Dr Mark Skidmore

Title: Senior Lecturer
Phone: +44 (0)1782 733945
Email: m.a.skidmore@keele.ac.uk
Location: Huxley Building : 174
Role:
Contacting me: Try my office or e-mail to set up an appointment.
Mark Skidmore

Dr Mark Skidmore was appointed as Lecturer in Biochemistry at Keele in October 2010, having spent 4 years as Research Associate at Liverpool University, where he had previously completed his PhD in 2006 on “Heparin / heparan sulphate method development and protein interactions” under the supervision of Prof  JE Turnbull and Dr EA Yates. His first degree and diploma in Biochemistry were at Imperial College London, and he has built up a range of links across academic collaborations and industrial partnerships. 

The general area of Dr Skidmore’s research interests is carbohydrate chemistry/biochemistry, in particular the role of anionic carbohydrates (for example the glysoaminoglycans (GAGs) as dynamic cell regulators. The major focus of his current research is the study of carbohydrate:protein structure-functions, in particular the development of new tools and technologies for elucidating protein-carbohydrate interactions and their application to biomedical sciences, biological sciences and medicine.

Further details (CAEP Homepage)

Selected Publications

  • Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E. 2017. Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Res, vol. 140, 13-17. link> doi>
  • Lima MA, Cavalheiro RP, M Viana G, Meneghetti MCZ, Rudd TR, Skidmore MA, Powell AK, Yates EA. 2017. (19)F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconj J, vol. 34(3), 405-410. link> doi>
  • Curtis ADM, Malekigorji M, Holman J, Skidmore M, Hoskins C. 2015. Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom. Journal of Nanomedicine and Nanotechnology. doi>
  • Skidmore MA, Kajaste-Rudnitski A, Wells NM, Guimond SE, Rudd TR, Yates EA, Vicenzi E. 2015. Inhibition of influenza H5N1 invasion by modified heparin derivatives. MEDCHEMCOMM, vol. 6(4), 640-646. link> doi>
  • Veraldi N, Hughes AJ, Rudd TR, Thomas HB, Edwards SW, Hadfield L, Skidmore MA, Siligardi G, Cosentino C, Shute JK, Naggi A, Yates EA. 2015. Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, vol. 117, 400-407. link> doi> link>

