Ying Yang

Biography

Ying completed her PhD at Manchester University in Materials Science and Technology in 1994. Before that, she obtained a BSc in Chemistry Engineering and a MSc in Polymer Science and Technology in Hunan University in 1981 and 1987 respectively. Between 1995 and 1997, she took up a postdoctoral research fellow in Tokyo Institute of Technology working on engineering polymer blends aiming to develop new automobile industrial materials. In the late 1997, Ying took a research associate position in Keele University and started her materials research in the medical field. Ying was appointed as a lecturer in Biomaterials and Tissue engineering in 2001 and promoted to senior lecturer in 2006 and reader in 2009. In December 2015, Ying was appointed as a chair and professor in Biomaterials and Tissue engineering.

Inaugural Lecture 3 July 2017 available on YouTube: https://www.youtube.com/watch?v=7LjN-hLJyZI&feature=youtu.be

Research and scholarship

Group Lead for Materials for Bioscience research group

and active member of Regenerative Medicine FReT & Orthopaedics & Biomechanics research group

Ying's current research has been focused on the application of engineering strategies in translational medicine. Great effort has been made to establish systematic study methods in utilizing smart/unique materials that trigger and detect specific cellular responses and application of non-destructive monitoring modalities for complicate cellular systems. The research includes smart nanofiber design and applications, detection of variation of cell adhesion capacities, developing immunemodulating materials, exploring unique techniques to detect heterogeneous cellular populations and correlating the structures of collagen based matrices to diseases. A few clinical relevant projects are being undertaken in relation to different tissues and organs, from colony growth of stem cells for cell therapy, rapid bone formation, osteogenic potency assay, pathological calcification of heart valves, the relation of pelvic organ prolapse and ageing. Ying's regeneration medicine research is centralized on bone, cartilage, blood vessel, cornea, retina, pseudoislets, skin, nerve generation and characterization.

THE ON-GOING PROJECTS INCLUDING:

• Establishment of 3D ARVC model from iPSC-CM cells
• Development/translation of xeno-free, nanofiber-based scaffold/actuator for human pluripotent stem cell expansion, differentiation, and implantation
• Replication and investigation of limbal stem cell niches
• Correlating the degradation in biomaterials and the associated immune response in macrophages by multimodal non-invasive imaging techniques
• Fabricating and characterization of fully functional blood vessel for homeostatic and vascular disease study
• Development of smart surface modification techniques with anti-biofilm, anti-fouling functions
• Separation and characterization of the progenitor cells in cardiac cell mixture
• Exploring novel nanofabrication protocols as matrix for iPSC-CM maturation
• Development of better pseudoislet model for diabetes treatment
• Investigation of relation of ageing and connective tissue disorder including prolapse, preterm premature rupture of membranes
• Development implantable 3D neuron circuits for treatment of disorder in CNS
• Application of FTIR techniques as diagnostic and characterization tool for disease and regenerative tissues
• Establishment of novel non-destructive optical modalities (OCT, Raman spectroscopy, microindentation) for tissue regeneration applications

Teaching

MSc courses in

Cell & Tissue Engineering
Biomedical Engineering

MTE-40036 Biomaterials, module leader
MTE-40024 Human Anatomy and Physiology, module leader
MTE-40033 Cell and Tissue Engineering, contributor
MTE-40034 Cell Biomechanics, contributor
MTE-40022 Bioreactor and Growth Environment, contributor
MTE-30002 Introduction of Biomedical Engineering, module leader

Coordinator: 3+1+1 programme with Guangzhou University

Supervising final year student projects in Life Science, Medicine and MSc projects

Further information

University Duties

Programme director of master course, Biomedical Engineering, 2008-2014, 2019 to present
Member of faculty postgraduate committee, 2019- present
Deputy lead of Faculty Regenerative Medicine theme
Group lead of Materials for Biomedicine in PhaB
Chair of Postgraduate Medical School Safety Committee 2006-2015
Departmental COSHH Officer in Postgraduate Medical School 2004 - 2017
Departmental Laser Safety Adviser in Postgraduate Medical School 2004 - present
Departmental Radiation Safety Adviser in Postgraduate Medical School 2004 - present

Membership of Professional Associations

Member of European Biomaterials Society
Member of European TERMIS
2003-2006 Member of IPEM (SIG)
2005-present member of SPIE
2006-present EPSRC College membership

BOOKS

Li J, Yang Y, Gu K, Dong G. (Eds.). 2004. Biological micro- and nanotribology – Nature’s solutions. China Machine Press, Beijing, China.
Yang Y, Yuan CQ, Li J, Gu KL, Hu B. (Eds.) (2008) Nanoscale technology in biological systems, (edited and translated from English to Chinese, original authors: Greco RS, Prinz FB, Smith RL), pp. 1-485, China Machine Press, Beijing.

