Prof Glenn Morris

Title: Professor of Biochemistry
Phone: +44 (0)1691 404155
Email: glenn.morris@rjah.nhs.uk
Location: Wolfson Centre for Neuromuscular Disease, TORCH Building, Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire SY10 7AG, United Kingdom
Role: ISTM Research theme: Therapeutics
Contacting me: By phone or e-mail.
Prof Glenn Morris

The main aim of the Group is to produce monoclonal antibodies and use them as highly-specific research tools for analysis of molecular mechanisms in the pathogenesis of human genetic disease and in the search for new therapies. The Research Laboratory interacts closely with consultant pathologist and physician members of the Wolfson Centre.

The Wolfson Centre runs the Muscular Dystrophy Association Monoclonal Antibody Resource (Manager: Dr Le Thanh Lam) which distributes free antibodies for research into neuromuscular disease worldwide (www.glennmorris.org.uk/mabs.htm). The antibodies are widely used in clinical trials of new treatments for Duchenne muscular dystrophy.

 

 

ISTM Research theme: Therapeutics

Research Interests:

• Monoclonal antibody studies of myotonic dystrophy (Dr Ian Holt).

• Monoclonal antibody studies Emery-Dreifuss MD(Dr Ian Holt).

• Proteomic studies of spinal muscular atrophy (Dr. Heidi Fuller).

• Cellular models for McArdle Disease (Dr. Kathryn Wright).

• An SMN ELISA to find new drugs for spinal muscular atrophy (Dr Nguyen thi Man and Dr Emma Humphrey).

• Monoclonal antibody studies of dystrophin and related proteins (Dr. Le Thanh Lam).

 

Funding:

The Group is entirely funded by medical research charities with a direct research income averaging £150-250K per annum.

Current research grant funding is provided by the British Heart Foundation, the Muscular Dystrophy Association (USA) and CureCMD (USA)

 

Please see: www.glennmorris.org.uk

Selected Publications

  • Zhou C, Li C, Zhou B, Sun H, Koullourou V, Holt I, Puckelwartz MJ, Warren DT, Hayward R, Lin Z, Zhang L, Morris GE, McNally EM, Shackleton S, Rao L, Shanahan CM, Zhang Q. Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis. Hum Mol Genet, vol. 26(12), 2258-2276. link> doi>
  • Holt I, Duong NT, Zhang Q, Lam LT, Sewry CA, Mamchaoui K, Shanahan CM, Morris GE. 2016. Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody. BMC cell biology, vol. 17(1). doi> link> full text>
  • Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM. 2016. Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113(3), E291-E299. link> doi>
  • Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, Morris GE, Sareen D. 2015. Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Front Cell Neurosci, vol. 9, 506. link> doi> full text>
  • Morris GE. 2015. Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery-Dreifuss muscular dystrophy. Neuromuscul Disord, vol. 25(2), 137. link> doi>

