Biography
Dr Jóhannes Reynisson FRSC began his academic career at the University of Iceland where he read chemistry (BSc/MSc). His PhD was obtained from the University of Copenhagen in 2000, the research work was carried out at the Risø national laboratory (Denmark) and Georgia Institute of Technology (GA, USA). He spent two and a half years in Germany as a post-doctoral fellow at the Max-Planck-Institut für Strahlenchemie, Mülheim and the University of Leipzig. He worked for five years at the Institute of Cancer Research in London as a molecular modeller developing anticancer drug candidates followed by a lectureship at the Nottingham Trent University. For ten years, he was a senior lecturer in computational chemistry and molecular modelling at the University of Auckland, New Zealand.
On the editorial board for Molecules medicinal chemistry section.
Guest editor of the special issues:
Hit Generation and Verification for Novel Lead compounds
Advances in Anticancer Drug Discovery
Research and scholarship
Dr Reynisson’s research interests lie within the field of drug discovery, in particular computer aided drug design (CADD) with emphasis on molecular modelling, virtual high throughput screening and density functional theory (DFT). His main interests now are:
i) Development of Tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors as anticancer agents
ii) Hit to lead development of autophagy inhibitors
iii) The use of natural products in conjunction with virtual high throughput screening to identify quality lead compounds
iv) Development of pharmacokinetic models based on density functional theory molecular descriptors
v) Investigations into the nature of known drug space (KDS) and its application as a navigational tool in chemical space
Selected Publications
- 2021.
- 2021.
- 2020.
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Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands. Inorg Chem, vol. 59(20), 14879-14890. link> doi> full text>2020.
- 2020.
Full Publications List show
Journal Articles
- 2021.
- 2021.
- 2020.
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Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands. Inorg Chem, vol. 59(20), 14879-14890. link> doi> full text>2020.
- 2020.
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Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1. Molecules, vol. 25(15). link> doi> full text>2020.
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Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment. Sci Rep, vol. 10(1), 11876. link> doi> full text>2020.
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7. Molecules, vol. 25(13). link> doi> full text>2020.
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A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor. Angew Chem Int Ed Engl, vol. 59(34), 14609-14614. link> doi> full text>2020.
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Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT). FEBS J, vol. 287(22), 4917-4932. link> doi> full text>2020.
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Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors. Eur J Med Chem, vol. 191, 112162. link> doi> full text>2020.
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Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. Int J Mol Sci, vol. 21(1). link> doi> full text>2019.
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Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates. Carbohydr Res, vol. 488, 107896. link> doi> full text>2020.
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Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations. Journal of Medicinal Chemistry. link> doi> link> full text>2019.
- 2020.
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Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorg Med Chem, vol. 28(1), 115234. link> doi> full text>2020.
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Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening. Molecules, vol. 24(23). link> doi> full text>2019.
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Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. Eur J Med Chem, vol. 187, 111919. link> doi> full text>2020.
- 2019.
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Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90). Int J Mol Sci, vol. 20(21). link> doi> full text>2019.
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New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. Molecules, vol. 24(20). link> doi> full text>2019.
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Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2. Nat Commun, vol. 10(1), 4639. link> doi> full text>2019.
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The cytotoxic potential of cationc triangulenes against tumour cells. MedChemComm. doi> link> full text>2019.
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The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges. APPLIED SCIENCES-BASEL, vol. 9(13), Article ARTN 2767. link> doi> full text>2019.
