Heidi Fuller

Biography

Dr Heidi Fuller is a Senior Lecturer at Keele University and research group leader within the Wolfson Centre for Inherited Neuromuscular Disease, based at Keele’s partner site, the RJAH Orthopaedic Hospital.

Heidi received her first degree in Biomolecular Science at the University of Wales, Bangor, and during her second year was awarded a North West Wales NHS-funded research scholarship under the supervision of Professor Michael Doenhoff. She then completed an industry-sponsored PhD studentship at the University of Wales, North East Wales Institute, where she developed expertise in proteomics technology, under the supervision of Professor Glenn Morris. Following a period of postdoctoral research within the NHS focused mainly on neuromuscular disorders and proteomics technology, Heidi joined Keele as an independent Research Fellow in 2013 and as a part-time Teaching Fellow in the School of Medicine in 2014. In 2016, she was appointed as a Lecturer in the School of Medicine and was subsequently promoted to Senior Lecturer in 2019. From 2016 – April 2021, Heidi was the Course Director for the Masters in Medical Sciences programmes within Postgraduate Medicine.

In April 2021, Heidi was appointed as Dean of Education for the Faculty of Medicine and Health Sciences and looks forward to supporting the Faculty to achieve its education-related goals.

Research and scholarship

Research theme: Cardio-Respiratory, Neuroscience & Neurology

Dr Fuller’s research group is based at the Wolfson Centre for Inherited Neuromuscular Disease (RJAH Orthopaedic Hospital), where they focus on several of the most severe muscle-wasting diseases, including muscular dystrophy, and the childhood form of motor neuron disease, spinal muscular atrophy. By combining the use of cutting edge proteomics and bioinformatics tools with biochemical approaches their aim is to understand disease mechanisms and to identify novel proteins and pathways that can be modulated by drug treatment.

External collaborators include:

Prof Tom Gillingwater (Edinburgh University, UK)
Prof Kevin Talbot (Oxford University, UK)
Dr Gillian Hunter (Glasgow Caledonian University)
Dr Tom Wishart (The Roslin Institute, Edinburgh)
Dr Dhruv Sareen (Ceders Sinai Medical Center, Los Angeles)
Prof Goran Simic (University of Zagreb, Croatia)

Funded projects (current):

Joint Sparks and GOSH Charity National Funding (UK)
Therapy development for childhood motor neuron disease
Awarded to Heidi Fuller (Principal Applicant)

Keele University
Funding for 3-year PhD studentship
Awarded to Heidi Fuller (Principal Applicant)

Newlife Foundation for Disabled Children, UK
Omics-assisted drug discovery for childhood motor neuron disease
Awarded to Heidi Fuller (Principal Applicant)

Spinal Injuries Fund, RJAH Orthopaedic Hospital (UK)
A Systems Biology Approach to Identify Prognostic Indicators and New Targets for the Treatment of Spinal Cord Injury
Awarded to Karina Wright (Principal Applicant) and Heidi Fuller (Co-applicant)

Keele University
Funding for 3-year PhD studentship
Awarded to Monte Gates (Principal Applicant) and Heidi Fuller (Co-applicant)

Arthritis Research (UK)
Individualisation of biological therapies for osteoarthritis – understanding and reducing failures. Awarded to Karina Wright (Principal Applicant), and co-applicants Sally Roberts, Heidi Fuller and James Richardson.

Funded projects (completed):

The SMA Trust (UK)
Two-year Career Development Fellowship: The molecular consequences of reduced SMN in iPS-derived human motor neurons
Awarded to Heidi Fuller (Principal Applicant)

Henry Smith Charity (UK)
Identifying and Quantifying Growth Promoting Signals in the Developing Spinal Cord
Awarded to Monte Gates (Principal Applicant) and Heidi Fuller (Co-applicant)

RJAH Charitable Funds (UK)
Anti-epileptic drugs and bone loss
Awarded to Heidi Fuller (Principal Applicant), and co-applicants Mark Garton & Glenn Morris

Henry Smith Charity (UK)
Identifying and Quantifying Growth Promoting Signals in the Developing Spinal Cord
Awarded to Monte Gates (Principal Applicant) and Heidi Fuller (Co-applicant)

RJAH Institute of Orthopaedics (UK)
Human stem-cell-derived motor neurons for testing potential therapeutic pathways in Spinal Muscular Atrophy (SMA), using both targeted and proteomic approaches
Awarded to Heidi Fuller (Principal Applicant).

