Biography

Dr. Forrester-Soto’s research focuses on the within-host evolution of RNA viruses, particularly how viruses infect mosquitoes at the molecular level. She spent the majority of her research career at the University of Texas Medical Branch in Galveston, Texas. Since moving to Keele University at the beginning of 2018, she is establishing a similar research programme, as well as branching out to investigate environmental pressures on the mosquito vectors of important viral infections. Her goal is to identify how viruses adapt to their mosquito vectors and how these evolutionary pressures result in successful infection and transmission of the mosquito vector.

Selected Publications

  • Warmbrod KL, Patterson EI, Kautz TF, Stanton A, Rockx-Brouwer D, Kalveram BK, Khanipov K, Thangamani S, Fofanov Y, Forrester NL. 2019. Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. PLoS Pathog, vol. 15(4), e1007610. link> doi> full text>
  • Forrester N and Kautz T. 2018. RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses. doi> link> full text>
  • Hernandez AD, Boag B, Neilson R, Forrester-Soto NL. 2018. Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand. International Journal for Parasitology: Parasites and Wildlife, vol. 7, 187-195. doi> link> full text>
  • Patterson EI, Warmbrod KL, Bouyer DH, Forrester NL. 2018. Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. Journal of virological methods, vol. 254, 31-34.
  • Kautz TF, Guerbois M, Khanipov K, Patterson EI, Langsjoen RM, Yun R, Warmbrod KL, Fofanov Y, Weaver SC, Forrester NL. 2018. Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy. Virus evolution, vol. 4(1), vey004. doi> link> full text>