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Antifungal screening and in silico mechanistic studies of an in-house azole library. Chem Biol Drug Des, vol. 94(5), 1944-1955. link>adoi>afull text>div>2019.Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5. Molecules, vol. 24(13). link>adoi>alink>afull text>div>2019.Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide. Bioconjug Chem, vol. 30(7), 1998-2010. link>adoi>/div>2019.Structural Modifications of the Antiinflammatory Oxicam Scaffold and Preparation of Anticancer Organometallic Compounds. ORGANOMETALLICS, vol. 38(2), 361-374. link>adoi>/div>2019.New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. Journal of Medicinal Chemistry. link>adoi>alink>afull text>div>2019.Generation of Quality Hit Matter for Successful Drug Discovery Projects. Molecules, vol. 24(3). link>adoi>afull text>div>2019.Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models. European Journal of Medicinal Chemistry, vol. 161, 581-593. link>adoi>alink>/div>2019.The Development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) Inhibitors Based on the Amines Combining Aromatic/Heteroaromatic and Monoterpenoid Moieties. LETTERS IN DRUG DESIGN & DISCOVERY, vol. 16(5), 597-605. link>adoi>/div>2019.Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments. Anticancer Agents in Medicinal Chemistry. link>adoi>/div>2018.From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents. Inorganic Chemistry, vol. 57(22), 14427-14434. link>adoi>/div>2018.The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening. Molecular Informatics. link>adoi>alink>/div>2018.A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold. Molecules, vol. 23(10). link>adoi>alink>afull text>div>2018.The Utility of Calculated Proton Affinities in Drug Design: A DFT Study. AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 71(8), 580-586. link>adoi>/div>2018.A Chemometric Analysis of Compounds from Native New Zealand Medicinal Flora. Chemistry - An Asian Journal. link>adoi>alink>/div>2018.Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors. Bioorganic and Medicinal Chemistry, vol. 26(15), 4470-4480. link>adoi>/div>2018.Organoruthenium and Organoosmium Complexes o f 2-Pyridinecarbothioamides Functionalized with a Sulfonamide Motif: Synthesis, Cytotoxicity and Biomolecule Interactions. ChemPlusChem, vol. 83(7), 612-619. link>adoi>alink>/div>2018.Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. PEPTIDE SCIENCE, vol. 110(4), Article ARTN e24076. link>adoi>alink>afull text>div>2018.Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Molecules, vol. 23(3). link>adoi>alink>afull text>div>2018.Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents. Molecules, vol. 23(145). doi>afull text>div>2018.Thieno[2,3-b]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin. European Journal of Medicinal Chemistry, vol. 143, 1997-2004. link>adoi>alink>afull text>div>2018.GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents. Molecules, vol. 22(12). link>adoi>alink>afull text>div>2017.Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors. Bioorganic Chemistry, vol. 76, 392-399. link>adoi>/div>2017.Development and Application of an NMR-Based Assay for Polyphenol Oxidases. ChemistrySelect, vol. 2(32), 10435-10441. link>adoi>alink>/div>2017.Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors. MedChemComm, vol. 8(11), 2155-2163. link>adoi>alink>afull text>div>2017.Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives. ChemMedChem, vol. 12(22), 1882-1892. link>adoi>/div>2017.Anti-influenza activity of diazaadamantanes combined with monoterpene moieties. Bioorganic and Medicinal Chemistry, vol. 27(19), 4531-4535. link>adoi>/div>2017.Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol. 40, 142-156. link>adoi>alink>/div>2017.New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies. Arch Pharm (Weinheim), vol. 350(6). link>adoi>/div>2017.Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound. Drug Design, Development and Therapy, vol. 11, 759-769. link>adoi>alink>afull text>div>2017.New Iminodiacetate-Thiosemicarbazone Hybrids and Their Copper(II) Complexes Are Potential Ribonucleotide Reductase R2 Inhibitors with High Antiproliferative Activity. Inorganic Chemistry, vol. 56(6), 3532-3549. link>adoi>alink>/div>2017.Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines. Bioorganic and Medicinal Chemistry, vol. 27(2), 135-138. link>adoi>/div>2016.3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells. Bioorganic and Medicinal Chemistry, vol. 25(2), 658-664. link>adoi>/div>2016.Virtual screening and biophysical studies lead to HSP90 inhibitors. Bioorganic and Medicinal Chemistry, vol. 27(2), 277-281. link>adoi>/div>2016.Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action. Molecules, vol. 21(10). link>adoi>afull text>div>2016.Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines. SYNLETT, vol. 27(20), 2811-2814. link>adoi>alink>/div>2016.New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties. Bioorganic and Medicinal Chemistry, vol. 24(21), 5573-5581. link>adoi>/div>2016.Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides. Chemical Research in Toxicology, vol. 29(8), 1310-1324. link>adoi>/div>2016.Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes. Chemistry - A European Journal, vol. 22(32), 11413-11421. link>adoi>alink>/div>2016.Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffolds. Bioorganic and Medicinal Chemistry, vol. 24(16), 3521-3526. link>adoi>/div>2016.Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study. Molecular Informatics, vol. 35(5), 207-214. link>adoi>/div>2016.Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative. Cancer Cell International, vol. 16, 18. link>adoi>alink>afull text>div>2016.A predictive multi-linear regression model for organic micropollutants, based on a laboratory-scale column study simulating the river bank filtration process. Journal of Hazardous Materials, vol. 304, 502-511. link>adoi>alink>/div>2016.Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives. Bioorganic and Medicinal Chemistry, vol. 24(5), 1142-1154. link>adoi>alink>/div>2016.Defining Known Drug Space Using DFT. Molecular Informatics, vol. 35(2), 46-53. link>adoi>/div>2015.A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues. MedChemComm, vol. 6(11), 1987-1997. link>adoi>alink>/div>2015.Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety. Bioorganic and Medicinal Chemistry, vol. 23(9), 2044-2052. link>adoi>alink>/div>2015.Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells. Chemistry, vol. 21(13), 5110-5117. link>adoi>alink>/div>2015.Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action. Chemical Science, vol. 6(4), 2449-2456. link>adoi>alink>afull text>div>2015.Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction. Chemical Communications, vol. 50(89), 13729-13731. link>adoi>alink>/div>2014.Virtual screening for novel Atg5-Atg16 complex inhibitors for autophagy modulation. MedChemComm, vol. 6(1), 239-246. link>adoi>/div>2014.Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives. European Journal of Medicinal Chemistry, vol. 86, 420-437. link>adoi>alink>/div>2014.Anticancer Ruthenium(eta(6)-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives. ORGANOMETALLICS, vol. 33(19), 5546-5553. link>adoi>/div>2014.Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000. Organic and Biomolecular Chemistry, vol. 12(21), 3386-3392. link>adoi>/div>2014.Sorption and biodegradation of organic micropollutants during river bank filtration: a laboratory column study. Water Research, vol. 52, 231-241. link>adoi>/div>2014.The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods. MedChemComm, vol. 5(2), 186-191. link>adoi>/div>2013.The effect of a thieno[2,3-b] pyridine PLC-gamma inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells. MedChemComm, vol. 5(1), 99-106. link>adoi>/div>2013.The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study. Carbohydrate Polymers, vol. 97(1), 177-187. link>adoi>/div>2013.A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution. POLYMER, vol. 54(4), 1305-1317. link>adoi>/div>2013.DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. COMPUTATIONAL AND THEORETICAL CHEMISTRY, vol. 1005, 9-15. link>adoi>/div>2013.Wine Compounds as a Source for HTS Screening Collections. A Feasibility Study. Mol Inform, vol. 31(11-12), 847-855. link>adoi>/div>2012.The impact of carbon-hydrogen bond dissociation energies on the prediction of the cytochrome P450 mediated major metabolic site of drug-like compounds. Eur J Med Chem, vol. 56, 48-55. link>adoi>/div>2012.The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem, vol. 54, 463-469. link>adoi>/div>2012.Size estimation of chemical space: how big is it?. J Pharm Pharmacol, vol. 64(4), 490-495. link>adoi>/div>2012.Serendipity in anticancer drug discovery. World J Clin Oncol, vol. 3(1), 1-6. link>adoi>/div>2012.The Bioreductive Alkylation of DNA by Kalafungin: A Theoretical Investigation. AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 65(4), 402-408. link>adoi>/div>2012.Bond stability of the "undesirable" heteroatom-heteroatom molecular moieties for high-throughput screening libraries. Eur J Med Chem, vol. 46(12), 5833-5837. link>adoi>/div>2011.Theoretical investigations on the formation of nitrobenzanthrone-DNA adducts. Org Biomol Chem, vol. 9(17), 6100-6110. link>adoi>/div>2011.Theoretical Investigations into the Role of Aryl Nitrenium Ions' Stability on Their Mutagenic Potential. AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 64(7), 910-915. link>adoi>/div>2011.Characteristics of known drug space. Natural products, their derivatives and synthetic drugs. Eur J Med Chem, vol. 45(12), 5646-5652. link>adoi>/div>2010.A facile synthesis of pyrazoles with multi-point structural diversity by 1,3-dipolar cycloaddition. TETRAHEDRON LETTERS, vol. 51(45), 5915-5918. link>adoi>/div>2010.Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation. World J Clin Oncol, vol. 1(1), 12-17. link>adoi>/div>2010.Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg Med Chem Lett, vol. 20(20), 5988-5993. link>adoi>/div>2010.DFT calculations on the deprotonation site of the one-electron oxidised guanine-cytosine base pair. Phys Chem Chem Phys, vol. 12(31), 9088-9093. link>adoi>/div>2010.Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem, vol. 53(14), 5213-5228. link>adoi>/div>2010.Known drug space as a metric in exploring the boundaries of drug-like chemical space. Eur J Med Chem, vol. 44(12), 5006-5011. link>adoi>/div>2009.The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem, vol. 17(8), 3169-3176. link>adoi>/div>2009.Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compounds. Eur J Med Chem, vol. 44(3), 1128-1134. link>adoi>/div>2009.Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment. Environ Mol Mutagen, vol. 49(8), 659-667. link>adoi>/div>2008.Benchmarking the reliability of QikProp. Correlation between experimental and predicted values. QSAR & COMBINATORIAL SCIENCE, vol. 27(4), 445-456. link>adoi>/div>2008.Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases. Bioorg Med Chem Lett, vol. 17(23), 6567-6571. link>adoi>/div>2007.Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone. Toxicol Sci, vol. 98(2), 445-457. link>adoi>/div>2007.Photoionization versus photoheterolysis of all-trans-retinol. The effects of solvent and laser radiation intensity. Phys Chem Chem Phys, vol. 9(2), 288-298. link>adoi>/div>2007.2,6,10-Tris(dialkylamino)trioxatriangulenium salts: a new promising fluorophore. Ion-pair formation and aggregation in non-polar solvents. Photochem Photobiol Sci, vol. 4(8), 568-576. link>adoi>/div>2005.The calculated base pairing energy of 8-oxoguanine in the syn-anti conformation with cytosine, thymine, adenine and guanine. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, vol. 723(1-3), 29-36. link>adoi>/div>2005.One-electron reduction of 2-aminopurine in the aqueous phase. A DFT and pulse radiolysis study. Phys Chem Chem Phys, vol. 7(4), 659-665. link>adoi>/div>2005.Hydrogen bonding between histidine and lignin model compounds or redox mediators as calculated with the DFT method. Effects on the ease of oxidation. Org Biomol Chem, vol. 2(4), 578-584. link>adoi>/div>2004.Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy. J Comput Aided Mol Des, vol. 18(6), 421-431. link>adoi>/div>2004.The complexation energy of the one-electron oxidized guanine-cytosine base pair and its parent system with small cations. A DFT-study. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, vol. 635, 133-139. link>adoi>/div>2003.Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure. J Am Chem Soc, vol. 125(8), 2072-2083. link>adoi>/div>2003.Photophysics of trioxatriangulenium ion. electrophilic reactivity in the ground state and excited singlet state. Photochem Photobiol Sci, vol. 1(10), 763-773. link>adoi>/div>2002.DFT calculations on the electrophilic reaction with water of the guanine and adenine radical cations. A model for the situation in DNA. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 4(3), 527-532. link>adoi>/div>2002.DFT studies on the pairing abilities of the one-electron reduced or oxidized adenine-thymine base pair. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 4(21), 5353-5358. link>adoi>/div>2002.DNA-base radicals. Their base pairing abilities as calculated by DFT. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 4(21), 5346-5352. link>adoi>/div>2002.Photo- and radiation-chemical formation and electrophilic and electron transfer reactivities of enolether radical cations in aqueous solution. Chemistry, vol. 7(21), 4640-4650. link>adoi>/div>2001.Is "frank" DNA-strand breakage via the guanine radical thermodynamically and sterically possible?. Chemistry, vol. 7(13), 2829-2833. link>adoi>/div>2001.Structural properties of DNO investigated with pyrene excimer formation. (vol 6, pg 603, 2000). JOURNAL OF PEPTIDE SCIENCE, vol. 7(7), 395. link>/div>2001.Structural properties of DNO investigated with pyrene excimer formation. JOURNAL OF PEPTIDE SCIENCE, vol. 6(12), 603-611. link>adoi>/div>2000.Structural properties of DNO investigated with pyrene excimer formation. J Pept Sci, vol. 6(12), 603-611. link>adoi>/div>2000.Vibrational spectroscopic and quantum chemical studies of the trioxatriangulenium carbocation. JOURNAL OF MOLECULAR STRUCTURE, vol. 520, 63-73. link>adoi>/div>2000.Photochemistry of substituted methyl-alpha-arylcinnamates: ortho- and para-substitution. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, vol. 115(1), 57-61. link>adoi>/div>1998.Reactions of 1-aza-1,3-butadienes. An expedient synthesis of unsymmetrically substituted N-benzyl-1,4-dihydropyridines and N-benzyl-1,4-dihydronicotinamides. ACTA CHEMICA SCANDINAVICA, vol. 51(3), 348-350. link>adoi>/div>1997.
Other
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Novel synthetic thienopyridine derivatives induce tubulin disruption and cell cycle arrest in malignant B cells with level of activity related to their chemical structure. British Journal of Haematology (vol. 189, pp. 227-228). Wiley. link>adoi>alink>/div>2020.Development of thienopyridines as potent antiproliferative agents. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (vol. 256). link>/div>2018.Synthesis of novel, potent phosphatidyl-choline specific phospholipase C inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (vol. 256). link>/div>2018.Targeting isocitrate lyase for the treatments of tuberculosis. FEBS OPEN BIO (vol. 8, p. 277). link>/div>2018.Development and application of an NMR-based activity and inhibition assay for mycobacterial isocitrate lyase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (vol. 253). link>/div>2017.Coumarin antifungal lead compounds, predicted mechanism of action. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (vol. 73, p. C406). link>adoi>/div>2017.The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells. FEBS JOURNAL (vol. 281, p. 507). link>/div>2014.Transformation of Bisphenol A, triclosan, and nonylphenol by the Fe-TAML/H2O2 system. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (vol. 248). link>/div>2014.Coumarin antifungal lead compounds, predicted mechanism of action. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (vol. 70, p. C406). link>/div>2014.Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment. MUTAGENESIS (vol. 24, p. 106). link>/div>2009.
- 2007.