Prof Alicia El Haj

Title: Institute Director
Phone: +44 (0)1782 674087
Email:
Location: Institute for Science & Technology in Medicine, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB United Kingdom
Role: ISTM Research theme: 1. Bioengineering & Therapeutics - Lead for B&T theme
2. Clinical & Diagnostic Science
MSc Cell & Tissue Engineering
Contacting me: Prof El Haj's secretary and Institute administrator is Ms Paula Marsh: p.marsh@keele.ac.uk +44 (0)1782 674087

Professor Alicia El Haj is Director of the Institute of Science & Technology in Medicine at Keele. She is a leading figure in Regenerative Medicine and has been involved in bringing together interdisciplinary groups within biomedicine, physical sciences and engineering interested in aspects of cell and tissue engineering. She has been a founder Director of The Institute of Science & Technology in Medicine (ISTM) which has rated highly; 5A, 5* and 5A through the past 3 RAE assessments. 

Professor El Haj is the Research Director of an EPSRC DTC in Regenerative Medicine, one of the co-directors of the new EPSRC Centre for Innovative Manufacturing Centre in Regenerative Medicine and a collaborator in the new AR UK Tissue Engineering Centre. She has published over a 100 publications with an emphasis on engineering solutions for controlling stem cell behaviour and new orthopaedic repair strategies using novel enabling technology approaches with funding from EPSRC, BBSRC, Welcome  Trust, AR UK and EU Framework.

Prof. El Haj is a Chair elect of the European council for TERMIS, a member of the UK National Stem Cell Advisory Board, the IFMBE Working Group for Cellular Engineering, and the IPEM Academic Advisory board. She is on the editorial board of JTERM and Tissue Engineering and is currently serving as a member of the Medical Research Council’s Developmental Pathway Funding Scheme (DPFS) Panel and the General Engineering UK REF 2014 Panel. 

Recent research career:

October 2012 - to date Director - Institute of Science & Technology in Medicine, Keele University
November 2009 - September 2012 Theme Leader, Bioengineering & Therapeutics
August 2004 - November 2009 Director - Institute of Science & Technology in Medicine, Keele University
March 2002 - 2004 Research Dean for the Faculty of Health, Keele University
October 1999 - 2004 Head of Centre, Centre for Science and Technology in Medicine, Keele University
July 1999 - present Chair in Cell Engineering, Institute for Science and Technology in Medicine, Keele University
April 1997 - 1999 Senior Lecturer, Dept of Biomedical Engineering and Medical Physics, Keele University

Research Interests:

  • Stem cell therapy for orthopaedic applications;

  • Bioreactors and in vitro conditioning for tissue growth;

  • Magnetic nanoparticle technologies for use in  Regenerative Medicine.

    Stem cells (green and blue) with nanoparticles (magenta) viewed through a microscope. The nanoparticles are used to control cell behaviour
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Selected Publications

  • Cunha-Reis C, El Haj AJ, Yang X, Yang Y. 2013. Fluorescent labeling of chitosan for use in non-invasive monitoring of degradation in tissue engineering. J Tissue Eng Regen Med, vol. 7(1), 39-50. link> doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2011. 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med, vol. 5(10), 770-779. link> doi>
  • Aydin HM, Hu B, Sule-Suso JS, El Haj AJ, Yang Y. 2011. Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, vol. 4, 775-780. doi>
  • Kanczler JM, Sura HS, Magnay J, Green D, Oreffo RO, Dobson JP, El Haj AJ. 2010. Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Eng Part A, vol. 16(10), 3241-3250. link> doi>
  • Chippendale TW, Hu B, El Haj AJ, Smith D. 2012. A study of enzymatic activity in cell cultures via the analysis of volatile biomarkers. Analyst, vol. 137(20), 4677-4685. link> doi>

Full Publications List show

Books

  • Lyall F and El Haj AJ. 2009. Biomechanics and Cells. Cambridge Univ Pr.
  • YANG Y and EL HAJ AJ. Ashammaki N and Waris T (Eds.). 2004. Enhancement of mechanical signals for tissue engineering bone. e-book, ..
  • El Haj AJ and Britain SFEBG. 1992. Molecular biology of muscle. Company of Biologists.

