Professor Anthony A Fryer

Title: Professor of Clinical Biochemistry
Phone: +44 (0)1782 675378
Email:
a.a.fryer@keele.ac.uk
Location: Institute for Science & Technology in Medicine, Keele University,
Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM Research themes:
1. Clinical & Diagnostic Science
2. Infection, Inflammation & Immunity
Contacting me: By e-mail please.
Tony_Fryer_150x190

Prof Tony Fryer completed his PhD at Keele in 1991 following work as a research biochemist in Department of Clinical Biochemistry, at North Staffordshire Hospital NHS Trust. He became a Keele Honorary Lecturer in 1999, Hon Senior Lecturer in 2003, in which year he became a Consultant Clinical Biochemist and was made Head of the Department of Clinical Biochemistry the following year.

Appointed as Keele Professor of Clinical Biochemistry in the Institute for Science & Technology in Medicine in 2008, Prof Fryer has also been chair of the West Midlands Association of Clinical Biochemistry since 2009. His involvement in research and training through Keele and the WM Association includes supervision of higher degrees and trainee Clinical Biochemists, and a wide range of research grants and awards from national and regional funders such National Institute for Health Research, Medical Research Council, Engineering and Physical Sciences Research Council, Cancer Research UK, British Lung Foundation, and the former NHS Locally Organised Research Scheme. Prof Fryer is a member of the  Fetal Epigenetics Group, and has output over 150 peer-reviewed publications and 24 book chapters/reviews.

In October 2012 Prof Fryer will succeed Prof Gordon Ferns as interim Research Director for the University Hospital of North Staffordshire.

ISTM Research themes:

1. Clinical & Diagnostic Science
2. Infection, Inflammation & Immunity 

Research Interests:

•    Performing the right test in the right patient at the right time: Assessment of the appropriateness of pathology testing and impact of guidance.
•    The impact of maternal folate supplementation during pregnancy on fetal epigenome..
•    Genetic and environmental risk factors for skin cancer in renal transplant recipients: use of statistical modelling approaches to predict risk.

Proportion of appropriate requests from primary care for the glycosylated haemoglobin test. Figure illustrates that 40% of requests are inappropriate (green/red bars), that this proportion is increasing and that national guidance has had little impact.  

Proportion of appropriate requests from primary care for the glycosylated haemoglobin test. Figure illustrates that 40% of requests are inappropriate (green/red bars), that this proportion is increasing and that national guidance has had little impact.

Association of mean LINE-1 methylation, as a surrogate for global methylation, with cord plasma homocysteine concentration. Figure illustrates a significant inverse relationship (p=0.001, r= -0.69) between markers of global methylation and functional methyl group supply.  

Association of mean LINE-1 methylation, as a surrogate for global methylation, with cord plasma homocysteine concentration. Figure illustrates a significant inverse relationship (p=0.001, r= -0.69) between markers of global methylation and functional methyl group supply.

Selected Publications

  • Driskell OJ, Holland D, Hanna FW, Jones PW, Pemberton RJ, Tran M, Fryer AA. 2012. Inappropriate requesting of glycated hemoglobin (Hb A1c) is widespread: assessment of prevalence, impact of national guidance, and practice-to-practice variability. Clin Chem, vol. 58(5), 906-915. link> doi>
  • Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2013. Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals. Epigenetics, vol. 8(11). link>
  • Haworth KE, Farrell WE, Emes RD, Ismail KM, Carroll WD, Borthwick HA, Yates AM, Hubball E, Rooney A, Khanam M, Aggarwal N, Jones PW, Fryer AA. 2013. Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. Epigenomics, vol. 5(1), 37-49. link> doi>
  • Emes RD, Clifford H, Haworth KE, Farrell WE, Fryer AA, Carroll WD, Ismail KM. 2013. Antiepileptic drugs and the fetal epigenome. Epilepsia, vol. 54(1), e16-e19. link> doi>
  • Fryer AA and Smellie WS. 2013. Managing demand for laboratory tests: a laboratory toolkit. J Clin Pathol, vol. 66(1), 62-72. link> doi>