Selected Publications

Sandhu AK, Yang Y, Li W-W. 2022. In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants─Systematic Review and Meta-Analysis. ACS Biomater Sci Eng, 1749-1762, vol. 8(5). link> doi> full text>
Bhunia S, O'Brien S, Ling Y, Huang Z, Wu P, Yang Y. 2022. New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Sci Rep, 5109, vol. 12(1). link> doi> full text>
Shen H-X, Liu J-Z, Yan X-Q, Yang H-N, Hu S-Q, Yan X-L, Xu T, El Haj AJ, Yang Y, Lü L-X. 2022. Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds. Colloids Surf B Biointerfaces, 112419, vol. 213. link> doi>
Lü L, Shen H, Kasai D, Yang Y. 2022. Fabrication and Characterization of Alveolus-Like Scaffolds with Control of the Pore Architecture and Gas Permeability. Stem Cells Int, 3437073, vol. 2022. link> doi>
Ng CY, Chai JY, Foo JB, Mohamad Yahaya NH, Yang Y, Ng MH, Law JX. 2021. Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review. Int J Nanomedicine, 6749-6781, vol. 16. link> doi>

Full Publications Listshow

Books

LI J, YANG Y, GU K, DONG G. Li J, Yang Y, Gu K, Dong G (Eds.). 2004. Biological micro- and nanotribology - Nature?s solutions. China Machine Press, Beijing, China.
YANG Y and EL HAJ AJ. Ashammaki N and Waris T (Eds.). 2004. Enhancement of mechanical signals for tissue engineering bone. e-book, ..