Full Publications List show

Journal Articles

  • Warmbrod KL, Patterson EI, Kautz TF, Stanton A, Rockx-Brouwer D, Kalveram BK, Khanipov K, Thangamani S, Fofanov Y, Forrester NL. 2019. Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. PLoS Pathog, vol. 15(4), e1007610. link> doi> full text>
  • Forrester N and Kautz T. 2018. RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses. doi> link> full text>
  • Hernandez AD, Boag B, Neilson R, Forrester-Soto NL. 2018. Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand. International Journal for Parasitology: Parasites and Wildlife, vol. 7, 187-195. doi> link> full text>
  • Patterson EI, Warmbrod KL, Bouyer DH, Forrester NL. 2018. Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. Journal of virological methods, vol. 254, 31-34.
  • Kautz TF, Guerbois M, Khanipov K, Patterson EI, Langsjoen RM, Yun R, Warmbrod KL, Fofanov Y, Weaver SC, Forrester NL. 2018. Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy. Virus evolution, vol. 4(1), vey004. doi> link> full text>
  • Patterson EI, Khanipov K, Rojas MM, Kautz TF, Rockx-Brouwer D, Golovko G, Albayrak L, Fofanov Y, Forrester NL. 2018. Mosquito bottlenecks alter viral mutant swarm in a tissue and time-dependent manner with contraction and expansion of variant positions and diversity. Virus evolution, vol. 4, vey001.
  • Forrester NL, Wertheim JO, Dugan VG, Auguste AJ, Lin D, Adams AP, Chen R, Gorchakov R, Leal G, Estrada-Franco JG, Pandya J, Halpin RA, Hari K, Jain R, Stockwell TB, Das SR, Wentworth DE, Smith MD, Kosakovsky Pond SL, Weaver SC. 2017. Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. PLoS Neglected Tropical Diseases, vol. 11, e0005693. doi> link> full text>
  • Xia H, Beck AS, Gargili A, Forrester N, Barrett ADT, Bente DA. 2016. Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. Scientific Reports, vol. 6, 35819. doi> link> full text>
  • Gardner SN, McLoughlin K, Be NA, Allen J, Weaver SC, Forrester N, Guerbois M, Jaing C. 2016. Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. PLoS ONE, vol. 11, e0152604. doi> link> full text>
  • Hidajat R, Nickols B, Forrester N, Tretyakova I, Weaver S, Pushko P. 2016. Next generation sequencing of DNA-launched Chikungunya vaccine virus. Virology, vol. 490, 83-90.
  • Kautz TF, Díaz-González EE, Erasmus JH, Malo-García IR, Langsjoen RM, Patterson EI, Auguste DI, Forrester NL, Sanchez-Casas RM, Hernández-Ávila M, Alpuche-Aranda CM, Weaver SC, Fernández-Salas I. 2015. Chikungunya Virus as Cause of Febrile Illness Outbreak, Chiapas, Mexico, 2014. Emerging infectious diseases, vol. 21, 2070-2073.
  • Auguste AJ, Liria J, Forrester NL, Giambalvo D, Moncada M, Long KC, Morón D, de Manzione N, Tesh RB, Halsey ES, Kochel TJ, Hernandez R, Navarro J-C, Weaver SC. 2015. Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010. Emerging infectious diseases, vol. 21, 1742-1750.
  • Manning JT, Forrester N, Paessler S. 2015. Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Frontiers in Microbiology, vol. 6, 1037. doi> link> full text>
  • Weaver SC and Forrester NL. 2015. Chikungunya: Evolutionary history and recent epidemic spread. Antiviral research, vol. 120, 32-39.
  • Moureau G, Cook S, Lemey P, Nougairede A, Forrester NL, Khasnatinov M, Charrel RN, Firth AE, Gould EA, de Lamballerie X. 2015. New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences. PLoS ONE, vol. 10, e0117849. doi> link> full text>
  • Forrester NL, Coffey LL, Weaver SC. 2014. Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission. Viruses, vol. 6, 3991-4004. doi> link> full text>
  • Weise WJ, Hermance ME, Forrester N, Adams AP, Langsjoen R, Gorchakov R, Wang E, Alcorn MDH, Tsetsarkin K, Weaver SC. 2014. A novel live-attenuated vaccine candidate for mayaro Fever. PLoS Neglected Tropical Diseases, vol. 8(8), Article e2969. doi> link> full text>
  • Bergren NA, Auguste AJ, Forrester NL, Negi SS, Braun WA, Weaver SC. 2014. Western equine encephalitis virus: evolutionary analysis of a declining alphavirus based on complete genome sequences. Journal of virology, vol. 88, 9260-9267.
  • Tsetsarkin KA, Chen R, Yun R, Rossi SL, Plante KS, Guerbois M, Forrester N, Perng GC, Sreekumar E, Leal G, Huang J, Mukhopadhyay S, Weaver SC. 2014. Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes. Nat Commun, vol. 5, 4084. link> doi>
  • Vasilakis N, Guzman H, Firth C, Forrester NL, Widen SG, Wood TG, Rossi SL, Ghedin E, Popov V, Blasdell KR, Walker PJ, Tesh RB. 2014. Mesoniviruses are mosquito-specific viruses with extensive geographic distribution and host range. Virology Journal, vol. 11, Article 97. doi> link> full text>
  • Auguste AJ, Carrington CVF, Forrester NL, Popov VL, Guzman H, Widen SG, Wood TG, Weaver SC, Tesh RB. 2014. Characterization of a novel Negevirus and a novel Bunyavirus isolated from Culex (Culex) declarator mosquitoes in Trinidad. The Journal of general virology, vol. 95, 481-485.
  • Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. 2013. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral research, vol. 100, 159-189.
  • Carrera J-P, Forrester N, Wang E, Vittor AY, Haddow AD, López-Vergès S, Abadía I, Casta no E, Sosa N, Báez C, Estripeaut D, Díaz Y, Beltrán D, Cisneros J, Cede no HG, Travassos da Rosa AP, Hernandez H, Martínez-Torres AO, Tesh RB, Weaver SC. 2013. Eastern equine encephalitis in Latin America. The New England journal of medicine, vol. 369, 732-744.
  • Forrester NL, Widen SG, Wood TG, Travassos da Rosa AP, Ksiazek TG, Vasilakis N, Tesh RB. 2013. Identification of a new Newcastle disease virus isolate from Indonesia represents an ancestral lineage of class II genotype XIII. Virus genes, vol. 47, 168-172.
