Karina Wright

Biography

I commenced my PhD studies at the Robert Jones & Agnes Hunt (RJAH) Orthopaedic Hospital in Oswestry in 2005, and in 2009, was awarded my PhD in Biomedical Engineering from Keele University. Since then I have been employed as a Senior Lecturer/Lecturer/Research Fellow/Research Associate in the School of Pharmacy and Bioengineering (formerly the Institute for Science & Technology in Medicine), Keele University.

Research and scholarship

Research theme: Regenerative medicine

My laboratory group at the RJAH develops biological therapies for orthopaedic and spinal cord injury patients. Our research transcends the bench to bedside translational pipeline, from in vitro analyses, organ-on-a-chip systems, pre-clinical models, clinical trials and finally NICE approved treatments. We are equally interested in learning from bedside to bench through reverse translational research, by collecting and analysing human cells and tissues and relating biological profiles to clinical outcomes in an effort to refine, tailor and develop novel treatments.

Teaching

I am currently a BSc module lead in Applied Regenerative Medicine with the School of Life Sciences and an MSc module lead in Bioreactors and Growth Environments with the School of Pharmacy and Bioengineering (the latter is delivered as an online post-graduate course, nationally and internationally).

Further information

PhD Students

John Garcia (Lead Supervisor 2013-2016)
Shiraz Ziya (Lead Supervisor 2014-2018)
Jingsong Wang (Lead Supervisor 2017-2020)
Mateus Bernardo Harrington (Lead Supervisor 2018-present)
Lauren Tierney (Lead Supervisor 2019-present)
Larissa Rix (Lead Supervisor 2019-present)
Tian Lan (Lead Supervisor 2020-present)
Jessica Fisher Stokes (Lead Supervisor 2021-present)
Soukaina Bahsoun (Co-supervisor 2016-2017)
Jessica Sykes (Co-supervisor 2016-2019)
Tim Hopkins (Co-supervisor 2016-2020)
Amy Byrne (Co-supervisor 2016-2017)
Rebecca Davies (Co-Supervisor 2018-present)

Equipment

BD FACS canto II flow cytometer (Arthritis Research UK Equipment Grant – PI)
Cell IQ II Live Cell Imaging Platform (Institute of Orthopaedics Equipment Grant – Co-I)
Quantum Hollow Fibre Bioreactor (MRC Biomedical Catalyst Grant - PI)

Funding

Versus Arthritis Project Grant (PI)
Medical Research Council Biomedical Catalyst Grant (PI)
Versus Arthritis Tissue Engineering Centre (Co-I)
Medical Research Council Experimental Medicine Grant (Co-I)
Medical Research Council DPFS Grant (Co-I)
Institute of Orthopaedics and Midlands Centre for Spinal Injuries (PI)

Team members

Dr Charlotte Hulme (Post-Doctoral Research Associate FT)
Dr Claire Mennan (Post-Doctoral Research Associate FT)
Dr Helen McCarthy (Post-Doctoral Research Associate PT)
Dr Tim Hopkins (Post-Doctoral Research Associate FT)
Dr Jade Perry (Post-Doctoral Research Associate PT)
Mike Williams (Data Analyst PT)

PUBLICATIONS

Wright KT, El Masri W, Osman A, Chowdhury J, Johnson WEB. Bone marrow for the treatment of spinal cord injury: mechanisms and clinical application. (2011) Stem Cells, Volume 29, 169-178.
Wright KT, Seabright RJ, Logan A, Lilly AJ, Khanim F, Bunce CM, Johnson WEB. Extracellular Nm23H1 stimulates neurite outgrowth from dorsal root ganglia neurons in vitro independently of nerve growth factor supplementation or its nucleoside diphosphate kinase activity. (2010). Biochemical and Biophysical Research Communications, Volume 398, 79-85.
Walter MN, Wright KT, Fuller HR, MacNeil S, Johnson WEB. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. (2010) Experimental Cell Research, Volume 316, Number 7; 1271-1281.

