Biography
Dr Jan-Herman Kuiper was appointed as a Lecturer in Biomechanics at Keele in 2001, but is based at the Robert Jones & Agnes Hunt Orthopaedic Hospital in Oswestry. His research training at MSc and PhD level was at the University of Twente and the University of Nijmegen in the Netherlands. He became a Senior Lecturer in 2017.
He has extensive experience in the use of Finite Element-based computer models for design optimization, modelling of hydrated tissues and bone, and biological processes such as adaptive bone remodelling and fracture repair One of his long standing interests is the control of biological processes through mechanical conditions. Most of his work in this area is concentrated on the control of long bone fracture repair by movements at the fracture site, which he has investigated experimentally and theoretically. Findings from these studies have aided his clinical collaborators including Prof James Richardson and Prof Sally Roberts.
Jan-Herman Kuiper's collaboration with other laboratory based scientists includes joint projects with Prof Alicia El Haj and Prof Ying Yang to control the response of bone cells (osteoblasts) to mechanical strains in order to improve bone formation on resorbable 3-dimensional scaffolds. These studies are supported by substantial joint grants from the Engineering & Physical Sciences Research Council and the European Commission Framework Programme.
In a collaboration with Dr Carol Evans at Manchester University, Dr Kuiper also receives funding from the AO Foundation in Switzerland to study the influence of fracture site movements on bone formation during limb lengthening.
Other European collaboration includes European Commission Framework VI “New and Emerging Science and Technology” funding in partnership with several European researchers, including Dr Patrick Warnke at the University of Kiel in Germany who has pioneered a clinical procedure to grow a complete new jaw for a patient inside a back muscle. The objective of this new high risk/high benefit "MYJOINT" project is to develop a clinical procedure to grow a complete synovial joint in a patient’s back muscle, similar to the procedure pioneered by Dr Warnke. One of Dr Kuiper's specific tasks is to model the control of articular joint formation by mechanical conditions.
Summary of previous posts (with dates):
- Lecturer in Biomechanics (Keele University, 2001-2017)
- Post-graduate researcher (Robert Jones and Agnes Hunt Orthopaedic Hospital, 1997-2001)
- Post-graduate researcher (Keele University, 1993-1997)
- Research assistant (University of Nijmegen, 1992-1993)
- Ph.D. student (University of Nijmegen, 1989-1992)
- Research assistant (University of Nijmegen,1988-1989)
Research and scholarship
Research theme:
All my current work is related to orthopaedics and broadly characterised by two interests.
1. Mechanical guidance of skeletal tissue formation.
Mechanical influences on tissue formation and differentiation, in particular with relation to fracture healing and cartilage repair
2 .Development and pre-clinical testing of joint replacement implants, bioresorbable orthopaedic devices and bone substitution products
Examples are the development and testing of impaction grafting for hip and knee revision surgery, and the development and testing of knee ligament repair systems using a composite bioresorbable materials.
Teaching
Teaching responsibilities:
1. Biomechanics module at MSc courses in Biomedical Engineering and Cell & Tissue Engineering, Keele University
2. Tribology in Joint replacement Implants module at Orthopaedic Science Course, Oswestry
3. Statistics module for postgraduate research students
4. Regular contributions to Friday afternoon teaching sessions, Oswestry
5. Supervision of BSc, MSc and MPhil-students who do placements and final-year projects. On average, seven students visit us yearly from Universities in The Netherlands, Germany and France.
6. Co-supervision of PhD and MD students.
Supervision of orthopaedic registrars doing biomechanical research.
Further information
Dr Kuiper is a reviewer for the EPSRC, several charities and several journals.
He is a member of a Special Interest Group in IPEM (Institute of Physics and Engineering and Medicine), the American Society of Mechanical Engineers, the European Society of Biomechanics and the British Orthopaedic Research Society.
Selected Publications
-
Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest. Cartilage, 19476035221149523. link> doi> full text>2023.
-
A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee. Am J Sports Med, 3635465221141907. link> doi> full text>2023.
-
Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors. Inflammopharmacology. link> doi> full text>2022.
-
Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy. Children (Basel), vol. 9(5). link> doi> full text>2022.
-
Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study. Journal of Orthopaedic Surgery and Research, Article 241, vol. 17(1). link> doi> link> full text>2022.
Full Publications Listshow
Journal Articles
-
Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest. Cartilage, 19476035221149523. link> doi> full text>2023.
-
A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee. Am J Sports Med, 3635465221141907. link> doi> full text>2023.
-
Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors. Inflammopharmacology. link> doi> full text>2022.
-
Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy. Children (Basel), vol. 9(5). link> doi> full text>2022.
-
Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study. Journal of Orthopaedic Surgery and Research, Article 241, vol. 17(1). link> doi> link> full text>2022.
-
Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. Cells, vol. 11(4). link> doi> full text>2022.
- 2021.
- 2021.
-
Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. Eur J Appl Physiol, 3551-3559, vol. 121(12). link> doi> full text>2021.
-
Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. Surgeries, 286-302, vol. 2(3). link> doi> link> full text>2021.