Journal Articles

Sandhu AK, Yang Y, Li W-W. 2022. In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants─Systematic Review and Meta-Analysis. ACS Biomater Sci Eng, 1749-1762, vol. 8(5). link> doi> full text>
Bhunia S, O'Brien S, Ling Y, Huang Z, Wu P, Yang Y. 2022. New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Sci Rep, 5109, vol. 12(1). link> doi> full text>
Shen H-X, Liu J-Z, Yan X-Q, Yang H-N, Hu S-Q, Yan X-L, Xu T, El Haj AJ, Yang Y, Lü L-X. 2022. Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds. Colloids Surf B Biointerfaces, 112419, vol. 213. link> doi>
Panpho P, Yang Y, Davies HA, Nawaytou O, Harky A, Torella F, Field M, Madine J, Akhtar R. 2022. Time-dependent mechanical behaviour of the aortic chronic dissection flap. Interact Cardiovasc Thorac Surg, 892-901, vol. 34(5). link> doi>
Lü L, Shen H, Kasai D, Yang Y. 2022. Fabrication and Characterization of Alveolus-Like Scaffolds with Control of the Pore Architecture and Gas Permeability. Stem Cells Int, 3437073, vol. 2022. link> doi>
Ng CY, Chai JY, Foo JB, Mohamad Yahaya NH, Yang Y, Ng MH, Law JX. 2021. Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review. Int J Nanomedicine, 6749-6781, vol. 16. link> doi>
Lou T, Bai X, He X, Yang Y, Yuan C. 2021. Molecular dynamics simulation of peptide attachment on Al-based surfaces. Progress in Organic Coatings, 106310, vol. 157. doi> link>
Njoroge W, Hernández ACH, Musa FI, Butler R, Harper AGS, Yang Y. 2021. The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, vol. 13(3). link> doi> full text>
Zhang Y, Ling Y, Zhang D, Wang M, Purslow C, Yang Y, Li C, Huang Z. 2021. Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE). Biomed Opt Express, 588-603, vol. 12(1). link> doi> full text>
Zhang J, Xie B, Xi Z, Zhao L, Cen L, Yang Y. 2020. A comparable study of polyglycolic acid's degradation on macrophages' activation. Mater Sci Eng C Mater Biol Appl, 110574, vol. 109. link> doi>
Zeng K, Sun E-J, Liu Z-W, Guo J, Yuan C, Yang Y, Xie H. 2020. Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins. RSC Adv, 11524-11534, vol. 10(19). link> doi> full text>
Podder S, Paul S, Basak P, Xie B, Fullwood NJ, Baldock SJ, Yang Y, Hardy JG, Ghosh CK. 2020. Bioactive silver phosphate/polyindole nanocomposites. RSC Adv, 11060-11073, vol. 10(19). link> doi> full text>
Dimmock RL, Wang X, Fu Y, Haj AJE, Yang Y. 2020. Biomedical Applications of Wrinkling Polymers. Recent Progress in Materials, 1-31, vol. 2(1). doi> link> full text>
Baig MS, Owida H, Njoroge W, Siddiqui A-U-R, Yang Y. 2020. Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, Article ARTN 101496, vol. 55. link> doi> full text>
Barreto S, Hamel L, Schiatti T, Yang Y, George V. 2019. Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, vol. 8(12). link> doi> full text>
Zhang J, Song C, Han Y, Xi Z, Zhao L, Cen L, Yang Y. 2019. Regulation of inflammatory response to polyglycolic acid scaffolds through incorporation of sodium tripolyphosphate. European Polymer Journal, 109349, vol. 122. doi> link>
Owida HA, Kuiper NL, Yang Y. 2021. Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models. Cartilage, 847S-861S, vol. 13(2_suppl). link> doi>
Deegan AJ, Hendrikson WJ, El Haj AJ, Rouwkema J, Yang Y. 2019. Regulation of endothelial cell arrangements within hMSC - HUVEC co-cultured aggregates. Biomed J, 166-177, vol. 42(3). link> doi> full text>
Wang L, Xu H, Liu Z, Sun T, Yuan C, Yang Y, Guo J, Xie H. 2019. Magnetic immobilization of a quorum sensing signal hydrolase, AiiA. Microbiologyopen, e00797, vol. 8(8). link> doi>
Helling AL, Viswanathan P, Cheliotis KS, Mobasseri SA, Yang Y, El Haj AJ, Watt FM. 2019. Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction. Tissue Engineering: Part A, 214-223, vol. 25(3-4). link> doi> link> full text>
Gater R, Ipek T, Sadiq S, Nguyen D, Jones L, El Haj A, Yang Y. 2019. Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model. Invest Ophthalmol Vis Sci, 605-614, vol. 60(2). link> doi> full text>
Weli H, Cooper J, Yang Y. 2018. New insight into glycation levels and pelvic organ prolapse - A combination of clinical and biochemical studies. Eur J Obstet Gynecol Reprod Biol, 129-135, vol. 231. link> doi>
Owida HA, Rutter AV, Cinque G, Kuiper NJ, Sulé-Suso J, Yang Y. 2018. Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. Analyst, 5979-5986, vol. 143(24). link> doi>
Owida HA, Yang R, Cen L, Kuiper NJ, Yang Y. 2018. Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. Journal of the Royal Society Interface, vol. 15(143). link> doi>
Lü L, Deegan A, Musa F, Xu T, Yang Y. 2018. The effects of biomimetically conjugated VEGF on osteogenesis and angiogenesis of MSCs (human and rat) and HUVECs co-culture models. Colloids Surf B Biointerfaces, 550-559, vol. 167. link> doi> full text>
Cao P, Yang Y, Uche FI, Hart SR, Li W-W, Yuan C. 2018. Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study. Int J Mol Sci, vol. 19(3). link> doi> full text>
Cao P, Li W-W, Morris AR, Horrocks PD, Yuan C-Q, Yang Y. 2018. Investigation of the antibiofilm capacity of peptide-modified stainless steel. R Soc Open Sci, 172165, vol. 5(3). link> doi> full text>
Zhang J, Yang S, Yang X, Xi Z, Zhao L, Cen L, Lu E, Yang Y. 2018. Novel Fabricating Process for Porous Polyglycolic Acid Scaffolds by Melt-Foaming Using Supercritical Carbon Dioxide. ACS Biomater Sci Eng, 694-706, vol. 4(2). link> doi>
