Dr Falko Drijfhout

Title: Senior Lecturer in Analytical Chemistry
Phone: (+44) 01782 7 33043
Email: f.drijfhout@keele.ac.uk
Location: Lennard-Jones 1.36
Role: Forensic Science Y2 Tutor
Contacting me: Drop in by my office or fix an appointment by email or telephone
Drijfhout_Falko

I obtained my MSc in 1996 from Wageningen University in The Netherlands and went on to obtain my PhD in Analytical Chemistry/Chemical Ecology from the same University in 2001 under the supervision of Prof. Ae. De Groot and Dr. T.A. van Beek entitled: “Studies towards the sex pheromone of the green capsid bug”.

I continued my research in chemical ecology as a post-doctoral researcher at Cornell University in the USA with Prof. N. W. Calderone (between 2001 and 2003) and from 2003 to 2005 at Keele University in the UK with Dr. Graeme Jones. In June 2005 I was appointed as a Lecturer at Keele University.

drijfhout image My research is within the area called chemical ecology, in which chemicals are identified that are involved in all different kinds of behavioural activities in insects. It is very much a hybrid between (analytical) chemistry and entomology.

Currently I work on the role of cuticular hydrocarbons in (nest-mate) recognition systems in ants and other social insects. In addition I investigate the queen egg marking pheromone of the European honeybee, which could be anything from a hydrocarbon to a more complex and larger polar compound. The main technique for identification of these kind of chemicals, such as cuticular hydrocarbons, is gas-chromatography coupled to Mass spectrometry, yet as in the latter project we may deal with a larger polar chemical, we used and will continue to use Liquid Chromatography coupled to Mass spectrometry (LC/MS).

These areas below are very important to my research and have my specific interested throughout my research and teaching:

  • Analytical Chemistry
  • Chemical Ecology
  • Chromatographic techniques
  • Hyphenated techniques

I am part of the Chemical Ecology group within the School, member of the Centre for Applied Entomology and Parasitology (CAEP) as well as the Research Institute for Science and Technology in Medicine (ISTM).

Selected Publications

  • Neupert S, DeMilto A, Drijfhout FP, Speller S, Adams R. 2018. Host colony integration: Megalomyrmex guest ant parasites maintain peace with their host using weaponry. Animal Behaviour, vol. 139, 71-79. doi> link> full text>
  • Moore HE, Butcher JB, Day CR, Drijfhout FP. 2017. Adult fly age estimations using cuticular hydrocarbons and Artificial Neural Networks in forensically important Calliphoridae species. Forensic Sci Int, vol. 280, 233-244. link> doi> full text>
  • Uche FI, Abed M, Abdullah MI, Drijfhout FP, McCullagh J, Claridge TWD, Richardson A, Li W-W. 2017. Isolation, identification and anti-cancer activity of minor alkaloids from Triclisia subcordata Oliv. BIOCHEMICAL PHARMACOLOGY (vol. 139, p. 112). link> doi> full text>
  • Uche FI, Abed MN, Abdullah MI, Drijfhout FP, McCullagh J, Claridge TWD, Richardson A, Li W-W. 2017. Isochondodendrine and 2 '-norcocsuline: additional alkaloids from Triclisia subcordata induce cytotoxicity and apoptosis in ovarian cancer cell lines. RSC ADVANCES, vol. 7(70), 44154-44161. link> doi> full text>
  • Uche F, Abed M, Abdullah M, Drijfhout FP, McCullagh J, Claridge T, Richardson A, Li WW. 2017. O9 Isolation, identification and anti-cancer activity of minor alkaloids from Triclisia subcordata Oliv. Biochemical Pharmacology (vol. 139). Elsevier BV. doi> link>