Full Publications List show

Journal Articles

  • Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E. 2017. Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Res, vol. 140, 13-17. link> doi>
  • Lima MA, Cavalheiro RP, M Viana G, Meneghetti MCZ, Rudd TR, Skidmore MA, Powell AK, Yates EA. 2017. (19)F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconj J, vol. 34(3), 405-410. link> doi>
  • Curtis ADM, Malekigorji M, Holman J, Skidmore M, Hoskins C. 2015. Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom. Journal of Nanomedicine and Nanotechnology. doi>
  • Skidmore MA, Kajaste-Rudnitski A, Wells NM, Guimond SE, Rudd TR, Yates EA, Vicenzi E. 2015. Inhibition of influenza H5N1 invasion by modified heparin derivatives. MEDCHEMCOMM, vol. 6(4), 640-646. link> doi>
  • Veraldi N, Hughes AJ, Rudd TR, Thomas HB, Edwards SW, Hadfield L, Skidmore MA, Siligardi G, Cosentino C, Shute JK, Naggi A, Yates EA. 2015. Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, vol. 117, 400-407. link> doi> link>
  • Xu R, Ori A, Rudd TR, Uniewicz KA, Ahmed YA, Guimond SE, Skidmore MA, Siligardi G, Yates EA, Fernig DG. 2012. Diversification of the Structural Determinants of Fibroblast Growth Factor-Heparin Interactions IMPLICATIONS FOR BINDING SPECIFICITY. JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287(47). link> doi>
  • Rudd TR, Gaudesi D, Skidmore MA, Ferro M, Guerrini M, Mulloy B, Torri G, Yates EA. 2011. Construction and use of a library of bona fide heparins employing H-1 NMR and multivariate analysis. ANALYST, vol. 136(7), 1380-1389. link> doi>
  • Rudd TR, Gaudesi D, Lima MA, Skidmore MA, Mulloy B, Torri G, Nader HB, Guerrini M, Yates EA. 2011. High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of H-1 NMR spectra. ANALYST, vol. 136(7), 1390-1398. link> doi>
  • SKIDMORE MA, GUIMOND SE, DUMAX-VORZET AF, YATES EA, TURNBULL JE. 2010. Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. NATURE PROTOCOLS. doi>
  • RUDD T, UNIEWICZ K, ORI A, GUIMOND S, SKIDMORE M, GAUDESI D, XU R, TURNBULL J, GUERRINI M, TORRI G, SILIGARDI G, FERNIG D, WILKINSON M, YATES E. 2010. Comparable stabilization, structural changes and activites can be induced in FGF by a variety of HS and non-GAG analogues: Implications for sequence-activity relationships. ORGANIC AND BIOMOLECULAR CHEMISTRY. doi>
  • Rudd TR, Skidmore MA, Guerrini M, Hricovini M, Powell AK, Siligardi G, Yates EA. 2010. The conformation and structure of GAGs: recent progress and perspectives. Current Opinions in structural biology, 567-574. doi>
  • HOLMAN J, SKIDMORE M, RUDD T, YATES E. 2010. The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing. ANALYTICAL METHODS, vol. 2(10), 1550-1554.
  • RUDD T, SKIDMORE M, GUIMOND S, HOLMAN J, TURNBULL J, LAUDER R, FERNIG D, YATES E. 2009. The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. THROMBOSIS AND HAEMOSTASIS, vol. 102(5), 874-878. doi>
  • GUIMOND S, SKIDMORE M, ORI A, GAUDESI D, COSENTINO C, GUERRINI M, EDGE R, COLLISON D, MCINNES E, TORRI G, TURNBULL J, FERNIG D, YATES E. 2009. Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution. BIOCHEMISTRY, vol. 48, 4772-4779.
  • RUDD T, SKIDMORE M, GUIMOND S, COSENTINO C, TORRI G, FERNIG D, LAUDER R, GUERRINI M, YATES E. 2009. Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra. GLYCOBIOLOGY, vol. 19, 52-67.
  • SKIDMORE M, ATRIH A, YATES E, TURNBULL E. 2009. Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations. METHODS IN MOLECULAR BIOLOGY, vol. 534, 157-169.
  • GUIMOND S, PUVIRAJESINGHE T, SKIDMORE M, KALUS I, DIERKS T, YATES E, TURNBULL J. 2009. Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, 25714-25722.
  • SKIDMORE M, DUMAX-VORZET A, GUIMOND S, RUDD T, EDWARDS E, TURNBULL J, CRAIG A, YATES E. 2008. Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives, possessing reduced anticoagulant and other serine protease inhibition activities. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 1453-1458.
  • RUDD T, SKIDMORE M, GUIMOND S, GUERRINI M, COSENTINO C, EDGE R, BROWN A, CLARKE D, TORRI G, TURNBULL J, NICHOLS R, FERNIG D, YATES E. 2008. Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques. CARBOHYDRATE RESEARCH, vol. 343, 2184-2193.
  • SKIDMORE M, GUIMOND S, RUDD T, FERNIG D, TURNBULL J, YATES E. 2008. The activities of the cell surface expressed glycosaminoglycan heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence and conformation. CONNECTIVE TISSUE RESEARCH, vol. 49, 140-144.
  • RUDD T, GUIMOND S, SKIDMORE M, DUSCHESNE L, GUERRINI M, TORRI G, COSENTINO C, BROWN A, CLARKE D, TURNBULL J, FERNIG D, YATES E. 2007. Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. GLYCOBIOLOGY, vol. 17(9), 983-993.
  • SKIDMORE M, GUIMOND S, DUMAX-VORZET A, ATRIH A, YATES E, TURNBULL J. 2006. High sensitivity separation and detection of heparin / heparan sulfate disaccharides. JOURNAL OF CHROMATOGRAPHY A, vol. 1135(1), 52.
  • SKIDMORE M, PATEY S, THANH N, FERNIG D, TURNBULL J, YATES E. 2004. Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces. CHEMICAL COMMUNICATIONS, vol. 7(23), 2700.
  • Boyle M, Skidmore M, Yates E, Horrocks P, Freeman C, Chai W, Beeson J. FORTHCOMING: Identification of novel carbohydrate inhibitors of Plasmodium falciparum merozoite invasion. Antimicrobial Agents and Chemotherapy.
  • Hoole D, kareem N, Skidmore M. FORTHCOMING: In vitro investigations on the effects of different polysaccharides structure and form on common carp (Cyprinus carpio) immune properties.
  • Maciej-Hulme M, LePrince A, Lavin A, Guimond SE, Turnbull JE, Pelletier J, Yates EA, Powell AK, Skidmore MA. FORTHCOMING: Reverse phase ion-paired HPLC separation and high sensitivity fluorescence detection of BODIPY-labelled heparin and heparan sulphate disaccharides. Analytical Chemistry.
  • Mustaffa K, Cooper L, Guimond SE, Yates EA, Craig AG, Skidmore MA. FORTHCOMING: Semi-synthetic glycosaminoglycan analogues inhibit and reverse P. falciparum cytoadherence. Malaria Journal.
  • Hoole D, Kareem N, Skidmore M. In vitro investigations on the effects of different polysaccharides structure and form on common carp (Cyprinus carpio) immune properties.
  • Kareem N, Skidmore M, Hoole D. 2017. In vitro investigations on the effects of different polysaccharides structure and form on common carp (Cyprinus carpio) immune properties. PH.D. project publication.