Gillies D, Gamal W, Downes A, Reinwald Y, Yang Y, El Haj AJ, Bagnaninchi PO. 2018. Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods, 126-133, vol. 136. link> doi> full text>
Bardsley K, Deegan AJ, El Haj A, Yang Y. 2017. Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging. Adv Exp Med Biol, 3-18, vol. 1035. link> doi>
Weli H, Cooper J, Yang Y. 2017. Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy. Med Hypotheses, 84-87, vol. 109. link> doi> full text>
Owida HA, De Las Heras Ruiz T, Dhillon A, Yang Y, Kuiper NJ. 2017. Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production. Histochem Cell Biol, 625-638, vol. 148(6). link> doi> full text>
Law JX, Liau LL, Saim A, Yang Y, Idrus R. 2017. Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering. Tissue Eng Regen Med, 699-718, vol. 14(6). link> doi>
Weli HK, Akhtar R, Chang Z, Li W-W, Cooper J, Yang Y. 2017. Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy. Eur J Obstet Gynecol Reprod Biol, 78-85, vol. 214. link> doi> full text>
Gopalakrishna G, Langendam M, Scholten R, Bossuyt P, Leeflang M, Noel-Storr A, Thomas J, Marshall I, Wallace B, Whiting P, Davenport C, Leeflang M, GopalaKrishna G, de Salis I, Mallett S, Wolff R, Whiting P, Riley R, Westwood M, Kleinen J, Collins G, Reitsma H, Moons K, Zapf A, Hoyer A, Kramer K, Kuss O, Ensor J, Deeks JJ, Martin EC, Riley RD, Rücker G, Steinhauser S, Schumacher M, Riley R, Ensor J, Snell K, Willis B, Debray T, Moons K, Deeks J, Collins G, di Ruffano LF, Willis B, Davenport C, Mallett S, Taylor-Phillips S, Hyde C, Deeks J, Mallett S, Taylor SA, Batnagar G, STREAMLINE COLON Investigators, STREAMLINE LUNG Investigators, METRIC Investigators, Taylor-Phillips S, Di Ruffano LF, Seedat F, Clarke A, Deeks J, Byron S, Nixon F, Albrow R, Walker T, Deakin C, Hyde C, Zhelev Z, Hunt H, di Ruffano LF, Yang Y, Abel L, Buchanan J, Fanshawe T, Shinkins B, Wynants L, Verbakel J, Van Huffel S, Timmerman D, Van Calster B, Leeflang M, Zwinderman A, Bossuyt P, Oke J, O'Sullivan J, Perera R, Nicholson B, Bromley HL, Roberts TE, Francis A, Petrie D, Mann GB, Malottki K, Smith H, Deeks J, Billingham L, Sitch A, Mallett S, Deeks J, Gerke O, Holm-Vilstrup M, Segtnan EA, Halekoh U, Høilund-Carlsen PF, Francq BG, Deeks J, Sitch A, Dinnes J, Parkes J, Gregory W, Hewison J, Altman D, Rosenberg W, Selby P, Asselineau J, Perez P, Paye A, Bessede E, Proust-Lima C, Naaktgeboren C, de Groot J, Rutjes A, Bossuyt P, Reitsma J, Moons K, Collins G, Ogundimu E, Cook J, Le Manach Y, Altman D, Wynants L, Vergouwe Y, Van Huffel S, Timmerman D, Van Calster B, Pajouheshnia R, Groenwold R, Moons K, Reitsma J, Peelen L, Van Calster B, Nieboer D, Vergouwe Y, De Cock B, Pencina MJ, Steyerberg EW, Cooper J, Taylor-Phillips S, Parsons N, Stinton C, Smith S, Dickens A, Jordan R, Enocson A, Fitzmaurice D, Sitch A, Adab P, Francq BG, Boachie C, Vidmar G, Freeman K, Connock M, Taylor-Phillips S, Court R, Clarke A, de Groot J, Naaktgeboren C, Reitsma H, Moons C, Harris J, Mumford A, Plummer Z, Lee K, Reeves B, Rogers C, Verheyden V, Angelini GD, Murphy GJ, Huddy J, Ni M, Good K, Cooke G, Bossuyt P, Hanna G, Ma J, Altman D, Collins G, Moons KGMC, de Groot JAH, Mallett S, Altman DG, Reitsma JB, Collins GS, Moons KGM, Altman DG, Reitsma JB, Collins GS, Kamarudin AN, Kolamunnage-Dona R, Cox T, Ni M, Huddy J, Borsci S, Hanna G, Pérez T, Pardo MC, Candela-Toha A, Muriel A, Zamora J, Sanghera S, Mohiuddin S, Martin R, Donovan J, Coast J, Seo MK, Cairns J, Mitchell E, Smith A, Wright J, Hall P, Messenger M, Calder N, Wickramasekera N, Vinall-Collier K, Lewington A, Pajouheshnia R, Damen J, Groenwold R, Moons K, Peelen L, Messenger M, Cairns D, Smith A, Hutchinson M, Wright J, Hall P, Calder N, Sturgeon C, Mitchel L, Kift R, Christakoudi S, Rungall M, Mobillo P, Montero R, Tsui T-L, Kon SP, Tucker B, Sacks S, Farmer C, Strom T, Chowdhury P, Rebollo-Mesa I, Hernandez-Fuentes M, Damen JAAG, Debray TPA, Heus P, Hooft L, Moons KGM, Pajouheshnia R, Reitsma JB, Scholten RJPM, Damen JAAG, Hooft L, Schuit E, Debray TPA, Collins GS, Tzoulaki I, Lassale CM, Siontis GCM, Chiocchia V, Roberts C, Schlüssel MM, Gerry S, Black JA, Heus P, van der Schouw YT, Peelen LM, Moons KGM, Damen JAAG, Debray TPA, Heus P, Hooft L, Moons KGM, Pajouheshnia R, Reitsma JB, Scholten RJPM, Ma J, Altman D, Collins G, Spence G, McCartney D, van den Bruel A, Lasserson D, Hayward G, Vach W, de Jong A, Burggraaff C, Hoekstra O, Zijlstra J, de Vet H, Hunt H, Hyde C, Graziadio S, Allen J, Johnston L, O'Leary R, Power M, Allen J, Graziadio S, Johnson L, O'Leary R, Power M, Waters R, Simpson J, Johnston L, Allen J, Graziadio S, O'Leary R, Waters R, Power M, Mallett S, Fanshawe TR, Phillips P, Plumb A, Helbren E, Halligan S, Taylor SA, Gale A, Mallett S, Sekula P, Altman DG, Sauerbrei W, Mallett S, Fanshawe TR, Forman JR, Dutton SJ, Takwoingi Y, Hensor EM, Nichols TE, Shinkins B, Yang Y, Abel L, Di Ruffano LF, Fanshawe T, Kempf E, Porcher R, de Beyer J, Moons K, Altman D, Reitsma H, Hopewell S, Sauerbrei W, Collins G, Dennis J, Shields B, Jones A, Henley W, Pearson E, Hattersley A, MASTERMIND consortium, Heus P, Damen JAAG, Pajouheshnia