Biography
Dr. Forrester-Soto’s research focuses on the within-host evolution of RNA viruses, particularly how viruses infect mosquitoes at the molecular level. She spent the majority of her research career at the University of Texas Medical Branch in Galveston, Texas. Since moving to Keele University at the beginning of 2018, she is establishing a similar research programme, as well as branching out to investigate environmental pressures on the mosquito vectors of important viral infections. Her goal is to identify how viruses adapt to their mosquito vectors and how these evolutionary pressures result in successful infection and transmission of the mosquito vector.
Selected Publications
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Negeviruses Reduce Replication of Alphaviruses during Coinfection. Journal of Virology, vol. 95(14). link> doi> link> full text>2021.
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Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. PLoS Pathog, e1007610, vol. 15(4). link> doi> full text>2019.
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RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses. doi> link> full text>2018.
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Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand. International Journal for Parasitology: Parasites and Wildlife, 187-195, vol. 7. doi> link> full text>2018.
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Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. Journal of virological methods, 31-34, vol. 254.2018.
Full Publications Listshow
Journal Articles
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Negeviruses Reduce Replication of Alphaviruses during Coinfection. Journal of Virology, vol. 95(14). link> doi> link> full text>2021.
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Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. PLoS Pathog, e1007610, vol. 15(4). link> doi> full text>2019.
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RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses. doi> link> full text>2018.
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Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand. International Journal for Parasitology: Parasites and Wildlife, 187-195, vol. 7. doi> link> full text>2018.
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Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. Journal of virological methods, 31-34, vol. 254.2018.
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Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy. Virus evolution, vey004, vol. 4(1). doi> link> full text>2018.
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Mosquito bottlenecks alter viral mutant swarm in a tissue and time-dependent manner with contraction and expansion of variant positions and diversity. Virus evolution, vey001, vol. 4.2018.
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Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. PLoS Neglected Tropical Diseases, e0005693, vol. 11. doi> link> full text>2017.
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Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. Scientific Reports, 35819, vol. 6. doi> link> full text>2016.
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Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. PLoS ONE, e0152604, vol. 11. doi> link> full text>2016.
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Next generation sequencing of DNA-launched Chikungunya vaccine virus. Virology, 83-90, vol. 490.2016.
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Chikungunya Virus as Cause of Febrile Illness Outbreak, Chiapas, Mexico, 2014. Emerging infectious diseases, 2070-2073, vol. 21.2015.
- 2015.
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Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Frontiers in Microbiology, 1037, vol. 6. doi> link> full text>2015.
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Chikungunya: Evolutionary history and recent epidemic spread. Antiviral research, 32-39, vol. 120.2015.
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New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences. PLoS ONE, e0117849, vol. 10. doi> link> full text>2015.
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Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission. Viruses, 3991-4004, vol. 6. doi> link> full text>2014.
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A novel live-attenuated vaccine candidate for mayaro Fever. PLoS Neglected Tropical Diseases, Article e2969, vol. 8(8). doi> link> full text>2014.
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Western equine encephalitis virus: evolutionary analysis of a declining alphavirus based on complete genome sequences. Journal of virology, 9260-9267, vol. 88.2014.
- 2014.
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Mesoniviruses are mosquito-specific viruses with extensive geographic distribution and host range. Virology Journal, Article 97, vol. 11. doi> link> full text>2014.
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Characterization of a novel Negevirus and a novel Bunyavirus isolated from Culex (Culex) declarator mosquitoes in Trinidad. The Journal of general virology, 481-485, vol. 95.2014.
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Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral research, 159-189, vol. 100.2013.
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Eastern equine encephalitis in Latin America. The New England journal of medicine, 732-744, vol. 369.2013.
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Identification of a new Newcastle disease virus isolate from Indonesia represents an ancestral lineage of class II genotype XIII. Virus genes, 168-172, vol. 47.2013.
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Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae. Virology journal, 219, vol. 10.2013.
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IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice. Virology, 81-88, vol. 437.2013.
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Negevirus: a proposed new taxon of insect-specific viruses with wide geographic distribution. Journal of virology, 2475-2488, vol. 87.2013.
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IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety. PLoS neglected tropical diseases, e2197, vol. 7.2013.
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Vector-borne transmission imposes a severe bottleneck on an RNA virus population. PLoS pathogens, e1002897, vol. 8.2012.
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Revisiting the clinal concept of evolution and dispersal for the tick-borne flaviviruses by using phylogenetic and biogeographic analyses. Journal of virology, 8663-8671, vol. 86.2012.
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Alphaviruses: population genetics and determinants of emergence. Antiviral research, 242-257, vol. 94.2012.
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Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein. Journal of virology, 6084-6096, vol. 86.2012.
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Genome-scale phylogeny of the alphavirus genus suggests a marine origin. Journal of virology, 2729-2738, vol. 86.2012.
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Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. Journal of virology, 8709-8717, vol. 85.2011.
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Experimental infections of Oryzomys couesi with sympatric arboviruses from Mexico. The American journal of tropical medicine and hygiene, 350-353, vol. 82.2010.
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Co-circulation of widely disparate strains of rabbit haemorrhagic disease virus could explain localised epidemicity in the United Kingdom. Virology, 42-48, vol. 393.2009.
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Experimental infection of potential reservoir hosts with Venezuelan equine encephalitis virus, Mexico. Emerging infectious diseases, 519-525, vol. 15.2009.
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Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence. Virology, 170-172, vol. 380.2008.
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IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. Virology, 160-169, vol. 377.2008.
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Recombination in rabbit haemorrhagic disease virus: possible impact on evolution and epidemiology. Virology, 390-396, vol. 376.2008.
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Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus. Virology, 249-255, vol. 374.2008.
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Structure and biochemical analysis of Kokobera virus helicase. Proteins, 1120-1123, vol. 70.2008.
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Universal primers that amplify RNA from all three flavivirus subgroups. Virology journal, 16, vol. 5.2008.
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Purification and crystallization of Kokobera virus helicase. Acta crystallographica. Section F, Structural biology and crystallization communications, 193-195, vol. 63.2007.
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Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire. Virology, 18-22, vol. 358.2007.
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Pseudocowpox virus: the etiological agent of contagious ecthyma (Auzdyk) in camels (Camelus dromedarius) in the Arabian peninsula. Vector borne and zoonotic diseases (Larchmont, N.Y.), 257-260, vol. 7.2007.
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Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia?. Virology, 277-282, vol. 344.2006.
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Epidemiology of rabbit haemorrhagic disease virus in the United Kingdom: evidence for seasonal transmission by both virulent and avirulent modes of infection. Epidemiology and infection, 555-567, vol. 132.2004.
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Long-term survival of New Zealand rabbit haemorrhagic disease virus RNA in wild rabbits, revealed by RT-PCR and phylogenetic analysis. The Journal of general virology, 3079-3086, vol. 84.2003.
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Molecular epidemiology of Rabbit haemorrhagic disease virus. The Journal of general virology, 2461-2467, vol. 83.2002.
School of Life Sciences,
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Tel: +44 (0) 1782 734414
Enquiries:
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