Wright KT, Griffiths G, Johnson WEB. A comparison of industrial high content analysis versus research-based manual analysis to assay the effects of mesenchymal stem cell conditioned medium on neurite outgrowth in vitro. (2010) Journal of Biomolecular Screening, Volume 15, Issue 5; 576-582.
Bajada S, Marshall MJ, Wright KT, Richardson JB, Johnson WEB. Decreased osteogenesis, increased cell senescence and elevated dickkopf-1 secretion in human fracture non union stromal cells. (2009) Bone. Volume 45, Issue 4; 726-735.
Wright KT, Griffiths G, Johnson WEB. A comparison of industrial high content analyses versus research lab-based methods to assay the effects of mesenchymal stem cell conditioned medium on neurite outgrowth in vitro. Abstract (2009) Neurorehabilitation and Neural Repair, Volume 23, Number 9, Page 984.
Chamberlain G, Wright KT, Rot A, Ashton BA, Middleton J. Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. (2008) PLoS ONE, Volume 3; 1-6.
Wright KT, El Masri W, Osman A, Roberts S, Trivedi J, Ashton BA, Johnson WEB. The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury: implications for future cell transplantation therapy. (2008) Spinal Cord, Volume 46; 811-817.
Wright KT, El Masri W, Osman A, Roberts S, Ashton BA, Johnson WEB. Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. (2007) Biochemical and Biophysical Research Communications, Volume 354; 559-566.
Wright KT, Khanim F, Bunce CM, Johnson WEB. The nucleoside diphosphatase kinase, nm23H1, is expressed by human bone marrow stromal cells and stimulates and directs neurite outgrowth in vitro. Abstract (2007) Neurorehabilitation and Neural Repair, Volume 21, Number 6, Page 62.
Johnson WEB, Sivan S, Wright KT, Eisenstein SM, Maroudas A, Roberts S. Human intevertebral disc cells promote nerve growth over substrata of human intevertebral disc aggrecan. (2006) Spine, Volume 31, Number 11; 1106-1114.
Wright KT, El Masri W, Osman A, Roberts S, Ashton BA, Johnson WEB. Marrow stromal cells from spinal cord injured patients promote nerve growth and reduce the inhibitory effects of chondroitin sulphated proteoglycans in vitro. Abstract (2006) Journal of Spinal Cord Medicine, Volume 29, Number 3, Page 270.

Selected Publications

McDonald J, Wright K, Mennan C, Peffers MJ, Perry J, Roberts S, Newall K, Henson F, Hulme C. Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells. full text>
Hulme CH, Mennan C, McCarthy HS, Davies R, Lan T, Rix L, Perry J, Wright K. 2023. A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy. link> doi> full text>
Hulme C, Roberts S, Gallacher P, Jermin P, Wright K. PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA. Orthopaedic Proceedings (p. 76, vols. 105-B). Bone & Joint. doi> link>
Hulme CH, Peffers MJ, Roberts S, Gallacher P, Jermin P, Wright KT. 2023. Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. Am J Sports Med, 1422-1433, vol. 51(6). link> doi> full text>
Hulme C, Williams A, Vincent T, Watt FE, Wright KT. 2023. Commonality Between The Proteome Signatures Of Clinical Response To Surgically Sustained And Acute Traumatic Cartilage Injuries In Two Human Knee Cohorts. Osteoarthritis and Cartilage (p. S357, vol. 31). Elsevier. doi> link> full text>