-
An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, vol. 10(8). link> doi> full text>2021.
-
Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?. J Shoulder Elbow Surg, 2465-2474, vol. 30(11). link> doi> full text>2021.
- 2021.
-
Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury. Sci Rep, 4361, vol. 11(1). link> doi> full text>2021.
-
Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?. Biomolecules, vol. 11(1). link> doi> full text>2021.
-
Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Sci Rep, 21658, vol. 10(1). link> doi> full text>2020.
-
Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. The Journal of Hand Surgery (Asian-Pacific Volume), 447-452, vol. 25(4). link> doi> link> full text>2020.
-
Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity. Bone, 115769, vol. 144. link> doi> full text>2021.
- 2020.
- 2020.
- 2020.
- 2020.
- 2020.
- 2020.
-
Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon. Clin Anat, 689-695, vol. 33(5). link> doi> full text>2020.
-
Isolated medial patellofemoral ligament reconstruction significantly improved quality of life in patients with recurrent patella dislocation: a response to Hiemstra et al.'s letter to the editor. Knee Surg Sports Traumatol Arthrosc, 3735-3737, vol. 27(11). link> doi> full text>2019.
-
A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - I: the effects of growth factors. J Tissue Eng, 2041731419827791, vol. 10. link> doi> full text>2019.
-
A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: the effects of co-implantation. J Tissue Eng, 2041731419827792, vol. 10. link> doi> full text>2019.
-
Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells. J Orthop Res, 1303-1309, vol. 37(6). link> doi> full text>2019.
- 2019.
- 2018.
-
Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Eur Cell Mater, 255-267, vol. 35. link> doi> full text>2018.
- 2018.
-
The twin peg Oxford knee - Medium term survivorship and surgical principles. Knee, 314-322, vol. 25(2). link> doi> full text>2018.
-
Low failure rate at short term for 40 mm heads and second generation triple annealed HCLPE liners in hybrid hip replacements. J Clin Orthop Trauma, 350-357, vol. 10(2). link> doi> full text>2019.
- 2005.
-
Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures. J Exp Orthop, 26, vol. 4(1). link> doi> full text>2017.
-
Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regen Med, 493-501, vol. 12(5). link> doi> full text>2017.
-
The Absence of Detectable ADAMTS-4 (Aggrecanase-1) Activity in Synovial Fluid Is a Predictive Indicator of Autologous Chondrocyte Implantation Success. Am J Sports Med, 1806-1814, vol. 45(8). link> doi> full text>2017.
-
Non-contraceptive oestrogen-containing preparations for controlling symptoms of premenstrual syndrome. Cochrane Database Syst Rev, CD010503, vol. 3. link> doi> full text>2017.
-
Surgical treatment for developmental dysplasia of the hip- a single surgeon series of 47 hips with a 7 year mean follow up). Acta Orthop Belg, 754-761, vol. 82(4). link>2016.
-
Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. Nanoscale, 17869-17880, vol. 8(41). link> doi> full text>2016.
-
Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella. Chin J Traumatol, 255-258, vol. 19(5). link> doi> full text>2016.
- 2006.
- 2003.
- 1996.
-
Incisional negative pressure wound therapy dressings (iNPWTd) in routine primary hip and knee arthroplasties: A randomised controlled trial. Bone Joint Res, 328-337, vol. 5(8). link> doi> full text>2016.
-
Development of a Tool to Predict Outcome of Autologous Chondrocyte Implantation. Cartilage, 119-130, vol. 8(2). link> doi> full text>2017.
-
Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific Reports, Article ARTN 24295, vol. 6. link> doi> link> full text>2016.
-
Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. The American journal of sports medicine, 1249-1259, vol. 44(5). doi> full text>2016.
- 2016.
- 2016.
-
Efficacy of hip resurfacing arthroplasty: 6 year results from an international multisurgeon prospective cohort study. Acta Orthop Belg, 197-208, vol. 81(2). link>2015.
-
The cemented twin-peg Oxford partial knee replacement survivorship: a cohort study. The Knee, 333-337, vol. 22(4). doi> link> full text>2015.
-
ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis Cartilage, 1622-1626, vol. 23(9). link> doi> full text>2015.
-
Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. J Stem Cells Regen Med, 18-24, vol. 11(1). link> doi> full text>2015.
- 2014.
-
A facile in vitro model to study rapid mineralization in bone tissues. Biomed Eng Online, 136, vol. 13. link> doi> full text>2014.
-
Hip resurfacing arthroplasty: A new method to assess and quantify learning phase. Acta Orthop Belg, 397-402, vol. 80(3). link>2014.
- 2014.
- 2013.
-
Effect of cotton padding on the setting properties of plaster slabs. Ann R Coll Surg Engl, 107-109, vol. 95(2). link> doi> full text>2013.
- 2013.
- 2012.
- 2012.
- 2012.
- 2012.
-
Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PLoS One, e47169, vol. 7(10). link> doi> full text>2012.
- 2011.
- 2011.
- 2011.