Chapters

  • YATES E, RUDD T, DUSCHESNE L, SKIDMORE M, NICHOLS R, CLARKE D, FERNIG D. 2007. Revealing the hidden dimensions of GAGs in solution and protein complexes with saccharide libraries, FTIR and SRCD. In GLYCOBIOLOGY. SAMSON C and MARKHAM O (Eds.). BLOXHAM, UK: SCION.
  • SKIDMORE M and TURNBULL J. 2005. Sequencing and separation of heparan sulfate. In Chemistry and Biology of Heparin and Heparan sulfate. GARG H, LINHARDT R, HALES C (Eds.). NEW YORK, USA: ELSEVIER B.V..
  • RUDD T, SKIDMORE M, YATES E. 2005. Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions. In Chemistry and Biology of Heparin and Heparan sulfate. GARG H, LINHARDT R, HALES C (Eds.). NEW YORK, USA: ELSEVIER B.V..

Other

  • SKIDMORE M, SWEENIE C, MUSTAFFA K, WILSON H, GUIMOND S, TURNBULL A, ROWE J, YATES E. 12th International Congress of Parasitology (ICOPA).

Dr Skidmore’s current research grants include:

  • Principal applicant and student supervisor:  “Novel glycotherapeutics for Alzheimer's disease”. (Co-Is:  Prof S Allin, Dr EA Yates, Dr MJ McKenzie, Dr P Horrocks) Medical Research Council industrial CASE studentship MR/J012246/1 with Charnwood Molecular Ltd, £109,288
  • Co-applicant and co-author: “Novel semi-synthetic carbohydrates as potential therapeutics for severe malaria” (PI: Dr EA Yates) Medical Research Council £554,479
  • Co-applicant and co-author: “Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria”. (PI: Dr EA Yates) Wellcome £59,769
  • Collaborator : “Investigation into Plasmodium falciparum rosetting mechanisms and development of rosette-disrupting interventions to treat or prevent severe malaria”. PI Alex Rowe – Wellcome Trust Senior Research Fellowship.