Journal Articles

  • Chippendale TW, Hu B, El Haj AJ, Smith D. 2012. A study of enzymatic activity in cell cultures via the analysis of volatile biomarkers. Analyst, vol. 137(20), 4677-4685. link> doi>
  • El Haj AJ. 2011. Engineering cells to grow tissue. Ingenia. link>
  • Cunha-Reis C, El Haj AJ, Yang X, Yang Y. 2013. Fluorescent labeling of chitosan for use in non-invasive monitoring of degradation in tissue engineering. J Tissue Eng Regen Med, vol. 7(1), 39-50. link> doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2011. 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med, vol. 5(10), 770-779. link> doi>
  • Aydin HM, Hu B, Sule-Suso JS, El Haj AJ, Yang Y. 2011. Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, vol. 4, 775-780. doi>
  • Then KY, Yang Y, Ahearne M, El Haj AJ. 2011. Effect of microtopographical cues on human keratocyte orientation and gene expression. Curr Eye Res, vol. 36(2), 88-93. link> doi>
  • Sura, H, Glossop, JR, Wolbank, S, van Griensven, M, Reidl, H, Dobson, J, El Haj AJ. 2011. An in Vitro model of mesenchymal stem cell targeting using magnetic particle labelling. Journal of Tissue Engineering and Regenerative Medicine. doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2010. 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med. doi>
  • El Haj AJ and Cartmell SH. 2010. Bioreactors for bone tissue engineering. Proc Inst Mech Eng H, vol. 224(12), 1523-1532. link> doi>
  • Jones GL, Walton R, Czernuszka J, Griffiths SL, El Haj AJ, Cartmell SH. 2010. Primary human osteoblast culture on 3D porous collagen-hydroxyapatite scaffolds. J Biomed Mater Res A, vol. 94(4), 1244-1250. link> doi>
  • Yiu HH, Maple MJ, Lees MR, Palona I, El Haj AJ, Dobson J. 2010. Preparation and characterization of iron oxide-silica composite particles using mesoporous SBA-15 silica as template and their internalization into mesenchymal stem cell and human bone cell lines. IEEE Trans Nanobioscience, vol. 9(3), 165-170. link> doi>
  • Ahearne M, Wilson SL, Liu KK, Rauz S, El Haj AJ, Yang Y. 2010. Influence of cell and collagen concentration on the cell-matrix mechanical relationship in a corneal stroma wound healing model. Exp Eye Res, vol. 91(5), 584-591. link> doi>
  • Bagnaninchi PO, Yang Y, Bonesi M, Maffulli G, Phelan C, Meglinski I, El Haj AJ, Maffulli N. 2010. In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography. Phys Med Biol. 2010 Jul 7;55(13):3777-87. Epub 2010 Jun 15., vol. 13(55), 3777-3787.
  • Whiteley NM, Magnay JL, McCleary SJ, Nia SK, El Haj AJ, Rock J. 2010. Characterisation of myosin heavy chain gene variants in the fast and slow muscle fibres of gammarid amphipods. Comp Biochem Physiol A Mol Integr Physiol, vol. 157(2), 116-122. link> doi>
  • Nguyen BV, Wang QG, Kuiper NJ, El Haj AJ, Thomas CR, Zhang Z. 2010. Biomechanical properties of single chondrocytes and chondrons determined by micromanipulation and finite-element modelling. J R Soc Interface, vol. 7(53), 1723-1733. link> doi>
  • Kanczler JM, Sura HS, Magnay J, Green D, Oreffo RO, Dobson JP, El Haj AJ. 2010. Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Eng Part A, vol. 16(10), 3241-3250. link> doi>
  • Baas E, Kuiper JH, Yang Y, Wood MA, El Haj AJ. 2010. In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds. JOURNAL OF BIOMECHANICS, vol. 43(4), 733-739. link> doi>
  • Kirkham GR, Elliot KJ, Keramane A, Salter DM, Dobson JP, El Haj AJ, Cartmell SH. 2010. Hyperpolarization of human mesenchymal stem cells in response to magnetic force. IEEE Trans Nanobioscience, vol. 9(1), 71-74. link> doi>