RJAH Institute of Orthopaedics (UK), Childwick Trust, and Lord Leverhulme’s Charitable Trust(UK)
Nutritional protection against neurodegenerative disease
Awarded to Heidi Fuller (Principal Applicant).

North Staffordshire Medical Institute (UK)
Identification of biomarkers using mass spectrometry
Awarded to Paul Roach (Principal Applicant), Heidi Fuller (co-applicant), et al.

RJAH Institute of Orthopaedics (UK)
Funding awarded to support the service contract of the 4800 MALDI TOF/TOF mass spectrometer. Awarded to Glenn Morris (Principal Applicant) and Heidi Fuller (co-applicant).

Teaching

Dr Fuller regularly supervises research students from the School of Medicine and the School of Pharmacy and Bioengineering.

Previous teaching roles include:

Director for the Masters in Medical Science (MMedSci), School of Medicine (2016 – 2021)

MMedSci dissertation module lead (2013 – 2019)

Selected Publications

Šoltić D, Shorrock HK, Allardyce H, Wilson EL, Holt I, Synowsky SA, Shirran SL, Parson SH, Gillingwater TH, Fuller HR. 2019. Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy. Hum Mol Genet, 3515-3527, vol. 28(21). link> doi> full text>
Llavero Hurtado M, Fuller HR, Wong AMS, Eaton SL, Gillingwater TH, Pennetta G, Cooper JD, Wishart TM. 2017. Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Sci Rep, 12412, vol. 7(1). link> doi> full text>
Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, Morris GE, Sareen D. 2015. Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Front Cell Neurosci, 506, vol. 9. link> doi> full text>
Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH. 2014. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. J Clin Invest, 1821-1834, vol. 124(4). link> doi> full text>
Nafchi NAM, Chilcott EM, Owen SJ, Fuller H, Bowerman M, Yáñez-Muñoz RJ. Enhanced expression of the human Survival motor neuron 1 gene from a sequence-optimised cDNA transgene in vitro and in vivo. Gene Therapy (Basingstoke). full text>

Full Publications Listshow

Books

Fuller HR and Gates MA (Eds.). 2016. Recovery of Motor Function Following Spinal Cord Injury. (12 vols.). Intech. link>