Full Publications Listshow

Journal Articles

Hulme CH, Mennan C, McCarthy HS, Davies R, Lan T, Rix L, Perry J, Wright K. 2023. A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy. link> doi> full text>
Hulme CH, Peffers MJ, Roberts S, Gallacher P, Jermin P, Wright KT. 2023. Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. Am J Sports Med, 1422-1433, vol. 51(6). link> doi> full text>
Harrison P, Hopkins T, Hulme C, McCarthy H, Wright K. 2023. Chondrocyte Isolation and Expansion. Methods Mol Biol, 9-19, vol. 2598. link> doi>
Hulme CH, Perry J, McCarthy HS, Wright KT, Snow M, Mennan C, Roberts S. 2021. Cell therapy for cartilage repair. Emerg Top Life Sci, 575-589, vol. 5(4). link> doi> full text>
Perry J, Roelofs AJ, Mennan C, McCarthy HS, Richmond A, Clark SM, Riemen AHK, Wright K, De Bari C, Roberts S. 2021. Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. Cells, vol. 10(8). link> doi> full text>
Hulme CH, Fuller HR, Riddell J, Shirran SL, Botting CH, Osman A, Wright KT. 2022. Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 320-325, vol. 60(4). link> doi> full text>
Hopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P, Kuiper JH. 2021. An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, vol. 10(8). link> doi> full text>
Lan T, McCarthy HS, Hulme CH, Wright KT, Makwana N. 2021. The management of talar osteochondral lesions - Current concepts. J Arthrosc Jt Surg, 231-237, vol. 8(3). link> doi> full text>
Hulme CH, Peffers MJ, Harrington GMB, Wilson E, Perry J, Roberts S, Gallacher P, Jermin P, Wright KT. 2021. Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy. Am J Sports Med, 1512-1523, vol. 49(6). link> doi> full text>
Bahsoun S, Kuiper J-H, Hulme CH, Twigg AJA, El Masri W, Glass C, Soni B, Kumar N, Chowdhury JR, Osman A, Wright KT. 2021. Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury. Sci Rep, 4361, vol. 11(1). link> doi> full text>
Wang J, Roberts S, Kuiper JH, Zhang W, Garcia J, Cui Z, Wright K. 2020. Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Sci Rep, 21658, vol. 10(1). link> doi> full text>
Harrington GMB, Cool P, Hulme C, Osman A, Chowdhury JR, Kumar N, Budithi S, Wright K. 2021. Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury. J Neurotrauma, 301-308, vol. 38(3). link> doi> full text>
Garcia J, Hulme C, Mennan C, Roberts S, Bastiaansen-Jenniskens YM, van Osch GJVM, Tins B, Gallacher P, Wright K. 2020. The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes. Osteoarthr Cartil Open, 100039, vol. 2(2). link> doi> full text>
Brown SJ, Harrington GMB, Hulme CH, Morris R, Bennett A, Tsang W-H, Osman A, Chowdhury J, Kumar N, Wright KT. 2020. A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury. J Neurotrauma, 466-480, vol. 37(3). link> doi> full text>
Wang J, Wright KT, Perry J, Tins B, Hopkins T, Hulme C, McCarthy HS, Brown A, Richardson JB. 2019. Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. Cell Transplant, 924-931, vol. 28(7). link> doi> full text>
Mennan C, Garcia J, Roberts S, Hulme C, Wright K. 2019. A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells. Stem Cell Res Ther, 99, vol. 10(1). link> doi> full text>
Wood CR, Al Dhahri D, Al Delfi I, Pickles NA, Sammons RL, Worthington T, Wright KT, Johnson WEB. 2018. Human adipose tissue-derived mesenchymal stem/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa. J Med Microbiol, 1789-1795, vol. 67(12). link> doi>
Sykes JG, Kuiper JH, Richardson JB, Roberts S, Wright KT, Kuiper NJ. 2018. Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Eur Cell Mater, 255-267, vol. 35. link> doi> full text>
Mennan C, Garcia J, Mccarthy H, Owen S, Perry J, Wright K, Banerjee R, Richardson J, Roberts S. 2018. Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential. Cartilage. doi> link> full text>
Hulme CH, Wilson EL, Fuller HR, Roberts S, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Res Ther, 87, vol. 20(1). link> doi> full text>
Hulme CH, Wilson EL, Peffers MJ, Roberts S, Simpson DM, Richardson JB, Gallacher P, Wright KT. 2017. Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles. Arthritis Res Ther, 150, vol. 19(1). link> doi> full text>
Richardson JB, Wright KT, Wales J, Kuiper JH, McCarthy HS, Gallacher P, Harrison PE, Roberts S. 2017. Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regen Med, 493-501, vol. 12(5). link> doi> full text>
Ziya S, Medcalf N, El A, Wright KT. 2017. 210 - Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy. Cytotherapy, S147, vol. 19(5). doi> link>
Wright KT, McCarthy H, Forsyth N, Roberts S. 2017. 283 - Characteristics of human bone marrow mscs are sensitive to mononuclear cell separation technique and oxygen tension. Cytotherapy, S197, vol. 19(5). doi> link>