Full Publications List show

Journal Articles

  • Glossop JR, Nixon NB, Emes RD, Haworth KE, Packham JC, Dawes PT, Fryer AA, Mattey DL, Farrell WE. 2013. Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals. Epigenetics, vol. 8(11). link>
  • Haworth KE, Farrell WE, Emes RD, Ismail KM, Carroll WD, Borthwick HA, Yates AM, Hubball E, Rooney A, Khanam M, Aggarwal N, Jones PW, Fryer AA. 2013. Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. Epigenomics, vol. 5(1), 37-49. link> doi>
  • Emes RD, Clifford H, Haworth KE, Farrell WE, Fryer AA, Carroll WD, Ismail KM. 2013. Antiepileptic drugs and the fetal epigenome. Epilepsia, vol. 54(1), e16-e19. link> doi>
  • Fryer AA and Smellie WS. 2013. Managing demand for laboratory tests: a laboratory toolkit. J Clin Pathol, vol. 66(1), 62-72. link> doi>
  • Driskell OJ, Holland D, Hanna FW, Jones PW, Pemberton RJ, Tran M, Fryer AA. 2012. Inappropriate requesting of glycated hemoglobin (Hb A1c) is widespread: assessment of prevalence, impact of national guidance, and practice-to-practice variability. Clin Chem, vol. 58(5), 906-915. link> doi>
  • Smith D, Spaněl P, Fryer AA, Hanna F, Ferns GA. 2011. Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus?. J Breath Res, vol. 5(2), 022001. link> doi>
  • Fryer AA, Emes RD, Ismail KM, Haworth KE, Mein C, Carroll WD, Farrell WE. 2011. Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics, vol. 6(1), 86-94. link> doi>
  • Tahrani AA, Geen J, Hanna FW, Jones PW, Cassidy D, Bates D, Fryer AA. 2011. Predicting dysglycaemia in patients under investigation for acute coronary syndrome. QJM, vol. 104(3), 231-236. link> doi>
  • Magnay JL, El-Shourbagy M, Fryer AA, O'Brien S, Ismail KM. 2010. Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder. Am J Obstet Gynecol, vol. 203(2), 181.e1-181.e5. link> doi>
  • Fryer AA and Hanna FW. 2009. Managing demand for pathology tests: financial imperative or duty of care?. Ann Clin Biochem, vol. 46(Pt 6), 435-437. link> doi>
  • Nafee T, Karpova E, Farrell W, Fryer A, Carroll W, Emes R, Ismail K. 2009. DNA methylation in cord blood, fetal plasma homocysteine, and fetal growth - A pilot study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol. 116(10), 1412. link>
  • Fryer AA, Nafee TM, Ismail KM, Carroll WD, Emes RD, Farrell WE. 2009. LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study. Epigenetics, vol. 4(6), 394-398. link>
  • Urwin HR, Jones PW, Harden PN, Ramsay HM, Hawley CM, Nicol DL, Fryer AA. 2009. Predicting risk of nonmelanoma skin cancer and premalignant skin lesions in renal transplant recipients. Transplantation, vol. 87(11), 1667-1671. link> doi>
  • Ghosh S, Fryer AA, Hoban PR, Wynn-Jones C, Maffulli N. 2009. Fibrillin 1 gene with R2726W mutation is absent in patients with primary protrusio acetabuli and developmental dysplasia of the hip. Med Sci Monit, vol. 15(5), CR199-CR202. link>
  • HUTTON HD, DRUMMOND HS, FRYER AA. 2009. The rise and fall of C-reactive protein: managing demand within clinical biochemistry. Annals of Clinical Biochemistry, vol. 46, 155-158.
  • Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban PR, Rukin N, Alldersea J, Strange RC, Hawkins CP. 2008. Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis. Mult Scler, vol. 14(9), 1280-1283. link> doi>
  • Millard TP, Fryer AA, McGregor JM. 2008. A protective effect of glutathione-S-transferase GSTP1*Val(105) against polymorphic light eruption. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 128(8), 1901-1905. link> doi>
  • Woolmore J, Stone M, Holley S, Jenkinson P, Ike A, Jones P, Fryer A, Strange R, Stephens R, Langdon D, Hawkins C. 2008. Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. Mult Scler, vol. 14(2), 177-182. link> doi>
  • Nafee TM, Farrell WE, Carroll WD, Fryer AA, Ismail KM. 2008. Epigenetic control of fetal gene expression. BJOG, vol. 115(2), 158-168. link> doi>
  • Woolmore J, Stone M, Holley S, Jenkinson P, Ike A, Jones P, Fryer AA, Strange R, Stephens R, Langdon D, Hawkins C. 2008. Predicting dysglycaemia in patients under investigation for acute coronary syndrome gene and cognitive impairment in multiple sclerosis. Multiple Sclerosis, vol. 14(2), 177-182.
  • Holley SL, Fryer AA, Haycock JW, Grubb SE, Strange RC, Hoban PR. 2007. Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis. Carcinogenesis, vol. 28(11), 2268-2273. link> doi>
  • Dhingra V, Magnay JL, O'Brien PM, Chapman G, Fryer AA, Ismail KM. 2007. Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder. Obstet Gynecol, vol. 110(4), 788-792. link> doi>
  • Ramsay HM, Reece SM, Fryer AA, Smith AG, Harden PN. 2007. Seven-year prospective study of nonmelanoma skin cancer incidence in UK renal transplant recipients. TRANSPLANTATION, vol. 84(3), 437-439. link> doi>
  • Lenney W and Fryer AA. 2007. The genetics of asthma - are the glutathione S-transferases serious players?. CLINICAL AND EXPERIMENTAL ALLERGY, vol. 37(8), 1124-1126. link> doi>
  • Woolmore JA, Stone M, Pye EM, Partridge JM, Boggild M, Young C, Jones PW, Fryer AA, Hawkins CP, Strange RC. 2007. Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation. Mult Scler, vol. 13(3), 369-375. link> doi>
  • Rukin NJ, Luscombe C, Moon S, Bodiwala D, Liu S, Saxby MF, Fryer AA, Alldersea J, Hoban PR, Strange RC. 2007. Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene. Cancer Lett, vol. 247(2), 328-335. link> doi>
  • Rukin N, Blagojevic M, Luscombe CJ, Liu S, Saxby MF, Ramachandran S, Fryer AA, Jones PW, Strange RC. 2007. Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer. Cancer Detect Prev, vol. 31(6), 443-449. link> doi>
  • FRYER AA, CARROLL WD, FARRELL WE, FRYER AA, NAFEE T, ISMAIL K. 2007. One man's meat is another man's poison. British Medical Journal, vol. 334, 1252.
  • KAPOOR B, DUNLOP C, WYNNE-JONES C, FRYER AA, STRANGE RC, MAFFULLI N. 2007. Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli- A preliminary study. Journal of Negative Results in Biomedicine, vol. 6, 7.
  • Gray A, Stewart H, Pravica V, Fryer AA, Lenney W, Hutchinson IV, Arkwright PD. 2006. Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis. PEDIATRIC ALLERGY AND IMMUNOLOGY, vol. 17(8), 578-582. link> doi>
  • Madan V, Hoban PR, Strange RC, Fryer AA, Lear JT. 2006. Prognostic factors for a subsequent basal cell carcinoma: implications for follow-up. BRITISH JOURNAL OF DERMATOLOGY, vol. 155(1), 217-218. link> doi>
  • Carroll WD, Lenney W, Child F, Strange RC, Jones PW, Whyte MK, Primhak RA, Fryer AA. 2006. Asthma severity and atopy: how clear is the relationship?. ARCHIVES OF DISEASE IN CHILDHOOD, vol. 91(5), 405-409. link> doi>
  • Moon S, Holley S, Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer A, Strange RC. 2006. Associations between G/A(1229), A/G(3944), T/C-30875 C/T-48200 and C/T-65013 genotypes and haplotype in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. ANNALS OF HUMAN GENETICS, vol. 70, 226-236. link> doi>
  • Moon S, Holley S, Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2006. Associations between G/A1229, A/G3944, T/C30875, C/T48200 and C/T65013 genotypes and haplotypes in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer. Ann Hum Genet, vol. 70(Pt 2), 226-236. link> doi>
  • Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2006. Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer. Int J Oncol, vol. 28(1), 231-236. link>
  • SALIM A, REECE SM, SMITH AG, HARRISON D, RAMSAY HM, HARDEN PN, FRYER AA. 2006. Sebaceous hyperplasia and skin cancer in renal transplant patients. Journal of the American Academy of Dermatology, vol. 55, 878-881.
  • Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. 2005. Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer. Carcinogenesis, vol. 26(12), 2157-2163. link> doi>
  • Moon SJ, Fryer AA, Strange RC. 2005. Ultraviolet radiation, vitamin D and risk of prostate cancer and other diseases. Photochem Photobiol, vol. 81(6), 1252-1260. link> doi>
  • Carroll WD, Lenney W, Jones PW, Strange RC, Child F, Whyte MK, Primhak RA, Fryer AA. 2005. Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. CLINICAL AND EXPERIMENTAL ALLERGY, vol. 35(9), 1155-1161. link> doi>
  • Lovatt T, Alldersea J, Lear JT, Hoban PR, Ramachandran S, Fryer AA, Smith AG, Strange RC. 2005. Polymorphism in the nuclear excision repair gene ERCC2/XPD: association between an exon 6-exon 10 haplotype and susceptibility to cutaneous basal cell carcinoma. Hum Mutat, vol. 25(4), 353-359. link> doi>
  • Carroll WD, Lenney W, Proctor A, Whyte MC, Primhak RA, Cliffe I, Jones PW, Strange RC, Fryer AA, Child F. 2005. Regional variation of airway hyperresponsiveness in children with asthma. RESPIRATORY MEDICINE, vol. 99(4), 403-407. link> doi>
  • Moon SJ, Fryer AA, Strange RC. 2005. Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers. Mutat Res, vol. 571(1-2), 207-219. link> doi>
  • Lovatt TJ, Lear JT, Bastrilles J, Wong C, Griffiths CE, Samarasinghe V, Roebuck J, Ramachandran S, Smith AG, Jones PW, Fryer AA, Strange RC. 2005. Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors. J Am Acad Dermatol, vol. 52(3 Pt 1), 468-473. link> doi>
  • Holley SL, Matthias C, Jahnke V, Fryer AA, Strange RC, Hoban PR. 2005. Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma. Oral Oncol, vol. 41(2), 156-160. link> doi>
  • Carroll WD, Lenney W, Child F, Strange RC, Jones PW, Fryer AA. 2005. Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. PEDIATRIC ALLERGY AND IMMUNOLOGY, vol. 16(1), 32-39. link> doi>
  • Lear JT, Hoban P, Strange RC, Fryer AA. 2005. Basal cell carcinoma: from host response and polymorphic variants to tumour suppressor genes. CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 30(1), 49-55. link> doi>
  • ALAM M, PRAVICA V, FRYER AA, HAWKINS CP, HUTCHINSON IV. 2005. Novel polymorphism in the promoter region of the human nerve growth-factor gene. International Journal of Immunogenetics, vol. 32, 379-382.
  • Fryer AA, Ramsay HM, Lovatt TJ, Jones PW, Hawley CM, Nicol DL, Strange RC, Harden PN. 2005. Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients. Carcinogenesis, vol. 26(1), 185-191. link> doi>
  • McCloud JM, Sivakumar R, Greenhough A, Elder J, Jones PW, Deakin M, Elder JB, Fryer AA, Hoban PR. 2004. p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer. Int J Oncol, vol. 25(5), 1447-1452. link>
  • Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Lear JT, Wong C, Jones PW, Ichii-Jones F, Hoban PR. 2004. Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms. Ann Hum Genet, vol. 68(Pt 6), 536-545. link> doi>