Full Publications List show

Journal Articles

  • Zhou C, Li C, Zhou B, Sun H, Koullourou V, Holt I, Puckelwartz MJ, Warren DT, Hayward R, Lin Z, Zhang L, Morris GE, McNally EM, Shackleton S, Rao L, Shanahan CM, Zhang Q. Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis. Hum Mol Genet, vol. 26(12), 2258-2276. link> doi>
  • Holt I, Duong NT, Zhang Q, Lam LT, Sewry CA, Mamchaoui K, Shanahan CM, Morris GE. 2016. Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody. BMC cell biology, vol. 17(1). doi> link> full text>
  • Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM. 2016. Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113(3), E291-E299. link> doi>
  • Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, Morris GE, Sareen D. 2015. Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Front Cell Neurosci, vol. 9, 506. link> doi> full text>
  • Morris GE. 2015. Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery-Dreifuss muscular dystrophy. Neuromuscul Disord, vol. 25(2), 137. link> doi>
  • Humphrey EL, Lacey E, Le LT, Feng L, Sciandra F, Morris CR, Hewitt JE, Holt I, Brancaccio A, Barresi R, Sewry CA, Brown SC, Morris GE. 2015. A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core protein in some, but not all, dystroglycanopathy patients. Neuromuscul Disord, vol. 25(1), 32-42. link> doi>
  • Wishart TM, Mutsaers CA, Riessland M, Reimer MM, Hunter G, Hannam ML, Eaton SL, Fuller HR, Roche SL, Somers E, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Joshi A, Hohenstein P, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH. 2014. Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. J Clin Invest, vol. 124(4), 1821-1834. link> doi> full text>
  • Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, Austin CP, Hayes CJ, Brook JD. 2014. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Hum Mol Genet, vol. 23(6), 1551-1562. link> doi>
  • Kodippili K, Vince L, Shin J-H, Yue Y, Morris GE, McIntosh MA, Duan D. 2014. Characterization of 65 epitope-specific dystrophin monoclonal antibodies in canine and murine models of duchenne muscular dystrophy by immunostaining and western blot. PLoS One, vol. 9(2), e88280. link> doi>
  • Duong NT, Morris GE, Lam LT, Zhang Q, Sewry CA, Shanahan CM, Holt I. 2014. Nesprins: tissue-specific expression of epsilon and other short isoforms. PLoS One, vol. 9(4), e94380. link> doi> full text>
  • Le TL, Nguyen TM, Morris GE. 2014. Monoclonal antibodies for clinical trials of Duchenne muscular dystrophy therapy. Neuromuscul Disord, vol. 24(3), 195-200. link> doi>
  • Lam LT, Fuller HR, Morris GE. 2013. The gemin2-binding site on SMN protein: accessibility to antibody. Biochem Biophys Res Commun, vol. 438(4), 624-627. link> doi>
  • Humphrey EL, Morris GE, Fuller HR. 2013. Valproate reduces collagen and osteonectin in cultured bone cells. Epilepsy Res, vol. 106(3), 446-450. link> doi>
  • Zuleger N, Boyle S, Kelly DA, de las Heras JI, Lazou V, Korfali N, Batrakou DG, Randles KN, Morris GE, Harrison DJ, Bickmore WA, Schirmer EC. 2013. Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. GENOME BIOLOGY, vol. 14(2), Article ARTN R14. link> doi>
  • Tome S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE. 2013. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA REPAIR, vol. 12(1), 46-52. link> doi>
  • Birch KE, Quinlivan RM, Morris GE. 2013. Cell models for McArdle disease and aminoglycoside-induced read-through of a premature termination codon. Neuromuscul Disord, vol. 23(1), 43-51. link> doi>
  • Lynch TA, Lam LT, Man NT, Kobayashi K, Toda T, Morris GE. 2012. Detection of the dystroglycanopathy protein, fukutin, using a new panel of site-specific monoclonal antibodies. Biochem Biophys Res Commun, vol. 424(2), 354-357. link> doi>
  • Sewry CA, Quinlivan RCM, Squier W, Morris GE, Holt I. 2012. A rapid immunohistochemical test to distinguish congenital myotonic dystrophy from X-linked myotubular myopathy. NEUROMUSCULAR DISORDERS, vol. 22(3), 225-230. link> doi>
  • Humphrey E, Fuller HR, Morris GE. 2012. Current research on SMN protein and treatment strategies for spinal muscular atrophy. Neuromuscul Disord, vol. 22(2), 193-197. link> doi>
  • Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. 2011. Expanded CUG Repeats Dysregulate RNA Splicing by Altering the Stoichiometry of the Muscleblind 1 Complex. JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286(44), 38427-38438. link> doi>
  • Lam LT, Boehm SV, Roberts RG, Morris GE. 2011. Nesprin-2 epsilon: A novel nesprin isoform expressed in human ovary and Ntera-2 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 412(2), 291-295. link> doi>
  • Comley LH, Fuller HR, Wishart TM, Mutsaers CA, Thomson D, Wright AK, Ribchester RR, Morris GE, Parson SH, Horsburgh K, Gillingwater TH. 2011. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. HUMAN MOLECULAR GENETICS, vol. 20(12), 2406-2421. link> doi>
  • Holt I, Lam LT, Tome S, Wansink DG, te Riele H, Gourdon G, Morris GE. 2011. The Mouse Mismatch Repair Protein, MSH3, is a Nucleoplasmic Protein that Aggregates into Denser Nuclear Bodies Under Conditions of Stress. JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 112(6), 1612-1621. link> doi>
  • Tran H, Gourrier N, Lemercier-Neuillet C, Dhaenens C-M, Vautrin A, Fernandez-Gomez FJ, Arandel L, Carpentier C, Obriot H, Eddarkaoui S, Delattre L, Van Brussels E, Holt I, Morris GE, Sablonniere B, Buee L, Charlet-Berguerand N, Schraen-Maschke S, Furling D, Behm-Ansmant I, Branlant C, Caillet-Boudin M-L, Sergeant N. 2011. Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms. JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286(18). link> doi>
  • Wielders EAL, Dekker RJ, Holt I, Morris GE, Riele HT. 2011. Characterization of MSH2 Variants by Endogenous Gene Modification in Mouse Embryonic Stem Cells. HUMAN MUTATION, vol. 32(4), 389-396. link> doi>
  • Fuller HR and Morris GE. 2010. SMN COMPLEXES OF NUCLEUS AND CYTOPLASM: A PROTEOMIC STUDY FOR SMA THERAPY. TRANSLATIONAL NEUROSCIENCE, vol. 1(4), 261-267. link> doi>
  • Fuller HR, Barisic M, Seso-Simic D, Speljko T, Morris GE, Simic G. 2010. TREATMENT STRATEGIES FOR SPINAL MUSCULAR ATROPHY. TRANSLATIONAL NEUROSCIENCE, vol. 1(4), 308-321. link> doi>
  • Mladinov M, Mayer D, Brcic L, Wolstencroft E, Man NT, Holt I, Hof PR, Morris GE, Simic G. 2010. ASTROCYTE EXPRESSION OF D2-LIKE DOPAMINE RECEPTORS IN THE PREFRONTAL CORTEX. TRANSLATIONAL NEUROSCIENCE, vol. 1(3), 238-243. link> doi>
