Journal Articles

• Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen Y-H, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. 2022. Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. ACS Cent Sci, 527-545, vol. 8(5). link> doi> full text>
• Davies SP, Mycroft-West CJ, Pagani I, Hill HJ, Chen Y-H, Karlsson R, Bagdonaite I, Guimond SE, Stamataki Z, De Lima MA, Turnbull JE, Yang Z, Vicenzi E, Skidmore MA, Khanim FL, Richardson A. 2021. The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models. Front Pharmacol, 660490, vol. 12. link> doi> full text>
• Mycroft-West CJ, Devlin AJ, Cooper LC, Guimond SE, Procter P, Guerrini M, Miller GJ, Fernig DG, Yates EA, Lima MA, Skidmore MA. 2021. Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease β Secretase, BACE1. Mar Drugs, vol. 19(4). link> doi> full text>
• Mycroft-West CJ, Su D, Pagani I, Rudd TR, Elli S, Gandhi NS, Guimond SE, Miller GJ, Meneghetti MCZ, Nader HB, Li Y, Nunes QM, Procter P, Mancini N, Clementi M, Bisio A, Forsyth NR, Ferro V, Turnbull JE, Guerrini M, Fernig DG, Vicenzi E, Yates EA, Lima MA, Skidmore MA. 2020. Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thromb Haemost, 1700-1715, vol. 120(12). link> doi> full text>
• Ní Cheallaigh A, Guimond SE, Oscarson S, Miller GJ. 2020. Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities. Carbohydr Res, 108085, vol. 495. link> doi> full text>
• Mycroft-West C, Su D, Li Y, Guimond S, Rudd T, Elli S, Miller G, Nunes Q, Procter P, Bisio A, Forsyth N, Turnbull J, Guerrini M, Fernig D, Yates E, Lima M, Skidmore M. 2020. Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. doi>
• Mycroft-West C, Su D, Li Y, Guimond S, Rudd T, Elli S, Miller G, Nunes Q, Procter P, Bisio A, Forsyth N, Turnbull J, Guerrini M, Fernig D, Yates E, Lima M, Skidmore M. 2020. SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. doi>
• Mycroft-West C, Su D, Pagani I, Rudd T, Elli S, Guimond S, Miller G, Meneghetti M, Nader H, Li Y, Nunes Q, Procter P, Mancini N, Clementi M, Bisio A, Forsyth N, Turnbull J, Guerrini M, Fernig D, Vicenzi E, Yates E, Lima M, Skidmore M. 2020. Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. doi>
• Miller RL, Guimond SE, Schwörer R, Zubkova OV, Tyler PC, Xu Y, Liu J, Chopra P, Boons G-J, Grabarics M, Manz C, Hofmann J, Karlsson NG, Turnbull JE, Struwe WB, Pagel K. 2020. Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. Nature Communications, Article 1481, vol. 11(1). link> doi> link> full text>
• Mycroft-West C, Su D, Elli S, Li Y, Li Y, Guimond S, Miller G, Turnbull J, Yates E, Guerrini M, Fernig D, Lima M, Skidmore M. 2020. The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. doi>
• Mycroft-West CJ, Devlin AJ, Cooper LC, Procter P, Miller GJ, Fernig DG, Guerrini M, Guimond SE, Lima MA, Yates EA, Skidmore MA. 2020. Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus. Neural Regen Res, 1546-1553, vol. 15(8). link> doi> full text>
• Devlin A, Mycroft-West C, Procter P, Cooper L, Guimond S, Lima M, Yates E, Skidmore M. 2019. Tools for the Quality Control of Pharmaceutical Heparin. Medicina (Kaunas), vol. 55(10). link> doi> full text>
• Mycroft-West CJ, Cooper LC, Devlin AJ, Procter P, Guimond SE, Guerrini M, Fernig DG, Lima MA, Yates EA, Skidmore MA. 2019. A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. Mar Drugs, vol. 17(5). link> doi> full text>
