Neuroscience

The Neuroscience Group specialises in several related basic, translational and clinical areas and applies state-of-the art approaches to the study of normal processes and disease mechanisms. There is basic research into neuroanatomy, cell physiology and pathology, development of new stem cell and other therapies for treatment of human disorders, and some of our research culminates in clinical trials and treatments in neurological diseases. Our work is based on multidisciplinary approaches to discover and treat the causes of disease and includes a wide range of approaches using different technologies such as single cell recording and systems physiology, nanoscale devices and nanoparticles, confocal and electron microscopy, and genetic studies.

In basic neuroscience, we conduct research into the molecular changes in the brain during development and pathology and the functioning of the auditory system at the organ, cellular and molecular level, along with the mechanisms of cortical and hippocampal plasticity. Development of in vitro models of neurological injury is also a major goal. Multidisciplinary studies investigate the application of nanotechnology and nanoscale devices for neural repair and neural circuit formation. There is also work on the functional variability of neurons in response to neuromodulation, the resulting changes in the functional neural circuits, and the computational modelling of these.

Some of our research is potentially translational, for example stem cell therapy to promote neural regeneration to treat diseases such as Parkinson’s disease and prevent hearing loss, along with the development of implantable materials to promote repair following spinal cord injury.

In the clinical area, we are researching genetics in multiple sclerosis (MS) and the range of neuropsychological deficits following stroke, including clinical trials towards their treatment.

Neuroscience Group Leader: Professor David Furness (interim lead)

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