BEEP (Benefits of Exercise for knee Pain)

Chief Investigator:

Study Co-ordinator:

Funder name / reference number: The National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (grant number: RP-PG-0407-10386) and the Arthritis Research UK Centre in Primary Care grant (Grant Number 18139).
UKCRN Study portfolio: No. 9270, ISRCTN: 93634563
Year 2009 to 2014

Study design

A multicentre, pragmatic, parallel group individually randomised controlled trial with embedded longitudinal qualitative interviews, to compare the clinical and cost-effectiveness of three physiotherapy-led exercise interventions for knee osteoarthritis in older adults.

Analysis was by intention-to-treat. This trial also included embedded longitudinal qualitative interviews.

Primary objective

The BEEP randomised trial aims were to improve patients' short and long-term outcomes from exercise. It will test the overall effectiveness and cost-effectiveness of two physiotherapy-led exercise interventions (Individually Tailored Exercise and Targeted Exercise Adherence) to improve the individual tailoring of, and adherence to exercise, compared with usual physiotherapy care.


Usual Care, up to 4 treatment sessions of advice and exercise over 12 weeks; Individually Tailored Exercise (ITE), an individualised, supervised and progressed lower-limb exercise programme in 6 to 8 treatment sessions over 12 weeks; or Targeted Exercise Adherence (TEA), supporting the transition from lower limb exercise to general physical activity in 8 to 10 treatment contacts over 6 months.