Full Publications List show

Journal Articles

  • Neupert S, DeMilto A, Drijfhout FP, Speller S, Adams R. 2018. Host colony integration: Megalomyrmex guest ant parasites maintain peace with their host using weaponry. Animal Behaviour, vol. 139, 71-79. doi> link> full text>
  • Moore HE, Butcher JB, Day CR, Drijfhout FP. 2017. Adult fly age estimations using cuticular hydrocarbons and Artificial Neural Networks in forensically important Calliphoridae species. Forensic Sci Int, vol. 280, 233-244. link> doi> full text>
  • Uche FI, Abed MN, Abdullah MI, Drijfhout FP, McCullagh J, Claridge TWD, Richardson A, Li W-W. 2017. Isochondodendrine and 2 '-norcocsuline: additional alkaloids from Triclisia subcordata induce cytotoxicity and apoptosis in ovarian cancer cell lines. RSC ADVANCES, vol. 7(70), 44154-44161. link> doi> full text>
  • de Wolf E, Abdullah MI, Jones SM, Menezes K, Moss DM, Drijfhout FP, Hart SR, Hoskins C, Stronach EA, Richardson A. 2017. Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer. Sci Rep, vol. 7(1), 5410. link> doi> full text>
  • Moore HE, Pechal JL, Benbow ME, Drijfhout FP. 2017. The potential use of cuticular hydrocarbons and multivariate analysis to age empty puparial cases of Calliphora vicina and Lucilia sericata. Sci Rep, vol. 7(1), 1933. link> doi> full text>
  • Norman V, Butterfield T, Drijfhout FP, Tasman K, Hughes W. 2017. Alarm Pheromone Composition and Behavioral Activity in Fungus-Growing Ants. Journal of Chemical Ecology. doi>
  • Aldulaimi O, Uche FI, Hameed H, Mbye H, Ullah I, Drijfhout F, Claridge TDW, Horrocks P, Li W-W. 2017. A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms. J Ethnopharmacol, vol. 198, 221-225. link> doi> full text>
  • Guillem RM, Drijfhout FP, Martin SJ. Species-Specific Cuticular Hydrocarbon Stability within European Myrmica Ants. Journal of Chemical Ecology, vol. 42(10), 1052-1062. link> doi> link> full text>
  • Rahman S, Hajong SR, Shemilt S, Drijfhout FP. 2016. Cuticular hydrocarbons in queens, workers and drones of the Indian honeybee Apis cerana indica (Fab.). ENTOMOLOGIA GENERALIS, vol. 36(2), 117-126. link> doi>
  • Moore HE, Butcher JB, Adam CD, Day CR, Drijfhout FP. 2016. Age estimation of Calliphora (Diptera: Calliphoridae) larvae using cuticular hydrocarbon analysis and Artificial Neural Networks. Forensic Sci Int, vol. 268, 81-91. link> doi> full text>
  • Uche FI, Drijfhout FP, McCullagh J, Richardson A, Li W-W. 2016. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res, vol. 30(9), 1533-1539. link> doi> full text>
  • Lubanga UK, Drijfhout FP, Farnier K, Steinbauer MJ. 2016. The Long and the Short of Mate Attraction in a Psylloid: do Semiochemicals Mediate Mating in Aacanthocnema dobsoni Froggatt?. J Chem Ecol, vol. 42(2), 163-172. link> doi> full text>
  • Poiani SB, Morgan E, Drijfhout FP, da Cruz-Landim C. 2015. Changes in the chemical profile of cephalic salivary glands of Scaptotrigona postica (Hymenoptera, Meliponini) workers are phase related. JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 218(17), 2738-2744. link> doi>
  • Poiani SB, Morgan E, Drijfhout FP, da Cruz-Landim C. 2015. Changes in chemical profile of cephalic salivary glands of Scaptotrigona postica (Hymenoptera, Meliponini) workers are phase-related. The Journal of experimental biology. doi>
  • Musah RA, Espinoza EO, Cody RB, Lesiak AD, Christensen ED, Moore HE, Maleknia S, Drijfhout FP. 2015. A High Throughput Ambient Mass Spectrometric Approach to Species Identification and Classification from Chemical Fingerprint Signatures. SCIENTIFIC REPORTS, vol. 5, Article ARTN 11520. link> doi> full text>
  • Kather R, Drijfhout FP, Martin SJ. 2015. Evidence for colony-specific differences in chemical mimicry in the parasitic mite Varroa destructor. CHEMOECOLOGY, vol. 25(4), 215-222. link> doi>
  • Kather R, Drijfhout FP, Shemilt S, Martin SJ. 2015. Evidence for Passive Chemical Camouflage in the Parasitic Mite Varroa destructor. JOURNAL OF CHEMICAL ECOLOGY, vol. 41(2), 178-186. link> doi>
  • Bridgett RJ, Kirk WDJ, Drijfhout FP. 2015. The use of a within-hive replication bioassay method to investigate the phagostimulatory effects of pollen, bee bread and pollen extracts, on free-flying honey bee colonies. APIDOLOGIE, vol. 46(3), 315-325. link> doi> full text>
  • Moore HE, Adam CD, Drijfhout FP. 2014. Identifying 1st instar larvae for three forensically important blowfly species using "fingerprint'' cuticular hydrocarbon analysis. FORENSIC SCIENCE INTERNATIONAL, vol. 240, 48-53. link> doi>