Wright KT, Kuiper JH, Richardson JB, Gallacher P, Roberts S. 2017. The Absence of Detectable ADAMTS-4 (Aggrecanase-1) Activity in Synovial Fluid Is a Predictive Indicator of Autologous Chondrocyte Implantation Success. Am J Sports Med, 1806-1814, vol. 45(8). link> doi> full text>
Hulme CH, Brown SJ, Fuller HR, Riddell J, Osman A, Chowdhury J, Kumar N, Johnson WE, Wright KT. 2017. The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood. Spinal Cord, 114-125, vol. 55(2). link> doi> full text>
Garcia J, Mennan C, McCarthy HS, Roberts S, Richardson JB, Wright KT. Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. Stem cells international, Article 6969726, vol. 2016. doi> link> full text>
Garcia J, Wright K, Roberts S, Kuiper JH, Mangham C, Richardson J, Mennan C. 2016. Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Sci Rep, 24295, vol. 6. link> doi> full text>
Turner SA, Wright KT, Jones PN, Balain B, Roberts S. 2016. Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation. Stem Cells Int, 5415901, vol. 2016. link> doi> full text>
Kohli N, Wright KT, Sammons RL, Jeys L, Snow M, Johnson WEB. 2015. An In Vitro Comparison of the Incorporation, Growth, and Chondrogenic Potential of Human Bone Marrow versus Adipose Tissue Mesenchymal Stem Cells in Clinically Relevant Cell Scaffolds Used for Cartilage Repair. Cartilage, 252-263, vol. 6(4). link> doi>
Roberts S, Evans H, Wright K, van Niekerk L, Caterson B, Richardson JB, Kumar KHS, Kuiper JH. 2015. ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis Cartilage, 1622-1626, vol. 23(9). link> doi> full text>
Walter MNM, Kohli N, Khan N, Major T, Fuller H, Wright KT, Kuiper J-H, Johnson WEB. 2015. Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. J Stem Cells Regen Med, 18-24, vol. 11(1). link> doi> full text>
Bara JJ, Turner S, Roberts S, Griffiths G, Benson R, Trivedi JM, Wright KT. 2015. High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro. Exp Cell Res, 93-104, vol. 333(1). link> doi> full text>
Wright KT, Uchida K, Bara JJ, Roberts S, El Masri W, Johnson WEB. 2014. Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine J, 1722-1733, vol. 14(8). link> doi> full text>
Wright KT, Mennan C, Fox H, Richardson JB, Banerjee R, Roberts S. 2013. Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regen Med, 699-709, vol. 8(6). link> doi> full text>
Mennan C, Wright K, Bhattacharjee A, Balain B, Richardson J, Roberts S. 2013. Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. Biomed Res Int, 916136, vol. 2013. link> doi> full text>
Nakajima H, Uchida K, Guerrero AR, Watanabe S, Sugita D, Takeura N, Yoshida A, Long G, Wright KT, Johnson WEB, Baba H. 2012. Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury. JOURNAL OF NEUROTRAUMA, 1614-1625, vol. 29(8). link> doi> full text>
Wright KT, El Masri W, Osman A, Chowdhury J, Johnson WEB. 2011. Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells, 169-178, vol. 29(2). link> doi> full text>
Wright KT, El Masri W, Osman A, Chowdhury J, Johnson WE. 2010. Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Application. Stem Cells. doi> full text>
Wright KT, Seabright R, Logan A, Lilly AJ, Khanim F, Bunce CM, Johnson WEB. 2010. Extracellular Nm23H1 stimulates neurite outgrowth from dorsal root ganglia neurons in vitro independently of nerve growth factor supplementation or its nucleoside diphosphate kinase activity. Biochem Biophys Res Commun, 79-85, vol. 398(1). link> doi> full text>
Wright KT, Griffiths GJ, Johnson WEB. 2010. A comparison of high-content screening versus manual analysis to assay the effects of mesenchymal stem cell-conditioned medium on neurite outgrowth in vitro. J Biomol Screen, 576-582, vol. 15(5). link> doi> full text>
Walter MNM, Wright KT, Fuller HR, MacNeil S, Johnson WEB. 2010. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res, 1271-1281, vol. 316(7). link> doi>
Bajada S, Marshall MJ, Wright KT, Richardson JB, Johnson WEB. 2009. Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells. Bone, 726-735, vol. 45(4). link> doi> full text>
Chamberlain G, Wright K, Rot A, Ashton B, Middleton J. 2008. Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. PLoS One, e2934, vol. 3(8). link> doi> full text>
Wright KT, Masri WE, Osman A, Roberts S, Trivedi J, Ashton BA, Johnson WEB. 2008. The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury: implications for future cell transplantation therapy. Spinal Cord, 811-817, vol. 46(12). link> doi> full text>
JOHNSON WEB, Osman A, Roberts S, Wright KT. 2007. Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. Biochemical and Biophysical Research Communications, 559-566, vol. 354(2). doi>
Johnson WE, Sivan S, Wright KT, Eisenstein SM, Maroudas A, Roberts S. 2006. Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan. Spine, 1187-1193, vol. 31. doi>