  • Wang QG, Nguyen B, Thomas CR, Zhang Z, El Haj AJ, Kuiper NJ. 2010. Molecular profiling of single cells in response to mechanical force: comparison of chondrocytes, chondrons and encapsulated chondrocytes. Biomaterials, vol. 31(7), 1619-1625. link> doi>
  • Jones GL, Motta A, Marshall MJ, El Haj AJ, Cartmell SH. 2009. Osteoblast: osteoclast co-cultures on silk fibroin, chitosan and PLLA films. Biomaterials, vol. 30(29), 5376-5384. link> doi>
  • Araujo JV, Cunha-Reis C, Rada T, da Silva MA, Gomes ME, Yang Y, Ashammakhi N, Reis RL, El-Haj AJ, Neves NM. 2010. Dynamic culture of osteogenic cells in biomimetically coated poly(caprolactone) nanofibre mesh constructs. Tissue Eng Part A, vol. 16(2), 557-563. link> doi>
  • Aydin HM, El Haj AJ, Pişkin E, Yang Y. 2009. Improving pore interconnectivity in polymeric scaffolds for tissue engineering. J Tissue Eng Regen Med, vol. 3(6), 470-476. link> doi>
  • Aydin HM, Yang Y, Kohler T, El Haj A, Mueller R, Piskin E. 2009. Interaction of Osteoblasts with Macroporous Scaffolds Made of PLLA/PCL Blends Modified with Collagen and Hydroxyapatite. ADVANCED ENGINEERING MATERIALS, vol. 11(8), B83-B88. link> doi>
  • Ahearne M, Liu KK, El Haj AJ, Then KY, Rauz S, Yang Y. 2010. Online monitoring of the mechanical behavior of collagen hydrogels: influence of corneal fibroblasts on elastic modulus. Tissue Eng Part C Methods, vol. 16(2), 319-327. link> doi>
  • Nguyen BV, Wang Q, Kuiper NJ, El Haj AJ, Thomas CR, Zhang Z. 2009. Strain-dependent viscoelastic behaviour and rupture force of single chondrocytes and chondrons under compression. Biotechnol Lett, vol. 31(6), 803-809. link> doi>
  • Rock J, Magnay JL, Beech S, El Haj AJ, Goldspink G, Lunt DH, Whiteley NM. 2009. Linking functional molecular variation with environmental gradients: myosin gene diversity in a crustacean broadly distributed across variable thermal environments. Gene, vol. 437(1-2), 60-70. link> doi>
  • Jia Y, Bagnaninchi PO, Yang Y, El Haj A, Hinds MT, Kirkpatrick SJ, Wang RK. 2009. Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds. JOURNAL OF BIOMEDICAL OPTICS, vol. 14(3), Article ARTN 034014. link> doi>
  • Wang QG, Magnay JL, Nguyen B, Thomas CR, Zhang Z, El Haj AJ, Kuiper NJ. 2009. Gene expression profiles of dynamically compressed single chondrocytes and chondrons. Biochem Biophys Res Commun, vol. 379(3), 738-742. link> doi>
  • El Haj AJ, Hampson K, Gogniat G. 2009. Bioreactors for Connective Tissue Engineering: Design and Monitoring Innovations. BIOREACTOR SYSTEMS FOR TISSUE ENGINEERING, vol. 112, 81-93. link> doi>
  • WHITELEY NM, ROACK J, MAGNAY JL, El Haj AJ, LUNT D, GOLDSPINK G. 2009. Natural variations in myosin heavy chain genotype in gammarid amphipods. Comparative Biochemistry and physiology, Part A: molecular & Interactive Physiology, vol. 2(153), S72. doi>
  • Zhang H, Liu K-K, El Haj AJ. 2009. Opto-Mechanical Manipulation of Stem Cells. The Open Nanomedicine Journal, vol. 2, 10-14. doi>
  • Lin MM, Kim DOK, El Haj AJ, Dobson J. 2008. Development of superparamagnetic iron oxide nanoparticles (SPIONS) for translation to clinical applications. IEEE Trans Nanobioscience, vol. 7(4), 298-305. link> doi>
  • Ahearne M, Bagnaninchi PO, Yang Y, El Haj AJ. 2008. Online monitoring of collagen fibre alignment in tissue-engineered tendon by PSOCT. J Tissue Eng Regen Med, vol. 2(8), 521-524. link> doi>
  • Yang Y, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Characterisation of scaffold architecture and tendons using optical coherence tomography and polarisation-sensitive optical coherence tomography. Optoelectronics, IET, vol. 2, 188-194. doi> link>
  • Wang QG, El Haj AJ, Kuiper NJ. 2008. Glycosaminoglycans in the pericellular matrix of chondrons and chondrocytes. J Anat, vol. 213(3), 266-273. link> doi>