  • Poiani SB, Morgan ED, Drijfhout FP, da Cruz-Landim C. 2014. Separation of Scaptotrigona postica workers into defined task groups by the chemical profile on their epicuticle wax layer. J Chem Ecol, vol. 40(4), 331-340. link> doi>
  • Martin SJ, Vitikainen E, Shemilt S, Drijfhout FP, Sundström L. 2013. Sources of variation in cuticular hydrocarbons in the ant Formica exsecta. J Chem Ecol, vol. 39(11-12), 1415-1423. link> doi>
  • Butcher JB, Moore HE, Day CR, Adam CD, Drijfhout FP. 2013. Artificial Neural Network analysis of hydrocarbon profiles for the ageing of Lucilia sericata for Post Mortem Interval estimation. Forensic Science International, vol. 232(1-3), 25-31. doi>
  • Moore HE, Adam CD, Drijfhout FP. 2013. Potential use of hydrocarbons for aging Lucilia sericata blowfly larvae to establish the postmortem interval. J Forensic Sci, vol. 58(2), 404-412. link> doi>
  • Olaniran OA, Sudhakar AVS, Drijfhout FP, Dublon IAN, Hall DR, Hamilton JGC, Kirk WDJ. 2013. A male-predominant cuticular hydrocarbon, 7 methyltricosane, is used as a contact pheromone in the western flower thrips (in press). Journal of Chemical Ecology. doi>
  • Vieira AS, Morgan ED, Drijfhout FP, Camargo-Mathias MI. 2012. Chemical composition of metapleural gland secretions of fungus-growing and non-fungus-growing ants. J Chem Ecol, vol. 38(10), 1289-1297. link> doi>
  • Blount JD, Rowland HM, Drijfhout FP, Endler JA, Inger R, Sloggett JJ, Hurst GDD, Hodgson DJ, Speed MP. 2012. How the ladybird got its spots: effects of resource limitation on the honesty of aposematic signals. FUNCTIONAL ECOLOGY, vol. 26(2), 334-342. link> doi>
  • Guillem RM, Drijfhout FP, Martin SJ. 2012. Using chemo-taxonomy of host ants to help conserve the large blue butterfly. BIOLOGICAL CONSERVATION, vol. 148(1), 39-43. link> doi>
  • Martin SJ, Shemilt S, Drijfhout FP. 2012. Effect of time on colony odour stability in the ant Formica exsecta. Naturwissenschaften, vol. 99(4), 327-331. link> doi>
  • Bonckaert W, Drijfhout FP, d'Ettorre P, Billen J, Wenseleers T. 2012. Hydrocarbon signatures of egg maternity, caste membership and reproductive status in the common wasp. J Chem Ecol, vol. 38(1), 42-51. link> doi>
  • Martin SJ, Vitikainen E, Drijfhout FP, Jackson D. 2012. Conspecific ant aggression is correlated with chemical distance, but not with genetic or spatial distance. Behav Genet, vol. 42(2), 323-331. link> doi>
  • Helantera H, Lee YR, Drijfhout FP, Martin SJ. 2011. Genetic diversity, colony chemical phenotype, and nest mate recognition in the ant Formica fusca. BEHAVIORAL ECOLOGY, vol. 22(4), 710-716. link> doi>
  • Kather R, Drijfhout FP, Martin SJ. 2011. Task group differences in cuticular lipids in the honey bee Apis mellifera. J Chem Ecol, vol. 37(2), 205-212. link> doi>
  • Nunes TM, Morgan ED, Drijfhout FP, Zucchi R. 2010. Caste-specific cuticular lipids in the stingless bee Friesella schrottkyi. APIDOLOGIE, vol. 41(5), 579-588. link> doi>
  • Martin SJ, Helanterä H, Drijfhout FP. 2011. Is parasite pressure a driver of chemical cue diversity in ants?. Proc Biol Sci, vol. 278(1705), 496-503. link> doi>
  • Martin SJ, Carruthers JM, Williams PH, Drijfhout FP. 2010. Host specific social parasites (Psithyrus) indicate chemical recognition system in bumblebees. J Chem Ecol, vol. 36(8), 855-863. link> doi>
  • Lommelen E, Wenseleers T, Johnson CA, Drijfhout FP, Billen J, Gobin B. 2010. A Combination of Fertility Signals and Aggression Regulates Reproduction in the Ant Gnamptogenys striatula. JOURNAL OF INSECT BEHAVIOR, vol. 23(3), 236-249. link> doi>
  • Vicente Hernandez J, Rodriguez D, Tarano Z, Drijfhout FP, Sainz-Borgo C. 2010. Are Postpharyngeal or Mandibular Gland Secretions the Source for Nestmate Recognition in Camponotus atriceps (Hymenoptera: Formicidae)?. SOCIOBIOLOGY, vol. 56(3), 775-793. link>
  • Martin SJ, Helantera H, Kiss K, Lee YR, Drijfhout FP. 2009. Polygyny reduces rather than increases nestmate discrimination cue diversity in Formica exsecta ants. INSECTES SOCIAUX, vol. 56(4), 375-383. link> doi>
  • Martin S and Drijfhout FP. 2009. A review of ant cuticular hydrocarbons. Journal of Chemical Ecology, vol. 35(10), 1151-1161. doi>
  • Martin SJ, Zhong W, Drijfhout FP. 2009. Long-term stability of hornet cuticular hydrocarbons facilitates chemotaxonomy using museum specimens. BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, vol. 96(4), 732-737. link> doi>
  • Martin SJ and Drijfhout FP. 2009. How reliable is the analysis of complex cuticular hydrocarbon profiles by multivariate statistical methods?. J Chem Ecol, vol. 35(3), 375-382. link> doi>
  • Martin SJ and Drijfhout FP. 2009. Nestmate and task cues are influenced and encoded differently within ant cuticular hydrocarbon profiles. J Chem Ecol, vol. 35(3), 368-374. link> doi>