Chapters

Harrison P, Hopkins T, Hulme C, Mccarthy H, Wright K. 2022. Chondrocyte Isolation and Expansion. In Cartilage Tissue Engineering. Springer Nature. doi> link>

Other

McDonald J, Wright K, Mennan C, Peffers MJ, Perry J, Roberts S, Newall K, Henson F, Hulme C. Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells. full text>
Hulme C, Roberts S, Gallacher P, Jermin P, Wright K. PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA. Orthopaedic Proceedings (p. 76, vols. 105-B). Bone & Joint. doi> link>
Hulme C, Williams A, Vincent T, Watt FE, Wright KT. 2023. Commonality Between The Proteome Signatures Of Clinical Response To Surgically Sustained And Acute Traumatic Cartilage Injuries In Two Human Knee Cohorts. Osteoarthritis and Cartilage (p. S357, vol. 31). Elsevier. doi> link> full text>
Perry J, Hulme C, Rix L, Mccarthy H, Lan T, Roberts S, Snow M, Wright K. 2023. Assessing Allogeneic Chondroprogenitor Manufacture Under Good Manufacturing Practice (GMP) Serum Free And Xeno-Free Conditions. Osteoarthritis and Cartilage (pp. S231-S232, vol. 31). Elsevier. doi> link> full text>
Hulme C, Garcia J, Perry J, Baird D, Freeman R, Kiely N, Wright KT. Up-scale Manufacture of Chondrocytes from Adult and Juvenile Cartilage Donors for Allogeneic Chondrocyte Therapies. Osteoarthritis and Cartilage. Elsevier. doi> full text>
Hulme C, Perry J, Lan T, Rix L, Freeman R, Kiely N, Williams D, Wright J, Wright K. CHONDROCYTES FROM TWO JUVENILE DONOR SOURCES (POLYDACTYLY DIGITS AND ILIAC APOPHYSIS) CAN BE UP-SCALE EXPANDED IN THE QUANTUM® BIOREACTOR. European Cells and Materials. European Cells & Materials Ltd.
Hulme C, Bailey S, Hopkins T, Mccarthy H, Snow M, Wright K. Assessing allogeneic chondroprogenitor manufacture in xeno-free and serum-free media. Cartilage. SAGE Publications. link>
Hulme C, Garcia J, Freeman R, Kiely N, Williams D, Wright J, Wright K. Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?. Cartilage. SAGE Publications. full text>
Hulme C, Gallacher P, Jermin P, Roberts S, Wright K. 2021. Altered Acute Phase Response signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation. link> doi> full text>
Hulme C, Perry J, Roberts S, Gallacher P, Jermin P, Wright K. 2021. Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. The Bone and Joint Journal (vols. 103-B). British Editorial Society of Bone and Joint Surgery. link> doi> full text>
Hulme C, Garcia J, Mennan C, Roberts S, Freeman R, Kiely N, Williams D, Banerjee R, Meyer C, Wright K. The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies. eCM Periodical. full text>
Hulme C, Roberts S, Mennan C, Wright K, Snow M. IS ORTHOPAEDICS LEADING THE WAY IN GETTING CELL THERAPY TO THE CLINIC?. European Cells and Materials (ECM). European Cells & Materials Ltd. full text>
Perry J, Mennan C, McCarthy HS, Bou-Gharios G, van 't Hof R, Milner P, Wright KT, Roberts S. 2019. HUMAN UMBILICAL CORD MESENCHYMAL STROMAL CELLS DO NOT EVOKE AN IMMUNE RESPONSE IN THE PARTIAL MEDIAL MENISCECTOMY MURINE MODEL OF OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE (pp. S438-S439, vol. 27). link> doi>
Hulme C, Roberts S, Gallacher P, Jermin P, Richardson J, Wright K. Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation. Journal of Cartilage and Joint Preservation. SAGE Publications. full text>
Hulme CH, Wilson E, Fuller HR, Roberts S, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A2, vol. 99). link>
Hulme CH, Wilson EL, Fuller HR, Roberts SR, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS CHONDROCYTE IMPLANTATION. OSTEOARTHRITIS AND CARTILAGE (p. S167, vol. 26). link> doi> full text>
Hulme CH, Richardson JB, Gallacher P, Roberts SR, Wright KT. 2018. ASSESSMENT OF CANDIDATE PREDICTIVE PROTEIN BIOMARKERS FOR MICROFRACTURE AND OSTEOTOMY. OSTEOARTHRITIS AND CARTILAGE (pp. S191-S192, vol. 26). link> doi> full text>