• Chanalaris A, Clarke H, Guimond SE, Vincent TL, Turnbull JE, Troeberg L. 2019. Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage. Am J Pathol, 632-647, vol. 189(3). link> doi>
• Zubkova OV, Ahmed YA, Guimond SE, Noble S-L, Miller JH, Alfred Smith RA, Nurcombe V, Tyler PC, Weissmann M, Vlodavsky I, Turnbull JE. 2018. Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy. ACS Chem Biol, 3236-3242, vol. 13(12). link> doi>
• Skidmore MA, Mustaffa KMF, Cooper LC, Guimond SE, Yates EA, Craig AG. 2017. A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence. PLoS One, e0186276, vol. 12(10). link> doi> full text>
• Miller RL, Guimond SE, Prescott M, Turnbull JE, Karlsson N. 2017. Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry. Anal Chem, 8942-8950, vol. 89(17). link> doi>
• Ghadiali RS, Guimond SE, Turnbull JE, Pisconti A. 2017. Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. Matrix Biol, 54-68, vol. 59. link> doi>
• O'Neill P, Lindsay SL, Pantiru A, Guimond SE, Fagoe N, Verhaagen J, Turnbull JE, Riddell JS, Barnett SC. 2017. Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface. Glia, 19-33, vol. 65(1). link> doi> full text>
• Kalus I, Rohn S, Puvirajesinghe TM, Guimond SE, Eyckerman-Kölln PJ, Ten Dam G, van Kuppevelt TH, Turnbull JE, Dierks T. 2015. Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions. PLoS One, e0139853, vol. 10(10). link> doi>
• Chan WK, Howe K, Clegg JM, Guimond SE, Price DJ, Turnbull JE, Pratt T. 2015. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS One, e0130147, vol. 10(6). link> doi>
• Skidmore MA, Kajaste-Rudnitski A, Wells NM, Guimond SE, Rudd TR, Yates EA, Vicenzi E. 2015. Inhibition of influenza H5N1 invasion by modified heparin derivatives. MEDCHEMCOMM, 640-646, vol. 6(4). link> doi>
• Tyler PC, Guimond SE, Turnbull JE, Zubkova OV. 2015. Single-entity heparan sulfate glycomimetic clusters for therapeutic applications. Angew Chem Int Ed Engl, 2718-2723, vol. 54(9). link> doi>
• Theodoraki A, Hu Y, Poopalasundaram S, Oosterhof A, Guimond SE, Disterer P, Khoo B, Hauge-Evans AC, Jones PM, Turnbull JE, van Kuppevelt TH, Bouloux P-M. 2015. Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. Mol Cell Endocrinol, 296-310, vol. 399. link> doi>
• Solari V, Rudd TR, Guimond SE, Powell AK, Turnbull JE, Yates EA. 2015. Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Org Biomol Chem, 6066-6072, vol. 13(21). link> doi>
• Xu R, Ori A, Rudd TR, Uniewicz KA, Ahmed YA, Guimond SE, Skidmore MA, Siligardi G, Yates EA, Fernig DG. 2012. Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity. J Biol Chem, 40061-40073, vol. 287(47). link> doi>
• Higginson JR, Thompson SM, Santos-Silva A, Guimond SE, Turnbull JE, Barnett SC. 2012. Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. J Neurosci, 15902-15912, vol. 32(45). link> doi>
• Puvirajesinghe TM, Ahmed YA, Powell AK, Fernig DG, Guimond SE, Turnbull JE. 2012. Array-based functional screening of heparin glycans. Chem Biol, 553-558, vol. 19(5). link> doi>
• Kim S-H, Turnbull J, Guimond S. 2011. Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol, 139-151, vol. 209(2). link> doi>
• Skidmore MA, Guimond SE, Dumax-Vorzet AF, Yates EA, Turnbull JE. 2010. Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. Nat Protoc, 1983-1992, vol. 5(12). link> doi>
• Rudd TR, Uniewicz KA, Ori A, Guimond SE, Skidmore MA, Gaudesi D, Xu R, Turnbull JE, Guerrini M, Torri G, Siligardi G, Wilkinson MC, Fernig DG, Yates EA. 2010. Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Org Biomol Chem, 5390-5397, vol. 8(23). link> doi>