  • Lam LT, Nguyen GH, Man NT, Sewry CA, Morris GE. 2010. EXON-SPECIFIC DYSTROPHIN ANTIBODIES FOR STUDIES OF DUCHENNE MUSCULAR DYSTROPHY. TRANSLATIONAL NEUROSCIENCE, vol. 1(3), 233-237. link> doi>
  • Holt I, Quinlivan RCM, Couto JM, Monckton DG, Morris GE. 2010. THE USE OF BUCCAL CELLS FOR RAPID DIAGNOSIS OF MYOTONIC DYSTROPHY TYPE 1. TRANSLATIONAL NEUROSCIENCE, vol. 1(3), 195-199. link> doi>
  • Fuller HR, Man NT, Lam LT, Shamanin VA, Androphy EJ, Morris GE. 2010. Valproate and Bone Loss: iTRAQ Proteomics Show that Valproate Reduces Collagens and Osteonectin in SMA Cells. JOURNAL OF PROTEOME RESEARCH, vol. 9(8), 4228-4233. link> doi>
  • Randles KN, Lam LT, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE. 2010. Nesprins, But Not Sun Proteins, Switch Isoforms at the Nuclear Envelope During Muscle Development. DEVELOPMENTAL DYNAMICS, vol. 239(3), 998-1009. link> doi>
  • Fuller HR, Man NT, Lam LT, Thanh LT, Keough RA, Asperger A, Gonda TJ, Morris GE. 2010. The SMN Interactome Includes Myb-Binding Protein 1a. JOURNAL OF PROTEOME RESEARCH, vol. 9(1), 556-563. link> doi>
  • Tome S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G. 2009. MSH2 ATPase Domain Mutation Affects CTG.CAG Repeat Instability in Transgenic Mice. PLOS GENETICS, vol. 5(5), Article ARTN e1000482. link> doi> full text>
  • Holt I, Jacquemin V, Fardaei M, Sewry CA, Butler-Browne GS, Furling D, Brook JD, Morris GE. 2009. Muscleblind-Like Proteins Similarities and Differences in Normal and Myotonic Dystrophy Muscle. AMERICAN JOURNAL OF PATHOLOGY, vol. 174(1), 216-227. link> doi>
  • Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC, Comai L, Berul CI, Reddy S. 2008. Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features. PLOS ONE, vol. 3(12), Article ARTN e3968. link> doi> full text>
  • Nguyen thi Man, Humphrey E, Lam LT, Fuller HR, Lynch TA, Sewry CA, Goodwin PR, Mackenzie AE, Morris GE. 2008. A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy. Neurology, vol. 71(22), 1757-1763. link> doi>
  • Morris GE. 2008. The Cajal body. Biochim Biophys Acta, vol. 1783(11), 2108-2115. link> doi>
  • Gavrilina TO, McGovern VL, Workman E, Crawford TO, Gogliotti RG, DiDonato CJ, Monani UR, Morris GE, Burghes AHM. 2008. Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect. HUMAN MOLECULAR GENETICS, vol. 17(8), 1063-1075. link> doi>
  • Holt I, Mittal S, Furling D, Butler-Browne GS, Brook JD, Morris GE. 2007. Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles. GENES TO CELLS, vol. 12(9), 1035-1048. link> doi>
  • Wolstencroft EC, Simic G, Man NT, Holt I, Lam LT, Buckland PR, Morris GE. 2007. Endosomal location of dopamine receptors in neuronal cell cytoplasm. JOURNAL OF MOLECULAR HISTOLOGY, vol. 38(4), 333-340. link> doi>
  • Hao LT, Fuller HR, Lam LT, Le TT, Burghes AHM, Morris GE. 2007. Absence of gemin5 from SMN complexes in nuclear Cajal bodies. BMC CELL BIOLOGY, vol. 8, Article ARTN 28. link> doi>
  • Meaburn KJ, Cabuy E, Bonne G, Levy N, Morris GE, Novelli G, Kill IR, Bridger JM. 2007. Primary laminopathy fibroblasts display altered genome organization and apoptosis. AGING CELL, vol. 6(2), 139-153. link> doi>
  • Xiong H, Kobayashi K, Tachikawa M, Manya H, Takeda S, Chiyonobu T, Fujikake N, Wang F, Nishimoto A, Morris GE, Nagai Y, Kanagawa M, Endo T, Toda T. 2006. Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 350(4), 935-941. link> doi>
  • Natalie Randles K and Morris GE. 2006. Workshop on the nuclear envelope and Emery-Dreifuss muscular dystrophy 29th March 2006, Oswestry, UK. Neuromuscul Disord, vol. 16(9-10), 608-612. link> doi>
  • Holt I, Nguyen TM, Wehnert M, Morris GE. 2006. Lamin A/C assembly defects in Emery-Dreifuss muscular dystrophy can be regulated by culture medium composition. Neuromuscul Disord, vol. 16(6), 368-373. link> doi>
  • Fuller HR, Goodwin PR, Morris GE. 2006. An enzyme-linked immunosorbent assay (ELISA) for the major crustacean allergen, tropomyosin, in food. FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 17(1), 43-52. link> doi>
  • Sharma A, Lambrechts A, Hao LT, Le TT, Sewry CA, Ampe C, Burghes AHM, Morris GE. 2005. A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells. Exp Cell Res, vol. 309(1), 185-197. link> doi>
  • Pham YCN, Man NT, Holt I, Sewry CA, Pall G, Johnson K, Morris GE. 2005. Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies. J Cell Biochem, vol. 95(5), 990-1001. link> doi>
  • Tunnah D, Sewry CA, Vaux D, Schirmer EC, Morris GE. 2005. The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking. J Mol Histol, vol. 36(5), 337-344. link> doi>
  • Limb GA, Matter K, Murphy G, Cambrey AD, Bishop PN, Morris GE, Khaw PT. 2005. Matrix metal loproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis. AMERICAN JOURNAL OF PATHOLOGY, vol. 166(5), 1555-1563. link> doi>
  • Bertoni C, Morris GE, Rando TA. 2005. Strand bias in oligonucleotide-mediated dystrophin gene editing. HUMAN MOLECULAR GENETICS, vol. 14(2), 221-233. link> doi>
  • Morris GE. 2005. Epitope mapping. Methods Mol Biol, vol. 295, 255-268. link>
  • Lunn MR, Root DE, Martino AM, Flaherty SP, Kelley BP, Coovert DD, Burghes AH, Man NT, Morris GE, Zhou JH, Androphy EJ, Sumner CJ, Stockwell BR. 2004. Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. CHEMISTRY & BIOLOGY, vol. 11(11), 1489-1493. link> doi>
  • Romero NB, Braun S, Benveniste O, Leturcq F, Hogrel JY, Morris GE, Barois A, Eymard B, Payan C, Ortega V, Boch AL, Lejean L, Thioudellet C, Mourot B, Escot C, Choquel A, Recan D, Kaplan JC, Dickson G, Klatzmann D, Molinier-Frenckel V, Guillet JG, Squiban P, Herson S, Fardeau M. 2004. Phase I study of dystrophin Duchenne/Becker plasmid-based gene therapy in muscular dystrophy. HUMAN GENE THERAPY, vol. 15(11), 1065-1076. link> doi>
  • Manilal S, Randles KN, Aunac C, Nguyen MT, Morris GE. 2004. A lamin A/C beta-strand containing the site of lipodystrophy mutations is a major surface epitope for a new panel of monoclonal antibodies. Biochim Biophys Acta, vol. 1671(1-3), 87-92. link> doi>
  • Masson JF, Barnhart M, Battaglia TM, Morris GE, Nieman RA, Young PJ, Lorson CL, Booksh KS. 2004. Monitoring of recombinant survival motor neuron protein using fiber-optic surface plasmon resonance. ANALYST, vol. 129(9), 855-859. link> doi>