Garcia JK, Mennan C, Roberts S, Richardson J, Gallagher P, Wright K. 2018. CHARACTERISATION OF SYNOVIAL FLUID CELLS OF EARLY OSTEOARTHRITIS PATIENTS. OSTEOARTHRITIS AND CARTILAGE (pp. S128-S129, vol. 26). link> doi>
Sykes JG, Kuiper J, Richardson JB, Wright KT, Kuiper NJ. 2018. IMPACT OF HUMAN PLATELET LYSATE ON THE EXPANSION AND CHONDROGENIC CAPACITY OF CULTURED HUMAN CHONDROCYTES FOR CARTILAGE CELL THERAPY. OSTEOARTHRITIS AND CARTILAGE (p. S103, vol. 26). link> doi>
Mennan C, Roberts S, Garcia J, Hulme C, Wright K. 2018. Modelling and predicting the long-term clinical outcome of autologous chondrocyte implantation. Osteoarthritis and Cartilage (pp. S146-S147, vol. 26). Elsevier. link> doi>
Mennan C, Roberts S, Garcia J, Hulme C, Wright K. 2018. ASSESSING THE CHARACTERISTICS OF HUMAN MESENCHYMAL STROMAL CELLS DERIVED FROM BONE MARROW AND UMBILICAL CORD FOLLOWING EXPANSION IN THE QUANTUM (R) HOLLOW-FIBRE BIOREACTOR SYSTEM. OSTEOARTHRITIS AND CARTILAGE (pp. S146-S147, vol. 26). link> doi> full text>
Hulme C, Wilson E, Fuller HR, Roberts S, Richardson J, Gallacher P, Peffers M, Shirran S, Botting C, Wright K. Can we identify altered biological pathways and novel candidate biomarkers in individuals who do respond clinically following Autologous Chondrocyte Implantation?. European Cells and Materials.
Garcia J, Hulme CH, Roberts S, Richardson JB, Kuiper JH, Wright KT. 2017. Similar phenotypes of cells in the repair tissues following microfracture or autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A23, vol. 98). link>
Wright KT, McCarthy H, Forsyth N, Roberts S. 2017. CHARACTERISTICS OF HUMAN BONE MARROW MSCS ARE SENSITIVE TO MONONUCLEAR CELL SEPARATION TECHNIQUE AND OXYGEN TENSION. CYTOTHERAPY (p. S119, vol. 19). link>
Ziya S, Medcalf N, El A, Wright KT. 2017. FACILITATING THE OPERATIONAL READINESS OF THE NHS FOR THE IN-HOUSE MANUFACTURE AND DELIVERY OF AUTOLOGOUS CELL THERAPY. CYTOTHERAPY (p. S89, vol. 19). link>
Hulme CH, Wilson EL, Peffers MJ, Peffers MJ, Fuller H, Roberts S, Simpson DM, Richardson JB, Gallacher P, Wright KT. 2017. POOR CLINICAL RESPONSE TO AUTOLOGOUS CHONDROCYTE IMPLANTATION IS ASSOCIATED WITH A UNIQUE SYNOVIAL FLUID PROTEOME PROFILE. OSTEOARTHRITIS AND CARTILAGE (p. S92, vol. 25). link> doi> full text>
McCarthy HS, Wright KT, Williams JM, Gallacher P, Richardson JB, Roberts S. 2016. Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (pp. A11-A12, vol. 97). Wiley. link> doi> link>
Wright KT, Wilson E, Hulme C, Kuiper JH, Gallacher P, Richardson JB, Roberts S. 2016. Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A24, vol. 97). link>
Turner SA, Wright KT, Trivedi J, Roberts S. 2014. The response of intervertebral disc cells and mesenchymal stromal cells to altered levels of glucose and serum in vitro. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A34, vol. 95). link>
Lam KP, Dempsy KP, Smith WA, Wright KT, Masri WE, Richardson JB, IEEE. 2013. A Computational Approach to Quantifying Axon Regeneration in the Presence of Mesenchymal Stem Cells (MSCs). 2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER) (pp. 1541-1544). link>
Jones P, Uchida K, Wright KT, Roberts S. 2011. Influence of small proteoglycans on nerve growth in the intervertebral disc. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A12, vol. 92). link>
Johnson WEB, Wright KT, Roberts S, Bishop P. 2007. The small leucine-rich proteoglycan, opticin, is inhibitory to neurite extension and endothelial migration and is present in the neonatal intervertebral disc and vertebral growth plate. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A65, vol. 88). link>