  • Cremer S, D'Ettorre P, Drijfhout FP, Sledge MF, Turillazzi S, Heinze J. 2008. Imperfect chemical female mimicry in males of the ant Cardiocondyla obscurior. Naturwissenschaften, vol. 95(11), 1101-1105. link> doi>
  • Martin SJ, Helanterae H, Drijfhout FP. 2008. Evolution of species-specific cuticular hydrocarbon patterns in Formica ants. BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, vol. 95(1), 131-140. link> doi>
  • Martin SJ, Helanterä H, Drijfhout FP. 2008. Colony-specific hydrocarbons identify nest mates in two species of Formica ant. J Chem Ecol, vol. 34(8), 1072-1080. link> doi>
  • Martin SJ, Vitikainen E, Helanterä H, Drijfhout FP. 2008. Chemical basis of nest-mate discrimination in the ant Formica exsecta. Proc Biol Sci, vol. 275(1640), 1271-1278. link> doi>
  • Lommelen E, Johnson CA, Drijfhout FP, Billen J, Gobin B. 2008. Egg marking in the facultatively queenless ant Gnamptogenys striatula: the source and mechanism. J Insect Physiol, vol. 54(4), 727-736. link> doi>
  • Martin SJ, Takahashi J-I, Ono M, Drijfhout FP. 2008. Is the social parasite Vespa dybowskii using chemical transparency to get her eggs accepted?. J Insect Physiol, vol. 54(4), 700-707. link> doi>
  • Cremer S, Ugelvig LV, Drijfhout FP, Schlick-Steiner BC, Steiner FM, Seifert B, Hughes DP, Schulz A, Petersen KS, Konrad H, Stauffer C, Kiran K, Espadaler X, d'Ettorre P, Aktaç N, Eilenberg J, Jones GR, Nash DR, Pedersen JS, Boomsma JJ. 2008. The evolution of invasiveness in garden ants. PLoS One, vol. 3(12), e3838. link> doi> full text>
  • Ugelvig LV, Drijfhout FP, Kronauer DJC, Boomsma JJ, Pedersen JS, Cremer S. 2008. The introduction history of invasive garden ants in Europe: integrating genetic, chemical and behavioural approaches. BMC Biol, vol. 6, 11. link> doi> full text>
  • Martin SJ, Jenner EA, Drijfhout FP. 2007. Chemical deterrent enables a socially parasitic ant to invade multiple hosts. Proc Biol Sci, vol. 274(1626), 2717-2721. link> doi>
  • Martin SJ, Takahashi J, Drijfhout FP. 2007. Setosa membrane structure and occurrence of eicosenol in honeybees (Apis sp.). APIDOLOGIE, vol. 38(1), 104-109. link> doi>
  • Lommelen E, Johnson CA, Drijfhout FP, Billen J, Wenseleers T, Gobin B. 2006. Cuticular hydrocarbons provide reliable cues of fertility in the ant Gnamptogenys striatula. J Chem Ecol, vol. 32(9), 2023-2034. link> doi>
  • Drijfhout FP, Kochansky J, Lin S, Calderone NW. 2005. Components of honeybee royal jelly as deterrents of the parasitic Varroa mite, Varroa destructor. J Chem Ecol, vol. 31(8), 1747-1764. link> doi>
  • Martin SJ, Chaline N, Drijfhout FP, Jones GR. 2005. Role of esters in egg removal behaviour in honeybee (Apis mellifera) colonies. Behavioral Ecology and Sociobiology, vol. 59(1), 24-29. doi>
  • Jungnickel H, da Costa AJS, Tentschert J, Patricio E, Imperatriz-Fonseca VL, Drijfhout F, Morgan ED. 2004. Chemical basis for intercolonial aggression in the stingless bee\fIScaptotrigona bipunctata\fP (Hymenoptera: Apidae). Journal of Insect Physiology.
  • Drijfhout FP, Groot AT, van Beek TA, Visser JH. 2003. Mate location in the green capsid bug, Lygocoris pabulinus. ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA, vol. 106(2), 73-77. link> doi>
  • Drijfhout FP, Groot AT, Posthumus MA, van Beek TA, de Groot A. 2002. Coupled gas chromatographic-electroantennographic responses of Lygocoris pabulinus (L.) to female and male produced volatiles. CHEMOECOLOGY, vol. 12(2), 113-118. link> doi>
  • Drijfhout FP and Groot AT. 2001. Close-range attraction in Lygocoris pabulinus (L.). J Chem Ecol, vol. 27(6), 1133-1149. link> doi>
  • Drijfhout FP, Van Beek TA, Visser JH, De Groot A. 2000. On-line thermal desorption-gas chromatography of intact insects for pheromone analysis. JOURNAL OF CHEMICAL ECOLOGY, vol. 26(6), 1383-1392. link> doi>
  • Griepink FC, Drijfhout FP, Van Beek TA, Visser JH, De Groot A. 2000. Analysis of sex pheromone gland content of individual Symmetrischema tangolias by means of direct gland introduction into a two-dimensional gas chromatograph. JOURNAL OF CHEMICAL ECOLOGY, vol. 26(4), 1013-1023. link> doi>
  • Groot AT, Timmer R, Gort G, Lelyveld GP, Drijfhout FP, Van Beek TA, Visser JH. 1999. Sex-related perception of insect and plant volatiles in Lygocoris pabulinus. JOURNAL OF CHEMICAL ECOLOGY, vol. 25(10), 2357-2371. link> doi>
  • Drijfhout FP, Fraaije MW, Jongejan H, van Berkel WJ, Franssen MC. 1998. Enantioselective hydroxylation of 4-alkylphenols by vanillyl alcohol oxidase. Biotechnol Bioeng, vol. 59(2), 171-177. link> doi>