  • Brind AM, Hurlstone A, Edrisinghe D, Gilmore I, Fisher N, Pirmohamed M, Fryer AA. 2004. The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. ALCOHOL AND ALCOHOLISM, vol. 39(6), 478-483. link> doi>
  • BARTON A, WOOLMORE JA, WARD D, EYRE S, HINKS A, OLLIER WE, STRANGE RC, FRYER AA, JOHN S, HAWKINS CP, WORTHINGTON J. 2004. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. Brain, vol. 127(8), 1717-1722. doi>
  • Howells RE, Dhar KK, Hoban PR, Jones PW, Fryer AA, Redman CW, Strange RC. 2004. Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer. Int J Gynecol Cancer, vol. 14(2), 242-250. link> doi>
  • Lovatt TJ, Lear JT, Bastrilles J, Wong C, Griffiths CE, Ramachandran S, Smith AG, Salim A, Fryer AA, Jones PW, Strange RC. 2004. Associations between UVR exposure and basal cell carcinoma site and histology. Cancer Lett, vol. 216(2), 191-197. link> doi>
  • STRANGE RC and FRYER AA. 2004. Glutathione S-transferase genotype- Clinical implications. Encyclopaedia of Medical Genomics and Preteomics, 536-542.
  • HODGSON R, SMITH SE, STRANGE RC, FRYER AA. 2004. Pharmacogenetic clinics in psychiatry: A clinical reality?. Psychiatric Bulletin, vol. 28, 298-300.
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2004. Polymorphisms in the vitamin D receptor gene, ultraviolet radiation, and susceptibility to prostate cancer. Environ Mol Mutagen, vol. 43(2), 121-127. link> doi>
  • Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Lear JT, Ichii-Jones F, Jones PW, Hoban PR. 2004. PTCH polymorphism is associated with the rate of increase in basal cell carcinoma numbers during follow-up: preliminary data on the influence of an exon 12-exon 23 haplotype. Environ Mol Mutagen, vol. 44(5), 469-476. link> doi>
  • Partridge JM, Weatherby SJ, Woolmore JA, Highland DJ, Fryer AA, Mann CL, Boggild MD, Ollier WE, Strange RC, Hawkins CP. 2004. Susceptibility and outcome in MS: associations with polymorphisms in pigmentation-related genes. Neurology, vol. 62(12), 2323-2325. link>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Alldersea J, Strange RC, Fryer A. 2003. The Association of material but not paternal genetic variation in GSTP1 with asthma phenotypes in children. Respiratory Medicine, vol. 97(12), 1247-1256. doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Strange RC, Fryer A. 2003. Correction of bronchial challenge data for age and size may affect the results of genetic association studies in children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology., vol. 14(3), 193-200. doi> link>
  • Carroll RP, Ramsay HM, Fryer AA, Hawley CM, Nicol DL, Harden PN. 2003. Incidence and prediction of nonmelanoma skin cancer post-renal transplantation: a prospective study in Queensland, Australia. Am J Kidney Dis, vol. 41(3), 676-683. link> doi>
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Strange RC, FRYER AA. 2003. Age and size adjustment of bronchial chanllange data may affect the results of genetic association studies in children. Paediatric Allergy and Immunology, vol. 14, 193-200.
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2003. Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation. Cancer Lett, vol. 200(2), 141-148. link> doi>
  • Ramachandran MS, Fryer AA, Lovatt T, Smith AG, Lear JT, Jones PW, Strange RC. 2003. Combined effects of gender, skin type and polymorphic genes in clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system. Cancer Letters, vol. 189(2), 175-181. doi>
  • Matthias C, Jahnke V, Fryer AA, Strange AA. 2003. First results on the influence of polymorphisms at glutahione s-tranferase, cytochrome p450, and tumer necrosis factor gene Loci on the development of multiple head and neck cancer. Laryngo-rhino-otologie, vol. 82(1), 25-30. doi>
  • HODGSON R, STRANGE RC, FRYER AA. 2003. Pharmacogenetics and psychiatry. Midlands Medicine, vol. 22, 267-269.
  • Bodiwala D, Luscombe CJ, Liu S, Saxby M, French M, Jones PW, Fryer AA, Strange RC. 2003. Prostate cancer risk and exposure to ultraviolet radiation: further support for the protective effect of sunlight. Cancer Lett, vol. 192(2), 145-149. link> doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Ramachandran S, Fryer AA, Strange RC. 2003. Susceptibility to prostate cancer: studies on interactions between UVR exposure and skin type. Carcinogenesis, vol. 24(4), 711-717. link> doi>
  • Ramachandran MS, Fryer AA, Lovatt T, Smith AG, Lear JT, Jones PW, Strange RC. 2003. The rate of increase in the numbers of primary sporadic basal cell carcinomas during follow up with age at first presentation. Carcenogenesis.
  • McGinnis R, Child F, Clayton S, Davies S, Lenney W, Illig T, Wjst M, Spurr N, Debouck C, Hajeer AH, Ollier WER, Strange R, Fryer AA. 2002. Further support for the association of CCR5 allelic variants with asthma susceptibility. EUROPEAN JOURNAL OF IMMUNOGENETICS, vol. 29(6), 525-528. link> doi>
  • Ramachandran MS, Fryer AA, Lovatt T, Smith AG, Lear JT, Jones PW, Strange RC. 2003. The rate of increase in the numbers of primary sporadic basal cell carcinomas during follow up with age at first presentation. Carcenogenesis. doi>
  • Ramsay HM, Fryer AA, Hawley CM, Smith AG, Harden PN. 2002. Non-melanoma skin cancer risk in the Queensland renal transplant population. Br J Dermatol, vol. 147(5), 950-956. link>
  • Henrion-Caude A, Flamant C, Roussey M, Housset C, Flahault A, Fryer AA, Chadelat K, Strange RC, Clement A. 2002. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. HEPATOLOGY, vol. 36(4), 913-917. link> doi>
  • Mann CL, Davies MB, Stevenson VL, Leary SM, Boggild MD, Ko Ko C, Jones PW, Fryer AA, Strange RC, Thompson AJ, Hawkins CP. 2002. Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity. J Neuroimmunol, vol. 129(1-2), 197-204. link> doi>
  • Mansur AH, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2002. An association study between the Clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes. Clin Exp Allergy, vol. 32(7), 994-999. link> doi>
  • Fawole AS, Simpson DJ, Rajagopal R, Elder J, Holland TA, Fryer A, Deakin M, Elder JB, Farrell WE. 2002. Loss of heterozygosity on chromosome 10q is associated with earlier onset sporadic colorectal adenocarcinoma. Int J Cancer, vol. 99(6), 829-833. link> doi>
  • Matthias C, Jahnke V, Fryer AA, Strange RC. 2002. Influence of glutathione S-transferase and cytochrome P450 polymorphisms on prognosis of head and neck cancer. LARYNGO-RHINO-OTOLOGIE, vol. 81(6), 406-412. link> doi>
  • Child F, Davies S, Clayton S, Fryer AA, Lenney W. 2002. Inhaler devices for asthma: do we follow the guidelines?. Arch Dis Child, vol. 86(3), 176-179. link> doi>
  • Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osborne JE, Lear JT, Smith AG, Hutchinson IV. 2002. Association between functional polymorphism in EGF gene and malignant melanoma. LANCET, vol. 359(9304), 397-401. link> doi>
  • Shahbazi M, Pravica V, Nareen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osbourne JE, Lear JT, Smith AG, Hutchinson IV. 2002. A functional polymorphism in the human EGF gene associated with malignant melanoma. Lancet.
  • Luscombe CJ, French ME, Liu S, Saxby MF, Farrell WE, Jones PW, Fryer AA, Strange RC. 2002. Glutathione S-transferase GSTP1 genotypes are associated with response to androgen ablation therapy in advanced prostate cancer. Cancer Detect Prev, vol. 26(5), 376-380. link> doi>
  • Mapp CE, Fryer AA, De Marzo N, Pozzato V, Padoan M, Boschetto P, Strange RC, Hemmingsem A, Spiteri M. 2002. Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by Isocyanates. The Journal of Clinical Immunology. doi>
  • FAWOLE AS, SIMPSON DJ, RAJAGOPAL R, ELDER J, HOLLAND TA, FRYER AA, DEAKIN M, ELDER JB, FARRELL WE. 2002. Loss of heterozygosity on chromosome 10q is associated with earlier onset sporadic coloractal adenocarcinoma. International Journal of Cancer, vol. 99, 829-833.
  • Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Clarke S, Fisher J, Brownfield A, Alldersea J, Fryer AA, Strange RC. 2002. Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus. Arthritis Rheum, vol. 46(3), 640-646. link> doi> full text>
  • Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, Harden PN. 2002. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol, vol. 13(1), 260-264. link>
  • Fryer AA and Strange RC (Plus 64 non keele authors). 2001. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology, Biomarkers & Prevention.
  • Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. Br J Cancer, vol. 85(10), 1504-1509. link> doi>
  • Simpson DJ, Fryer AA, Grossman AB, Wass JA, Pfeifer M, Kros JM, Clayton RN, Farrell WE. 2001. Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. Carcinogenesis, vol. 22(11), 1801-1807. link> doi>
  • Bamber DE, Fryer AA, Strange RC, Elder JB, Deakin M, Rajagopal R, Fawole A, Gilissen RA, Campbell FC, Coughtrie MW. 2001. Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics, vol. 11(8), 679-685. link> doi>
  • Holland TA, Elder J, McCloud JM, Hall C, Deakin M, Fryer AA, Elder JB, Hoban PR. 2001. Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21(WAF1/CIP1) expression and correlates with patient survival. Int J Cancer, vol. 95(5), 302-306. link> doi>
  • Harden PN, Reece SM, Fryer AA, Smith AG, Ramsay HM. 2001. Skin cancer surveillance in renal transplant recipients: questionnaire survey of current UK practice. BMJ, vol. 323(7313), 600-601. link>
  • Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001. Outcome in prostate cancer associations with skin type and polymorphism in pigmentation-related genes. Carcinogenesis, vol. 22(9), 1343-1347. link> doi>
  • Luscombe CJ, Fryer AA, French ME, Liu S, Saxby MF, Jones PW, Strange RC. 2001. Exposure to ultraviolet radiation: Association with susceptibility and age at presentation with prostate cancer. Lancet. doi>
  • Ramsay HM, Harden PN, Reece S, Smith AG, Jones PW, Strange RC, Fryer AA. 2001. Polymorphisms in glutathione S-transferases are associated with altered risk of nonmelanoma skin cancer in renal transplant recipients: a preliminary analysis. J Invest Dermatol, vol. 117(2), 251-255. link> doi>
  • Ramachandran S, Fryer AA, Smith A, Lear J, Bowers B, Jones PW, Strange RC. 2001. Cutaneous basal cell carcinomas: distinct host factors are associated with the development of tumors on the trunk and on the head and neck. Cancer, vol. 92(2), 354-358. link> doi>