Journal Articles

Nafchi NAM, Chilcott EM, Owen SJ, Fuller H, Bowerman M, Yáñez-Muñoz RJ. Enhanced expression of the human Survival motor neuron 1 gene from a sequence-optimised cDNA transgene in vitro and in vivo. Gene Therapy (Basingstoke). full text>
Storey EC and Fuller HR. 2022. Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary. Cells, vol. 11(24). link> doi> full text>
Ghanem M, Brown SJ, Eat Mohamed A, Fuller HR. 2022. A meta-summary and bioinformatic analysis identified interleukin 6 as a master regulator of COVID-19 severity biomarkers. Cytokine, 156011, vol. 159. link> doi> full text>
Brown SJ, Kline RA, Synowsky SA, Shirran SL, Holt I, Sillence KA, Claus P, Wirth B, Wishart TM, Fuller HR. 2022. The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap. Cells, vol. 11(17). link> doi> full text>
Hulme CH, Fuller HR, Riddell J, Shirran SL, Botting CH, Osman A, Wright KT. 2022. Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 320-325, vol. 60(4). link> doi> full text>
Murphy LJ, Fuller HR, Willan PLT, Gates M. 2021. An Anatomy of the Blood Eagle: The Practicalities of Viking Torture. Speculum. full text>
Holt I, Fuller HR, Schindler RFR, Shirran SL, Brand T, Morris GE. 2020. An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. BMC Mol Cell Biol, 88, vol. 21(1). link> doi> full text>
Storey EC, Holt I, Morris GE, Fuller HR. 2020. Muscle cell differentiation and development pathway defects in Emery-Dreifuss muscular dystrophy. Neuromuscul Disord, 443-456, vol. 30(6). link> doi> full text>
Gómez-Gálvez Y, Fuller HR, Synowsky S, Shirran SL, Gates MA. 2020. Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. J Neurosci Res, 1417-1432, vol. 98(7). link> doi> full text>
Šoltić D and Fuller HR. 2020. Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy. Neuroscience Insights. link> doi> link> full text>
Holt I, Fuller HR, Lam LT, Sewry CA, Shirran SL, Zhang Q, Shanahan CM, Morris GE. 2019. Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle. Sci Rep, 14202, vol. 9(1). link> doi> full text>
Šoltić D, Shorrock HK, Allardyce H, Wilson EL, Holt I, Synowsky SA, Shirran SL, Parson SH, Gillingwater TH, Fuller HR. 2019. Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy. Hum Mol Genet, 3515-3527, vol. 28(21). link> doi> full text>
Šoltić D, Bowerman M, Stock J, Shorrock HK, Gillingwater TH, Fuller HR. 2018. Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA). Brain Sci, vol. 8(12). link> doi> full text>
Gul W, Fuller HR, Wright H, Sen J. 2018. A Systematic Review and Meta-Analysis of the Effectiveness of Surgical Decompression in Treating Patients with Malignant Middle Cerebral Artery Infarction. World Neurosurg, e902-e920, vol. 120. link> doi> full text>
Chen CPC, Preston JE, Zhou S, Fuller HR, Morgan DGA, Chen R. 2018. Proteomic analysis of age-related changes in ovine cerebrospinal fluid. Exp Gerontol, 181-188, vol. 108. link> doi> full text>
Hulme CH, Wilson EL, Fuller HR, Roberts S, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Res Ther, 87, vol. 20(1). link> doi> full text>
Lake B, Fuller HR, Rastall S, Usman T. 2019. Breast Reconstruction Affects Coping Mechanisms in Breast Cancer Survivors. INDIAN JOURNAL OF SURGERY, 43-50, vol. 81(1). link> doi> full text>
Fuller HR, Shorrock HK, Gillingwater TH, Pigott A, Smith V, Kulshrestha R, Sewry CS, Willis TA. 2017. Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis. Journal of Neuromuscular Diseases, Article 4, vol. 4. doi> link> full text>
Llavero Hurtado M, Fuller HR, Wong AMS, Eaton SL, Gillingwater TH, Pennetta G, Cooper JD, Wishart TM. 2017. Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Sci Rep, 12412, vol. 7(1). link> doi> full text>
Fuller HR. Reflections on an issue of student diversity: unintentional plagiarism among international students. The Journal of Academic Development and Education. full text>
Brown SJ, Fuller HR, Jones P, Caterson B, Shirran SL, Botting CH, Roberts S. 2017. Contaminants in commercial preparations of 'purified' small leucine-rich proteoglycans may distort mechanistic studies. Biosci Rep, vol. 37(1). link> doi> full text>
Hulme CH, Brown SJ, Fuller HR, Riddell J, Osman A, Chowdhury J, Kumar N, Johnson WE, Wright KT. 2017. The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood. Spinal Cord, 114-125, vol. 55(2). link> doi> full text>
Mladinov M, Sedmak G, Fuller HR, Babić Leko M, Mayer D, Kirincich J, Štajduhar A, Borovečki F, Hof PR, Šimić G. 2016. Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia. Transl Neurosci, 139-150, vol. 7(1). link> doi> full text>
Fuller HR, Gillingwater TH, Wishart TM. 2016. Commonality amid diversity: Multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy. Neuromuscul Disord, 560-569, vol. 26(9). link> doi> full text>
Doenhoff MJ, El-Faham M, Liddell S, Fuller HR, Stanley RG, Schramm G, Igetei JE. 2016. Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs). PLoS One, e0159542, vol. 11(7). link> doi> full text>