  • Morris GE. 2004. Protein interactions, right or wrong, in Emery-Dreifuss muscular dystrophy. Symp Soc Exp Biol, 57-68. link>
  • Lu QL, Mann CJ, Lou F, Bou-Gharios G, Morris GE, Xue SA, Fletcher S, Partridge TA, Wilton SD. 2003. Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. NATURE MEDICINE, vol. 9(8), 1009-1014. link> doi>
  • Holt I, Ostlund C, Stewart CL, Man NT, Worman HJ, Morris GE. 2003. Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. J Cell Sci, vol. 116(Pt 14), 3027-3035. link> doi>
  • Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE. 2003. Emerin interacts in vitro with the splicing-associated factor, YT521-B. Eur J Biochem, vol. 270(11), 2459-2466. link> doi>
  • Furling D, Lam LT, Agbulut O, Butler-Browne GS, Morris GE. 2003. Changes in myotonic dystrophy protein kinase levels and muscle development in congenital myotonic dystrophy. AMERICAN JOURNAL OF PATHOLOGY, vol. 162(3), 1001-1009. link> doi>
  • Gussoni E, Bennett RR, Muskiewicz KR, Meyerrose T, Nolta JA, Gilgoff I, Stein J, Chan YM, Lidov HG, Bonnemann CG, von Moers A, Morris GE, den Dunnen JT, Chamberlain JS, Kunkel LM, Weinberg K. 2002. Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation. JOURNAL OF CLINICAL INVESTIGATION, vol. 110(6), 807-814. link> doi>
  • Young PJ, Day PM, Zhou J, Androphy EJ, Morris GE, Lorson CL. 2002. A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277(4), 2852-2859. link> doi>
  • Colomer J, Iturriaga C, Bonne G, Schwartz K, Manilal S, Morris GE, Puche M, Fernandez-Alvareza E. 2002. Autosomal dominant Emery-Dreifuss muscular dystrophy: a new family with late diagnosis. NEUROMUSCULAR DISORDERS, vol. 12(1), 19-25. link> doi>
  • Morris GE. 2001. The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy. Trends Mol Med, vol. 7(12), 572-577. link> doi>
  • Holt I, Clements L, Manilal S, Morris GE. 2001. How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?. Biochem Biophys Res Commun, vol. 287(5), 1129-1133. link> doi>
  • Sewry CA, Man NT, Morris GE. 2001. Absence of utrophin in intercalated discs of human cardiac muscle. NEUROMUSCULAR DISORDERS, vol. 11(6-7), 651. link>
  • Brown SC, Vorgerd M, Piercy R, Morris GE, Sewry CA. 2001. Skeletal and cardiac muscle pathology in a proven case of autosomal dominant Emery-Dreifuss muscular dystrophy. NEUROMUSCULAR DISORDERS, vol. 11(6-7), 656. link>
  • Vainzof M, Canovas M, Cerqueira A, Man NT, Morris GE, Zatz M. 2001. SMN protein studies in spinal muscular atrophy. NEUROMUSCULAR DISORDERS, vol. 11(6-7), 647-648. link>
  • Chambers SP, Dodd A, Overall R, Sirey T, Lam LT, Morris GE, Love DR. 2001. Dystrophin in adult zebrafish muscle. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 286(3), 478-483. link> doi>
  • Sewry CA, Brown SC, Mercuri E, Bonne G, Feng L, Camici G, Morris GE, Muntoni F. 2001. Skeletal muscle pathology in autosomal dominant Emery-Dreifuss muscular dystrophy with lamin A/C mutations. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, vol. 27(4), 281-290. link> doi>
  • Pereboev AV, Ahmed N, thi Man N, Morris GE. 2001. Epitopes in the interacting regions of beta-dystroglycan (PPxY motif) and dystrophin (WW domain). Biochim Biophys Acta, vol. 1527(1-2), 54-60. link> doi>
  • Vaughan OA, Alvarez-Reyes M, Bridger JM, Broers JLV, Ramaekers FCS, Wehnert M, Morris GE, Whitfield WGF, Hutchison CJ. 2001. Both emerin and lamin C depend on lamin A for localization at the nuclear envelope. JOURNAL OF CELL SCIENCE, vol. 114(14), 2577-2590. link>
  • Young PJ, Le TT, Dunckley M, Nguyen TM, Burghes AH, Morris GE. 2001. Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN. Exp Cell Res, vol. 265(2), 252-261. link> doi>
  • Holt I, Clements L, Manilal S, Brown SC, Morris GE. 2001. The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin. Eur J Hum Genet, vol. 9(3), 204-208. link> doi>
  • Webb TI and Morris GE. 2001. Structure of an intermediate in the unfolding of creatine kinase. Proteins, vol. 42(2), 269-278. link> doi>
  • Sewry CA, Man NT, Lynch T, Morris GE. 2001. Absence of utrophin in intercalated discs of human cardiac muscle. Histochem J, vol. 33(1), 9-12. link> doi>
  • Young PJ, Man NT, Lorson CL, Le TT, Androphy EJ, Burghes AH, Morris GE. 2000. The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding. Hum Mol Genet, vol. 9(19), 2869-2877. link> doi>
  • Jones L, Duce J, Hartog C, Elliston L, Caswell R, Wilkinson F, Morris GE, Man NT, Neal J, Harper PS. 2000. Transcriptional regulation by huntingtin. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 67(4), 365. link>
  • Lam LT, Pham YC, Nguyen TM, Morris GE. 2000. Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. Hum Mol Genet, vol. 9(14), 2167-2173. link> doi>
  • Le TT, Coovert DD, Monani UR, Morris GE, Burghes AHM. 2000. The survival motor neuron (SMN) protein: effect of exon loss and mutation on protein localization. NEUROGENETICS, vol. 3(1), 7-16. link> doi>
  • Coovert DD, Le TT, Morris GE, Man NT, Kralewski M, Sendtners M, Burghes AHM. 2000. Does the survival motor neuron protein (SMN) interact with Bcl-2?. JOURNAL OF MEDICAL GENETICS, vol. 37(7), 536-539. link> doi>
  • Bartlett RJ, Stockinger S, Denis MM, Bartlett WT, Inverardi L, Le TT, Man NT, Morris GE, Bogan DJ, Metcalf-Bogan J, Kornegay JN. 2000. In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide. NATURE BIOTECHNOLOGY, vol. 18(6), 615-622. link> doi>
  • Morris GE. 2000. Nuclear proteins and cell death in inherited neuromuscular disease. Neuromuscul Disord, vol. 10(4-5), 217-227. link> doi>
  • Young PJ, Le TT, thi Man N, Burghes AH, Morris GE. 2000. The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells. Exp Cell Res, vol. 256(2), 365-374. link> doi>
  • Gonzalez I, Ohsawa N, Singer RH, Devillers M, Ashizawa T, Balasubramanyam A, Cooper TA, Khajavi M, Lia-Baldini AS, Miller G, Philips AV, Timchenko LT, Waring J, Yamagata H, Barbet JP, Klesert TR, Tapscott SJ, Roses AD, Wagner M, Baiget M, Martorell L, Browne GB, Eymard B, Gourdon G, Junien C, Seznec H, Carey N, Gosling M, Maire P, Gennarelli M, Sato S, Ansved T, Kvist U, Eriksson M, Furling D, Chen EJ, Housman DE, Luciano B, Siciliano M, Spring N, Shimizu M, Eddy E, Morris GE, Krahe R, Furuya H, Adelman J, Pribnow D, Furutama D, Mathieu J, Hilton-Jones D, Kinoshita M, Abbruzzese C, Sinden RR, Wells RD, Pearson CE, Kobayashi T, Johansson A, Salvatori S, Perryman B, Swanson MS, Gould FK, Harris SE, Johnson K, Mitchell AM, Monckton DG, Winchester CL, Antonini G, Day JW, Liquori C, Ranum LPW, Westerlaken J, Wieringa B, Griffith JD, Michalowski S, Moore H, Hamshere M, Korade Z, Thornton CA, Jaeger H, Lehmann F, Moorman JR, Mounsey JP, Mahadevan MS, IDMC. 2000. New nomenclature and DNA testing guidelines for myotonic dystrophy type 1(DM1). NEUROLOGY, vol. 54(6), 1218-1221. link>
