Dr Simon Trent
Through previous positions (Cardiff) to current Lectureship at Keele, I have developed expertise in behavioural and molecular neuroscience. I utilise preclinical, genetic models of psychiatric illness to provide translatable, clinical insight into debilitating human psychiatric illnesses such as autism (Trent et al., 2014) and schizophrenia (Hall, Trent et al., 2015).
I have leveraged behavioural neuroscience techniques, particularly learning and memory in rodents, and complementary molecular, pharmacological and genetic techniques (including RNA sequencing), allowing me to interrogate critical, plasticity- (Trent et al., 2015, 2017, Clifton et al., 2017) and disorder-relevant (Silva et al., 2019, Trent et al., 2019) neurobiological pathways.
- My profile
- FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability
- Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
- Rescue of long-term memory after reconsolidation blockade
- AMPA receptors control fear extinction through an Arc-dependent mechanism