R, Scholten RJPM, Reitsma JB, Collins GS, Altman DG, Moons KGM, Hooft L, Shields B, Dennis J, Jones A, Henley W, Pearson E, Hattersley A, MASTERMIND consortium, Scheibler F, Rummer A, Sturtz S, Großelfinger R, Banister K, Ramsay C, Azuara-Blanco A, Cook J, Boachie C, Burr J, Kumarasamy M, Bourne R, Uchegbu I, Borsci S, Murphy J, Hanna G, Uchegbu I, Carter A, Murphy J, Ni M, Marti J, Eatock J, Uchegbu I, Robotham J, Dudareva M, Gilchrist M, Holmes A, Uchegbu I, Borsci S, Monaghan P, Lord S, StJohn A, Sandberg S, Cobbaert C, Lennartz L, Verhagen-Kamerbeek W, Ebert C, Bossuyt P, Horvath A, Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine, Jenniskens K, Naaktgeboren C, Reitsma J, Moons K, de Groot J, Hyde C, Peters J, Grigore B, Peters J, Hyde C, Hyde C, Ukoumunne O, Peters J, Zhelev Z, Levis B, Benedetti A, Levis AW, Ioannidis JPA, Shrier I, Cuijpers P, Gilbody S, Kloda LA, McMillan D, Patten SB, Steele RJ, Ziegelstein RC, Bombardier CH, Osório FDL, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Loureiro SR, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Williams LS, Wittkampf KA, Yeung AS, Thombs BD, Peters J, Cooper C, Buchanan J, Nieto T, Smith C, Tucker O, Dretzke J, Beggs A, Rai N, Davenport C, Bayliss S, Stevens S, Snell K, Mallet S, Deeks J, Sundar S, Hall E, Porta N, Estelles DL, de Bono J, CTC-STOP protocol development group. 2017. Erratum to: Methods for evaluating medical tests and biomarkers. Diagn Progn Res, 11, vol. 1. link> doi>
Bardsley K, Yang Y, El Haj AJ. 2017. Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. Tissue Eng Part C Methods, 228-236, vol. 23(4). link> doi> full text>
Hendrikson WJ, Deegan AJ, Yang Y, van Blitterswijk CA, Verdonschot N, Moroni L, Rouwkema J. 2017. Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation. Front Bioeng Biotechnol, 6, vol. 5. link> doi> full text>
Bardsley K, Wimpenny I, Wechsler R, Shachaf Y, Yang Y, El Haj AJ. 2016. Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques. Acta biomaterialia. doi> link>
Williams DJ, Archer R, Archibald P, Bantounas I, Baptista R, Barker R, Barry J, Bietrix F, Blair N, Braybrook J, Campbell J, Canham M, Chandra A, Foldes G, Gilmanshin R, Girard M, Gorjup E, Hewitt Z, Hourd P, Hyllner J, Jesson H, Kee J, Kerby J, Kotsopoulou N, Kowalski S, Leidel C, Marshall D, Masi L, McCall M, McCann C, Medcalf N, Moore H, Ozawa H, Pan D, Parmar M, Plant AL, Reinwald Y, Sebastian S, Stacey G, Thomas RJ, Thomas D, Thurman-Newell J, Turner M, Vitillo L, Wall I, Wilson A, Wolfrum J, Yang Y, Zimmerman H. 2016. Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. Regen Med, 483-492, vol. 11(5). link> doi> full text>
Musa F, Harper AGS, Yang Y. 2016. A real-time monitoring system to assess the platelet aggregatory capacity of components of a tissue-engineered blood vessel wall. Tissue Engineering Part C: Methods. link> doi> link>
Law JX, Musa F, Ruszymah BHI, El Haj AJ, Yang Y. 2016. A comparative study of skin cell activities in collagen and fibrin constructs. Med Eng Phys, 854-861, vol. 38(9). link> doi> full text>
Lyu LX, Huang NP, Yang Y. 2016. Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. Journal of biomaterials science. Polymer edition, 1155-1169, vol. 27(11). doi> link> full text>
Yang Y. 2016. Correction: Optofluidic lens with low spherical and low field curvature aberrations. Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering. doi>
Bardsley K, Wimpenny I, Yang Y, El Haj AJ. 2016. Fluorescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC ADVANCES, 44364-44370, vol. 6(50). link> doi> full text>
Ren XY, Bai XQ, Yuan CQ, Yang Y, Xie H, Cao P, Ma CY, Wang XJ, Yan XP. 2015. Protein engineering of a new recombinant peptide to increase the surface contact angle of stainless steel. RSC ADVANCES, 101309-101318, vol. 5(123). link> doi>
Kumar D, Dale TP, Yang Y, Forsyth NR. 2015. Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers. Biomed Mater, 065017, vol. 10(6). link> doi> full text>
Yang Y and Wimpenny I. 2015. 9 - Image analysis and quantification of tissue scaffolds. Characterisation and Design of Tissue Scaffolds, 201-223. doi>
Yang Y. 2015. First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST. Nuclear Fusion. doi>
Roach P, Kamudzandu M, Yang Y, Fricker R. 2015. Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 123-131, vol. 2015(3). doi> full text>
Cao P, Yuan CQ, Ma CY, Yang Y, Bai XQ, Wang XJ, Ren XY, Xie H, Yan XP. 2015. Preparation and analysis of a new bioorganic metallic material. RSC ADVANCES, 78030-78037, vol. 5(95). link> doi> full text>
Lally F, Soorani M, Woo T, Nayak S, Jadun C, Yang Y, McCrudden J, Naire S, Grunwald I, Roffe C. 2016. In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow. J Neurointerv Surg, 969-972, vol. 8(9). link> doi> full text>
Mázl Chánová E, Knotek P, Yang Y, Machová L, Proks V, Kučka J, Popelka Š, Pop-Georgievski O, El Haj A, Kubies D, Rypáček F. 2015. Nano-colloid printing of functionalized PLA-b-PEO copolymers: tailoring the surface pattern of adhesive motif and its effect on cell attachment. Physiol Res, S61-S73, vol. 64(Suppl 1). link> doi> full text>
Yang Y. 2015. Freezeout concept and dynamical transport model in intermediate-energy heavy-ion reactions. Physical Review C: Nuclear Physics, vol. 92(1). doi>