  • Lu QL, Morris GE, Wilton SD, Ly T, Artem'yeva OV, Strong P, Partridge TA. 2000. Massive idiosyncratic exon skipping corrects the nonsense mutation in dystrophic mouse muscle and produces functional revertant fibers by clonal expansion. JOURNAL OF CELL BIOLOGY, vol. 148(5), 985-995. link> doi>
  • Austin RC, Morris GE, Howard PL, Klamut HJ, Ray PN. 2000. Expression and synthesis of alternatively spliced variants of Dp71 in adult human brain. NEUROMUSCULAR DISORDERS, vol. 10(3), 187-193. link> doi>
  • Monani UR, Sendtner M, Coovert DD, Parsons DW, Andreassi C, Le TT, Jablonka S, Schrank B, Rossol W, Prior TW, Morris GE, Burghes AHM. 2000. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. HUMAN MOLECULAR GENETICS, vol. 9(3), 333-339. link> doi>
  • Pereboeva LA, Pereboev AV, Wang LF, Morris GE. 2000. Hepatitis C epitopes from phage-displayed cDNA libraries and improved diagnosis with a chimeric antigen. J Med Virol, vol. 60(2), 144-151. link> doi>
  • Clements L, Manilal S, Love DR, Morris GE. 2000. Direct interaction between emerin and lamin A. Biochem Biophys Res Commun, vol. 267(3), 709-714. link> doi>
  • Manilal S, Man NT, Sewry CA, Morris GE, Grp MRICB. 1999. Emerin is associated with lamin A/C in one subset of kidney cell nuclei while lamin B1 is present in the emerin-negative nuclei. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 65(4), A478. link>
  • Lam LT, Pham YNC, Man NT, Morris GE. 1999. Is the myotonic dystrophy protein kinase (DMPK) a muscle-specific protein?. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 65(4), A279. link>
  • Young PJ, Le TT, Man NT, Burghes AHM, Morris GE. 1999. The spinal muscular atrophy protein, SMN, fails to form nuclear gems in some mammalian cell types which also lack coiled bodies. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 65(4), A114. link>
  • Schatzberg SJ, Olby NJ, Breen M, Anderson LVB, Langford CF, Dickens HF, Wilton SD, Zeiss CJ, Binns MM, Kornegay JN, Morris GE, Sharp NJH. 1999. Molecular analysis of a spontaneous dystrophin 'knockout' dog. NEUROMUSCULAR DISORDERS, vol. 9(5), 289-295. link> doi>
  • Wilkinson FL, Nguyen TM, Manilal SB, Thomas P, Neal JW, Harper PS, Jones AL, Morris GE. 1999. Localization of rabbit huntingtin using a new panel of monoclonal antibodies. Brain Res Mol Brain Res, vol. 69(1), 10-20. link> doi>
  • Manilal S, Sewry CA, Pereboev A, Man N, Gobbi P, Hawkes S, Love DR, Morris GE. 1999. Distribution of emerin and lamins in the heart and implications for Emery-Dreifuss muscular dystrophy. Hum Mol Genet, vol. 8(2), 353-359. link> doi>
  • Morris GE, Nguyen TM, Nguyen TN, Pereboev A, Kendrick-Jones J, Winder SJ. 1999. Disruption of the utrophin-actin interaction by monoclonal antibodies and prediction of an actin-binding surface of utrophin. Biochem J, vol. 337 ( Pt 1), 119-123. link> doi>
  • Morris GE and Manilal S. 1999. Heart to heart: from nuclear proteins to Emery-Dreifuss muscular dystrophy. Hum Mol Genet, vol. 8(10), 1847-1851. link> doi>
  • Pham YC, Man N, Lam LT, Morris GE. 1998. Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies. Hum Mol Genet, vol. 7(12), 1957-1965. link> doi>
  • Pereboeva LA, Pereboev AV, Morris GE. 1998. Identification of antigenic sites on three hepatitis C virus proteins using phage-displayed peptide libraries. J Med Virol, vol. 56(2), 105-111. link> doi>
  • Manilal S, Nguyen TM, Morris GE. 1998. Colocalization of emerin and lamins in interphase nuclei and changes during mitosis. Biochem Biophys Res Commun, vol. 249(3), 643-647. link> doi>
  • Morris GE, Sedgwick SG, Ellis JM, Pereboev A, Chamberlain JS, Nguyen thi Man. 1998. An epitope structure for the C-terminal domain of dystrophin and utrophin. Biochemistry, vol. 37(31), 11117-11127. link> doi>
  • Manilal S, Recan D, Sewry CA, Hoeltzenbein M, Llense S, Leturcq F, Deburgrave N, Barbot J, Man N, Muntoni F, Wehnert M, Kaplan J, Morris GE. 1998. Mutations in Emery-Dreifuss muscular dystrophy and their effects on emerin protein expression. Hum Mol Genet, vol. 7(5), 855-864. link> doi>
  • Muntoni F, Lichtarowicz-Krynska EJ, Sewry CA, Manilal S, Recan D, Llense S, Taylor J, Morris GE, Dubowitz V. 1998. Early presentation of X-linked Emery-Dreifuss muscular dystrophy resembling limb-girdle muscular dystrophy. NEUROMUSCULAR DISORDERS, vol. 8(2), 72-76. link> doi>
  • Morris GE. 1998. Epitope mapping. Methods Mol Biol, vol. 80, 161-172. link> doi>
  • Thomas P, Wilkinson F, Nguyen TM, Harper PS, Neal JW, Morris GE, Jones AL. 1998. Full length huntingtin is not detected in intranuclear inclusions in Huntington's disease brain. EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 6, 150. link>
  • Morris GE. 1997. Dystrophin is replaced by utrophin in frog heart; implications for muscular dystrophy. Neuromuscul Disord, vol. 7(8), 493-498. link> doi>
  • Morris GE, Pereboev A, Ahmed N, Man NT. 1997. Structural studies of dystrophin and utrophin using monoclonal antibodies. FASEB JOURNAL, vol. 11(9), A1213. link>
  • James M, Man NT, Edwards YH, Morris GE. 1997. The molecular basis for cross-reaction of an anti-dystrophin antibody with alpha-actinin. Biochim Biophys Acta, vol. 1360(2), 169-176. link> doi>
  • Cohen MW, Jacobson C, Yurchenco PD, Morris GE, Carbonetto S. 1997. Laminin-induced clustering of dystroglycan on embryonic muscle cells: Comparison with agrin-induced clustering. JOURNAL OF CELL BIOLOGY, vol. 136(5), 1047-1058. link> doi>
  • Wilkinson F, Nguyen TM, Morris GE. 1997. Monoclonal antibodies from three new regions of huntingtin, the Huntington's disease protein. Biochem Soc Trans, vol. 25(1), 51S. link> doi>
  • Nguyen NH, Tran VB, Morris GE. 1997. Nucleotide sequences from the capsid and pre-protein regions of dengue viruses from VietNam. Biochem Soc Trans, vol. 25(1), 54S. link> doi>
  • Manilal S, Sewry CA, Man N, Muntoni F, Morris GE. 1997. Diagnosis of X-linked Emery-Dreifuss muscular dystrophy by protein analysis of leucocytes and skin with monoclonal antibodies. Neuromuscul Disord, vol. 7(1), 63-66. link> doi>
