The PMR Cohort Study

PMR logo


The PMR Cohort study is an inception cohort of people diagnosed with polymyalgia rheumatica (PMR) in UK general practice between 2012 and 2014. They received seven questionnaires over the first 2 years of the study, asking about their PMR symptoms and general health. In 2019, all participants who had not withdrawn consent and whose practices were willing to take part were sent a further questionnaire to understand better the long-term impact of PMR on the lives of people with the condition.

Chief Investigator: Professor Christian Mallen
Associate Investigator: Dr Sara Muller
Sponsor / reference number: Keele University / RG-0026-16
Funder / reference number:

Arthritis Research UK Clinician Scientist Award / 19634
Versus Arthritis / 21827

Registration reference number: N/A
Start date: 2012 / 01/03/2018
End date:  2014 / 30/11/2021

Study design

This is an observational inception cohort study.

Aim and objectives

Original study objectives
  • Describe the natural history and prognosis of PMR in primary care.
Follow-up study objectives
  • Understand who has a prolonged course of PMR (defined by continued glucocorticoid treatment) and whether this can be predicted from clinical symptoms at diagnosis.
  • Understand who experiences significant glucocorticoid related side effects and whether this can be predicted at diagnosis.
  • Understand the effect of PMR on long-term quality-of-life and whether it is possible to identify those who will experience a significant deterioration and may benefit from additional interventions