Nicky Birks

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Biography

I joined the School of Pharmacy's Department of Medicines Management in 2009, having previously worked within research and regulatory affair functions in the pharmaceutical industry. My PhD, awarded from Sheffield University, is in molecular microbiology/microbial biochemistry of Helicobacter pylori. I work for the department’s Medicines Management Service and am involved in marketing our prescribing data analysis services to healthcare organisations.

Selected Publications

Stratford R, McKelvie ND, Hughes NJ, Aldred E, Wiseman C, Curtis J, Bellaby T, Bentley M, Hindle Z, Brennan FR, Chatfield SN, Dougan G, Khan SA. 2005. Optimization of Salmonella enterica serovar typhi DeltaaroC DeltassaV derivatives as vehicles for delivering heterologous antigens by chromosomal integration and in vivo inducible promoters. Infect Immun, vol. 73(1), 362-368. link> doi>
McKelvie ND, Stratford R, Wu T, Bellaby T, Aldred E, Hughes NJ, Chatfield SN, Pickard D, Hale C, Dougan G, Khan SA. 2004. Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG. Vaccine, vol. 22(25-26), 3243-3255. link> doi>
van Vliet AHM, Stoof J, Vlasblom R, Wainwright SA, Hughes NJ, Kelly DJ, Bereswill S, Bijlsma JJE, Hoogenboezem T, Vandenbroucke-Grauls CMJE, Kist M, Kuipers EJ, Kusters JG. 2002. The role of the ferric uptake regulator (Fur) in regulation of Helicobacter pylori iron uptake. HELICOBACTER, vol. 7(4), 237-244. link> doi>
Sisson G, Goodwin A, Raudonikiene A, Hughes NJ, Mukhopadhyay AK, Berg DE, Hoffman PS. 2002. Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46(7), 2116-2123. link> doi>
Bijlsma JJE, Waidner B, van Vliet AHM, Hughes NJ, Hag S, Bereswill S, Kelly DJ, Vandenbroucke-Grauls CMJE, Kist M, Kusters JG. 2002. The Helicobacter pylori homologue of the ferric uptake regulator is involved in acid resistance. INFECTION AND IMMUNITY, vol. 70(2), 606-611. link> doi>

Full Publications List show

Journal Articles

Stratford R, McKelvie ND, Hughes NJ, Aldred E, Wiseman C, Curtis J, Bellaby T, Bentley M, Hindle Z, Brennan FR, Chatfield SN, Dougan G, Khan SA. 2005. Optimization of Salmonella enterica serovar typhi DeltaaroC DeltassaV derivatives as vehicles for delivering heterologous antigens by chromosomal integration and in vivo inducible promoters. Infect Immun, vol. 73(1), 362-368. link> doi>
McKelvie ND, Stratford R, Wu T, Bellaby T, Aldred E, Hughes NJ, Chatfield SN, Pickard D, Hale C, Dougan G, Khan SA. 2004. Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG. Vaccine, vol. 22(25-26), 3243-3255. link> doi>
van Vliet AHM, Stoof J, Vlasblom R, Wainwright SA, Hughes NJ, Kelly DJ, Bereswill S, Bijlsma JJE, Hoogenboezem T, Vandenbroucke-Grauls CMJE, Kist M, Kuipers EJ, Kusters JG. 2002. The role of the ferric uptake regulator (Fur) in regulation of Helicobacter pylori iron uptake. HELICOBACTER, vol. 7(4), 237-244. link> doi>
Sisson G, Goodwin A, Raudonikiene A, Hughes NJ, Mukhopadhyay AK, Berg DE, Hoffman PS. 2002. Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46(7), 2116-2123. link> doi>
Bijlsma JJE, Waidner B, van Vliet AHM, Hughes NJ, Hag S, Bereswill S, Kelly DJ, Vandenbroucke-Grauls CMJE, Kist M, Kusters JG. 2002. The Helicobacter pylori homologue of the ferric uptake regulator is involved in acid resistance. INFECTION AND IMMUNITY, vol. 70(2), 606-611. link> doi>
Chalker AF, Minehart HW, Hughes NJ, Koretke KK, Lonetto MA, Brinkman KK, Warren PV, Lupas A, Stanhope MJ, Brown JR, Hoffman PS. 2001. Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis. J Bacteriol, vol. 183(4), 1259-1268. link> doi>
Velayudhan J, Hughes NJ, McColm AA, Bagshaw J, Clayton CL, Andrews SC, Kelly DJ. 2000. Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter. Mol Microbiol, vol. 37(2), 274-286. link> doi>
Hughes NJ, Clayton CL, Chalk PA, Kelly DJ. 1998. Helicobacter pylori porCDAB and oorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases which mediate electron transport to NADP. J Bacteriol, vol. 180(5), 1119-1128. link> doi>
Hughes NJ, Chalk PA, Clayton CL, Kelly DJ. 1995. Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate:flavodoxin oxidoreductase from Helicobacter pylori. J Bacteriol, vol. 177(14), 3953-3959. link> doi>

Chapters

Kelly DJ, Hughes NJ, Poole RK. 2001. Chapter 10: Microaerobic Physiology: Aerobic Respiration, Anaerobic Respiration, and Carbon Dioxide Metabolism. In Helicobacter pylori: Physiology and Genetics. Mobley HLT, Mendz GL, Hazell SL (Eds.). Washington (DC): ASM Press.
Kelly DJ, Hughes N, Poole RK. 2001. Chapter 12: The Citric Acid Cycle and Fatty Acid Biosynthesis. In Helicobacter pylori: Physiology and Genetics. Mobley HLT, Mendz GL, Hazell SL (Eds.). Washington (DC): ASM Press.