  • Webb T, Jackson PJ, Morris GE. 1997. Protease digestion studies of an equilibrium intermediate in the unfolding of creatine kinase. Biochem J, vol. 321 ( Pt 1), 83-88. link> doi>
  • Manilal S, Nguyen TM, Sewry CA, Morris GE. 1996. The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein. Hum Mol Genet, vol. 5(6), 801-808. link> doi>
  • Morris GE. 1996. Epitope mapping by chemical fragmentation. Methods Mol Biol, vol. 66, 121-127. link> doi>
  • Morris GE. 1996. Overview. Choosing a method for epitope mapping. Methods Mol Biol, vol. 66, 1-9. link> doi>
  • Nguyen TM and Morris GE. 1996. Production of panels of monoclonal antibodies by the hybridoma method. Methods Mol Biol, vol. 66, 377-389. link> doi>
  • Pereboev A and Morris GE. 1996. Reiterative screening of phage-display peptide libraries with antibodies. Methods Mol Biol, vol. 66, 195-206. link> doi>
  • Morris GE. 1996. Use of natural or selected mutants and variants for epitope mapping. Methods Mol Biol, vol. 66, 373-376. link> doi>
  • James M, Nguyen TM, Wise CJ, Jones GE, Morris GE. 1996. Utrophin-dystroglycan complex in membranes of adherent cultured cells. Cell Motil Cytoskeleton, vol. 33(3), 163-174. link> doi>
  • Morris GE, Simmons C, Nguyen TM. 1995. Apo-dystrophins (Dp140 and Dp71) and dystrophin splicing isoforms in developing brain. Biochem Biophys Res Commun, vol. 215(1), 361-367. link> doi>
  • MENDELL JR, KISSEL JT, AMATO AA, KING W, SIGNORE L, PRIOR TW, SAHENK Z, BESSON S, MCANDREW PE, RICE R, NAGARAJA H, STEPHENS R, LANTRY L, MORRIS GE, BURGHES AHM. 1995. MYOBLAST TRANSFER IN THE TREATMENT OF DUCHENNES MUSCULAR-DYSTROPHY. NEW ENGLAND JOURNAL OF MEDICINE, vol. 333(13), 832-838. link> doi>
  • Le Thiet Thanh, Nguyen Thi Man, Hori S, Sewry CA, Dubowitz V, Morris GE. 1995. Characterization of genetic deletions in Becker muscular dystrophy using monoclonal antibodies against a deletion-prone region of dystrophin. Am J Med Genet, vol. 58(2), 177-186. link> doi>
  • Morris GE, Nguyen thi Man, Sedgwick SG. 1995. Epitope mapping of recombinant antigens by transposon mutagenesis. Mol Biotechnol, vol. 4(1), 45-54. link> doi>
  • James M, Simmons C, Wise CJ, Jones GE, Morris GE. 1995. Evidence for a utrophin-glycoprotein complex in cultured cell lines and a possible role in cell adhesion. Biochem Soc Trans, vol. 23(3), 398S. link>
  • Webb T, Jackson PJ, Morris GE. 1995. Probing protein structure with proteases: studies of an equilibrium intermediate in protein unfolding. Biochem Soc Trans, vol. 23(3), 477S. link>
  • Morris GE, Nguyen C, Nguyen thi Man. 1995. Specificity and VH sequence of two monoclonal antibodies against the N-terminus of dystrophin. Biochem J, vol. 309 ( Pt 1), 355-359. link> doi>
  • DSOUZA VN, MAN NT, MORRIS GE, KARGES W, PILLERS DAM, RAY PN. 1995. A NOVEL DYSTROPHIN ISOFORM IS REQUIRED FOR NORMAL RETINAL ELECTROPHYSIOLOGY. HUMAN MOLECULAR GENETICS, vol. 4(5), 837-842. link> doi>
  • HORI S, OHTANI S, MAN NT, MORRIS GE. 1995. THE N-TERMINAL HALF OF DYSTROPHIN IS PROTECTED FROM PROTEOLYSIS IN-SITU. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 209(3), 1062-1067. link> doi>
  • Wallgren-Pettersson C, Jasani B, Newman GR, Morris GE, Jones S, Singhrao S, Clarke A, Virtanen I, Holmberg C, Rapola J. 1995. Alpha-actinin in nemaline bodies in congenital nemaline myopathy: immunological confirmation by light and electron microscopy. Neuromuscul Disord, vol. 5(2), 93-104. link> doi>
  • Thanh LT, Nguyen TM, Helliwell TR, Morris GE. 1995. Characterization of revertant muscle fibers in Duchenne muscular dystrophy, using exon-specific monoclonal antibodies against dystrophin. Am J Hum Genet, vol. 56(3), 725-731. link>
  • Nguyen TM, Helliwell TR, Simmons C, Winder SJ, Kendrick-Jones J, Davies KE, Morris GE. 1995. Full-length and short forms of utrophin, the dystrophin-related protein. FEBS Lett, vol. 358(3), 262-266. link> doi>
  • Vu TT, Tran VB, Phan NT, Le TT, Luong VH, O'Brien E, Morris GE. 1995. Screening donor blood for malaria by polymerase chain reaction. Trans R Soc Trop Med Hyg, vol. 89(1), 44-47. link> doi>
  • SCHOFIELD JN, BLAKE DJ, SIMMONS C, MORRIS GE, TINSLEY JM, DAVIES KE, EDWARDS YH. 1994. APO-DYSTROPHIN-1 AND APO-DYSTROPHIN-2, PRODUCTS OF THE DUCHENNE MUSCULAR-DYSTROPHY LOCUS - EXPRESSION DURING MOUSE EMBRYOGENESIS AND IN CULTURED-CELL LINES. HUMAN MOLECULAR GENETICS, vol. 3(8), 1309-1316. link> doi>
  • HELLIWELL TR, MAN NT, MORRIS GE. 1994. EXPRESSION OF THE 43 KDA DYSTROPHIN-ASSOCIATED GLYCOPROTEIN IN HUMAN NEUROMUSCULAR DISEASE. NEUROMUSCULAR DISORDERS, vol. 4(2), 101-113. link> doi>
  • CLERK A, MORRIS GE, DUBOWITZ V, DAVIES KE, SEWRY CA. 1993. DYSTROPHIN-RELATED PROTEIN, UTROPHIN, IN NORMAL AND DYSTROPHIC HUMAN FETAL SKELETAL-MUSCLE. HISTOCHEMICAL JOURNAL, vol. 25(8), 554-561. link> doi>
  • Le TT, Nguyen TM, Love DR, Helliwell TR, Davies KE, Morris GE. 1993. Monoclonal antibodies against the muscle-specific N-terminus of dystrophin: characterization of dystrophin in a muscular dystrophy patient with a frameshift deletion of exons 3-7. Am J Hum Genet, vol. 53(1), 131-139. link>
  • Nguyen TM and Morris GE. 1993. Use of epitope libraries to identify exon-specific monoclonal antibodies for characterization of altered dystrophins in muscular dystrophy. Am J Hum Genet, vol. 52(6), 1057-1066. link>
  • Morris GE, Ellis JM, Nguyen TM. 1993. A quantitative ELISA for dystrophin. J Immunol Methods, vol. 161(1), 23-28. link> doi>
  • VANBE T, MAT B, MAN NT, MORRIS GE. 1993. HEPATITIS-B IN HO-CHI-MINH-CITY, VIETNAM. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, vol. 87(3), 262. link> doi>
  • KARPATI G, CARPENTER S, MORRIS GE, DAVIES KE, GUERIN C, HOLLAND P. 1993. LOCALIZATION AND QUANTITATION OF THE CHROMOSOME 6-ENCODED DYSTROPHIN-RELATED PROTEIN IN NORMAL AND PATHOLOGICAL HUMAN MUSCLE. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 52(2), 119-128. link> doi>
  • DICKSON G, AZAD A, MORRIS GE, SIMON H, NOURSADEGHI M, WALSH FS. 1992. COLOCALIZATION AND MOLECULAR ASSOCIATION OF DYSTROPHIN WITH LAMININ AT THE SURFACE OF MOUSE AND HUMAN MYOTUBES. JOURNAL OF CELL SCIENCE, vol. 103, 1223-&. link>
  • Nguyen TM, Ginjaar IB, van Ommen GJ, Morris GE. 1992. Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections. Biochem J, vol. 288 ( Pt 2), 663-668. link> doi>