  • Wood MA, Yang Y, Baas E, Meredith DO, Richards RG, Kuiper JH, El Haj AJ. 2008. Correlating cell morphology and osteoid mineralization relative to strain profile for bone tissue engineering applications. J R Soc Interface, vol. 5(25), 899-907. link> doi>
  • Hughes S, McBain S, Dobson J, El Haj AJ. 2008. Selective activation of mechanosensitive ion channels using magnetic particles. J R Soc Interface, vol. 5(25), 855-863. link> doi>
  • Baas E, Kuiper JH, Yang Y, Wood MA, El Haj AJ. 2010. In vitro bone growth responds to local mechanical strain in three-dimensional polymer scaffolds. J Biomech, vol. 43(4), 733-739. link> doi>
  • Yiu HH, Keane MA, Lethbridge ZA, Lees MR, El Haj AJ, Dobson J. 2008. Synthesis of novel magnetic iron metal-silica (Fe-SBA-15) and magnetite-silica (Fe(3)O(4)-SBA-15) nanocomposites with a high iron content using temperature-programed reduction. Nanotechnology, vol. 19(25), 255606. link> doi>
  • Yiu HHP, McBain SC, El Haj AJ, Dobson J. 2007. A triple-layer design for polyethyleneimine-coated, nanostructured magnetic particles and their use in DNA binding and transfection. NANOTECHNOLOGY, vol. 18(43), Article ARTN 435601. link> doi>
  • Bagnaninchi PO, Yang Y, El Haj AJ, Maffulli N. 2007. Tissue engineering for tendon repair. Br J Sports Med, vol. 41(8), e10. link> doi>
  • Magra M, Hughes S, El Haj AJ, Maffulli N. 2007. VOCCs and TREK-1 ion channel expression in human tenocytes. Am J Physiol Cell Physiol, vol. 292(3), C1053-C1060. link> doi>
  • EL HAJ AJ. 2007. Chitosan Microchannel Scaffolds for Tendon Tissue Engineering Characterized Using Optical Coherence Tomography. Tissue Engineering, vol. 13(2), 323-331. link> doi>
  • McBain SC, Yiu HHP, El Haj AJ, Dobson J. 2007. DNA delivery using polyethyleneimine (PEI) coated iron oxide-silica mesostructured particles. Studies in Surface Science and Catalysis, vol. 165, 869-872. doi>
  • Hughes S, Dobson J, El Haj AJ. 2007. Magnetic targeting of mechanosensors in bone cells for tissue engineering applications. J Biomech, vol. 40 Suppl 1, S96-104. link> doi>
  • McBain SC, Yiu HHP, El Haj A, Dobson J. 2007. Polyethyleneimine functionalized iron oxide nanoparticles as agents for DNA delivery and transfection. JOURNAL OF MATERIALS CHEMISTRY, vol. 17(24), 2561-2565. link> doi>
  • Dobson J, Cartmell SH, Keramane A, El Haj AJ. 2006. Principles and design of a novel magnetic force mechanical conditioning bioreactor for tissue engineering, stem cell conditioning, and dynamic in vitro screening. IEEE Trans Nanobioscience, vol. 5(3), 173-177. link> doi>
  • Wood MA, Yang Y, Thomas PB, Haj AJ. 2006. Using dihydropyridine-release strategies to enhance load effects in engineered human bone constructs. Tissue Eng, vol. 12(9), 2489-2497. link> doi>
  • Johnson WE, Wootton A, El Haj A, Eisenstein SM, Curtis AS, Roberts S. 2006. Topographical guidance of intervertebral disc cell growth in vitro: towards the development of tissue repair strategies for the anulus fibrosus. EUROPEAN SPINE JOURNAL, vol. 15, S389-S396. link> doi>
  • Yang Y and El Haj AJ. 2006. Biodegradable scaffolds--delivery systems for cell therapies. Expert Opin Biol Ther, vol. 6(5), 485-498. link> doi>
  • Wood MA, Hughes S, Yang Y, El Haj AJ. 2006. Characterizing the efficacy of calcium channel agonist-release strategies for bone tissue engineering applications. J Control Release, vol. 112(1), 96-102. link> doi>
  • YANG Y, El Haj, Guyot, Wang. 2006. Investigation of optical coherence tomography as an imaging modality in tissue engineering. Physics in Medicine and Biology, vol. 51(7), 1-11. doi>
  • EL HAJ AJ, Dobson J, Hughes S, Magnay J. 2006. Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. Journal of Cellular Physiology, vol. 206(3), 738-748. doi>