  • Child F, Clayton S, Davies S, Fryer AA, Jones PW, Lenney W. 2001. How should airways resistance be measured in young children: mask or mouthpiece?. Eur Respir J, vol. 17(6), 1244-1249. link> doi>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Hartland AJ, Whiteside JR, Jones PW, Strange RC. 2001. Basal cell carcinomas: association of allelic variants with a high-risk subgroup of patients with the multiple presentation phenotype. Pharmacogenetics, vol. 11(3), 247-254. link> doi>
  • Strange RC, Lear JT, Fryer AA. 2001. How important are GST polymorphisms in defining clinical phenotypes: some answers from studies in high risk groups. Chemico-Biological Interactions.
  • Weatherby SJM, Fryer AA, Mann C, Ollier W, Strange R, Hawkins CP. 2001. Epistasis: a potentially important concept in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 70(2), 283. link>
  • Pozzato V, Padoan M, De Marzo N, Ferrarese S, Boschetto P, FRYER AA, Strange RC, Hemmingsen A, Spiteri MA, Mapp CE. 2001. G Ital Med Lav Ergon. G Ital Med Lav Ergon, vol. 23(3), 276.
  • Howells RE, Holland T, Dhar KK, Redman CW, Hand P, Hoban PR, Jones PW, Fryer AA, Strange RC. 2001. Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 expression and survival. Int J Gynecol Cancer, vol. 11(2), 107-112. link> doi>
  • Strange RC, Spiteri MA, Ramachandran S, Fryer AA. 2001. Glutathione-S-transferase family of enzymes. Mutat Res, vol. 482(1-2), 21-26. link> doi>
  • Weatherby SJ, Thomson W, Pepper L, Donn R, Worthington J, Mann CL, Davies MB, Fryer AA, Boggild MD, Young CA, Jones PW, Strange RC, Ollier WE, Hawkins CP. 2001. HLA-DRB1 and disease outcome in multiple sclerosis. J Neurol, vol. 248(4), 304-310. link> doi>
  • GARTE S, GASPARI L, ALEXANDRIE AK, AMBROSONE C, AUTRUP H, AUTRUP JL, BARANOVA H, BATHUM L, BENHAMOU S, BOFFETTA P, BOUCHARDY C, BRESKVAR K, BROCKMOLLER J, CASCORBI I, CLAPPER ML, COUTELLE C, DALY A, DELL'OMO M, DOLZAN V, DRESLER CM, FRYER AA, HAUGEN A, HEIN DW, HILDESHEIM A, HIRVONEN A, HSIEH LL, INGELMAN-SUNDBERG M, KALINA I, KANG D, KIHARA M, KIYOHARA C, KREMERS P, LAZARUS P, LE MARCHAND L, LECHNER MC, VAN LIESHOUT EM, LONDON S, MANNI JJ, MAUGARD CM, MORITA S, NAZAR-STEWART V, NODA K, ODA Y, PARL FF, PASTORELLI R, PERSSON I, PETERS WH, RANNUG A, REBBECK T, RISCH A, ROELANDT L, ROMKES M, RYBERG D, SALAGOVIC J, SCHOKET B, SEIDEGARD J, SHIELDS PG, SIM E, SINNET D, STRANGE RC, STUCKER I, SUGIMURA H, TO-FIGUERAS J, VINEIS P, YU MC, TAIOLI E. 2001. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology, Biomarkers and Prevention, vol. 10, 1239-1248.
  • JONES PW, STRANGE RC, RAMACHANDRAN S, FRYER AA. 2001. Models for determining genetic susceptibility and predicting outcome. Biostatistical Methods, 131-142.
  • FRYER AA, BIANCO A, HEPPLE M, JONES PW, STRANGE RC, SPITERI MA. 2001. Polymorphism at the glutathione S-transferase, GSTP1, locus: A new marker for bronchial hyperresponsiveness and asthma. Allergy Review Journal, vol. 3, 7-9.
  • Hemmingsen A, Fryer AA, Hepple M, Strange RC, Spiteri MA. 2001. Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respir Res, vol. 2(4), 255-260. link>
  • Ramachandran S, Fryer AA, Lovatt T, Lear J, Smith AG, Strange RC. 2001. Susceptibility and modifier genes in cutaneous basal cell carcinomas and their associations with clinical phenotype. J Photochem Photobiol B, vol. 63(1-3), 1-7. link>
  • Hemmingsen A, Fryer AA, Allen JT, Strange RC, Spiteri MA. 2000. Measurement of glutathione S-transferease, GSTP1 expression in human bronchial epithelial cells following oxidative stress. THORAX, vol. 55, A59. link>
  • Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC, Makki R, Tavernier G, Smilie FI, Custovic A, Woodcock AA, Ollier WE, Hajeer AH. 2000. The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun, vol. 1(8), 509-514. link> doi>
  • Ramachandran S, Fryer AA, Smith AG, Lear JT, Bowers B, Griffiths CE, Jones PW, Strange RC. 2000. Basal cell carcinoma. Cancer, vol. 89(5), 1012-1018. link> doi>
  • Ramachandran S, Hoban PR, Ichii-Jones F, Pleasants L, Ali-Osman F, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. 2000. Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours. Pharmacogenetics, vol. 10(6), 545-556. link> doi>
  • Beswick SJ, Garrido MC, Fryer AA, Strange RC, Smith AG. 2000. Multiple basal cell carcinomas and malignant melanoma following radiotherapy for ankylosing spondylitis. Clin Exp Dermatol, vol. 25(5), 381-383. link>
  • Weatherby SJM, Mann CLA, Davies MB, Fryer AA, Haq N, Strange RC, Hawkins CP. 2000. A pilot study of the relationship between gadolinium-enhancing lesions, gender effect and polymorphisms of antioxidant enzymes in multiple sclerosis. JOURNAL OF NEUROLOGY, vol. 247(6), 467-470. link> doi>
  • Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. 2000. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med, vol. 161(5), 1437-1442. link> doi>
  • Mattey DL, Hassell AB, Dawes PT, Jones PW, Yengi L, Alldersea J, Strange RC, Fryer AA. 2000. Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: evidence for interaction with glutathione S-transferase genes. Arthritis Rheum, vol. 43(4), 859-864. link> doi>
  • Weatherby SJM, Mann CLA, Fryer AA, Strange RC, Hawkins CP, Stevenson VL, Leary SM, Thompson AJ. 2000. No association between the APOE epsilon 4 allele and outcome and susceptibility in primary progressive multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 68(4), 532. link> doi>
  • Fawole AS, Elder J, Holland TA, Fryer AA, Anwar S, Rajagopal R, Deakin M, Hall C, Elder JB, Farrell WE. 2000. Region of frequent loss of heterozygosity on long arm of chromosome 10 associated with earlier age of presentation in sporadic colorectal adenocarcinoma. GUT, vol. 46, A53. link>
  • Hajeer AH, Lear JT, Ollier WER, Naves M, Worthington J, Bell DA, Smith AG, Bowers WP, Jones PW, Strange RC, Fryer AA. 2000. Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas. BRITISH JOURNAL OF DERMATOLOGY, vol. 142(3), 441-445. link> doi>
  • Mann CLA, Davies MB, Boggild MD, Alldersea J, Fryer AA, Jones PW, Ko CK, Young C, Strange RC, Hawkins CP. 2000. Glutathione S-transferase polymorphisms in MS - Their relationship to disability. NEUROLOGY, vol. 54(3), 552-557. link>
  • Weatherby SJ, Mann CL, Davies MB, Carthy D, Fryer AA, Boggild MD, Young C, Strange RC, Ollier W, Hawkins CP. 2000. Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis. Mult Scler, vol. 6(1), 32-36. link> doi>
  • Hutchinson PE, Osborne JE, Lear JT, Smith AG, Bowers PW, Morris PN, Jones PW, York C, Strange RC, Fryer AA. 2000. Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. CLINICAL CANCER RESEARCH, vol. 6(2), 498-504. link>
  • Lear JT, Smith AG, Strange RC, Fryer AA. 2000. Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy. BRITISH JOURNAL OF DERMATOLOGY, vol. 142(1), 8-15. link> doi>
  • Hurlstone A, Fisher N, FRYER AA, Brind AM. 2000. Glutathione S-transferase M3 (GSTM3) and Mn superoxide dismutase (MnSOD) polymorphisms in decompensated alcoholic liver disease. Gut, vol. 46, Article A59.
  • Dhar KK, Branigan K, Parkes J, Howells RE, Hand P, Musgrove C, Strange RC, Fryer AA, Redman CW, Hoban PR. 1999. Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells. Br J Cancer, vol. 81(7), 1174-1181. link> doi>
  • Anwar S, Fryer AA, Gilissen RAHJ, Holland T, Bamber DE, Elder JB, Elder J, White J, Bicknell EJ, Strange RC, Coughtrie MWH. 1999. p53 protein overexpression correlates with phenol sulphotransferase (SULTIA1) genotype in colorectal cancer. BRITISH JOURNAL OF CANCER, vol. 81(4), 571-572. link>
  • Lear J, Sies H, Clairmont A, Ramachandran S, Smith A, Bowers B, Jones P, Fryer A, Strange R. 1999. Association of quinone oxidoreductase genotypes with basal cell carcinomas. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 113(3), 462. link>
  • Matthias C, Jahnke V, Jones PW, Hoban PR, Alldersea JE, Worrall SF, Fryer AA, Strange RC. 1999. Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: Assessment of the importance of individual genes using multivariate analysis. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, vol. 8(9), 815-823. link>
  • Clairmont A, Sies H, Ramachandran S, Lear JT, Smith AG, Bowers B, Jones PW, Fryer AA, Strange RC. 1999. Association of NAD(P)H : quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci. CARCINOGENESIS, vol. 20(7), 1235-1240. link> doi>
  • Dhar KK, Branigan K, Howells R, Musgrove C, Strange RC, Fryer AA, Redman CWE, Hoban PR. 1999. Expression and subcellular localisation of cyclin DI protein in epithelial ovarian tumour cells. BRITISH JOURNAL OF CANCER, vol. 80, 74. link>
  • Ramsay HM, Fryer A, Strange RC, Smith AG. 1999. Multiple basal cell carcinomas in a patient with acute myeloid leukaemia and chronic lymphocytic leukaemia. Clin Exp Dermatol, vol. 24(4), 281-282. link>
  • Dhar KK, Branigan K, Howells RE, Musgrove C, Jones PW, Strange RC, Fryer AA, Redman CW, Hoban PR. 1999. Prognostic significance of cyclin D1 gene (CCND1) polymorphism in epithelial ovarian cancer. Int J Gynecol Cancer, vol. 9(4), 342-347. link> doi>
  • Holland TA, Elder J, Deakin M, Hall C, Fryer AA, Elder JB, Hoban PR. 1999. Protein expression and subcellular localisation of cyclin D1 and p21 in human colorectal carcinoma. BRITISH JOURNAL OF CANCER, vol. 80, 10. link>
  • Strange RC, Ellison T, Ichii-Jones F, Bath J, Hoban P, Lear JT, Smith AG, Hutchinson PE, Osborne J, Bowers B, Jones PW, Fryer AA. 1999. Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma. Pharmacogenetics, vol. 9(3), 269-276. link> doi>
  • Holland TA, Elder J, Deakin M, Hall C, Strange RC, Fryer AA, Hoban PR, Elder JB. 1999. Cyclin D1 protein expression in human colorectal carcinoma. GUT, vol. 44, A141. link>
  • Strange RC, Ichii-Jones F, Lear JT, Hutchinson PE, Fryer AA. 1999. Skin type, melanoma, and melanocortin 1 receptor variants - Reply. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 112(4), 513. link>
  • Jones FI, Ramachandran S, Lear J, Smith A, Bowers B, Ollier WE, Jones P, Fryer AA, Strange RC. 1999. The melanocyte stimulating hormone receptor polymorphism: association of the V92M and A294H alleles with basal cell carcinoma. Clin Chim Acta, vol. 282(1-2), 125-134. link> doi>
  • Mattey DL, Hassell AB, Plant M, Dawes PT, Ollier WR, Jones PW, Fryer AA, Alldersea JE, Strange RC. 1999. Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. Ann Rheum Dis, vol. 58(3), 164-168. link> doi> full text>