  • Nguyen TM, Le TT, Blake DJ, Davies KE, Morris GE. 1992. Utrophin, the autosomal homologue of dystrophin, is widely-expressed and membrane-associated in cultured cell lines. FEBS Lett, vol. 313(1), 19-22. link> doi>
  • GINJAAR HB, VANPAASSEN HBM, DENDUNNEN JT, MAN NT, MORRIS GE, MOORMAN AFM, VANOMMEN GJB. 1992. CONSTRUCTION OF DYSTROPHIN FUSION PROTEINS TO RAISE TARGETED ANTIBODIES TO DIFFERENT EPITOPES. FEBS LETTERS, vol. 308(3), 293-297. link> doi>
  • HUGNOT JP, GILGENKRANTZ H, VINCENT N, CHAFEY P, MORRIS GE, MONACO AP, BERWALDNETTER Y, KOULAKOFF A, KAPLAN JC, KAHN A, CHELLY J. 1992. DISTAL TRANSCRIPT OF THE DYSTROPHIN GENE INITIATED FROM AN ALTERNATIVE 1ST EXON AND ENCODING A 75-KDA PROTEIN WIDELY DISTRIBUTED IN NONMUSCLE TISSUES. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 89(16), 7506-7510. link> doi>
  • YAROM R, MORRIS GE, FROEDE R, SCHAPER J. 1992. MYOCARDIAL DYSTROPHIN IMMUNOLOCALIZATION AT SARCOLEMMA AND TRANSVERSE TUBULES. EXPERIENTIA, vol. 48(6), 614-616. link> doi>
  • DOWDALL MJ, ELLIS JM, MAN NT, MORRIS GE. 1992. IMMUNOREACTIVITY OF SKATE ELECTROCYTES TOWARDS MONOCLONAL-ANTIBODIES AGAINST HUMAN DYSTROPHIN AND DYSTROPHIN-RELATED (DMDL) PROTEIN. NEUROSCIENCE LETTERS, vol. 138(1), 27-31. link> doi>
  • Morris GE and Man NT. 1992. Changes at the N-terminus of human brain creatine kinase during a transition between inactive folding intermediate and active enzyme. Biochim Biophys Acta, vol. 1120(2), 233-238. link> doi>
  • HELLIWELL TR, ELLIS JM, MOUNTFORD RC, APPLETON RE, MORRIS GE. 1992. A TRUNCATED DYSTROPHIN LACKING THE C-TERMINAL DOMAINS IS LOCALIZED AT THE MUSCLE MEMBRANE. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 50(3), 508-514. link>
  • DUNCKLEY MG, LOVE DR, DAVIES KE, WALSH FS, MORRIS GE, DICKSON G. 1992. RETROVIRAL-MEDIATED TRANSFER OF A DYSTROPHIN MINIGENE INTO MDX MOUSE MYOBLASTS INVITRO. FEBS LETTERS, vol. 296(2), 128-134. link> doi>
  • Morris GE and Jackson PJ. 1991. Identification by protein microsequencing of a proteinase-V8-cleavage site in a folding intermediate of chick muscle creatine kinase. Biochem J, vol. 280 ( Pt 3), 809-811. link> doi>
  • Nguyen TM, Ellis JM, Love DR, Davies KE, Gatter KC, Dickson G, Morris GE. 1991. Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines. J Cell Biol, vol. 115(6), 1695-1700. link> doi>
  • SEDGWICK SG, MAN N, ELLIS JM, CROWNE H, MORRIS GE. 1991. RAPID MAPPING BY TRANSPOSON MUTAGENESIS OF EPITOPES ON THE MUSCULAR-DYSTROPHY PROTEIN, DYSTROPHIN. NUCLEIC ACIDS RESEARCH, vol. 19(21), 5889-5894. link> doi>
  • SUTHERS GK, BYTH BC, LOVE DR, MORRIS GE, EDWARDS YH, FAIRBROTHER U, SLATER CP, DAVIES KE. 1991. SEQUENCE EVOLUTION AND TISSUE EXPRESSION OF THE DMD-LIKE LOCUS (DMDL) ON CHROMOSOME 6. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 49(4), 420. link>
  • Thanh LT, Man NT, Mat B, Tran PN, Ha NT, Morris GE. 1991. Structural relationships between hepatitis B surface antigen in human plasma and dimers from recombinant vaccine: a monoclonal antibody study. Virus Res, vol. 21(2), 141-154. link> doi>
  • GINJAAR IB, SOFFERS S, MOORMAN AFM, NICHOLSON LVB, MORRIS GE, BAKKER E, VANHAERINGEN A, VANOMMEN GJB. 1991. FETAL DYSTROPHIN TO DIAGNOSE CARRIER STATUS. LANCET, vol. 338(8761), 258-259. link> doi>
  • LOVE DR, MORRIS GE, ELLIS JM, FAIRBROTHER U, MARSDEN RF, BLOOMFIELD JF, EDWARDS YH, SLATER CP, PARRY DJ, DAVIES KE. 1991. TISSUE DISTRIBUTION OF THE DYSTROPHIN-RELATED GENE-PRODUCT AND EXPRESSION IN THE MDX AND DY MOUSE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 88(8), 3243-3247. link> doi>
  • Nguyen thi Man, Cartwright AJ, Osborne M, Morris GE. 1991. Structural changes in the C-terminal region of human brain creatine kinase studied with monoclonal antibodies. Biochim Biophys Acta, vol. 1076(2), 245-251. link> doi>
  • Nguyen TM, Ellis JM, Ginjaar IB, van Paassen MM, van Ommen GJ, Moorman AF, Cartwright AJ, Morris GE. 1990. Monoclonal antibody evidence for structural similarities between the central rod regions of actinin and dystrophin. FEBS Lett, vol. 272(1-2), 109-112. link> doi>
  • ELLIS JM, MAN NT, MORRIS GE, GINJAAR IB, MOORMAN AFM, VANOMMEN GJB. 1990. SPECIFICITY OF DYSTROPHIN ANALYSIS IMPROVED WITH MONOCLONAL-ANTIBODIES. LANCET, vol. 336(8719), 881-882. link> doi>
  • WESSELS A, VERMEULEN JLM, VIRAGH S, KALMAN F, MORRIS GE, MAN NT, LAMERS WH, MOORMAN AFM. 1990. SPATIAL-DISTRIBUTION OF TISSUE-SPECIFIC ANTIGENS IN THE DEVELOPING HUMAN HEART AND SKELETAL-MUSCLE .1. AN IMMUNOHISTOCHEMICAL ANALYSIS OF CREATINE-KINASE ISOENZYME EXPRESSION PATTERNS. ANATOMICAL RECORD, vol. 228(2), 163-176. link> doi>
  • Morris GE and Cartwright AJ. 1990. Monoclonal antibody studies suggest a catalytic site at the interface between domains in creatine kinase. Biochim Biophys Acta, vol. 1039(3), 318-322. link> doi>
  • Nguyen thi Man, Cartwright AJ, Morris GE, Love DR, Bloomfield JF, Davies KE. 1990. Monoclonal antibodies against defined regions of the muscular dystrophy protein, dystrophin. FEBS Lett, vol. 262(2), 237-240. link> doi>
  • Man N, Cartwright AJ, Andrews KM, Morris GE. 1989. Treatment of human muscle creatine kinase with glutaraldehyde preferentially increases the immunogenicity of the native conformation and permits production of high-affinity monoclonal antibodies which recognize two distinct surface epitopes. J Immunol Methods, vol. 125(1-2), 251-259. link> doi>
  • Morris GE. 1989. Monoclonal antibody studies of creatine kinase. The ART epitope: evidence for an intermediate in protein folding. Biochem J, vol. 257(2), 461-469. link> doi>
  • MORRIS GE, MACKENZIE SM, MAN NT. 1988. IDENTIFICATION OF C-TERMINAL EPITOPES ON CREATINE-KINASE USING MONOCLONAL-ANTIBODIES. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 16(5), 717-718. link> doi>
  • Morris GE, Frost LC, Newport PA, Hudson N. 1987. Monoclonal antibody studies of creatine kinase. Antibody-binding sites in the N-terminal region of creatine kinase and effects of antibody on enzyme refolding. Biochem J, vol. 248(1), 53-59. link> doi>
  • MORRIS GE and FROST LC. 1986. MONOCLONAL-ANTIBODY STUDIES OF CREATINE-KINASE - CROSS-REACTION BETWEEN CHICKEN AND HUMAN ENZYMES. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 14(2), 304. link> doi>
  • MORRIS GE. 1986. MONOCLONAL-ANTIBODIES AS PROBES OF CREATINE-KINASE STRUCTURE AND FUNCTION. MUSCLE & NERVE, vol. 9(5), 175. link>

