Charlotte Hulme

Biography

Dr Charlotte Hulme is a Lecturer at in the School of Pharmacy and Bioengineering (PhaB) based at Keele’s partner site, the Robert Jones and Agnes Hunt Orthopaedic Hospital (RJAH), Oswestry.

Charlotte obtained a BSc (Hons) in Biology from The University of Manchester in 2011. She then completed a joint MRC/ Manchester Alumni Impact Scholarship funded PhD in Developmental Medicine at the University of Manchester. Here, she developed an interest in using systems biology approaches (transcriptomics/ proteomics/ metabolomics) to identify important biological mechanisms underlying disease/injury that can be validated using cellular and molecular laboratory techniques.

In 2015, she joined Keele University as a postdoctoral research associate working in the groups of Dr Karina Wright and Prof Sally Roberts. She has worked on projects to identify biomarkers to predict outcome following Spinal Cord Injury and treatments for cartilage repair/early Osteoarthritis.

In 2017, Charlotte became a part-time Teaching Fellow in the School of Medicine. In 2021, she was appointed as a part-time Lecturer (Education and Scholarship contract) in the School of Medicine in 2021, acting as Director for the Masters in Medical Sciences programme. Charlotte was promoted to a research and scholarship post as a Lecturer in Regenerative Medicine from December 2022.

Charlotte is a membership lead for the Centre for Regenerative Medicine and is a member of the Keele FMHS Ethics committee.

Research and scholarship

Research Theme: Regenerative Medicine

Dr Charlotte Hulme’s research groups sits within the Oswestry Keele Orthopaedic Research group. Her work focuses on using ‘omic (transcriptomic, quantitative proteomics and metabolomics) and bioinformatics approaches coupled with biochemical/ molecular biology techniques to address significant questions in orthopaedics.

This includes identifying biomarkers for stratification of therapies for cartilage repair/early osteoarthritis and to predict the outcome/severity of spinal cord injury (SCI). Her current research is focused on understanding the role of cellular metabolism in contributing to osteoarthritis and affiliated therapies. She is also highly involved in projects aimed at developing novel allogeneic therapies for the treatment of cartilage defects and is currently funded on an MRC project aimed at developing novel chondrocyte therapies.

• Utilising ‘omic and systems biology approaches to address important clinical/biomedical issues
• Bioinformatics analysis of ‘omic datasets
• Biomarker identification and validation (SCI and early osteoarthritis/cartilage injury and its’ treatments)
• Biology & pathology of musculoskeletal disorders and spinal cord injury
• Cell-based therapies for the repair of cartilage defects
• Up-scale manufacture of cells in bioreactor systems (QuantumTM)

Charlotte has been PI and Co-I on several studies including funding from the Institute of Orthopaedics and the MRC.

Please contact Dr Hulme via email for enquiries relating to self-funded PhD studentships. 

Teaching

Dr Hulme is the Module Lead for a third year undergraduate module (PHA-30033 Precision Medicine) and co-module lead for a masters module (MTE-40022). She also contributes to delivery of others undergraduate and postgraduate modules in the Schools of Pharmacy and Bioengineering and School of Life Sciences (e.g. LSC-30068- Applied Regenerative Medicine and MTE-40055 - Disease Modelling & Therapy for Regenerative Medicine).

Charlotte supervises undergraduate project and undergraduate/postgraduate research students from the School of Pharmacy and Bioengineering.

Director for the Masters in Medical Science (MMedSci), School of Medicine (April 2021- December 2022)
MMedSci dissertation module lead (2017-2018)

PhD students

• Mateus Bernardo Harrington (Co-supervisor 2018-2021)
• Tian Lan (Joint Lead Supervisor 2020-present)
• Jessica Fisher Stokes (Co-supervisor 2021-present)
• Henry Barrett (Co-supervisor 2022-present)
• Abigail Jones (Co-supervisor 2022-present)