Doenhoff MD, El-Faham M, Liddell S, Fuller HR, Stanley RG, Schramm G, Igetei JE. Antigenic cross-reactivity between Schistosoma mansoni and allergens: invesigations centered on a 43kDa rubber latex allergen (Hev b 7) and implication of cross-reactive carbohydrate determinants (CCDs). PLoS One.
Fuller HR, Graham LC, Llavero Hurtado M, Wishart TM. 2016. Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation. Expert Rev Proteomics, 659-671, vol. 13(7). link> doi> full text>
Fuller HR, Marani L, Holt I, Woodhams PL, Webb MM, Gates MA. 2017. Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain. Brain Struct Funct, 867-879, vol. 222(2). link> doi> full text>
Wilson EL, Garton M, Fuller HR. 2016. Anti-epileptic drugs and bone loss: Phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells. Epilepsy Res, 97-101, vol. 122. link> doi> full text>
Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, Morris GE, Sareen D. 2015. Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Front Cell Neurosci, 506, vol. 9. link> doi> full text>
Fuller HR, Slade R, Jovanov-Milošević N, Babić M, Sedmak G, Šimić G, Fuszard MA, Shirran SL, Botting CH, Gates MA. 2015. Stathmin is enriched in the developing corticospinal tract. Mol Cell Neurosci, 12-21, vol. 69. link> doi> full text>
Walter MNM, Kohli N, Khan N, Major T, Fuller H, Wright KT, Kuiper J-H, Johnson WEB. 2015. Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. J Stem Cells Regen Med, 18-24, vol. 11(1). link> doi> full text>
Hunter G, Roche SL, Somers E, Fuller HR, Gillingwater TH. 2014. The influence of storage parameters on measurement of survival motor neuron (SMN) protein levels: implications for pre-clinical studies and clinical trials for spinal muscular atrophy. Neuromuscul Disord, 973-977, vol. 24(11). link> doi>
Fuller HR, Hurtado ML, Wishart TM, Gates MA. 2014. The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Sci, 20, vol. 12. link> doi> full text>
Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH. 2014. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. J Clin Invest, 1821-1834, vol. 124(4). link> doi> full text>
Fuller HR, Humphrey EL, Morris GE. 2013. Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases. Future Med Chem, 2091-2101, vol. 5(17). link> doi>
Humphrey EL, Morris GE, Fuller HR. 2013. Valproate reduces collagen and osteonectin in cultured bone cells. Epilepsy Res, 446-450, vol. 106(3). link> doi>
Lam LT, Fuller HR, Morris GE. 2013. The gemin2-binding site on SMN protein: accessibility to antibody. Biochem Biophys Res Commun, 624-627, vol. 438(4). link> doi>
Roberts S, Fuller HR, Caterson B. 2013. Uphold standards for lab reagents. NATURE, 300, vol. 496(7445). link> doi>
Humphrey E, Fuller HR, Morris GE. 2012. Current research on SMN protein and treatment strategies for spinal muscular atrophy. Neuromuscul Disord, 193-197, vol. 22(2). link> doi>
Comley LH, Fuller HR, Wishart TM, Mutsaers CA, Thomson D, Wright AK, Ribchester RR, Morris GE, Parson SH, Horsburgh K, Gillingwater TH. 2011. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. HUMAN MOLECULAR GENETICS, 2406-2421, vol. 20(12). link> doi>
Fuller HR and Morris GE. 2010. SMN COMPLEXES OF NUCLEUS AND CYTOPLASM: A PROTEOMIC STUDY FOR SMA THERAPY. TRANSLATIONAL NEUROSCIENCE, 261-267, vol. 1(4). link> doi>
Fuller HR, Barisic M, Seso-Simic D, Speljko T, Morris GE, Simic G. 2010. TREATMENT STRATEGIES FOR SPINAL MUSCULAR ATROPHY. TRANSLATIONAL NEUROSCIENCE, 308-321, vol. 1(4). link> doi>
Fuller HR, Man NT, Lam LT, Shamanin VA, Androphy EJ, Morris GE. 2010. Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells. JOURNAL OF PROTEOME RESEARCH, 4228-4233, vol. 9(8). link> doi>
Walter MNM, Wright KT, Fuller HR, MacNeil S, Johnson WEB. 2010. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res, 1271-1281, vol. 316(7). link> doi>
Fuller HR, Man NT, Lam LT, Thanh LT, Keough RA, Asperger A, Gonda TJ, Morris GE. 2010. The SMN Interactome Includes Myb-Binding Protein 1a. JOURNAL OF PROTEOME RESEARCH, 556-563, vol. 9(1). link> doi>
Nguyen thi Man, Humphrey E, Lam LT, Fuller HR, Lynch TA, Sewry CA, Goodwin PR, Mackenzie AE, Morris GE. 2008. A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy. Neurology, 1757-1763, vol. 71(22). link> doi>
Hao LT, Fuller HR, Lam LT, Le TT, Burghes AHM, Morris GE. 2007. Absence of gemin5 from SMN complexes in nuclear Cajal bodies. BMC CELL BIOLOGY, Article ARTN 28, vol. 8. link> doi>
Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding CG, Galle J, Fuller HR, Stanley RG, Chiodini PL, Haas H, Doenhoff MJ. 2006. IPSE/alpha-1: A major immunogenic component secreted from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 9-19, vol. 147(1). link> doi>
Fuller HR, Goodwin PR, Morris GE. 2006. An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food. FOOD AND AGRICULTURAL IMMUNOLOGY, 43-52, vol. 17(1). link> doi>
Fuller HR, Goodwin PR, Morris GE. 2006. An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food. Food and Agricultural Immunology, 43-52.
Fuller HR, Goodwin PR, Morris GE. 2004. Shellfish allergen testing kit for food manufacturers. Advances Wales, 12.

