I came to Keele University as a postdoctoral researcher in 2015 working in the group of Dr Karina Wright based at the Robert Jones & Agnes Hunt (RJAH) Orthopaedic Hospital in Oswestry. My work involves utilising large ‘omic datasets and systems biology approaches coupled with bioinformatics to address important orthopaedic issues. Specifically, looking to identify predictive/prognostic biomarkers and to better understand the biology underlying both spinal cord injury and early osteoarthritis and its’ treatments.
I obtained a BSc (Hons) in Biology from The University of Manchester in 2011. My PhD in Developmental Biomedicine was awarded from The University of Manchester in 2016, where I was based in the Maternal and Fetal Health Research Centre (2011-2015), St Mary’s Hospital. During my PhD studies, I developed an interest in using systems biology approaches to identify important biological mechanisms underlying disease/injury that can be validated using cellular and molecular laboratory techniques. My thesis was entitled, ‘Investigating the effect of Diabetes mellitus on placental function: a systems biology approach’.
Research and scholarship
My research is based in the Centre for Spinal Studies at the Robert Jones and Agnes Hunt Orthopaedic Hospital. My work focusses on using innovative ‘omic (transciptomic, quantitative proteomics and metabolomics) and bioinformatic approaches coupled with biochemical/ molecular biology techniques to address significant questions in orthopaedics namely, identifying biomarkers for stratification of therapies for cartilage repair/early osteoarthritis and to predict the outcome/severity of spinal cord injury (SCI).
- Utilising ‘omic and systems biology approaches to address important clinical/biomedical issues
- Bioinformatic analysis of ‘omic datasets (network ontology analysis)
- Biomarker identification and validation (SCI and early osteoarthritis/cartilage injury)
- Biology & pathology of musculoskeletal disorders and spinal cord injury
- Cell-based therapies for the repair of musculoskeletal and spinal cord tissues