Biography

Gordon Dent is a pharmacologist with interests in medical student selection, pharmacology, therapeutics & prescribing education, and pathophysiology of inflammatory diseases.
He studied at the University of London, gaining a BSc (Hons) in Pharmacology at King’s College in 1985 and a PhD in Immunopharmacology at the National Heart & Lung Institute in 1991. He subsequently worked at the Großhansdorf Institute for Pneumology and Thoracic Surgery, Germany, and the University of Southampton before joining the new School of Medicine at Keele in 2003.
Dr Dent is a board member of the Medical Schools Council Selection Alliance, a question author and peer-reviewer for the Prescribing Safety Assessment and an associate editor of the American Journal of Immunology. He is a member of the British Pharmacological Society and the Association for the Study of Medical Education.

Research and scholarship

Research theme: Therapeutics

Dr Dent’s research has focused on the roles of leukocytes and epithelium in inflammatory diseases of the lungs (asthma and COPD) and intestine (ulcerative colitis). He has a particular interest in intracellular signalling pathways in leukocytes and the mechanisms of cell-cell interactions between epithelial cells and leukocytes.
He is also active in the field of undergraduate medicine admissions, engaging in regional and national groups exploring policies and procedures.

Teaching

MBChB: Unit lead – Mechanisms of Disease (year 2); pharmacology, physiology and pathophysiology teaching across years 1, 2 & 3
V100/V300 supplementary prescribing: general pharmacology
Physiology & Pharmacology of Pain: pharmacology of inflammation and pain

Further information

Dr Dent has contributed to the development and implementation of curriculums for medicine, pharmacy and veterinary medicine. He is currently a member of the joint academic board and curriculum, programme and admissions groups for Harper Keele Veterinary School.
Along with the Access to HE team at the QAA, he has led the development of a national subject descriptor for Access to Medicine diplomas.

He engages in extensive outreach and widening participation work across the north and west midlands, as well as national events co-ordinated by the Medical Schools Council and UCAS.

 

 

Selected Publications

  • Hasan AM and Dent G. 2017. Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, vol. 13(4), 209-215. doi> full text>
  • Rees EL, Hawarden AW, Dent G, Hays R, Bates J, Hassell AB. 2016. Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37. Med Teach, vol. 38(5), 443-455. link> doi> full text>
  • Dent G, Loweth SC, Hasan AM, Leslie FM. 2014. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology, vol. 219(10), 793-797. link> doi>
  • Dent G. 2014. Eosinophil chemotaxis. Methods Mol Biol, vol. 1178, 101-110. link> doi>
  • Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. 2010. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol, vol. 10(9), 1017-1021. link> doi>

Full Publications List show

Journal Articles

  • Hasan AM and Dent G. 2017. Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, vol. 13(4), 209-215. doi> full text>
  • Rees EL, Hawarden AW, Dent G, Hays R, Bates J, Hassell AB. 2016. Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37. Med Teach, vol. 38(5), 443-455. link> doi> full text>
  • Dent G, Loweth SC, Hasan AM, Leslie FM. 2014. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology, vol. 219(10), 793-797. link> doi>
  • Dent G. 2014. Eosinophil chemotaxis. Methods Mol Biol, vol. 1178, 101-110. link> doi>
  • Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. 2010. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol, vol. 10(9), 1017-1021. link> doi>
  • Yoshikawa T, Dent G, Ward J, Angco G, Nong G, Nomura N, Hirata K, Djukanovic R. 2007. Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 175(5), 473-479. link> doi>
  • Mishra RK, Scaife JE, Harb Z, Gray BC, Djukanovic R, Dent G. 2005. Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K). ALLERGY, vol. 60(9), 1204-1207. link> doi>
  • Dent G, Hadjicharalambous C, Yoshikawa T, Handy R L C, Powell J, Anderson I K, Louis R, Davies D E, Djukanovic R. 2004. Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum. Amercian Journal of Respiratory & Crictical Care Medicine. doi>
  • Hadjicharalambous C, Dent G, May RD, Handy RLC, Anderson IK, Davies DE, Djukanovic R. 2004. Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma. Journal of Allergy & Clinical Immunology.
  • Dent G. 2003. IgE modulation in asthma. Expert Opinion on Therapeutic Patents, vol. 13(10), 1607-1617. doi>
  • Dent G. 2002. Ciclesonide. Curr Opin Invest Drugs, vol. 3, 78-83.
  • Dent G, Hosking LA, Lordan JL, Steel MD, Cruikshank WW, Center DM, Ellis JH, Holgate ST, Davies DE, Djukanovic R. 2002. Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthamatic individuals. J Allergy Clin Immunol, vol. 110, 906-914.
  • Schmidt DT, Dent G, Ruhlmann E, Munoz NM, Leff AR, Rabe KF. 2002. Studying human airway pharmacology in microsections: application of videomicrometry. Eur Respir, vol. 19, 991-996.
  • Dent G. 2001. Protein Kinase A-independent responses to beta-adrenoceptor agonists. Br J Pharmacol, vol. 133, 1199-1200.
  • Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, Davies DE. 2001. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol, vol. 25, 385-391.
  • Lordan JL, Davies DE, Wilson SJ, Dent G, Corkhill A, Jaffar Z, Roberts K, Djukanovic R, Holgate ST. 2001. The role of CD28-B7 costimulation in allergen-induced cytokine release in bronchial mucosa from patients with moderately severe asthma. J Allergy Clin Immunol, vol. 108, 976-981.

Chapters

  • DENT G. 2006. Airway Inflammation. In The Year in Allergy. (vol. 3). Clinical Publishing, Oxford.
  • DENT G, Holgate ST, Buckley MG. 2006. Asthma. In Principles of Molecular Medicine. Runge MS and Patterson C (Eds.). Humana Press.
  • Haitchi H M, Krishna M T, Holloway J H, Dent G, Buckley M G, Holgate S T. 2004. Asthma: clinical aspects and mucosal immunity. In Mucosal Immunology (3rd Edition). Mestecky J, Beinenstock J, Lamm M, Strober W, McGhee J, Mayer L (Eds.). Academic Press, San Diego.
  • Dent G and Cowling MG. Drugs used in vascular interventional radiology. In Vascular Interventional Radiology. Springer. doi>

Other

  • Dent G. 2004. BLT-1 leukotriene receptor.
  • Dent G. 2004. BLT-2 leukotriene receptor.
  • Dent G. 2004. CysLT-1 leukotriene receptor.
  • Dent G. 2004. CysLT-2 leukotriene receptor.
  • Dent G, Uddin M, Puddicombe SM, Davies E D, Djukanovic R. 2004. Eosinophils stimulate the secretion of neutrophil chemoattracants by bronichal epithelial cells. European Respiratory Journal.
  • Uddin M, Rytila P, Dent G, Davies D E, Djukanovic R. 2004. Modulation of neutrophil activation and survival by bronchial epithelial cells. European Respiratory Journal.
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