Collaborations and grants awards

Collaborators

• Professor Sally Roberts
Director of Spinal Research
RJAH Orthopaedic Hospital

• Professor James Richardson
Professor of Orthopaedic and Traumatic Surgery
RJAH Orthopaedic Hospital

• Dr Eustace Johnson
   Professor of Stem Cells and Regenerative Biology
   Senior Faculty Postgraduate Research Tutor Faculty Research Co-ordinator Biological Sciences
   Faculty of Medicine Dentistry and Life Sciences
   University of Chester

• Dr Gareth Griffiths
   Director of Science
   Imagenbiotech
   University of Manchester

• Wagih S El Masry
   Consultant Surgeon in Spinal Injuries
   Former President of International Spinal Cord Society (ISCOS)
   RJAH Orthopaedic Hospital

• Aheed Osman
   Consultant Surgeon in Spinal Injuries
   Midland Centre for Spinal Injuries
   RJAH Orthopaedic Hospital

• J Roy Chowdhury
   Consultant in Spinal Injuries & Rehabilitation Medicine
   Midlands Centre for Spinal Injuries
   RJAH Orthopaedic Hospital

School address:
School of Pharmacy and Bioengineering
Hornbeam Building
Keele University
Staffordshire
ST5 5BG

Research centre address:
School of Pharmacy and Bioengineering
Guy Hilton Research Centre
Thornburrow Drive
Stoke-on-Trent
ST4 7QB
Tel: +44 (0) 1782 674988

Jack Ashley building accessibility

Undergraduate enquiries:
Email: enquiries@keele.ac.uk
Tel: +44 (0)1782 734010

Postgraduate enquiries:
Please contact the CPD4ALL team:
Email: phab.postgraduate@keele.ac.uk

Keele Centre for Medicines Optimisation (KCMO)
Tel: +44 (0)1782 733831 / 734131

The Virtual Patient project enquiries:
Contact our Digital Development team:
Email: pharmacy.digital@keele.ac.uk

Dr Karina Wright