li_wen-wu - Keele University

Dr Wen-Wu Li

Title: Lecturer in Analytical Biochemistry
Phone: +44 (0)1782 555288
Email:
Location: Institute for Science and Technology in Medicine, Keele University,
Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM research themes: 1. Clinical & Diagnostic Science
2. Neuroscience & Human Metabolism
Contacting me: By phone or e-mail please.
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Dr W-W Li studied biochemistry at Jilin University and Chinese Academy of Sciences, and obtained his PhD in organic chemistry from Zhejiang University, China. Then he did research on plant biotechnology with Prof. Wolfgang Barz at Muenster University and on protein chemistry with Prof. Wolfgang Haehnel at Freiburg University, Germany. He then moved to Oxford University in England, where he worked with Prof Hagan Bayley and Ben Davis on chemical biology of carbohydrate and proteins.

In November 2011 Dr Li moved to the Institute for Science & Technology in Medicine at Keele University to take up a faculty position as Lecturer in Analytical Biochemistry. His initial lecture was entitled “Single-molecule detection of biomolecules using protein nanopores”, for an abstract see Dr Wen-Wu Li presentation Nov2011.   

 

ISTM research themes: 1. Clinical & Diagnostic Science
                                     2. Neuroscience & Human Metabolism

  Research interests:

  • Biomarker (volatile and non-volatile metabolites, proteins and DNA) discovery for lung cancer and diabetes using mass spectrometry (GC-MS, SIFT-MS, ESI-MS, and MALDI-MS);
  • Kinetic and mechanistic studies on the covalent and non-covalent chemistries (including quinone, cyclodextrins and anti-cancer drugs) using protein nanopores and patch clamp electrophysiology;
  • Drug discovery from nature and via chemical synthesis. 

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Selected publications:

  • Li WW, Claridge T, Li Q, Wormald M, Davis B, Bayley H. 2011. Tuning the cavity of cyclodextrins: altered sugar adaptors in protein pores. J. AM. CHEM. SOC., vol. 113, 1987-2011.
  • Lu S, Li WW, Rotem D, Mikhailova E, Bayley H. 2010. A primary hydrogen-deuterium isotope effect observed at the single-molecule level. NATURE CHEMISTRY, vol. 2, 821-828 (Cover story; News and Views in Nature Chemistry; News in Chemistry World).
  • Li WW, Hellwig P, Ritter M, Haehnel W. 2006. De novo design, synthesis and characterization of quinoproteins. CHEM. EUR. J., vol. 12, 7236-7245.
  • Li WW, Barz W. 2006. Structure and accumulation of phenolics in elicited Echinacea purpurea cell cultures. PLANTA MED., vol.  72, 248-254.
  • Li WW, Heinze J, Haehnel W. 2005. Site-specific binding of quinones to proteins through thiol addition and addition-elimination reactions. J. AM. CHEM. SOC., vol. 127, 6140-6141. 

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Memberships of professional societies:

  • Royal Society of Chemistry;
  • European Peptide Society ;
  • Phytochemical Society of Europe