> full text>
  • Mendecki L, Chen X, Callan N, Thompson DF, Schazmann B, Granados-Focil S, Radu A. 2016. Simple, Robust, and Plasticizer-Free Iodide-Selective Sensor Based on Copolymerized Triazole-Based Ionic Liquid. Anal Chem, vol. 88(8), 4311-4317. link> doi> full text>
  • Thompson DF. 2014. Rapid production of cyclonic spray chambers for inductively coupled plasma applications using low cost 3D printer technology. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, vol. 29(12), 2262-2266. link> doi> link>
  • Thompson DF, Michopoulos F, Smith CJ, Duckett CJ, Wilkinson RW, Jarvis P, Wilson ID. 2013. Phosphorus and sulfur metabonomic profiling of tissue and plasma obtained from tumour-bearing mice using ultra-performance liquid chromatography/inductively coupled plasma mass spectrometry. Rapid Commun Mass Spectrom, vol. 27(22), 2539-2545. link> doi>
  • Thompson DF, Michopoulos F, Smith CJ, Duckett CJ, Wilkinson RW, Jarvis P, Wilson ID. 2011. Profiling biological samples using ultra performance liquid chromatography-inductively coupled plasma-mass spectrometry (UPLC-ICP-MS) for the determination of phosphorus and sulfur-containing metabolites. Mol Biosyst, vol. 7(4), 1149-1157. link> doi>
  • Thompson DF, Eborall W, Dinsmore A, Smith CJ, Duckett CJ. 2010. Development and validation of a NANOGold immunoassay for the detection of vascular endothelial growth factor (VEGF) in human serum using inductively coupled plasma mass spectrometry. Rapid Commun Mass Spectrom, vol. 24(7), 927-932. link> doi>
  • Thompson DF, Sidwick K, Pereira L. FORTHCOMING: Evaluation into the effect of column chemistry on the equilibration time required for metabonomic studies. Analytical Chemistry.
  • Thompson DF, Sidwick K, Pereira L. FORTHCOMING: The use of metabonomic profiling to differentiate between dead on arrival and normally slaughtered poultry.
  • CHE-10040 : Crime, Science and Investigation
  • CHE-30010 : Forensic Toxicology (Module leader)
  • CHE-30028 : Interpretation, Evaluation and Presentation of Evidence
  • CHE-30011 : Forensic Science Team Project