-
No drain, autologous transfusion drain or suction drain? A randomised prospective study in total hip replacement surgery of 168 patients. Acta Orthop Belg, 619-627, vol. 76(5). link> full text>2010.
- 2011.
- 2010.
- 2010.
- 2009.
- 2009.
- 2010.
- 2009.
-
The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. J Orthop Surg Res, 17, vol. 4. link> doi> full text>2009.
- 2009.
- 2009.
-
Age at follow-up and mechanical axis are good predictors of function after unicompartmental knee arthroplasty. An analysis of patients over 17 years follow-up. Acta Orthop Belg, 45-50, vol. 75(1). link> full text>2009.
- 2009.
- 2008.
- 2008.
- 2008.
- 2008.
- 2008.
- 2007.
- 2007.
- 2007.
- 2006.
- 2007.
- 2006.
-
Factors affecting the cohesion of impaction bone graft. Journal of Bone and Joint Surgery - British Volume, 828-831, vol. 88-B(6). doi>2006.
- 2006.
-
Reconstruction of femoral defects in revision hip surgery: risk of fracture and stem migration after impaction bone grafting. Journal of Bone and Joint Surgery - British Volume, 832-836, vol. 88. doi>2006.
-
Current in vivo wear of metal-on-metal bearings assessed by exercise-related rise in plasma cobalt level. Journal of Orthopaedic Research, 1657, vol. 24(11). doi>2006.
-
Stiffness measurements to assess healing in bone transport: a preliminary report. Journal of Orthopaedics and Traumatology, 84-87, vol. 7.2006.
- 2001.
- 2006.
- 2005.
- 2005.
- 2005.
- 2005.
- 2004.
- 2004.
- 2003.
-
Untitled. AMERICAN JOURNAL OF SPORTS MEDICINE, 325-326, vol. 31(2). link>2003.
-
Fatigue testing of some orthopaedic fixation devices. Am J Sports Med, 325-326, vol. 31(2). link>2003.
-
Letter. The American journal of sports medicine, 525-527, vol. 31(2).2003.
-
Untitled (vol 31, pg 325, 2003). AMERICAN JOURNAL OF SPORTS MEDICINE, 814, vol. 31(5). link>2003.
- 2001.
- 2000.
- 1999.
- 1997.
- 1997.
-
A comparison of finite element codes for the solution of biphasic poroelastic problems. PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, 209-211, vol. 211(2). link>1997.
- 1996.
- 1996.
-
DYNAMIZATION OF TIBIAL FRACTURES (VOL 77, PG 412, 1995). JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 985, vol. 77B(6). link>1995.
- 1995.
- 1992.
- 1991.
Other
-
The natural repair of articular cartilage in humans: an immunohistological study. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (pp. A26-A27, vol. 100). link>2019.
- 2018.
- 2018.
-
Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A23, vol. 98). link>2017.
-
Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A24, vol. 97). link>2016.
-
A systematic review - ovarian suppression with GnRH analogues for management of PMS. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (p. 186, vol. 123). link>2016.
-
The validation of a novel compression bioreactor to ensure the accurate application of loading regimes. TISSUE ENGINEERING PART A (p. 919, vol. 14). link>2008.
-
Clinical trial of bone marrow stromal stem cell implantation for refractory fracture non-union: Results from the first patients. TISSUE ENGINEERING (p. 1657, vol. 13). link>2007.
-
Factors affecting the cohesion of impaction bone graft. JOURNAL OF BONE AND MINERAL RESEARCH (p. 1161, vol. 21). link>2006.
-
Autologous chondrocyte implantation: 2-to-9 year OsCell experience. TISSUE ENGINEERING (p. 1022, vol. 12). link>2006.
-
Clinical application of adult bone marrow mesenchymal stem cells for treatment of fracture nonunions. TISSUE ENGINEERING (p. 1023, vol. 12). link>2006.
- 2006.
- 1998.
-
Dynamic mechanical testing of prosthetic acetabular components. EXPERIMENTAL MECHANICS, VOLS 1 AND 2 (pp. 839-844). link>1998.
-
NUMERICAL OPTIMIZATION OF HIP-PROSTHETIC STEM MATERIAL. RECENT ADVANCES IN COMPUTER METHODS IN BIOMECHANICS & BIOMEDICAL ENGINEERING (pp. 76-84). link>1992.
School address:
School of Pharmacy and Bioengineering
Hornbeam Building
Keele University
Staffordshire
ST5 5BG
Research centre address:
School of Pharmacy and Bioengineering
Guy Hilton Research Centre
Thornburrow Drive
Stoke-on-Trent
ST4 7QB
Tel: +44 (0) 1782 674988
Undergraduate enquiries:
Email: enquiries@keele.ac.uk
Tel: +44 (0)1782 734010
Postgraduate enquiries:
Please contact the CPD4ALL team:
Email: phab.postgraduate@keele.ac.uk
Keele Centre for Medicines Optimisation (KCMO)
Tel: +44 (0)1782 733831 / 734131
The Virtual Patient project enquiries:
Contact our Digital Development team:
Email: pharmacy.digital@keele.ac.uk