Other

  • Humphrey EL, Lacey E, Le LT, Sciandra F, Morris C, Hewitt JE, Holt I, Brancaccio A, Barresi R, Sewry CA, Brown SC, Morris GE. 2014. A new monoclonal antibody against human alpha-dystroglycan has potential diagnostic applications. NEUROMUSCULAR DISORDERS (vol. 24, p. 918). link> doi>
  • Morris GE and Randles KN. 2010. Nesprin isoforms: are they inside or outside the nucleus?. BIOCHEMICAL SOCIETY TRANSACTIONS (vol. 38, pp. 278-280). link> doi>
  • Holt I, Mittal S, Furling D, Butler-Browne GS, Brook JD, Morris GE. 2008. Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles. NEUROMUSCULAR DISORDERS (vol. 18, pp. 798-799). link> doi>
  • Holt I, Furling D, Fardaei M, Sewry CA, Jacquemin V, Butler-Browne GS, Brook JD, Morris GE. 2008. Muscleblind-like proteins: Similarities and differences in normal and myotonic dystrophy muscle. NEUROMUSCULAR DISORDERS (vol. 18, p. 799). link> doi>
  • Vainzof M, Yamamoto LU, Ayub D, Kossuge P, Man NT, Morris GE. 2006. Utrophin in the dystrophic muscle: evaluation of the contribution of connective tissue replacement. NEUROMUSCULAR DISORDERS (vol. 16, pp. 697-698). link> doi>
  • Hao LT, Lam LT, Man NT, Morris GE. 2005. A monoclonal antibody study of the role of the SMN complex in spinal muscular atrophy. NEUROMUSCULAR DISORDERS (vol. 15, p. 725). link>
  • Man NT, Lam LT, Lynch T, Sewry C, MacKenzie A, Morris GE. 2005. An ELISA assay for measuring the survival of motor neurons (SMN) protein and the search for a drug treatment for spinal muscular atrophy. NEUROMUSCULAR DISORDERS (vol. 15, p. 726). link>
  • Holt I, Sewry CA, Furling D, Butler-Browne GS, Brook JD, Morris GE. 2004. Localisation and tissue distribution of the three human muscleblind proteins associated with expanded repeats in myotonic dystrophy. NEUROMUSCULAR DISORDERS (vol. 14, p. 585). link>
  • Morris GE and Man MNT. 2004. One hundred and fifty monoclonal antibodies against dystrophin and their application to studies of pathogenesis and therapy in Duchenne muscular dystrophy. NEUROMUSCULAR DISORDERS (vol. 14, p. 578). link>
  • Man MNT, Lam LT, Stockwell BR, McKenzie AE, Morris GE, Sewry CA. 2004. Towards a treatment for spinal muscular atrophy: looking for drugs that increase SMN protein levels. NEUROMUSCULAR DISORDERS (vol. 14, pp. 595-596). link>
  • Lu QL, Yokota T, Bou-Gharios G, Partridge TA, Fletcher S, Wilton SD, Mann CJ, Lou F, Morris GE, Xue SA. 2004. Use of antisense-mediated exon skipping to generate dystrophin in muscles of the mdx dystrophic mouse. NEUROMUSCULAR DISORDERS (vol. 14, p. 624). link>
  • Smith BF, Morris GE, Kornegay JN, Bartlett RJ. 2003. Rapid identification of novel canine models of Duchenne muscular dystrophy. MOLECULAR THERAPY (vol. 7, p. S101). link>
  • Romero NB, Benveniste O, Choquel A, Payan C, Morris GE, Guillet JG, Kaplan JC, Leturcq F, Braun S, Mourot B, Thioudellet C, Squiban P, Herson S, Fardeau M. 2003. Results of phase I clinical trial of plasmid-dystrophin intramuscular administration into Duchenne and Becker dystrophy patients. MOLECULAR THERAPY (vol. 7, p. S449). link>
  • Ahmed N, Nguyen TM, Morris GE. 1998. Flexible hinges in dystrophin. Biochem Soc Trans (vol. 26, p. S310). link> doi>
  • Thomas P, Wilkinson F, Nguyen TM, Harper PS, Neal JW, Morris GE, Jones AL. 1998. Full length huntingtin is not detected in intranuclear inclusions in Huntington's disease brain. Biochem Soc Trans (vol. 26, p. S243). link> doi>
  • JAMES M, SIMMONS C, WISE CJ, JONES GE, MORRIS GE. 1995. EVIDENCE FOR A UTROPHIN-GLYCOPROTEIN COMPLEX IN CULTURED-CELL LINES AND A POSSIBLE ROLE IN CELL-ADHESION. BIOCHEMICAL SOCIETY TRANSACTIONS (vol. 23, p. S398). link> doi>
  • WEBB T, JACKSON PJ, MORRIS GE. 1995. PROBING PROTEIN-STRUCTURE WITH PROTEASES - STUDIES OF AN EQUILIBRIUM INTERMEDIATE IN PROTEIN UNFOLDING. BIOCHEMICAL SOCIETY TRANSACTIONS (vol. 23, p. S477). link> doi>
  • LAMBERT M, CHAFEY P, HUGNOT JP, KOULAKOFF A, BERWALDNETTER Y, BILLARD C, MORRIS GE, KAHN A, KAPLAN JC, GILGENKRANTZ H. 1993. EXPRESSION OF THE TRANSCRIPTS INITIATED IN THE 62ND INTRON OF THE DYSTROPHIN GENE. NEUROMUSCULAR DISORDERS (vol. 3, pp. 519-524). link> doi>

Personal website: www.glennmorris.org.uk

Check out our NEW monoclonal antibody website at: http://glennmorris.org.uk/mabs.htm


Professor Morris is on the Editorial Boards of:
- “Neuromuscular Disorders” 
- “Translational Neuroscience”