Evidence synthesis​

The School of Medicine hosts an active and productive evidence synthesis team, including systematic reviewers, information specialists and data analysts. The team works together with healthcare professionals and other researchers to generate a wide range of systematic reviews and meta-analyses, including scoping reviews, network meta-analyses, individual participant data meta-analysis, realist synthesis, and mixed method reviews.

Our core team works on a wide range of systematic reviews and meta-analyses, including scoping reviews, network meta-analyses, individual participant data meta-analysis, realist reviews, and mixed method reviews, focusing on questions related to the prevalence and burden of health conditions; diagnosis and assessment; prognosis and prediction; effectiveness of interventions; and guideline development.

Collaborations

The Keele team is part of the NIHR West Midlands Evidence Synthesis Group, led by the University of Warwick and co-led by The University of Birmingham, which aims to provide best evidence, including on the effectiveness and cost-effectiveness of treatments, tests and other interventions, to support decision-making across health, public health and social care in the UK.​

We support the guideline development programme of the British Society of Rheumatology, working with multidisciplinary working groups to ensure guidelines are underpinned by high quality evidence reviews.

We have strong national and international collaborations focusing on evidence synthesis methods. This includes the NIHR School for Primary Care Research Evidence Synthesis group, and Cochrane methods or editorial groups.​

Teaching and training​

The team offers training and systematic review support to staff, postgraduate researchers and students across Keele University and the local NHS community.

Our active and productive evidence synthesis team, hosted by the School of Medicine, includes systematic reviewers, information specialists and data analysts working with clinicians and other researchers to generate evidence reviews. ​

We generate a wide range of systematic reviews and meta-analyses, including scoping reviews, network meta-analyses, Individual Participant Data meta-analysis, realist synthesis, and mixed method reviews on a variety of topics.

Our team at Keele is part of the NIHR West Midlands Evidence Synthesis Group, co-led by the University of Warwick and The University of Birmingham. This aims to provide best evidence on the effectiveness and cost-effectiveness of treatments, tests and other interventions, to support decision-making across health, public health and social care in the UK.

We support the British Society of Rheumatology’s guideline development programme alongside their multidisciplinary working groups to ensure guidelines are underpinned by high quality evidence reviews.

Our team has strong links with national and international collaborations focusing on evidence synthesis methods, such as the NIHR School for Primary Care Research Evidence Synthesis group, and Cochrane methods and editorial groups.

We provide training and support on systematic review methodology and literature searching to staff, postgraduate researchers and students across Keele University and the local NHS community.

Melanie A Holden, Miriam Hattle, Jos Runhaar, Richard D Riley, Emma L Healey, Jonathan Quicke, Danielle A van der Windt, Krysia Dziedzic, Marienke van Middelkoop, Danielle Burke, Nadia Corp, Amardeep Legha, Sita Bierma-Zeinstra, Nadine E Foster, on behalf of the STEER OA Patient Advisory Group and the OA Trial Bank Exercise Collaborative*​

Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. Lancet Rheumatology. Published online June 12, 2023  doi: 10.1016/S2665-9913(23)00122-4​

Tom Kingstone, Carolyn A. Chew‐Graham, Nadia Corp. Interventions to identify and manage depression delivered by ‘nontraditional’ providers to community-dwelling older adults: A realist review. Health Expect. 2022 Dec; 25(6): 2658–2679. doi: 10.1111/hex.13594​

J. Lucas, P. van Doorn, E. Hegedus, J. Lewis, D. van der Windt. A systematic review of the global prevalence and incidence of shoulder pain. BMC Musculoskelet Disord. 2022; 23: 1073. doi: 10.1186/s12891-022-05973-8​

Peat G, Jordan KP, Wilkie R, Corp N, van der Windt DA, Yu D, Narle G, Ali N. Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness. J Public Health (Oxf). 2022 Aug 25;44(3):e376-e387. doi: 10.1093/pubmed/fdac014 ​

Babatunde OO, Bucknall M, Burton C, Forsyth JJ, Corp N, Gwilym S, Paskins Z, van der Windt DA. Long-term clinical and socio-economic outcomes following wrist fracture: a systematic review and meta-analysis. Osteoporos Int. 2022 Apr;33(4):753-782. doi: 10.1007/s00198-021-06214-9​

Coates LC, Corp N, van der Windt DA, Soriano ER, Kavanaugh A. GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting. J Rheumatol. 2021 Feb 15:jrheum.201681. doi: 10.3899/jrheum.201681.​

Opeyemi O. Babatunde, Joie Ensor, Chris Littlewood, Linda Chesterton, Joanne L. Jordan, Nadia Corp, Gwenllian Wynne-Jones, Edward Roddy, Nadine E. Foster, Danielle A. van der Windt. Comparative effectiveness of treatment options for subacromial shoulder conditions: a systematic review and network meta-analysis. Ther Adv Musculoskelet Dis. 2021; 13: 1759720X211037530.  doi: 10.1177/1759720X211037530​

Yahaya, I., Wright, T., Babatunde, O.O. et al. Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatol Int 41, 1221–1231 (2021). doi: 10.1007/s00296-021-04838​

Corp N, Mansell G, Stynes S, Wynne-Jones G, Morsø L, Hill JC, van der Windt DA. Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines. Eur J Pain. 2020 Oct 16. doi: 10.1002/ejp.1679.