Biography
I was appointed as a Lecturer at Keele University in 2003 and was promoted to Senior Lecturer in 2006. Having worked in the pharmaceutical industry for a number of years, I took a career break to have my family in 1985 before coming to Keele in 1989, as a mature undergraduate student. I obtained a BSc (Hons) in Biochemistry in 1992 and enjoyed the academic environment so much that I stayed on to complete my PhD, on the mechanisms of cell death in the endocrine pancreas, in 1995. I then spent a further three years at Keele as a postdoctoral research fellow, continuing my research in the field of diabetes mellitus, before taking up a lectureship at Liverpool John Moores University in 1998. Five years later I came back to Keele – there’s obviously something about the place that I like!
Research and scholarship
Throughout my academic career, my research interests have focussed on how pancreatic beta cells are destroyed during the onset of type 1 diabetes mellitus. In particular, looking at how signalling pathways involving nitric oxide and reactive oxygen species can lead to apoptosis in beta cells.
Teaching
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LSC10030 Case Studies in Medicine (Module Manager)
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LSC20005 Endocrinology and Signalling (Module Manager)
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LSC20040 Professional Relationships
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LSC30007 Biology Dissertation
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LSC30008/ 12 Experimental Research Projects
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LSC-30014 Biochemistry research Project (Non-experimental)
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LSC30015 Biology of Disease
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LSC30019 Applied Life Sciences Placement
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LSC30026 Case Studies in Biomedical Sciences (Module Manager)
Selected Publications
- 2009.
- 1993.
- 2001.
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A bioinformatics approach to assessing the functional and structural role of protein S-nitrosylation in beta cell apoptosis. Diabetic Medicine, 49, vol. 25(Suppl 1).2008.
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A role for mitochondrial calcium uptake in oxidant-induced beta-cell death. DIABETIC MEDICINE (p. 34, vol. 24). link>2007.
Full Publications Listshow
Journal Articles
- 2009.
- 1993.
- 2001.
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A bioinformatics approach to assessing the functional and structural role of protein S-nitrosylation in beta cell apoptosis. Diabetic Medicine, 49, vol. 25(Suppl 1).2008.
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Differential use of calcium stores in reactive oxygen species-dependent pancreatic beta cell death. Diabetologia, Article S182, vol. 50(Suppl 1).2007.
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Nitric oxide, but not peroxynitrite, activities p38 mitogen activated protein kinase (MAPK) and induces apoptosis in RINm5F pancreatic beta cells. Diabetic Medicine, vol. 20(Suppl 2).2003.
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Sequential nitrosylation, p38MAPK activation and apoptosis in RINm5F ß-cells in response to nitric oxide. Diabetologia, 531, vol. 46(Suppl 2).2003.
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A spectrophotometric method for measuring S-nitrosylation of proteins in RINm5F cells. Diabetologia, Article A172, vol. Suppl 2.2002.
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Effects of reactive nitrogen species on protein S-nitrosylation and apoptosis in pancreatic -cells. Biochem Soc, Article Trans 30.2002.
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Quantification of the contribution of peroxynitrite to mixed radical- and nitric oxide-mediated beta cell death. DIABETOLOGIA, A144, vol. 44. link>2001.
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Expression of Fas isoforms in isolated human islets of Langerhans. Diabetic Medicine, vol. 18.2001.
- 2000.
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Fas engagement leads to apoptosis of human islet cells following exposure to interleukin-1 beta. DIABETOLOGIA, A57, vol. 41. link>1998.
- 1998.
- 1998.
- 1997.
- 1997.
- 1996.
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Evidence for the involvement of cGMP in nitric oxide-induced apoptosis in HIT-T15 cells. DIABETOLOGIA, 391, vol. 39. link>1996.
- 1996.
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PHOSPHOLIPASE A(2) EXPRESSION IN HUMAN AND RODENT INSULIN-SECRETING CELLS (VOL 112, PG 177, 1995). MOLECULAR AND CELLULAR ENDOCRINOLOGY, 227-228, vol. 114(1-2). link>1995.
- 1995.
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EFFECTS OF MODULATORS OF G-PROTEIN FUNCTION OF APOPTOSIS IN RINM5F CELLS AND RAT ISLETS. DIABETOLOGIA, A45, vol. 38. link>1995.
- 1994.
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IMMUNOLOGICAL CHARACTERIZATION OF PHOSPHOLIPASE-A2 EXPRESSION IN INSULIN-SECRETING CELLS. DIABETOLOGIA, A101, vol. 37. link>1994.
Other
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A role for mitochondrial calcium uptake in oxidant-induced beta-cell death. DIABETIC MEDICINE (p. 34, vol. 24). link>2007.
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Sequential nitrosylation, p38MAPK activation and apoptosis in RINm5F beta-cells in response to nitric oxide. DIABETOLOGIA (pp. A185-A186, vol. 46). link>2003.
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A spectrophotometric method for measuring S-nitrosylation of proteins in RINm5F cells. DIABETOLOGIA (pp. A172-A173, vol. 45). link>2002.
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The mechanism of nitric oxide-induced apoptosis in the pancreatic beta-cell may involve cGMP and protein kinase G. NITRIC OXIDE AND THE CELL (pp. 115-124). link>1998.
- 1994.
School of Life Sciences,
Huxley Building,
Keele University,
Staffordshire,
ST5 5BG
Tel: +44 (0) 1782 734414
Enquiries:
Tel: +44 (0) 1782 734414
Email: lifesciences.office@keele.ac.uk