  • Bianco A, Fryer AA, Hepple M, Alldersea J, Strange RC, Spiteri MA. 1999. Polymorphism at the glutathione S-transferase, GSTP1, locus is associated with atopy/airway responsiveness. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 159(3), A649. link>
  • Lear J, Sies H, Clairmont A, Ramachandran S, Smith A, Bowers B, Jones P, FRYER A, Strange R. 1999. Association of quinone oxidoreductase genotypes with basal cell carcinomas. Journal of Investigative Dermatology, vol. 113, 189.
  • HARDEN PN, RAMSAY HM, STRANGE RC, FRYER AA. 1999. Glutathione S-transferase (GSTT1) polymorphism is associated with acute rejection risk. Transplantation, 67.
  • Harden PN, Ramsay HM, Strange RC, FRYER AA. 1999. Glutathione S-transferase (GSTT1) polymorphism is associated with acute rjection risk. Transplantation, vol. 67, 12.
  • RAMACHANDRAN S, LEAR JT, FRYER AA, STRANGE RC. 1999. Glutathione S-transferase polymorphisms and outcome in cancer: Association with clinical phenotype in patients with multiple cutaneous basal cell carcinomas. Clinical Chemistry and Enzymology Communications, vol. 8, 417-430.
  • MATTHIAS C, JAHNKE V, HAND P, FRYER AA, STRANGE RC. 1999. Immunohistochemical and molecular genetic studies of the influence of glutathione-S-transferase as risk factors for the development of head and neck carcinomas. Laryngorhinootologie, vol. 78, 182-188.
  • Fryer AA and Jones PW. 1999. Interactions between detoxifying enzyme polymorphisms and susceptibility to cancer. IARC Sci Publ, 303-322. link>
  • Coughtrie MWH, Gilissen RAHJ, Shek B, Strange RC, Fryer AA, Jones PW, Bamber DE. 1999. Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. BIOCHEMICAL JOURNAL, vol. 337, 45-49. link> doi>
  • STRANGE RC, ICHII-JONES F, LEAR JT, HUTCHINSON PE, FRYER AA. 1999. Polymorphisms in the melanocortin 1 receptor: Association with red hair, skin type and susceptibility to malignant melanoma. Journal of Investigative Dermatology, vol. 112, 513.
  • Ramachandran S, Lear JT, Ramsay H, Smith AG, Bowers B, Hutchinson PE, Jones PW, Fryer AA, Strange RC. 1999. Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. Cancer Epidemiol Biomarkers Prev, vol. 8(1), 61-67. link>
  • Hemmingsen A, FRYER AA, Strange RC, Spiteri MA. 1999. Simultaneous determination of the glutathione S-transferase, GSTP1, A(114)V and I105V alleles using ARMS-PCR: Studies in patients with asthma. Thorax, vol. 54, S33.
  • White J, Anwar S, Deakin M, Elder J, Fryer A, Bamber D, Jones P, Strange R. 1999. The effect of glutathione S-transferase GSTT1 and GSTM1 genotypes on susceptibility and outcome in coloractal cancer. British Journal of Cancer, vol. 81, 18.
  • Strange RC and Fryer AA. 1999. The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ, 231-249. link>
  • Layton MA, Jones PW, Alldersea JE, Strange RC, Fryer AA, Dawes PT, Mattey DL. 1999. The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Rheumatology (Oxford), vol. 38(1), 43-47. link> doi> full text>
  • Lear JT, Harvey I, de Berker D, Strange RC, Fryer AA. 1998. Basal cell carcinoma. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, vol. 91(11), 585-588. link>
  • Howells RE, Redman CW, Dhar KK, Sarhanis P, Musgrove C, Jones PW, Alldersea J, Fryer AA, Hoban PR, Strange RC. 1998. Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. Clin Cancer Res, vol. 4(10), 2439-2445. link>
  • Matthias C, Branigan K, Jahnke V, Leder K, Haas J, Heighway J, Jones PW, Strange RC, Fryer AA, Hoban PR. 1998. Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. CLINICAL CANCER RESEARCH, vol. 4(10), 2411-2418. link>
  • Worrall SF, Corrigan M, High A, Starr D, Matthias C, Wolf CR, Jones PW, Hand P, Gilford J, Farrell WE, Hoban P, Fryer AA, Strange RC. 1998. Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6. Pharmacogenetics, vol. 8(5), 433-439. link> doi>
  • Ichii-Jones F, Lear JT, Heagerty AH, Smith AG, Hutchinson PE, Osborne J, Bowers B, Jones PW, Davies E, Ollier WE, Thomson W, Yengi L, Bath J, Fryer AA, Strange RC. 1998. Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene. J Invest Dermatol, vol. 111(2), 218-221. link> doi>
  • Lear JT, Tan BB, Smith AG, Jones PW, Heagerty AH, Strange RC, Fryer AA. 1998. A comparison of risk factors for malignant melanoma, squamous cell carcinoma and basal cell carcinoma in the UK. Int J Clin Pract, vol. 52(3), 145-149. link>
  • Matthias C, Bockmuhl U, Jahnke V, Jones PW, Hayes JD, Alldersea J, Gilford J, Bailey L, Bath J, Worrall SF, Hand P, Fryer AA, Strange RC. 1998. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. PHARMACOGENETICS, vol. 8(2), 91-100. link>
  • Matthias C, Bockmuhl U, Jahnke V, Harries LW, Wolf CR, Jones PW, Alldersea J, Worrall SF, Hand P, Fryer AA, Strange RC. 1998. The glutathione S-transferase GSTP1 polymorphism: Effects on susceptibility to oral/pharyngeal and laryngeal carcinomas. PHARMACOGENETICS, vol. 8(1), 1-6. link> doi>
  • MATTHIAS C, BOCKMUHL U, JAHNKE V, PETERSEN I, DIETEL M, FRYER AA, STRANGE RC. 1998. Effect of gene polymorphism on detoxifying glutathione-S-transferase enzymes on chromosomal stability of squamous epithelial carcinomas in the area of the head-neck. Laryngorhinootologie, vol. 77, 201-206.
  • MATTHIAS C, JAHNKE V, FRYER AA, STRANGE R, OLLIER W, HAJEER A. 1998. Influence of tumour necrosis factor microsatellite polymorphisms on susceptibility to head and neck cancer. Acta Otolaryngol, vol. 118, 284-288.
  • Lear J, Jones F, Smith AG, Hutchinson P, Osbourne J, Ollier W, FRYER AA, Strange RC. 1998. Malignant melanoma, skin type and polymorphism in the melanocyte stimulating hormone receptor gene. British Journal of Dermatology, vol. 138, 746.
  • Elexpuru-Camiruaga J, FRYER AA, Sankaran M, Kanduala V, Strange RC. 1998. Outcome of astrocytoma: Value of identification of polymorphisms at loci encoding detoxifying enzymes as prognostic factors. Journal of Neuro-Oncology.
  • Lear JT, Smith AG, Strange RC, FRYER AA. 1998. Patients with truncal basal cell carcinoma (BCC) represent a high risk group. Archives of Dermatology, vol. 134, 373.
  • Strange RC, Lear JT, Fryer AA. 1998. Polymorphism in glutathione S-transferase loci as a risk factor for common cancers. Arch Toxicol Suppl, vol. 20, 419-428. link>
  • Lear J, Smith A, Bowers W, Heagerty A, Strange R, FRYER AA. 1998. Risk Factors in those with skin cancer of different histological types. British Journal of Dermatology, vol. 139(supp 51), 65.
  • Lear J, Hajeer A, Ollier W, Smith AG, Bowers B, Heagerty A, Jones R, Jones PW, Strange R, FRYER AA. 1998. Tumor necrosis factor microsatallite alleles identify those at high risk of multiple basal cell carcinoma. British Journal of Dermatology, vol. 139(supp 51), 66.
  • Mattey DL, Hassell AB, Plant MJ, Davis MJ, Dawes PT, Ollier WER, Jones PW, Fryer AA, Alldersea J, Strange RC. 1997. Association of radiological outcome in RA with polymorphisms in the glutathione S-transferase supergene family. ARTHRITIS AND RHEUMATISM, vol. 40(9), 1790. link>
  • Matthias C, Jahnke V, Hand P, Fryer AA, Strange RC. 1997. Influence of allelism at GSTM1, GSTM3 and GSTP1 gene loci and enzyme expression on site-specific susceptibility to head and neck cancer. EUROPEAN JOURNAL OF CANCER, vol. 33, 822. link>
  • Lear JT, Smith A, Bowers W, Heagerty A, Jones P, Gilford J, Alldersea J, Strange R, Fryer A. 1997. Truncal site, detoxifying enzyme genotypes and time to presentation of next basal cell carcinoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 109(3), 435. link>
  • Lear JT, Smith AG, Heagerty AH, Bowers B, Jones PW, Gilford J, Alldersea J, Strange RC, Fryer AA. 1997. Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of further primary cutaneous basal cell carcinoma. Carcinogenesis, vol. 18(8), 1499-1503. link> doi>
  • Lear JT, Tan BB, Smith AG, Bowers W, Jones PW, Heagerty AH, Strange RC, Fryer AA. 1997. Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. J R Soc Med, vol. 90(7), 371-374. link>
  • Lear JT, Smith AG, Bowers B, Heagearty AH, Jones PW, Gilford J, Alldersea J, Strange RC, Fryer AA. 1997. Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. J Invest Dermatol, vol. 108(4), 519-522. link> doi>
  • Lear JT, Tan BB, Smith AG, Bowers B, Heagerty AHM, Jones PW, FRYER AA, Strange RC. 1997. A comparison of risk factors and tumour site for malignant melanoma, squamous cell carcinoma and basal cell carcinoma in the UK. British Journal of Dermatology, vol. 137(supp 50), 38.
  • FRYER AA. 1997. Allele 2 of the interleukin-1 receptor antagonist gene protects against disability in multiple sclerosis. The International MS Journal, vol. 4, 5027.
  • Lear JT, Smith AG, Bowers W, Jones PW, FRYER AA, Strange RC. 1997. Glutathione S-transferase and cytochrome P450 gene polymorphisms, gender and skin type. British Journal of Dermatology, vol. 136, 452.
  • JAHNKE V, STRANGE R, MATTHIAS C, FRYER AA. 1997. Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. European Archives of Otorhinolayngology, vol. 254(1), S147-S149. doi>
  • Jahnke V, Strange RC, Matthias C, FRYER AA. 1997. Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. European Archives of Otorhinolayngology, vol. 254(Suppl 1), S147-S149.
  • Davies MB, Mann CL, Boggild M, FRYER AA, Alldersea J, Jones PW, Strange RC, Hawkins CP. 1997. Prognosis in multiple sclerosis and glutathione S-transfease gene polymorphisms. The International MS Journal, vol. 4, 5044.
  • LEAR JT, STRANGE RC, FRYER AA. 1997. Re: Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. Journal of the National Cancer Institute, vol. 89, 454-455.
  • Lear JT, Tan BB, Smith AG, Bowers B, Heagerty AHM, Jones PW, FRYER AA, Strange RC. 1997. Risk factors for basal cell carcinoma in the UK: a matched case control study in 806 patients. British Journal of Dermatology, vol. 137(supp 50), 43.
  • Lear JT, Heagerty AHM, Smith A, Bowers B, Jones PW, Gilford J, Alldersea J, Strange RC, FRYER AA. 1997. Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of next cutaneous basal cell carcinoma. Journal of Investigative Dermatology, vol. 109, 435.
  • HAJEER A, JOHN S, OLLIER WE, SILMAN AJ, DAWES P, HASSALL A, MATTEY D, FRYER AA, STRANGE R, WORTHINGTON J. 1997. Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. Journal of Rheumatology, vol. 24, 217-219.
  • Lear J, Hajeer A, Ollier WR, Naves M, Worthington J, Bell DA, Smith AG, Bowers W, Jones PW, Strange RC, FRYER AA. 1997. Tumour necrosis factor polymorphisms, skin type and risk of multiple basal cell carcinoma. British Society for Investigative Dermatology. British Journal of Dermatology, vol. 136, 452.