Dong CL, Yuan CQ, Bai XQ, Yang Y, Yan XP. 2015. Study on wear behaviours for NBR/stainless steel under sand water-lubricated conditions. WEAR, 1012-1020, vol. 332. link> doi>
Musa FI, Harper AGS, Yang Y. 2015. Validating A 3D tissue-engineered human blood vessel model for use as a novel model system for the assessment of thrombus formation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 110-111, vol. 13. link>
Kamudzandu M, Yang Y, Roach P, Fricker RA. 2015. Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC ADVANCES, 22053-22059, vol. 5(28). link> doi> full text>
Deegan AJ, Cinque G, Wehbe K, Konduru S, Yang Y. 2015. Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Anal Bioanal Chem, 1097-1105, vol. 407(4). link> doi>
Naslim N, Kemper F, Madden SC, Hony S, Chu Y-H, Galliano F, Bot C, Yang Y, Seok J, Oliveira JM, van Loon JT, Meixner M, Li A, Hughes A, Gordon KD, Otsuka M, Hirashita H, Morata O, Lebouteiller V, Indebetouw R, Srinivasan S, Bernard J-P, Reach WT. 2015. Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud. MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, 2490-2504, vol. 446(3). link> doi> full text>
Deegan AJ, Aydin HM, Hu B, Konduru S, Kuiper JH, Yang Y. 2014. A facile in vitro model to study rapid mineralization in bone tissues. Biomed Eng Online, 136, vol. 13. link> doi> full text>
Guilbert M, Eklouh-Molinier C, Wehbe K, Sulé-Suso J, Yang Y, Cinque G, Jeannesson P, Sockalingum GD. 2014. Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy. J Biomed Opt, 111612, vol. 19(11). link> doi>
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Wilson SL, Guilbert M, Sule-Suso J, Torbet J, Jeannesson P, Sockalingum GD, Yang Y. 2012. The effect of collagen ageing on its structure and cellular behaviour. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS IX (vol. 8222). link> doi>
Yang Y, Rupani A, Weightman A, Wimpenny I, Bagnaninchi P, Ahearne M. 2011. The study of optical properties and proteoglycan content of tendons by PS-OCT. DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS VIII (vol. 7898). link> doi>
Aydin HM, Hu B, Kesri S, El Haj AJ, Yang Y. 2011. A Morphological Study of Cell Aggregations on Mineralization. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (pp. 9-12, vol. 30). link>
Hu B, Yang Y, Dobson JP, El Haj AJ. 2011. Mechanical Conditioning Using Magnetic Nanoparticles Bound to PDGF Receptors on HBMSCs Promotes the Smooth Muscle Alpha Actin (SMA) Expression. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (pp. 23-25, vol. 30). link>
Ahearne M, El Haj AJ, Rauz S, Yang Y. 2011. Online Monitoring the Mechanical Remodeling of Hydrogels by Corneal Fibroblasts. 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) (pp. 1-+, vol. 30). link>
Yang Y, Iftimia A, Jia Y, Gould T, El Haj A, Wang RK. 2010. The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE IV (vol. 7566). link> doi>
Pijanka JK, Stone N, Cinque G, Yang Y, Kohler A, Wehbe K, Frogley M, Parkes G, Parkes J, Dumas P, Sandt C, van Pittius DG, Douce G, Sockalingum GD, Sule-Suso J. 2010. FTIR microspectroscopy of stained cells and tissues. Application in cancer diagnosis. SPECTROSCOPY-AN INTERNATIONAL JOURNAL (pp. 73-78, vol. 24). link> doi>
Pijanka JK, Kohler A, Yang Y, Dumas P, Chio-Srichan S, Manfait M, Sockalingum GD, Sulé-Suso J. 2009. Spectroscopic signatures of single, isolated cancer cell nuclei using synchrotron infrared microscopy. Analyst (pp. 1176-1181, vol. 134). link> doi>
Yang Y, Aydin HM, Piskin E, El Haj AJ. 2009. Assessment of a new biomimetic scaffold and its effects on bone formation by OCT. OPTICS IN BONE BIOLOGY AND DIAGNOSTICS (vol. 7166). link> doi>
Pijanka JK, Yang Y, Bagnaninchi PO, Debelle L, Sockalingum GD, Sule-Suso J. 2009. Elastin peptides increase lung cancer cell growth in 3D models. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE III (vol. 7179). link> doi>
Yang Y, Ahearne M, Wimpenny I, Torbet J. 2009. Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by PSOCT. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE III (vol. 7179). link> doi>
Ahearne M, Liu KK, Yang Y. 2009. Dual-Camera Spherical Indentation System for Examining the Mechanical Characteristics of Hydrogels. 4TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING (pp. 2011-2014, vol. 22). link>
Yang Y, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Characterisation of scaffold architecture and tendons using optical coherence tomography and polarisation-sensitive optical coherence tomography. IET OPTOELECTRONICS (pp. 188-194, vol. 2). link> doi>
Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2008. Three-dimensional ingrowth of bone cells within biodegradable cryogel scaffolds in bioreactors at different regimes. Tissue Eng Part A (pp. 1743-1750, vol. 14). link> doi>
Bagnaninchi PO, Churmakov D, Bonesi M, Yang Y, Phelan C, Maffulli N, Meglinski I, El Haj A. 2008. Tendon collagen orientation and crimp pattern characterized by PSOCT. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (pp. A28-A29, vol. 89). link>
Araujo JV, Cunha-Reis C, Gogniat G, Yang Y, Ashammakhi N, Reis RL, El Haj AJ, Neves NM. 2008. Dynamic studies of biomimetic coated polycaprolactone nanofiber meshes as bone extracellular matrix analogues. TISSUE ENGINEERING PART A (pp. 723-724, vol. 14). link>