• Turnbull JE, Miller RL, Ahmed Y, Puvirajesinghe TM, Guimond SE. 2010. Glycomics profiling of heparan sulfate structure and activity. Methods Enzymol, 65-85, vol. 480. link> doi>
• Rudd TR, Skidmore MA, Guimond SE, Holman J, Turnbull JE, Lauder RM, Fernig DG, Yates EA. 2009. The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thromb Haemost, 874-878, vol. 102(5). link> doi>
• Hu Y, Guimond SE, Travers P, Cadman S, Hohenester E, Turnbull JE, Kim S-H, Bouloux P-M. 2009. Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. J Biol Chem, 29905-29920, vol. 284(43). link> doi>
• Guimond SE, Puvirajesinghe TM, Skidmore MA, Kalus I, Dierks T, Yates EA, Turnbull JE. 2009. Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. J Biol Chem, 25714-25722, vol. 284(38). link> doi>
• Skidmore MA, Guimond SE, Rudd TR, Fernig DG, Turnbull JE, Yates EA. 2008. The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation. Connect Tissue Res, 140-144, vol. 49(3). link> doi>
• Guimond SE, Rudd TR, Skidmore MA, Ori A, Gaudesi D, Cosentino C, Guerrini M, Edge R, Collison D, McInnes E, Torri G, Turnbull JE, Fernig DG, Yates EA. 2009. Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution. Biochemistry, 4772-4779, vol. 48(22). link> doi>
• Puvirajesinghe TM, Guimond SE, Turnbull JE, Guenneau S. 2009. Chemometric analysis for comparison of heparan sulphate oligosaccharides. J R Soc Interface, 997-1004, vol. 6(40). link> doi>
• Rudd TR, Skidmore MA, Guimond SE, Cosentino C, Torri G, Fernig DG, Lauder RM, Guerrini M, Yates EA. 2009. Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra. Glycobiology, 52-67, vol. 19(1). link> doi>
• Rudd TR, Skidmore MA, Guimond SE, Guerrini M, Cosentino C, Edge R, Brown A, Clarke DT, Torri G, Turnbull JE, Nichols RJ, Fernig DG, Yates EA. 2008. Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques. Carbohydr Res, 2184-2193, vol. 343(12). link> doi>
• Skidmore MA, Dumax-Vorzet AF, Guimond SE, Rudd TR, Edwards EA, Turnbull JE, Craig AG, Yates EA. 2008. Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities. J Med Chem, 1453-1458, vol. 51(5). link> doi>
• Skidmore MA, Guimond SE, Dumax-Vorzet AF, Atrih A, Yates EA, Turnbull JE. 2006. High sensitivity separation and detection of heparan sulfate disaccharides. J Chromatogr A, 52-56, vol. 1135(1). link> doi>
• Guimond SE, Turnbull JE, Yates EA. 2006. Engineered bio-active polysaccharides from heparin. Macromol Biosci, 681-686, vol. 6(8). link> doi>
• Guimond S and Turnbull JE. 2004. Proteoglycans make the grade-ient. Mol Cell, 159-160, vol. 16(2). link> doi>
• Turnbull J, Drummond K, Huang Z, Kinnunen T, Ford-Perriss M, Murphy M, Guimond S. 2003. Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. Biochem Soc Trans, 343-348, vol. 31(2). link> doi>
• Guimond S, Turner K, Kita M, Ford-Perriss M, Turnbull J. 2001. Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development. Biochem Soc Trans, 177-181, vol. 29(Pt 2). link> doi>
• Turnbull J, Powell A, Guimond S. 2001. Heparan sulfate: decoding a dynamic multifunctional cell regulator. Trends Cell Biol, 75-82, vol. 11(2). link> doi>
• Guimond SE and Turnbull JE. 1999. Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides. Curr Biol, 1343-1346, vol. 9(22). link> doi>
• Rapraeger AC, Guimond S, Krufka A, Olwin BB. 1994. Regulation by heparan sulfate in fibroblast growth factor signaling. Methods Enzymol, 219-240, vol. 245. link> doi>