  • Lear JT, Smith AG, Bowers B, Heagerty AHM, Jones PW, Gilford J, Alldersea J, Strange RC, FRYER AA. 1997. Tumour site in cutaneous basal cell carcinoma: Influence of glutathione S-transferase, GSTT1 and cytochrome P450, CYP1A1 genotypes and their interactions. British Journal of Dermatology, vol. 137(supp 50), 43.
  • Sarhanis P, Redman C, Perrett C, Brannigan K, Clayton RN, Hand P, Musgrove C, Suarez V, Jones P, Fryer AA, Farrell WE, Strange RC. 1996. Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. Br J Cancer, vol. 74(11), 1757-1761. link> doi>
  • Hand PA, Inskip A, Gilford J, Alldersea J, Elexpuru-Camiruaga J, Hayes JD, Jones PW, Strange RC, Fryer AA. 1996. Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis, vol. 17(9), 1919-1922. link> doi>
  • Lear JT, Heagerty AH, Smith A, Bowers B, Payne CR, Smith CA, Jones PW, Gilford J, Yengi L, Alldersea J, Fryer AA, Strange RC. 1996. Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis, vol. 17(9), 1891-1896. link> doi>
  • Lear JT, Tan BB, Smith AG, Fryer AA, Strange RC, Jones PW. 1996. Non-Hodgkin's lymphoma and solar ultraviolet radiation - Basal cell carcinoma may be linked to haematological malignancy. BRITISH MEDICAL JOURNAL, vol. 313(7052), 298-299. link>
  • Yengi L, Inskip A, Gilford J, Alldersea J, Bailey L, Smith A, Lear JT, Heagerty AH, Bowers B, Hand P, Hayes JD, Jones PW, Strange RC, Fryer AA. 1996. Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Res, vol. 56(9), 1974-1977. link>
  • Deakin M, Elder J, Hendrickse C, Peckham D, Baldwin D, Pantin C, Wild N, Leopard P, Bell DA, Jones P, Duncan H, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1996. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, vol. 17(4), 881-884. link> doi>
  • Lear J, Heagerty A, Smith A, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange R. 1996. Polymorphism in detoxifying enzymes and susceptibility to skin cancer. Photochem Photobiol, vol. 63(4), 424-428. link> doi>
  • OLLIER WER, DAVIES E, SNOWDEN N, ALLDERSEA J, FRYER AA, JONES P, STRANGE RC. 1996. Association of homozygosity for glutathione-S-transferase GSTM1 null alleles is associated with the RO+/La- autoantibody profile in patients with systemic lupus erythematosus. Arthritis and Rheumatism, vol. 39, 1763-1764.
  • LEAR JT, TAN BB, SMITH AG, JONES PW, FRYER AA, STRANGE RC. 1996. Basal cell carcinoma and haematological malignancy. British Medical Journal, vol. 313, 298-299.
  • Lear JT, Smith AG, Bowers B, Jones PW, Gilford J, Alldersea J, Yengi L, FRYER AA, Strange RC. 1996. Cutaneous basal cell carcinoma (BCC). Influence of glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) on number of primary tumours. British Journal of Dermatology, vol. 134, 572.
  • Lear JT, FRYER AA, Smith AG, Bowers B, Jones PW, Alldersea J, Yengi L, Gilford J, Strange RC. 1996. Cutaneous basal cell carcinoma: Influence of glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6), CYP1A1) on rate of accural of primary tumours. British Journal of Dermatology, vol. 135((suppl. 47)), 35.
  • Lear JT, FRYER AA, Smith AG, Bowers B, Jones PW, Gilford J, Alldersea J, Strange RC. 1996. Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy. British Journal of Dermatology, vol. 135((suppl. 47)), 24.
  • JAHNKE V, MATTHIAS C, FRYER AA, STRANGE R. 1996. Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. American Journal of Surgery, vol. 172, 671-673. doi>
  • Heagerty A, Smith A, English J, Lear J, Perkins W, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange RC. 1996. Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. Br J Cancer, vol. 73(1), 44-48. link> doi>
  • Poulton K, Hajeer A, Worthington J, FRYER AA, Strange R, Ollier WER. 1996. TNF microsatellite polymorphisms: A comparision of allele frequencies in UK and other European populations. Human Immunology, vol. 47, 576.
  • Inskip A, Elexperu-Camiruaga J, Buxton N, Dias PS, MacIntosh J, Campbell D, Jones PW, Yengi L, Talbot JA, Strange RC. 1995. Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A. Biochem J, vol. 312 ( Pt 3), 713-716. link>
  • Elexpuru-Camiruaga J, Buxton N, Kandula V, Dias PS, Campbell D, McIntosh J, Broome J, Jones P, Inskip A, Alldersea J. 1995. Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res, vol. 55(19), 4237-4239. link>
  • Ollier WER, Davies E, Snowden N, Alldersea J, Fryer A, Strange R, Jones P. 1995. Homozygosity for glutathione-transferase GSTM1 and GSTT1 null alleles may confer risk for anti-Ro antibodies in systemic lupus-erythematosus (SLE). Arthritis and Rheumatism, vol. 38, 183.
  • Duncan H, Swan C, Green J, Jones P, Brannigan K, Alldersea J, Fryer AA, Strange RC. 1995. Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. Clin Chim Acta, vol. 240(1), 53-61. link> doi>
  • Perrett CW, Clayton RN, Pistorello M, Boscaro M, Scanarini M, Bates AS, Buckley N, Jones P, Fryer AA, Gilford J. 1995. GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp. Carcinogenesis, vol. 16(7), 1643-1645. link> doi>
  • JANKHE V, STRANGE R, MATTHIAS C, FRYER AA. 1995. Studies on glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to laryngeal cancer. Laryngorhinootologie, vol. 74, 691-694.
  • Warwick A, Sarhanis P, Redman C, Pemble S, Taylor JB, Ketterer B, Jones P, Alldersea J, Gilford J, Yengi L. 1994. Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking. Carcinogenesis, vol. 15(12), 2841-2845. link> doi>
  • Warwick AP, Redman CW, Jones PW, Fryer AA, Gilford J, Alldersea J, Strange RC. 1994. Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. Br J Cancer, vol. 70(4), 704-708. link> doi>
  • ZHAO L, ALLDERSEA J, FRYER AA, TIGHE A, OLLIER B, THOMSON W, JONES P, STRANGE RC. 1994. Polymorphism at the glutathione S-transferase GSTM1 locus: a study of the frequencies of the GSTM1 A, B, A/B and null phenotypes in Nigerians. Clinica Chimica Acta, vol. 225, 85-88. doi>
  • Heagerty AH, Fitzgerald D, Smith A, Bowers B, Jones P, Fryer AA, Zhao L, Alldersea J, Strange RC. 1994. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Lancet, vol. 343(8892), 266-268. link> doi>
  • Fryer AA, Zhao L, Alldersea J, Pearson WR, Strange RC. 1993. Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus. Biochem J, vol. 295 ( Pt 1), 313-315. link>
  • Fryer AA, Jones P, Strange R, Hume R, Bell JE. 1993. Plasma protein levels in normal human fetuses: 13 to 41 weeks' gestation. Br J Obstet Gynaecol, vol. 100(9), 850-855. link> doi>
  • DAVIES M, ELIAS E, ACHARYA S, COTTON W, FAULDER G, FRYER A, STRANGE R. 1993. GSTM1 NULL POLYMORPHISM AT THE GLUTATHIONE-S-TRANSFERASE M1 LOCUS - PHENOTYPE AND GENOTYPE STUDIES IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS. GUT, vol. 34(4), 549-553. link> doi>
  • Fryer AA, Zhao L, Alldersea J, Boggild MD, Perrett CW, Clayton RN, Jones PW, Strange RC. 1993. The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas. Carcinogenesis, vol. 14(4), 563-566. link> doi>
  • Mattey DL, Nixon N, Alldersea JE, Cotton W, Fryer AA, Zhao L, Jones P, Strange RC. 1993. Alpha, mu and pi class glutathione S-transferases in human synovium and cultured synovial fibroblasts: effects of interleukin-1 alpha, hydrogen peroxide and inhibition of eicosanoid synthesis. Free Radic Res Commun, vol. 19(3), 159-171. link> doi>
  • Strange RC, Fryer AA, Matharoo B, Zhao L, Broome J, Campbell DA, Jones P, Pastor IC, Singh RV. 1992. The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain. Biochim Biophys Acta, vol. 1139(3), 222-228. link> doi>
  • DAVIES M, ACHARYA S, ELIAS E, COTTON W, FRYER A, FAULDER G, STRANGE R. 1992. THE GST1-0 POLYMORPHISM AT THE GLUTATHIONE S-TRANSFERASE-1 LOCUS - PHENOTYPE AND GENOTYPE STUDIES IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS. GUT, vol. 33(2), S8. link>
  • BELL J, FRYER A, COLLINS M, MARSHALL T, JONES P, STRANGE R, HUME R. 1991. DEVELOPMENTAL PROFILE OF PLASMA-PROTEINS IN HUMAN FETAL CEREBROSPINAL-FLUID AND BLOOD. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, vol. 17(6), 441-456. link> doi>
  • Strange RC, Cotton W, Fryer AA, Jones P, Bell J, Hume R. 1990. Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. J Lab Clin Med, vol. 116(5), 666-673. link>
  • CARDER P, HUME R, FRYER A, STRANGE R, LAUDER J, BELL J. 1990. GLUTATHIONE-S-TRANSFERASE IN HUMAN BRAIN. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, vol. 16(4), 293-303. link> doi>
  • STRANGE R, FRYER A, BELL J, HUME R. 1990. STUDIES INTO THE ROLE OF REACTIVE OXYGEN SPECIES IN THE PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA. CLINICAL CHEMISTRY, vol. 36(6), 981. link>
  • STRANGE RC, FRYER AA, HILEY C, BELL J, COSSAR D, HUME R. 1990. Developmental expression of GST in human tissues. Glutathione S-transferase and drug resistance, 262-271.
  • CARTER ND, FRYER AA, GRANT AG, HUME R, STRANGE RC, WISTRAND PJ. 1990. Membrane-specific carbonic anhydrase (CAIV) expression in human tissues. Biochimica et Biophysica Acta, vol. 1026, 113-116. doi>
  • CARTER N, FRYER A, HUME R, STRANGE R, WISTRAND P. 1989. EXPRESSION OF MEMBRANE-BOUND CARBONIC-ANHYDRASE IN DEVELOPING HUMAN-LUNG AND KIDNEY. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 17(6), 1122-1123. link>
  • FRYER A, COTTON W, BELL J, HUME R, STRANGE R. 1989. STUDIES ON THE DEVELOPMENTAL EXPRESSION OF SUPEROXIDE-DISMUTASE IN HUMAN-TISSUES. BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 17(4), 794. link>
  • Hiley C, Fryer A, Bell J, Hume R, Strange RC. 1988. The human glutathione S-transferases. Immunohistochemical studies of the developmental expression of Alpha- and Pi-class isoenzymes in liver. Biochem J, vol. 254(1), 255-259. link>
  • Strange RC, Cotton W, Fryer AA, Drew R, Bradwell AR, Marshall T, Collins MF, Bell J, Hume R. 1988. Studies on the expression of Cu,Zn superoxide dismutase in human tissues during development. Biochim Biophys Acta, vol. 964(2), 260-265. link> doi>
  • Hirrell PA, Hume R, Fryer AA, Collins MF, Drew R, Bradwell AR, Strange RC. 1987. Studies on the developmental expression of glutathione S-transferase isoenzymes in human heart and diaphragm. Biochim Biophys Acta, vol. 915(3), 371-377. link> doi>
  • FRYER A, HUME R, STRANGE R. 1986. THE DEVELOPMENT OF GLUTATHIONE-S-TRANSFERASE AND GLUTATHIONE-PEROXIDASE ACTIVITIES IN HUMAN-LUNG. BIOCHIMICA ET BIOPHYSICA ACTA, vol. 883(3), 448-453. link> doi>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Ramachandran S, FRYER AA, Grant WB, Strange RC. Prostrate cancer susceptibility: A role for interactions between polymorphic genes and exposure to ultraviolet radiation. Przeglad Epidemiologicny.