Chapters

Fuller HR and Morris GE. 2012. Quantitative proteomics using iTRAQ labeling and mass spectrometry” in Integrative Proteomics. Eastwood Leung HC (Ed.). InTech. doi>

Other

Shaqoura E, McCallion E, Fuller H, Bowerman M. 2022. Differential expression of intermediate filament proteins: lamins A/C and desmin within and between adult skeletal muscles. NEUROMUSCULAR DISORDERS (p. S109, vol. 32). link> doi> full text>
Storey E, Holt I, Owen S, Synowsky S, Shirran S, Morris G, Fuller H. 2022. Characterising the molecular consequences of LMNA-related congenital muscular dystrophy in patient myoblasts. NEUROMUSCULAR DISORDERS (p. S108, vol. 32). link> doi>
Storey E and Fuller H. Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Neuromuscular Disorders (vol. 32). Elsevier. link> doi> link> full text>
Storey E, Khilar S, Holt I, Shirran S, Morris G, Fuller H. 2021. Identification of lamin A interactors in healthy and congenital muscular dystrophy immortalized myoblasts. NEUROMUSCULAR DISORDERS (p. S69, vol. 31). link> doi>
Storey E, Holt I, Morris G, Fuller H. 2021. A study of LINC complex proteins reveals temporal emerin and SUN2 expression changes during myoblast differentiation. NEUROMUSCULAR DISORDERS (pp. S156-S157, vol. 31). link> doi>
Owen S, Soltic D, Synowsky S, Crompton E, Yanez-Munoz R, Schneider B, Shorrock H, Shirran S, Gillingwater T, Bowerman M, Fuller H. 2021. Proteins associated with the sarcomere and costamere in hearts are dysregulated in two mouse models of spinal muscular atrophy. NEUROMUSCULAR DISORDERS (pp. S131-S132, vol. 31). link> doi>
Hulme CH, Wilson E, Fuller HR, Roberts S, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A2, vol. 99). link>
Hulme CH, Wilson EL, Fuller HR, Roberts SR, Richardson JB, Gallacher P, Peffers MJ, Shirran SL, Botting CH, Wright KT. 2018. ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS CHONDROCYTE IMPLANTATION. OSTEOARTHRITIS AND CARTILAGE (p. S167, vol. 26). link> doi> full text>
Hulme C, Wilson E, Fuller HR, Roberts S, Richardson J, Gallacher P, Peffers M, Shirran S, Botting C, Wright K. Can we identify altered biological pathways and novel candidate biomarkers in individuals who do respond clinically following Autologous Chondrocyte Implantation?. European Cells and Materials.
Owen SJ, Fuller HR, Jones P, Caterson B, Shirran SL, Botting CH, Roberts S. 2017. We may not be buying what the label says on the tin: a cautionary tale from a study of the influence of proteoglycans on nerve growth. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A4, vol. 98). link>
Hulme C, Wilson E, Peffers M, Fuller HR, Roberts S, Simpson D, Richardson J, Gallacher P, Wright K. Poor clinical response to Autologous Chondrocyte Implantation is associated with a unique synovial fluid proteome profile. Osteoarthritis and Cartilage. W. B. Saunders Co., Ltd.. doi> full text>
Lake B, Fuller HR, Rastall S, Usman T. 2016. Breast reconstruction changes coping mechanisms in breast cancer survivorship. CANCER RESEARCH (vol. 76). link> doi>
Wright K, Richardson JB, Fuller HR, Humphrey E, Jones P, Kerr A, Roberts S. 2013. Biomarker discovery for autologous chondrocyte implantation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (p. A46, vol. 94). link>
Nguyen Thi M, Humphrey E, Le T, Fuller HR, Lynch T, Sewry C, MacKenzie A, Goodwin P, Morris G. 2007. A two-site ELISA for measurement of SMN protein and its application to finding drugs for treatment of spinal muscular atrophy (SMA). NEUROMUSCULAR DISORDERS (pp. 781-782, vol. 17). link> doi>

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