  • Hughes S, Magnay J, Foreman M, Publicover SJ, Dobson P, El Haj AJ. 2006. Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. Journal of cellular physiology, vol. 206(3), 738-748.
  • Ahearne M, Yang Y, El Haj AJ, Then KY, Liu KK. 2005. Characterizing the viscoelastic properties of thin hydrogel-based constructs for tissue engineering applications. J R Soc Interface, vol. 2(5), 455-463. link> doi>
  • El Haj AJ, Wood MA, Thomas P, Yang Y. 2005. Controlling cell biomechanics in orthopaedic tissue engineering and repair. Pathol Biol (Paris), vol. 53(10), 581-589. link> doi>
  • Hughes S, El Haj AJ, Dobson J. 2005. Magnetic micro- and nanoparticle mediated activation of mechanosensitive ion channels. Med Eng Phys, vol. 27(9), 754-762. link> doi>
  • Yang Y, Yiu HH, El Haj AJ. 2005. On-line fluorescent monitoring of the degradation of polymeric scaffolds for tissue engineering. Analyst, vol. 130(11), 1502-1506. link> doi>
  • Sule-Suso J, Yang Y, Tobin M, Bahrami F, Sockalingum G, Kohler A, Manfait M, El Haj AJ. 2005. Sensitivity of single, in vitro growing lung cancer cells to gemcitabine measured with synchrotron based fourier transform infrared microspectroscopy. EJC SUPPLEMENTS, vol. 3(2), 51. link>
  • Yang Y, Sulé-Suso J, Sockalingum GD, Kegelaer G, Manfait M, El Haj AJ. 2005. Study of tumor cell invasion by Fourier transform infrared microspectroscopy. Biopolymers, vol. 78(6), 311-317. link> doi>
  • Yang Y, Bagnaninchi PO, Whiteman SC, van Pittius DG, El Haj AJ, Spiteri MA, Wang RKK. 2005. A naturally occurring contrast agent for OCT imaging of smokers' lung. JOURNAL OF PHYSICS D-APPLIED PHYSICS, vol. 38(15), 2590-2596. link> doi>
  • Hughes S, El Haj AJ, Dobson J, Martinac B. 2005. The influence of static magnetic fields on mechanosensitive ion channel activity in artificial liposomes. Eur Biophys J, vol. 34(5), 461-468. link> doi>
  • Rock J, Magneyh JL, Beech S, El Haj AJ, Goldspink G, Whiteley NM. 2005. The plasticity of myosin heavy chain genes in gammarid amphipods distributed along a latitudinal thermal gradient. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, vol. 141(3), S353. link>
  • Freyria AM, Yang Y, Chajra H, Rousseau CF, Ronzière MC, Herbage D, El Haj AJ. 2005. Optimization of dynamic culture conditions: effects on biosynthetic activities of chondrocytes grown in collagen sponges. Tissue Eng, vol. 11(5-6), 674-684. link> doi>
  • Cartmell SH, Keramane A, Kirkham GR, Verschueren SB, Magnay JL, El Haj AJ, Dobson J. 2005. Use of magnetic particles to apply mechanical forces for bone tissue engineering purposes. Journal of Physics: Conference Series, vol. 17(1), 77-80.
  • YANG Y, SULE-SUSO J, EL HAJ AJ, HOBAN PR, WANG R. 2004. Monitoring of lung tumour cell growth in artificial membranes. Biosens Bioelectron, vol. 20(3), 442-447. doi>
  • EL HAJ AJ. 2004. Biomechanical interactions in tissue engineering and surgical repair (BITES). Med Biol Eng Comput, vol. 42(1), 2.
  • YANG Y and EL HAJ AJ. 2004. Bone tissue engineering. Scope, vol. 13(3), 33-35.
  • SULE-SUSO J, FORSTER A, ZHOLOBENKO V, STONE N, EL HAJ A. 2004. Effects of CaCl2 and MgCl2 on Fourier transform infrared spectra of lung cancer cells. Applied Spectroscopy, vol. 1(58), 61-67.
  • Yang Y, Magnay J, Cooling L, Cooper JJ, El Haj AJ. 2004. Effects of substrate characteristics on bone cell response to the mechanical environment. Med Biol Eng Comput, vol. 42(1), 22-29. link> doi>
  • MULLENDER M, EL HAJ AJ, YANG Y, VAN DUIN MA, BURGER EH. 2004. Mechanotransduction of bone cells in vitro; mechanobiology of bone tissue. Med Biol Eng Comput, vol. 42(1), 14-21. doi>