Chapters

  • Holley SL, FRYER AA, Carroll W, Hoban PR, Strange RC. 2006. GST polymorphism: Where to now? Clinical applications and functional analysis. In Toxicology of Glutathione S-Transferases. Awasthi Y (Ed.). Boca Raton, FL: CRC Press.

Other

  • Milborrow S, Dalley J, Lear J, Russell S, Samarasinghe V, FRYER AA. 2009. Predicting risk of nonmelanoma skin cancer in renal transplant recipients. WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA.
  • Stone MJ, Woolmore JA, Jenkinson P, Stephens R, Mihalova T, Langdon D, Fryer AA, Strange R, Hawkins CP. 2007. Cognitive impairment and polymorphisms of cathepsin D in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 254, p. 163). link>
  • Mihalova T, Eyre S, Barton A, Bowes J, Rukin N, Stone M, Boggild M, Young CA, Fryer A, Hoban P, Worthington J, Strange R, Hawkins CP. 2006. Genetic polymorphism in type III promoter of the major histocompatibility complex class II transactivator gene is associated with susceptibility to multiple sclerosis. MULTIPLE SCLEROSIS (vol. 12, pp. S73-S74). link>
  • Madan V, Hoban P, Strange RC, Fryer AA, Lear JT. 2006. Genetics and risk factors for basal cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY (vol. 154, pp. 5-7). link> doi>
  • Arkwright PD, Gray A, Stewart H, Pravica V, Fryer AA, Lenney W, Hutchinson IV. 2006. Polymorphisms of the Bcl-2 family member bfl-1 and the genetic predisposition to atopic dermatitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (vol. 117, p. S234). link> doi>
  • Mamutse G, Woolmore JA, Alldersea J, Boggild M, Young CA, Fryer AA, Strange RC, Hawkins CP. 2006. Association of vitamin D receptor gene polymorphism with reduced disability in multiple sclerosis. Journal of Neurology (vol. 253 Suppl. 2, pp. 50-51).
  • Varughese GI, Driskell O, Tahrani A, Baskar V, FRYER A, Strange RC, Hanna FWF. 2006. Discrepancies in calculating estimated GFR: implications for metformin therapy.
  • Ismail KMK, Carroll W, Holley S, Hoban P, Rooney A, FRYER A. 2006. Effect of Folate on Fetal Cord blood Total Methylation (EFFECT-M).
  • Mihalova T, Eyre S, Bowes J, Rukin N, Stone MJ, Boggild M, Young C, FRYER A, Hoban P, Worthington J, Strange RC, Hawkins CP. 2006. Genetic polymorphism in type III promoter of the major histocompatibility complex class II transactivator gene is associated with susceptibility to multiple sclerosis.
  • Ismail K, Carroll W, Holley S, Hoban P, FRYER A. 2006. The effect of folate on fetal cord blood total methylation.
  • Holley S, Fryer A, Carroll W, Strange R, Hoban P, Lenney W. 2005. Functional analysis of GSTP1 haplotypes on cell growth and apoptosis in NIH3T3 fibroblasts. THORAX (vol. 60, pp. II22-II23). link>
  • Woolmore JA, Jenkinson PM, Stephens R, Weatherby SJ, Payton A, Fryer AA, Strange RS, Ollier WER, Jones PW, Langdon D, Hawkins CP. 2005. Neuropsychological outcome and apolipoprotein E epsilon 4 polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 252, p. 131). link>
  • Woolmore JA, Ike A, Jenkinson RM, Stephens R, Holley S, Fryer AA, Strange RS, Jones RW, Langdon D, Hawkins CP. 2005. Neuropsychological outcome and cannabinoid receptor 1 polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 252, p. 66). link>
  • Woolmore JA, Pye E, Partridge JM, Boggild M, Young C, Jones PW, Fryer AA, Hawkins CP, Strange RS. 2005. Ultraviolet radiation and outcome in multiple sclerosis. JOURNAL OF NEUROLOGY (vol. 252, p. 74). link>
  • Mamutse G, Woolmore JA, Alldersea J, Boggild M, Young C, FRYER A, Strange RC, Hawkins CP. 2005. Association of a vitamin D receptor polymorphism with reduced disability in multiple sclerosis. Multiple Sclerosis (vol. 11 (Suppl 1), pp. S114-S115).
  • Holley SL, FRYER A, Hoban PR. 2005. Functional analysis of GSTP1 haplotypes on cell growth and apoptosis in NIH3T3 fibroblasts. oral.
  • Carroll WD, FRYER A, Child F, Primhak RA, Strange RC, Whyte MK, Lenney W. 2005. Glutathione S-Transferase P1 genotype and lung function: Evidence for a gene-environment interaction.
  • Woolmore JA, Jenkinson PM, Stephens R, Weatherby SJ, Fryer AA, Strange RC, Payton A, Ollier W, Jones P, Langdon D, Hawkins CP, Keele MS. 2005. Neuropsychological outcome and APOE polymorphism in multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 76, p. 158). link>
  • Mamutse G, Ramtahal J, Jacob A, Embrey NH, Rowley C, Boggild M, Young C, FRYER A, Strange RC, Hawkins CP. 2005. Relationship between a vitamin D receptor polymorphism and responsiveness to beta interferon. Multiple Sclerosis (vol. 11 (Suppl 1), p. S114).
  • CARROLL W, FRYER AA, CLIFF, STRANGE RC, SILVERMAN, WHYTE, LENNEY W. 2004. Familial segregation of lung function in asthmatic families: both parents are important but mother's influence may predominate earlier. Thorax.
  • CARROLL W, CHILD F, STRANGE RC, LENNEY W, FRYER AA. 2004. Glutathione s-transferase, oxidative stress and seasonal allergic responses. Thorax.
  • CARROLL W, CHILD F, FRYER AA, STRANGE RC, LENNEY W. 2004. Maternal Clasa Cell Secretory Protein (CC16) genotype is associated with fev in asthmatic children. Thorax.
  • CARROLL W, CHILD F, FRYER AA, STRANGE RC, WHYTE, PRIMHAK, LENNEY W. 2004. Relation of total immunoglobulin E, allergic sensitisation and asthma severity on children with asthma. Thorax.
  • Woolmore JA, Jenkinson P, Stephens R, Payton A, Weatherby SJ, Strange RC, Fryer AA, Ollier W, Jones PW, Langdon DW, Hawkins CR. 2004. Neuropsychological outcome and APOE polymorphism in multiple sclerosis. MULTIPLE SCLEROSIS (vol. 10, pp. S207-S208). link>
  • Lear JT, Lovatt TJ, Bastrilles J, Wong C, Griffiths CEM, Ramachandran S, Smith AG, Fryer AA, Jones PW, Strange RC. 2004. Associations between exposure to ultraviolet radiation and site and histology of basal cell carcinoma. BRITISH JOURNAL OF DERMATOLOGY (vol. 151, p. 28). link>
  • Lear JT, Strange RC, El-Genidy N, Ramachandran S, Lovatt TJ, Fryer AA, Smith AG, Wong C, Jones PW, Ichii-Jones F, Hoban PR. 2004. Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms. BRITISH JOURNAL OF DERMATOLOGY (vol. 151, p. 28). link>
  • Woolmore JA, Barton A, John S, Fryer AA, Strange RC, Worthington J, Hawkins CR. 2004. High-density single nucleotide polymorphism mapping of protein kinase C alpha gene in a UK population of multiple sclerosis patients. JOURNAL OF NEUROLOGY (vol. 251, p. 61). link>
  • Woolmore JA, Barton A, John S, Worthington J, Fryer AA, Strange RC, Hawkins CP. 2004. High density single nucleotide polymorphism mapping of protein kinase C alpha gene in a UK population of multiple sclerosis patients. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (vol. 75, p. 517). link>
  • Reece SM, FRYER A, Smith AG, Harden PN, Ramsay HM. 2004. Audit of Patients' Vies of Nurse-led Skin Cancer Screening Service in a Renal Transplant Clinic.
  • Carroll W, Child F, Kwong GNM, Proctor A, Primhak R, Clayton S, Davies S, Strange RC, Whyte M, FRYER A, Lenney W. 2004. Effects of Glutathione S-Transferease P1 on Childhood Lung Function in Asthmatic Children and Their Families.
  • Carroll WD, Child F, Kwong GNM, Proctor A, Primhak R, Clayton S, Davies S, Strange RC, Whyte M, FRYER A, Lenney W. 2004. Glutathione S-Transferase P1 Val/Val genotype exerts a complex effect on asthma phenotype in asthmatic children and their families.
  • Woolmore JA, Barton A, John S, FRYER A, Strange RC, Worthington J, Hawkins CP. 2004. HLA-DRB1*15 stratification of associates of PRKCA and multiple sclerosis. Multiple Sclerosis (vol. 10 (Suppl 2), p. S204).
  • Ramsay HM and FRYER A. 2004. Incidence of non-melanoma skin cancer in UK renal transplant recipients: a 5-year nurse-led prospective study. British Journal of Dermatologists (vol. 151 (Suppl 68), p. 29).
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Carroll WD, FRYER A, Strange RC, Child F, Lenney W. 2004. LTC4 synthase polymorphism is associated with lung function in children with asthma.
  • Salim A, Reece SM, Smith AG, Harrison D, Ramsay HM, Harden PN, FRYER A. 2004. Sebaceous hyperplasia and skin cancer in renal transplant patients. British Journal of Dermatologists (vol. 151 (Suppl 68), p. 28).
  • Irwin H, Ramsay HM, Harden PN, Hawley C, Nicol D, Jones P, FRYER A. 2004. Stratification of non-melanoma skin cancer risk post-transplantation using a predictive index.
  • Harden PN, Reece S, Fryer AA, Smith A, Ramsay HM. 2003. A prospective study of non-melanoma skin cancer incidence in UK renal transplant recipients. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (vol. 14, p. 66A). link>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby F, Jones PW, Ramachandran S, Fryer AA, Strange RC. 2003. Susceptibility to prostate cancer: studies on interactions between ultraviolet exposure and skin type. BJU INTERNATIONAL (vol. 92, p. 832). link>
  • Ramsay HM, Fryer AA, Hawley CM, Smith AG, Nicol DL, Harden PN. 2003. Factors associated with nonmelanoma skin cancer following renal transplantation in Queensland, Australia. J Am Acad Dermatol (vol. 49, pp. 397-406). link> doi>
  • Millard TP, Hawk JLM, Fryer AA, McGregor JM. 2003. Protective effect of glutathione S-transferase GSTP1 Val(105) against polymorphic light eruption. BRITISH JOURNAL OF DERMATOLOGY (vol. 149, pp. 88-89). link>
  • Lear JT, Ramachandran S, Fryer AA, Lovatt T, Smith AG, Jones PW, Strange RC. 2003. Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system. BRITISH JOURNAL OF DERMATOLOGY (vol. 148, p. 858). link>
  • Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, FRYER AA, Jones PW, Strange RC. 2003. Prosrate cancer risk and exposure to ultraviolet radiation: Studies on interactions between ultraviolet exposure and polymorphisms in genes that mediate skin pigmentation and vitamin D-dependant pathways. Journal of Urology (vol. 169, p. 276).
  • Woolmore JA, Barton A, John S, Worthington J, FRYER AA, Strange RC, Hawkins CP. 2003. Protein kinase C alpha gene; High density single nucleutide polymorphism mapping in a UK population of multiple sclerosis patients.
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Alldersea J, Strange RC, Fryer AA. 2002. Maternal but not paternal genetic variation in GSTP1 is associated with asthma phenotypes in children. THORAX (vol. 57). link>
  • Partridge JM, FRYER A, Boggild M, Hawkins C. 2002. Polymorphism in the glutathione S-transferases, GSTA1 and GSTA2, in multiple sclerosis.
  • Partridge JM, FRYER A, Ollier W, Boggild M, Strange R, Hawkins C. 2002. RANTES and chemokine receptor 5 polymorphisms: susceptibility to and outcome in multiple sclerosis.
  • Matthias C, Jahnke V, Hajeer A, Ollier W, Fryer AA, Strange RC. 2001. Influence of genetic variation in the major histocompatibility complex on head and neck cancer susceptibility. Laryngorhinootolgie. doi>
  • Ramachandran S, Fryer AA, Strange RC. 2001. Genetic factors determining cutaneous basal cell carcinoma phenotype. Med Pediatr Oncol (vol. 36, pp. 559-563). link> doi>
  • Bamber DE, Board PG, Coggan M, Elder JB, Deakin M, Rajagopal R, Fawole AS, Strange RC, Fryer AA. 2001. Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 95-97). link>
  • Rajagopal R, Fawole AS, White J, Holland TA, Deakin M, Elder JB, Strange RC, Fryer AA. 2001. Glutathione S-transferase M1, M3, P1 and T1 in susceptibility to and outcome in patients with colorectal adenocarcinoma. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 109-112). link>
  • Hemmingsen A, Fryer AA, Strange RC, De Marzo N, Pozzato V, Jovine L, Spiteri MA, Mapp CE. 2001. Polymorphism at the glutathione S-transferase: GSTP1 locus is associated with isocyanate-induced asthma: use of an ARMS-PCR assay for the simultaneous determination of (I105-V105) and A(114)-V-114 alleles. CHEMICO-BIOLOGICAL INTERACTIONS (vol. 133, pp. 120-122). link>
  • Harden PN, Fryer AA, Reece S, Smith AG, Ramsay HM. 2001. Annual incidence and predicted risk of nonmelanoma skin cancer in renal transplant recipients. Transplant Proc (vol. 33, pp. 1302-1304). link> doi>
  • Reece SM, Ramsay HM, FRYER AA, Smith AG, Harden PN. 2001. Current LTK practice for skin cancer surveillance following renal transplantation.
  • Holley SL, Parkes G, Matthias C, Bockmühl U, Jahnke V, Leder K, Strange RC, Fryer AA, Hoban PR. 2001. Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. Am J Pathol (vol. 159, pp. 1917-1924). link> doi>
  • Lovatt TJ, Ramsey HM, FRYER AA, Strange RC, Hawley CM, Harden PN, Nicol DL. 2001. Genetic factors mediating protection against oxidative stress and nonmelanoma skin cancer accural rates in renal transplant recipients.
  • Strange RC, Spiteri M, Ramachandran S, FRYER AA. 2001. How important are GST polymorphisms in defining clinical phenotypes some answers from studis in high-risk groups. Chemico-Biological Interactions (vol. 133, pp. 87-90).
  • Ramsay HM, Fryer AA, Reece S, Smith AG, Harden PN. 2000. Clinical risk factors associated with nonmelanoma skin cancer in renal transplant recipients. Am J Kidney Dis (vol. 36, pp. 167-176). link> doi>
  • Strange RC, Jones PW, Fryer AA. 2000. Glutathione S-transferase: genetics and role in toxicology. Toxicol Lett (vols. 112-113, pp. 357-363). link> doi>
  • Strange RC, Alldersea J, Hoban PR, Fryer AA, Matthias C, Jahnke V, Jones PW. 2000. Genetic polymorphism and clinical outcome: identification of individuals at risk of a poor clinical outcome. Allergy (vol. 55 Suppl 61, pp. 10-14). link> doi>
  • Spiteri MA, Bianco A, Strange RC, Fryer AA. 2000. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy (vol. 55 Suppl 61, pp. 15-20). link> doi>
  • FRYER AA. 1999. Molecular diagnostics in clinical biochemistry: what does the future hold? Focus 99.
  • Ramsay HM, FRYER AA, Strange RC, Smith AG. 1999. Multiple basal cell carcinomas in a patient with acute myeloid leukaemia and chronic lymphocytic leukaemia.
  • Strange RC, Lear JT, Fryer AA. 1998. Glutathione S-transferase polymorphisms: influence on susceptibility to cancer. Chem Biol Interact (vols. 111-112, pp. 351-364). link>
  • Mann CL, Davies MB, Boggild M, Jones PW, FRYER AA, Strange RC, Hawkins CP. 1998. Disability in multiple sclerosis: polymorphism at the IL-1 beta, TNF alpha and IL-1RN loci.
  • Weatherby SJM, Mann CL, Davies MB, FRYER AA, Haq N, Strange RC, Hawkins CP. 1998. Relationship between genetic polymorphisms controlling inflammatory cytokines, antioxidants and gadolinium-enhancing lesions in multiple sclerosis.
  • Davies MB, Boggild M, Alldersea J, Mann CL, FRYER AA, Jones PW, Ko Ko C, Young C, Strange RC, Hawkins CP. 1997. Glutathione S-transferase gene polymorphisms and disbility in multiple sclerosis.
  • Hajeer A, John S, Ollier W, Silman AJ, Dawes PT, Hassal AB, Mattey DL, FRYER AA, Strange RC, Worthington J. 1996. Association of extended TNF-HLA haplotypes with rheumatoid arthritis in males and females. British Journal of Rheumatology (vol. 35, p. 189).
  • Jahnke V, Strange R, Matthias C, FRYER AA. 1996. Glutathione S-transferase and cytochrome P-450 polymorphism as risk factor for squamous cell carcinoma of the larynx. American Journal of Surgery (vol. 172, pp. 671-673).
  • Jahnke V, Strange R, Matthias C, FRYER AA. 1996. Glutathione S-transferase GSTM1 and GSTT1 genotypes as risk factor for laryngeal carcinoma. In JA. Werner, BM. Lippert & HH. Rudert (Eds.). Head and Neck Cancer - Advances In Basic Research, International Congress Series (vol. 1114, pp. 25-28).
  • Yengi LG, Inskip A, Hand P, Gilford J, Lear JT, Jones PW, Strange RC, FRYER AA. 1996. Identification of polymorphism at the glutathione S-transferase GSTM3 locus: assessment of genotypes as risk factors for multiple cutaneous basal cell carcinoma. OP44 oral.
  • Matthias C, Bockmuhl U, Jahnke V, Jones PW, Alldersea J, Worrall SF, Hand P, Harries LW, Wolf CR, FRYER AA, Strange RC. 1996. Susceptibility to head and neck cancer: Influence of allelism at GSTM3 and GSTP1 loci. OP51. oral.
  • Hajeer A, John S, Ollier W, FRYER A, Strange R, Worthington J. 1996. TNF-HLA haplotypes differ in males and females with rheumatoid arthritis (RA). Human Immunology (vol. 47, p. 418).
  • FRYER AA, Heagerty A, Warwick A, Zhao L, Redman C, Strange RC. 1994. GSTM1 null and A,B polymorphisms at the glutathione S-transferase GSTM1 locus. Factors that confer protection and susceptibility to epithelial cancers. Proceedings of the American Association for Cancer Research (vol. 35, p. 120).
  • Strange RC, FRYER AA, Hiley C, Bell J, Cossar D, Hume R. 1990. Developmental expression of GST in human tissues. In JD. Hayes, CB. Pickett & TJ. Mantle (Eds.). Glutathione S-transferase and Drug Resistance (pp. 262-271). London: Taylor and Francis Ltd.
  • Bell JE, Sandison A, FRYER AA, Collins M, Strange RC, Hume R. 1990. Human fetal cerebrospinal fluid proteins. Neuropathology and Applied Neurobiology (vol. 16, pp. 257-274).
  • FRYER AA, Cotton W, Hume R, Strange RC. 1989. Carbonic anhydrases and the regulation of human lung liquid secretion.
  • FRYER AA, Cotton W, Hume R, Strange RC. 1989. Detoxification of oxygen-derived free radicals in developing human lung.
  • Hiley C, FRYER AA, Faulder C, Hume, Bell J, Strange R. 1989. Developmental expression of alpha, mu an pi subsets of GST in human kidney - an immunohistochemical study.
  • Carter N, FRYER A, Hume R, Strange R, Wistrand P. 1989. Expression of membrane-bound carbonic-anhydrase in developing human-lung and kidney. Biochemical Society Transactions (vol. 17, pp. 1122-1123).
  • Carder PJ, Hume R, Strange RC, FRYER AA, Lauder J, Bell JE. 1989. Glutathione S-transferase is located at te 'blood-brain barrier' in human fetal brain.
  • FRYER AA, Faulder CG, Hiley C, Hume R, Bell J, Strange JE. 1989. The development of glutathione S-transferases in human liver.
  • FRYER AA, Hume R, Strange RC. 1989. The role of oncoproteins in the maturation of the human foetal lung.
  • FRYER AA, Cotton W, Hume R, Strange RC. 1989. The role of reactive oxygen species in the aetiology of lung disease in the human neonate. Ames Award shortlisted oral presentation.
  • FRYER AA, Hume R, Strange RC. 1986. The development of glutathione-S-tranferase and glutathione-peroxidase activities in the human lung. Biochemical Society Transactions (vol. 14, p. 896).
  • FRYER AA. Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. European Archives of Oto-Rhino-Laryngological (vol. 254, pp. S147-S149). 1997.
  • Carder PJ, Strange RC, FRYER AA, Lauder J, Bell JE. Glutathione S-transferase in human brain tumours.
  • Ichii-Jones F, Hutchinson PE, Osbourne J, Lear JT, Heagerty AH, Smith AG, Bowers B, Jones PW, Davies E, Ollier WER, FRYER AA, Thompson W, Yengi L, Strange RC. Susceptibility to malignant melanoma: Influence of skin type and polymorphism in the melanocytes stimulating hormone receptor gene.