  • Palacios G, Forrester NL, Savji N, Travassos da Rosa APA, Guzman H, Detoy K, Popov VL, Walker PJ, Lipkin WI, Vasilakis N, Tesh RB. 2013. Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae. Virology journal, vol. 10, 219.
  • Rossi SL, Guerbois M, Gorchakov R, Plante KS, Forrester NL, Weaver SC. 2013. IRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice. Virology, vol. 437, 81-88.
  • Vasilakis N, Forrester NL, Palacios G, Nasar F, Savji N, Rossi SL, Guzman H, Wood TG, Popov V, Gorchakov R, González AV, Haddow AD, Watts DM, da Rosa APAT, Weaver SC, Lipkin WI, Tesh RB. 2013. Negevirus: a proposed new taxon of insect-specific viruses with wide geographic distribution. Journal of virology, vol. 87, 2475-2488.
  • Guerbois M, Volkova E, Forrester NL, Rossi SL, Frolov I, Weaver SC. 2013. IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety. PLoS neglected tropical diseases, vol. 7, e2197.
  • Forrester NL, Guerbois M, Seymour RL, Spratt H, Weaver SC. 2012. Vector-borne transmission imposes a severe bottleneck on an RNA virus population. PLoS pathogens, vol. 8, e1002897.
  • Heinze DM, Gould EA, Forrester NL. 2012. Revisiting the clinal concept of evolution and dispersal for the tick-borne flaviviruses by using phylogenetic and biogeographic analyses. Journal of virology, vol. 86, 8663-8671.
  • Weaver SC, Winegar R, Manger ID, Forrester NL. 2012. Alphaviruses: population genetics and determinants of emergence. Antiviral research, vol. 94, 242-257.
  • Gorchakov R, Wang E, Leal G, Forrester NL, Plante K, Rossi SL, Partidos CD, Adams AP, Seymour RL, Weger J, Borland EM, Sherman MB, Powers AM, Osorio JE, Weaver SC. 2012. Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein. Journal of virology, vol. 86, 6084-6096.
  • Forrester NL, Palacios G, Tesh RB, Savji N, Guzman H, Sherman M, Weaver SC, Lipkin WI. 2012. Genome-scale phylogeny of the alphavirus genus suggests a marine origin. Journal of virology, vol. 86, 2729-2738.
  • Forrester NL, Guerbois M, Adams AP, Liang X, Weaver SC. 2011. Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. Journal of virology, vol. 85, 8709-8717.
  • Deardorff ER, Forrester NL, Travassos da Rosa AP, Estrada-Franco JG, Navarro-Lopez R, Tesh RB, Weaver SC. 2010. Experimental infections of Oryzomys couesi with sympatric arboviruses from Mexico. The American journal of tropical medicine and hygiene, vol. 82, 350-353.
  • Forrester NL, Boag B, Buckley A, Moureau G, Gould EA. 2009. Co-circulation of widely disparate strains of rabbit haemorrhagic disease virus could explain localised epidemicity in the United Kingdom. Virology, vol. 393, 42-48.
  • Deardorff ER, Forrester NL, Travassos da Rosa AP, Estrada-Franco JG, Navarro-Lopez R, Tesh RB, Weaver SC. 2009. Experimental infection of potential reservoir hosts with Venezuelan equine encephalitis virus, Mexico. Emerging infectious diseases, vol. 15, 519-525.
  • Forrester NL, Kenney JL, Deardorff E, Wang E, Weaver SC. 2008. Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence. Virology, vol. 380, 170-172.
  • Volkova E, Frolova E, Darwin JR, Forrester NL, Weaver SC, Frolov I. 2008. IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. Virology, vol. 377, 160-169.
  • Forrester NL, Moss SR, Turner SL, Schirrmeier H, Gould EA. 2008. Recombination in rabbit haemorrhagic disease virus: possible impact on evolution and epidemiology. Virology, vol. 376, 390-396.
  • R ruzek D, Gritsun TS, Forrester NL, Gould EA, Kopecký J, Golovchenko M, Rudenko N, Grubhoffer L. 2008. Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus. Virology, vol. 374, 249-255.
  • Speroni S, De Colibus L, Mastrangelo E, Gould E, Coutard B, Forrester NL, Blanc S, Canard B, Mattevi A. 2008. Structure and biochemical analysis of Kokobera virus helicase. Proteins, vol. 70, 1120-1123.
  • Maher-Sturgess SL, Forrester NL, Wayper PJ, Gould EA, Hall RA, Barnard RT, Gibbs MJ. 2008. Universal primers that amplify RNA from all three flavivirus subgroups. Virology journal, vol. 5, 16.
  • De Colibus L, Speroni S, Coutard B, Forrester NL, Gould E, Canard B, Mattevi A. 2007. Purification and crystallization of Kokobera virus helicase. Acta crystallographica. Section F, Structural biology and crystallization communications, vol. 63, 193-195.
  • Forrester NL, Trout RC, Gould EA. 2007. Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire. Virology, vol. 358, 18-22.
  • Abubakr MI, Abu-Elzein EME, Housawi FMT, Abdelrahman AO, Fadlallah ME, Nayel MN, Adam AS, Moss S, Forrester NL, Coloyan E, Gameel A, Al-Afaleq AI, Gould EA. 2007. Pseudocowpox virus: the etiological agent of contagious ecthyma (Auzdyk) in camels (Camelus dromedarius) in the Arabian peninsula. Vector borne and zoonotic diseases (Larchmont, N.Y.), vol. 7, 257-260.
  • Forrester NL, Abubakr MI, Abu-Elzein EME, Al-Afaleq AI, Housawi FMT, Moss SR, Turner SL, Gould EA. 2006. Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia?. Virology, vol. 344, 277-282.
  • White PJ, Trout RC, Moss SR, Desai A, Armesto M, Forrester NL, Gould EA, Hudson PJ. 2004. Epidemiology of rabbit haemorrhagic disease virus in the United Kingdom: evidence for seasonal transmission by both virulent and avirulent modes of infection. Epidemiology and infection, vol. 132, 555-567.
  • Forrester NL, Boag B, Moss SR, Turner SL, Trout RC, White PJ, Hudson PJ, Gould EA. 2003. Long-term survival of New Zealand rabbit haemorrhagic disease virus RNA in wild rabbits, revealed by RT-PCR and phylogenetic analysis. The Journal of general virology, vol. 84, 3079-3086.
  • Moss SR, Turner SL, Trout RC, White PJ, Hudson PJ, Desai A, Armesto M, Forrester NL, Gould EA. 2002. Molecular epidemiology of Rabbit haemorrhagic disease virus. The Journal of general virology, vol. 83, 2461-2467.