  • Yang Y, Zhang S, Jones G, Morgan N, El Haj AJ. 2004. Phosphorylcholine-containing polymers for use in cell encapsulation. Artif Cells Blood Substit Immobil Biotechnol, vol. 32(1), 91-104. link> doi>
  • Sharma P, Yang Y, El Haj A. 2004. Scaffold design and synthesis for bone tissue engineering. CME Orthopaedics, vol. 3(3), 71-76.
  • YANG Y, SULE-SUSO J, EL HAJ AJ, HOBAN PR, WANG RK. 2004. Use of OCT to study tumor cell growth in 3D membranes. Proceedings of SPIE.
  • YANG Y, SULE-SUSO J, EL HAJ AJ, HOBAN PR, WANG RK. 2004. Use of OCT to study tumor cell growth in 3D membranes. Proceedings of SPIE. doi>
  • Magnay JL, Holmes JM, Neil DM, El Haj AJ. 2003. Temperature-dependent developmental variation in lobster muscle myosin heavy chain isoforms. Gene, vol. 316, 119-126. link> doi>
  • Yang Y, Porte MC, Marmey P, El Haj AJ, Amedee J, Baquey C. 2003. Covalent bonding of collagen on poly(L-lactic acid) by gamma irradiation. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, vol. 207(2), 165-174. link> doi>
  • Cartmell SH, Magnay J, Dobson J, El Haj AJ. 2003. Effects of mechanical force application on 3D bone tissue engineered constructs using magnetic microparticles. European Cells & Materials, vol. 6(2), 7.
  • Cartmell SH, Porter BD, Garcia AJ, Guldberg RE. 2003. Effects of media perfusion rate on cell seeded 3D bone constructs in vitro. Tissue Engineering, vol. 9(6), 1197-1203.
  • Xu XQ, Wang RKK, El Haj AJ. 2003. Investigation of changes in optical attenuation of bone and neuronal cells in organ culture or 3D constructs in vitro with OCT; relevance to cytochrome oxidase monitoring. Biophysics Journal with Biophysics Letters, vol. 32(4), 355-362.
  • Sharma P, El Haj A, Maffulli N, Hoyland J, Le Maitre C. 2003. Ion channel expression in intervertebral disc cells. European Cells and Materials.
  • Hughes S, Dobson J, El Haj AJ. 2003. Mechanical stimulation of calcium signalling pathways in human bone cells using ferromagnetic microparticles: Implications for tissue engineering. European Cells & Materials, vol. 6(2), 43.
  • Peake MA and El Haj AJ. 2003. Preliminary characterisation of mechanoresponsive regions of the c-fos promoter in bone cells. FEBS Lett, vol. 537(1-3), 117-120. link> doi>
  • Smith D, Wang T, Sule-Suso J, Spanel P, El Haj AJ. 2003. Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Communcations Mass Spectometry, vol. 17(8), 845-850. doi>
  • Cartmell SH, Dobson J, Verschueren SB, El Haj AJ. 2002. Development of magnetic particle techniques for long-term culture of bone cells with intermittent mechanical activation. IEEE Trans Nanobioscience, vol. 1(2), 92-97. link> doi>
  • Yang Y, Magnay JL, Cooling L, El HA. 2002. Development of a 'mechano-active' scaffold for tissue engineering. Biomaterials, vol. 23(10), 2119-2126. link> doi>
  • Peake MA and El Haj AJ. 2002. Characterisation of the mechanoresponsive regions of the c-fos promoter in osteoblasts. BONE, vol. 30(3), 9S. link>
  • Then KY and El Haj AJ. 2002. Advances in tissue engineering and regenerative medicine. Eye News, vol. 8(5), 14-20.
  • Holmes JM, Whitely NM, Magnay J, El Haj AJ. 2002. Comparsion of the variable loop regions of myosin heavy chain genes from Antarctic and temperate isopods. Comparative Biochemistry and Physiology B-Biochemistry and Molecular Biology, vol. 131, 349-359. doi>
  • Xu X, Wang RK, El Haj A. 2002. Does light scattering affect the OCT quantitation of redox state of cytochrome oxidase in bone tissue?. Proceedings of SPIE, vol. 4619, 219-222.
  • Robertson RF, El-Haj AJ, Clarke A, Peck LS, Taylor EW. 2001. The effects of temperature on metabolic rate and protein synthesis following a meal in the isopod Glyptonotus antarcticus Eights (1852). POLAR BIOLOGY, vol. 24(9), 677-686. link>