Other

  • Uche FI, Abed M, Abdullah MI, Drijfhout FP, McCullagh J, Claridge TWD, Richardson A, Li W-W. 2017. Isolation, identification and anti-cancer activity of minor alkaloids from Triclisia subcordata Oliv. BIOCHEMICAL PHARMACOLOGY (vol. 139, p. 112). link> doi> full text>
  • Uche F, Abed M, Abdullah M, Drijfhout FP, McCullagh J, Claridge T, Richardson A, Li WW. 2017. O9 Isolation, identification and anti-cancer activity of minor alkaloids from Triclisia subcordata Oliv. Biochemical Pharmacology (vol. 139). Elsevier BV. doi> link>
  • Groot AT, Visser JH, Geerts R, Drijfhout FP, van Beek TA. 1998. Behavioural response of Lygocoris pabulinus (Heteroptera : Miridae) to potential sex pheromone compounds. PROCEEDINGS OF THE SECTION EXPERIMENTAL AND APPLIED ENTOMOLOGY OF THE NETHERLANDS ENTOMOLOGICAL SOCIETY (NEV) (pp. 191-195). link>

Year 1

  • CHE-10021: Forensic Investigation and Analysis
  • CHE-10053: General Chemistry 1 (NXU) (Module Leader)

Year 2

  • CHE-20011: Spectroscopy and Advanced Analysis (Module Leader)

Year 3

  • CHE-30011: Forensic Science Team Research Project (Supervisor)
  • CHE-30032: Advanced Chemical Analysis (Module Leader)
  • CHE-30002/40/41: Chemistry and Medicinal Chemistry Research Projects, experimental & non-experimental (Supervisor)