Dr Ruoli Chen
My research interests include hypoxia biology, stroke medicine and blood-brain barriers. In particular, my work focuses on pharmacological activation of hypoxia-inducible factor pathways in stroke therapy and prevention. This work involves the application of a novel class of prolyl hydroxylase inhibitors in stroke and vascular dementia treatments. I also study glia–neuron interaction in hypoxia and ischaemia, and analyse the astrocyte secretome at different duration of ischaemia and study their effects on ischaemic neurons. Furthermore, I am interested in neuroinflammation in hypoxia and investigating the effects of microglial activation on blood-brain barrier functions in hypoxia. I use a combination of in vitro and in vivo cerebral ischaemia models.
For more information please visit my profile.