Wimpenny I, Yang Y, Ashammakhi N. 2008. Modified collector geometry for electrospun nanofibers. TISSUE ENGINEERING PART A (pp. 881-882, vol. 14). link>
Aydin HM, Yang Y, Kohler T, Piskin E. 2008. Novel technique for HA particle coating within 3D polymeric structures. TISSUE ENGINEERING PART A (p. 890, vol. 14). link>
Cunha-Reis C, El Haj AJ, Yang Y. 2008. Real time monitoring of scaffold degradation under culture conditions. TISSUE ENGINEERING PART A (p. 903, vol. 14). link>
Yang Y, Ahearne M, Bagnaninchi PO, El Haj AJ. 2008. Visualization of structural evolution in tissue engineering tendon. TISSUE ENGINEERING PART A (p. 795, vol. 14). link>
Yang Y, Ahearne M, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Application of polarization OCT in tissue engineering - art. no. 68580K. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE II (p. K8580, vol. 6858). link> doi>
Bagnaninchi PO, Churmakov D, Bonesi M, Yang Y, Phelan C, Maffulli N, Meglinski I, El Haj A. 2008. Optical properties of human tendons characterized by PSOCT and their relation to tendinopothy: A clinical study. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XIX (vol. 6854). link> doi>
Yang Y, Sule-Suso J, Sockalingum GD. 2008. Study of melanoma invasion by FTIR spectroscopy. IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES VI (vol. 6859). link> doi>
Liu K-K, Ahearne M, Siamantouras E, Yang Y. 2008. Micro-Shaft-Poking - a Novel Instrument for Mechanically Characterizing Soft Biomimetic Membrance. In TFB. Filho & H. Gamboa (Eds.). BIODEVICES (2) (pp. 210-215). INSTICC - Institute for Systems and Technologies of Information, Control and Communication. link>
Cunha-Reis C, Bagnaninchi PO, El Haj AJ, Yang Y. 2007. Exploring fluorescence as a tool for real-time monitoring of scaffolds degradation. TISSUE ENGINEERING (p. 1694, vol. 13). link>
Bolgen N, Yang Y, Korkusuz P, El Haj AJ, Piskin E. 2007. Interaction of cells with novel biodegradable cryogels in bioreactors. TISSUE ENGINEERING (p. 1718, vol. 13). link>
Yang Y, Bagnaninchi PO, Ahearne M, Wang RK, Liu K-K. 2007. A novel OCT-based micro-indentation technique for mechanical characterization of soft tissues. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
Yang Y, Bagnaninchi PO, Cunha-Reis C, Aydin HM, Piskin E, El Haj A. 2007. Characterisation of scaffold architecture by optical coherence tomography. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
Bagnaninchi PO, Yang Y, El Haj A, Hinds MT, Wang RK. 2007. Characterization of local fluid flow in 3D porous construct characterized by fourier domain doppler optical coherence tomography. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
Bagnaninchi PO, El Haj A, Yang Y. 2007. Continuous monitoring of tissue growth inside a perfusion bioreactor by optical coherence tomography. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (vol. 6439). link> doi>
Cunha-Reis C, TuzlaKoglu K, Baas E, Yang Y, El Haj A, Reis RL. 2007. Influence of porosity and fibre diameter on the degradation of chitosan fibre-mesh scaffolds and cell adhesion. J Mater Sci Mater Med (pp. 195-200, vol. 18). link> doi>
Bagnaninchi PO, Yang Y, Maffulli N, Wang RK, El Haj A. 2006. Monitoring tissue formation and organization of engineered tendon by optical coherence tomography. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XVII (vol. 6084). link> doi>
Yang Y, Hoban PR, Sule-Suso J, Holley S, El Haj AJ, Bahrami F, Wang RK. 2006. Study cell invasion by optical techniques. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XVII (vol. 6084). link> doi>
Yang Y, Bagnaninch PO, Wood MA, El Haj AJ, Guyot E, Dubois A, Wang RKK. 2005. Monitoring cell profile in tissue engineered constructs by OCT. Optical Interactions with Tissue and Cells XVI (pp. 51-57, vol. 5695). link> doi>
Yang Y, Wang RKK, Guyot E, El Haj A, Dubois A. 2005. Application of optical coherence tomography for issue engineering. Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX (pp. 18-23, vol. 5690). link> doi>
HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. A study of the effects of seeding density, media flow and biochemical stimuli on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of the Combined Meeting of the Tissue Engineering Society International ? European Tissue Engineering Society Meeting.
HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. The effects of a 3D environment on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of Tissue and Cell Engineering Society Spring Meeting.
Then KY, Yang Y, Curtis A, Monaghan W, Shah S, McDonnell P, El Haj AJ. 2003. Effect of microtopographical cue on human corneal keratocytes orientation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (p. U254, vol. 44). link>
Then KY, Yang Y, Shah S, McDonnell P, El Haj AJ, IPD, IPD. 2003. Reconstruction of 3D human cornea using processed porcine cornea as a biological scaffold. SOE 2003: XIV CONGRESS OF THE EUROPEAN SOCIETY OF OPHTHALMOLOGY (pp. 275-280). link>
Cowell A, Yang Y, Rolfe P, El Haj AJ. 1998. In vitro monitoring of cytochrome oxidase activity in neuronal cells. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (pp. 2939-2940, vol. 20). link>