  • Robertson RF, El-Haj AJ, Clarke A, Taylor EW. 2001. Effects of temperature on specific dynamic action and protein synthesis rates in the Baltic isopod crustacean, Saduria entomon. JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY, vol. 262(1), 113-129. link> doi>
  • Walker LM, Preston M, Magnay JL, Thomas PBM, Elhaj AJ. 2001. Nicotinic regulation of C-Fos and osteopontin expression in human-derived osteoblast like cells and human trabecular bone organ culture. Bone, vol. 28(6), 603-608. doi>
  • Gu Y, Preston MR, Magnay J, El Haj AJ, Publicover SJ. 2001. Hormonally-regulated expression of voltage-operated Ca(2+) channels in osteocytic (MLO-Y4) cells. Biochem Biophys Res Commun, vol. 282(2), 536-542. link> doi>
  • Wang RK, Yang Y, El Haj A, Elder JB. 2001. High resolution optical tomographic imaging of biological tissues. Scope, vol. 10, 12-14.
  • Johnson E, El Haj A, Eistenstein S, Roberts S. 2001. Immuno histochemical detection of schwann cells and vascularisation in the degenerating human intervertebral discs. Spine, vol. 26, 2550-2557.
  • Xu X, Wang RK, Ej Haj A. 2001. In-vitro imaging of bone tissue and monitoring of tissue viability by optical coherence tomography. Proceedings of SPIE, vol. 4257, 442-447.
  • Xu X, Wang RK, El Haj A. 2001. In vitro monitoring of redox state of cytochrome oxidase in bone by optical coherence quantitation based on low-coherence interferometry. Proceddings of SPIE, vol. 4251, 117-122.
  • Gu Y, Preston MR, El Haj AJ, Howl JD, Publicover SJ. 2001. Three types of K(+) currents in murine osteocyte-like cells (MLO-Y4). Bone, vol. 28(1), 29-37. link> doi>
  • Peake MA, Cooling LM, Magnay JL, Thomas PB, El Haj AJ. 2000. Selected contribution: regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells. J Appl Physiol (1985), vol. 89(6), 2498-2507. link>
  • Said Ahmed MA, Walker LM, Publicover SJ, El Haj AJ. 2000. Hormonal regulation of [Ca(2+)](i) in periosteal-derived osteoblasts: effects of parathyroid hormone, 1,25(OH)(2)D(3) and prostaglandin E(2). J Cell Physiol, vol. 183(2), 163-171. link> doi>
  • Walker LM, Publicover SJ, Preston MR, Said Ahmed MA, El Haj AJ. 2000. Calcium-channel activation and matrix protein upregulation in bone cells in response to mechanical strain. J Cell Biochem, vol. 79(4), 648-661. link> doi>
  • Sule-Suso J, Zhang S, Yang Y, Forster A, Hand PA, El Haj AJ. 1999. Study of lung cancer cells by Fourier Transform Infrared spectroscopy. THORAX, vol. 54, A83. link>
  • Walker LM, Holm A, Cooling L, Maxwell L, Oberg A, Sundqvist T, El Haj AJ. 1999. Mechanical manipulation of bone and cartilage cells with 'optical tweezers'. FEBS Lett, vol. 459(1), 39-42. link> doi>
  • Walker LM, Thomas PBM, Magnay JM, Preston M, El Haj AJ. 1999. Nicotine promotes proliferation and cfos induction in bone cells - The effects of smoking on skeletal repair and remodeling. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, S477. link>
  • Gu Y, Preston MR, el Haj AJ, Hamid J, Zamponi GW, Howl J, Publicover SJ. 1999. Osteoblasts derived from load-bearing bones of the rat express both L- and T-like voltage-operated calcium channels and mRNA for alpha 1C, alpha 1D and alpha 1G subunits. Pflugers Arch, vol. 438(4), 553-560. link> doi>
  • Gu Y, Preston MR, Hamid J, Zamponi GW, Publicover SJ, El Haj AJ. 1999. Upregulation of calcium channel expression in the mouse osteocyte cell line, MLO-Y4, by bone regulating factors. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, S472. link>
  • Walker LM, Thomas PBM, Mapnay JL, El Haj AJ. 1999. Effects of smoking on fracture repair; A study of the possible direct effects on bone cell activity. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14(6), 1045. link>
