Biography
Following degrees in Computer Science (University of Essex) and Biochemistry & Neuroscience (Keele), I earned my PhD in Biomedical Engineering, studying under Prof Divya Chari (Keele, 2013). During my PhD, I was awarded an EPSRC E-TERM Landscape Fellowship, also hosted in Prof Chari’s lab (2013-15). I then held a postdoc position with Dr David Morgan (Keele, School of Pharmacy; 2015-16), before becoming a Lecturer at Keele’s School of Medicine (Nov 2016-).
- PhD title: Applications of magnetic particles for oligodendrocyte precursor cell transplantation strategies
- Fellowship project, E-TERM (Engineering – Tissue Engineering and Regenerative Medicine; EP/I017801/1): Magnetically-assisted neuroengineering techniques
- Postdoc project: Investigating the roles of microglia in neurodegenerative disease and regenerative processes
Research and scholarship
I am interested in improving preclinical models of neurodegeneration in the central nervous system, particularly for screening nanomaterials with therapeutic potential for tissue engineering/regenerative medicine (TERM).
I mainly work with glial cells (astrocytes, oligodendrocytes, OPCs and microglia), but also embryonic stem cells (ESCs) and neurons (particularly dopaminergic).
I am associated with two themes at the Institute for Science and Technology in Medicine (ISTM):
I organised the ATREUM conference (3-6 April 2017) for early career researchers in Tissue Engineering and Regenerative Medicine (TERM)
In Feb 2014, I organised a Preclinical Modelling Workshop for Regenerative Medicine at Keele Hall.
I am a member of the British Neuroscience Association (BNA) and the British Society for Immunology (BSI).
Teaching
I teach at Keele University Medical School, and am currently involved in curriculum development (MBChB).
Postgraduate Supervision:LSC-40043, MSc in Scientific Research Training
Further information
Links, Resources, News
- I am organising the ATREUM conference (3-6 April 2017) for early career researchers in Tissue Engineering and Regenerative Medicine (TERM)
- I coordinate the Brains for Breakfast (B4B) seminar series
School of Life Sciences, Huxley003, Weds 09:00-10:00
Informal seminars discussing recent and proposed research in Neuroscience-related subjects, including Computer Science.
Please contact me if you are interested in presenting, or would like to join the mailing list.
- I have contributed to the HEART (Healthcare Engineering & Regenerative Therapies) blog, aimed at teenagers interested in science
Are nanoparticles too small to be seen interacting with cells? [Jun 2014]
Can ‘stealth’ nanoparticles deliver medicine to the brain? [Apr 2014]
News, Events
- Drs Stuart Jenkins & Chris Adams appointed to Lectureships [Oct 2016]
- Teenagers in UK Science + Engineering Competition final [Feb 2016]
- Are nanoparticles too small to be seen interacting with cells? [Jun 2014]
- Can ‘stealth’ nanoparticles deliver medicine to the brain? [Apr 2014]
- Preclinical Modelling Workshop for Regenerative Medicine [Feb 2014]
- Cover image in prestigious publication [Jan 2014]
- Journal Cover Image for Dr Divya Chari and Dr Stuart Jenkins [Jul 2013]
- Dr Stuart Jenkins has been awarded an Engineering & Physical Sciences Research Council (EPSRC) Landscape Fellowship [Nov 2012]
- British Neuroscience Association Abstract Competition Winner [Jul 2012]
- ISTM student paper in top nanotechnology journal [Oct 2011]
Selected Publications
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'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release, 136-145, vol. 224. link> doi> full text>2016.
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Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research. doi> link> full text>2016.
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Development of a nanomaterial bio-screening platform for neurological applications. Nanomedicine, 77-87, vol. 11(1). link> doi> full text>2015.
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Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond), 951-968, vol. 8(6). link> doi> full text>2013.
- 2011.
Full Publications Listshow
Journal Articles
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In vitro model of traumatic brain injury to screen neuro-regenerative biomaterials. Materials Science and Engineering: C, Article 112253, vol. 128. doi> link> full text>2021.
