Macromolecular Structure Research Group
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About the Group
The group uses physical techniques for the study of macromolecular systems. Integrated approaches involving a variety of complementary techniques are used to optimise the information obtained. Key techniques are neutron and X-ray scattering methods applied to crystalline, fibrous and solution state samples. The group has a close relationship with some of the world's most powerful facilities for this type of work including the Institut Laue Langevin (ILL) and the European Synchrotron Radiation Facility (ESRF), and a large part of the group is located within the Partnership for Structural Biology (PSB) in Grenoble under secondment/joint appointment arrangements. The PSB offers outstanding facilities for interdisciplinary research on biological systems.
The Keele group is involved in a variety of research projects including structural studies of nucleic acids, nucleic acid-drug complexes, naturally occurring and synthetic amyloid-forming systems, protein-nucleic acid complexes, as well as developments for novel instrumentation and laboratory facilities at the Grenoble science campus. Techniques used include crystallography, fibre diffraction, and solution scattering as well as a range of complementing techniques available at the PSB. Keele was instrumental in the conception, creation and funding of the ILL-EMBL Deuteration Laboratory. This was geared towards the generation of a completely new line of work in the life sciences at the ILL and resulted in the provision of specialised laboratories that are run by Dr. Michael Haertlein, an experienced molecular biologist and a permanent member of the ILL staff. The group has extensive EPSRC Keele-based funding as well as substantial EU funding at the ILL.