Molecular Structure and Signalling

Theme Lead: Dr Annette Shrive

Our research involves using a range of biochemical approaches to address underlying mechanisms and processes in a range of biological and health related areas including innate immunity, rheumatoid arthritis, cancer, virology (including COVID19) and parasitology. This includes a wide range of complementary techniques and expertise in molecular biology and cellular signalling, glycobiology, and structural biology and is underpinned by a wide range of national and international collaborations and access to world-leading Central Facilities including Institute Laue Langevin (Life Sciences Group and Deuteration Laboratory), Diamond Light Source and Harwell Campus, Liverpool Technology Directorate and Midlands Innovation

Key areas of research and techniques include the following:

  • Cellular and molecular pathways in cell fate decision
  • Development of custom next generation sequencing and bioinformatic workflows
  • RNA sequencing, de novo assembly and discovery of novel functional ncRNAs
  • Conjugative DNA transfer in gram-positive pathogens
  • Microbiome characterization
  • Biomarker discovery and characterisation
  • Structural biology, including x-ray crystallography and cryo-electron microscopy
  • Effector mechanisms in innate immunity
  • Characterisation of pathogen-host interactions
  • Structure, function and recognition properties of secreted pattern recognition receptors
  • Glycosaminoglycan research
  • Role of heparin in health and disease
  • Characterisation of cellular mechanotransduction pathways
  • Mechanical manipulation of cells and tissues