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Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. International Journal of Molecular Sciences, 1-22, vol. 22(8). doi> link> full text>2021.
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Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. Int J Mol Sci, vol. 22(8). link> doi> full text>2021.
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Characterizing Ischaemic Tolerance in Rat Pheochromocytoma (PC12) Cells and Primary Rat Neurons. Neuroscience, 17-31, vol. 453. link> doi> full text>2021.
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Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain Sci, vol. 10(3). link> doi> full text>2020.
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Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics. Nanomaterials (Basel), vol. 10(3). link> doi> full text>2020.
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Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death. APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, Article ARTN 226, vol. 125(4). link> doi> link> full text>2019.
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The Influence of Nicotinamide on Health and Disease in the Central Nervous System. Int J Tryptophan Res, 1178646918776658, vol. 11. link> doi> full text>2018.
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Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles. NANO RESEARCH, 2881-2890, vol. 10(8). link> doi> full text>2017.
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'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release, 136-145, vol. 224. link> doi> full text>2016.
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Endocytotic potential governs magnetic particle loading in dividing neural cells: studying modes of particle inheritance. Nanomedicine (Lond), 345-358, vol. 11(4). link> doi> full text>2016.
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Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research. doi> link> full text>2016.
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The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regenerative Medicine, 989-1003, vol. 10(8). link> doi> full text>2015.
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Development of a nanomaterial bio-screening platform for neurological applications. Nanomedicine, 77-87, vol. 11(1). link> doi> full text>2015.
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Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Mol Cell Ther, 23, vol. 2. link> doi> full text>2014.
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Influence of amplitude of oscillating magnetic fields on magnetic nanoparticle-mediated gene transfer to astrocytes. nanoLife. doi>2014.
- 2014.
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Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS Chem Neurosci, 51-63, vol. 5(1). link> doi> full text>2014.
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Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond), 951-968, vol. 8(6). link> doi> full text>2013.
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Magnetic nanoparticle mediated gene delivery in oligodendroglial cells: a comparison of differentiated versus precursor forms. NanoLIFE, vol. 3(1243001).2012.
- 2011.
- 2011.
Chapters
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A Stoichiometrically Defined Neural Coculture Model to Screen Nanoparticles for Neurological Applications. Santamaria F and Peralta X (Eds.). Humana Press, Inc.. doi> link> full text>2018.
Other
- 2021.
Gallery
- Three of my publications have featured as journal covers
- Videos, produced using time-lapse fluorescence microscopy
Fluorescent magnetic nanoparticles being internalised by brain cells
PhD Students
Lab members, opportunities
- Emma Green, PhD student (2016-)
Vitamin driven generation of dopaminergic neurons as cell replacement therapy for Parkinson’s disease
- Michael Santer, MSc Scientific Research Training (2016-)
Serum-free media for neural cell culture
- Shida “Tiggs” Gholamian, Keele medical student, INSPIRE Summer Studentship (2016, with Dr David Morgan)
Eight week project: “Does repeated activation generate an ‘experienced’ microglial phenotype, with altered pro-inflammatory responses?”
- Anna Biju, Nuffield Research Placement (2016, with Dr David Morgan)
Anna Biju won a place in the national finals of the National Science + Engineering Competition (British Science Association, BSA), presenting our work at The Big Bang Fair. Covered in The Sentinel.
- Students wanted:
I welcome applications to undertake postgraduate (PhD or MPhil) studies in my laboratory. Please contact me directly (s.i.jenkins@keele.ac.uk) to discuss potential projects and the application process. See the "Research and Scholarship" tab for my research interests.
School of Life Sciences,
Huxley Building,
Keele University,
Staffordshire,
ST5 5BG
Tel: +44 (0) 1782 734414
Enquiries:
Tel: +44 (0) 1782 734414
Email: lifesciences.enquiries@keele.ac.uk