I obtained my MSc in Biochemistry from Freie Universität Berlin, Germany, in 2004 and then went on to do a PhD at the University of Edinburgh. After a brief stay in Brisbane, Australia, I took up a postdoctoral position with Prof. Sir Tom Blundell at the University of Cambridge in 2008. During this post I became interested in fragment-based drug discovery, which is still an emerging field when targeting protein-protein interactions. In 2012 I joined Prof. Richard Bayliss’ lab at the University of Leicester where I worked on separases. In September 2016 I was delighted to start a lectureship position at Keele University which was a joint appointment with ILL in Grenoble, France. I am married with two children.
Research and scholarship
I am passionate about conducting science in an area that is helpful to the community – drug research to prevent or cure diseases. My research is focussed on proteins, studying their molecular make-up, investigating how they interact with other proteins and how these interactions can be targeted through drug-discovery. During the past 10 years I developed skills in crystallography, biophysical techniques (CD, fluorescence, DSF, SPR), biochemical and cell-based assays as well as compound design, molecular docking and comparative modelling.
My current focus is on investigating the molecular make-up of prohibitins and to study their interaction with viral envelope proteins. Recent research suggests that several viruses, such as Chikungunya virus, dengue serotype 2 virus and white spot syndrome virus, realise entry into host cells via interaction with prohibitins. But these proteins have also been identified as important players in mitochondrion homeostasis, cell signalling and tumour development.
My post as lecturer is a joint appointment with the Institut Laue-Langevin in Grenoble, France, where I will be utilising their Neutron scattering and X-ray scattering facilities to further my research.
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Full Publications List show
Assessing molecular mechanisms of curcumin and its in vivo efficacy in targeting colorectal cancer stem-like cells. MUTAGENESIS (vol. 29, pp. 525-526). link>2014.