Funding

2016 £6000, The British Council Newton Fund: PhD Placement grant (PI)
2015 £55,000, EPSRC CDT PhD studentship (PI), ‘Tissue engineering retinal and glaucoma eye models for better clinical treatment’
2015 £30,000, EPSRC, min-project (PI), Diagnostic tool to identify donor dependent heterogeneity population
2015 £29,000 , Acorn fund (Co-I), ‘A tissue engineering approach to improve lung function and clinical outcome in patients with emphysema’
2015 £195,000, MRC (Co-I), ‘Hub of engineering and exploiting the stem cell niche’
2015 £12,000 Chinese Studentship Council (PI), One year joint PhD studentship, ‘Novel peptides and surface modification strategies for anti-microbial devices’
2014 €181,000 EC Maria Curie incoming fellowship (PI), ‘Smart scaffolds for bone regeneration’
2014 £12,000 UHNS fund (PI), ‘Prolapse mechanism study with ethical approval for 100 patient samples’
2014 £81,000 PhD studentship (PI), Jordan local organization, ‘New strategies for cartilage regeneration’
2014 £100,000 PhD studentship (PI), Iraqi Government, ‘Pseudoislet formation on diabetes study’
2014 £72,000 PhD studentship (PI), Rivers state sustainable development agency, Nigeria, ‘Prolapse and ageing study’
2014 £100,000 Medical Institute of North Staffordshire (PI), ‘Better glaucoma treatment’
2013 ¥880,000 Chinese NSFC (Co-I), ‘New bioorganic-metal for ship antifouling and drag reduction’
2013 £100,000 EPSRC manufacture centre (Co-I), ‘Challenge-Led Regenerative Medicine Manufacturing Research’
2012 £104,000 BHF PhD Studentship (PI), ‘Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis’
2012 £20,000 NHS Charitable fund (PI), ‘Development of a rapid bone formation technique for clinical applications’
2012 £371,000 EU FP7 project (Co-I), ‘Biodesign’
2012 £11,400 Royal society of International exchange (PI), ‘Control and mapping of mechanical signals in pre-vascularized engineered bone’
2012 £25,000 Acorn fund (PI), PhD studentship, ‘Acceleration of bone formation’
2011 2 month high magnetic field time and secondment funding, EuroMagNET II (PI), ‘Generation of orthogonal aligned fibers in hybrid hydrogels for corneal regeneration’
2011 £68,000 EPSRC DTC PhD studentship (Co-I), ‘Generating 3D neuronal networks in vitro – towards therapies for Huntington’s disease’
2010 £68,000 EPSRC DTC PhD studentship (Co-I), ‘Development new nanotechnology for spinal cord repair’
2010 £21,000 Acorn fund (PI), PhD studentship, ‘Study of calcification mechanism in heart valve’
2009 £68,000 EPSRC DTC PhD studentship (PI), ‘Development new corneal model for drug screening’
2009 € 90,000 EU, 7th Framework, Marie Curie Action (PI), ‘Development of new strategies for osteochondral regeneration
2008 £9,000 BBSRC pathfinder (PI), ‘Development and commercialization of a surgical phantom system for the brain research, therapy and education’
2008 £10,000 The Innovation Keele (PI), one postdoctoral, ‘Development of phantom kit for mammal brain therapeutic surgery’
2007 £413,000 BBSRC (PI), one postdoctoral, ‘Novel in vitro corneal model with on-line mechanical characterisation for pharmaceutical screening and tissue engineering’
2007 £22,000 Acorn fund (Co-I), PhD student, ‘Study of cancer cell sensitivity to chemotherapy and tumour cell invasion’
2007 £525,000 BBSRC (Co-I), two postdoctorals, ‘In vitro (pre)construction of neural circuits in transplantable, biodegradable scaffolds for CNS repair in vivo’
2006 £54,000 BBSRC CASE studentship (PI), ‘Development of degradable nanofiber scaffolds for regenerative medicine’
2006 £20,000 Institute of orthopaedics, Oswestry (Co-I), ‘Development of nanofiber based constructs for regenerative medicine’
2005 £280,000 EU network, EXPERTISSUE (Co-PI), ‘Novel therapeutic strategies for tissue engineering of bone and cartilage using second generation biomimetic scaffolds’
2005 £60,000 Marie Curie scholarship (PI), PhD studentship, ‘Novel sensing scaffolds for tissue engineering’
2004 £171,000 BBSRC (Co-I), one postdoctoral, ‘Quantitative on-line assessment of collagen fibre organization in connective tissue in vivo and during conditioning in vitro’
2003 £207,000 EPSRC (PI), one postdoctoral and one PhD studentship, ‘Development of mechano-active scaffolds for tissue engineering’

School address:
School of Pharmacy and Bioengineering
Hornbeam Building
Keele University
Staffordshire
ST5 5BG
Email: pharmacy@keele.ac.uk

Research centre address:
School of Pharmacy and Bioengineering
Guy Hilton Research Centre
Thornburrow Drive
Stoke-on-Trent
ST4 7QB
Tel: +44 (0) 1782 674988

Jack Ashley building accessibility

Undergraduate enquiries:
Email: pharmacy@keele.ac.uk
Tel: +44 (0) 1782 734786

Postgraduate enquiries:
Please contact the CPD4ALL team:
Email: phab.postgraduate@keele.ac.uk

Keele Centre for Medicines Optimisation (KCMO)
Tel: +44 (0)1782 733831 / 734131

The Virtual Patient project enquiries:
Contact our Digital Development team:
Email: pharmacy.digital@keele.ac.uk

Professor Ying Yang