  • Gu Y, Preston MR, Publicover SJ, El Haj AJ. 1999. Expression of voltage operated calcium channels in the mouse osteocyte cell line MLO-Y4. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14(6), 1047. link>
  • Peake MA, Cooling LM, Magnay JL, El Haj AJ. 1999. Interaction between substrates and mechanical loading of human bone cells, responses in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14(6), 1050. link>
  • el Haj AJ, Walker LM, Preston MR, Publicover SJ. 1999. Mechanotransduction pathways in bone: calcium fluxes and the role of voltage-operated calcium channels. Med Biol Eng Comput, vol. 37(3), 403-409. link>
  • Cartmell SH, Doherty PJ, Hunt JA, Healy DM, Gilchrist T. 1998. Soft tissue response to glycerol-suspended controlled-release glass particulate. J Mater Sci Mater Med, vol. 9(12), 773-777. link> doi>
  • Mohammed MAAA, Walker LM, Publicover SJ, El Haj AJ. 1998. Hormonal regulation of [Ca2+]i in periosteal, derived osteoblasts; Effects of PTH, vitamin D and PGE(2). JOURNAL OF BONE AND MINERAL RESEARCH, vol. 13(9), 1512. link>
  • Walker LM, Holm A, Oberg A, Sundqvist T, El Haj AJ. 1998. Mechanical manipulation of human osteoblast and chondrocyte cells with 'optical tweezers'. JOURNAL OF BONE AND MINERAL RESEARCH, vol. 13(9), 1506. link>
  • Bishop CM, Butler PJ, El Haj AJ, Egginton S. 1998. Comparative development in captive and migratory populations of the barnacle goose. Physiol Zool, vol. 71(2), 198-207. link>
  • Whiteley NM, Taylor EW, El Haj AJ. 1997. Seasonal and latitudinal adaptation to temperature in crustaceans. JOURNAL OF THERMAL BIOLOGY, vol. 22(6), 419-427. link> doi>
  • El Haj AJ, Tamone SL, Peake M, Sreenivasula Reddy P, Chang ES. 1997. An ecdysteroid-responsive gene in a lobster - a potential crustacean member of the steroid hormone receptor superfamily. Gene, vol. 201(1-2), 127-135. link> doi>
  • Whiteley NM, Taylor EW, el Haj AJ. 1996. A comparison of the metabolic cost of protein synthesis in stenothermal and eurythermal isopod crustaceans. Am J Physiol, vol. 271(5 Pt 2), R1295-R1303. link>
  • Preston MR, el Haj AJ, Publicover SJ. 1996. Expression of voltage-operated Ca2+ channels in rat bone marrow stromal cells in vitro. Bone, vol. 19(2), 101-106. link>
  • Thomas GP and el Haj AJ. 1996. Bone marrow stromal cells are load responsive in vitro. Calcif Tissue Int, vol. 58(2), 101-108. link>
  • Publicover SJ, Preston MR, El Haj AJ. 1995. Voltage-dependent potentiation of low-voltage-activated Ca2+ channel currents in cultured rat bone marrow cells. J Physiol, vol. 489 ( Pt 3), 649-661. link>
  • Bishop CM, Butler PJ, Egginton S, el Haj AJ, Gabrielsen GW. 1995. Development of metabolic enzyme activity in locomotor and cardiac muscles of the migratory barnacle goose. Am J Physiol, vol. 269(1 Pt 2), R64-R72. link>
  • Sammons RL, el Haj AJ, Marquis PM. 1994. Novel culture procedure permitting the synthesis of proteins by rat calvarial cells cultured on hydroxyapatite particles to be quantified. Biomaterials, vol. 15(7), 536-542. link>
  • Harrison P and el Haj AJ. 1994. Actin mRNA levels and myofibrillar growth in leg muscles of the European lobster (Homarus gammarus) in response to passive stretch. Mol Mar Biol Biotechnol, vol. 3(1), 35-41. link>
  • Publicover SJ, Thomas GP, el Haj AJ. 1994. Induction of a low voltage-activated, fast-inactivating Ca2+ channel in cultured bone marrow stromal cells by dexamethasone. Calcif Tissue Int, vol. 54(2), 125-132. link>
  • Shelton RM and el Haj AJ. 1992. A novel microcarrier bead model to investigate bone cell responses to mechanical compression in vitro. J Bone Miner Res, vol. 7 Suppl 2, S403-S405. link> doi>
  • el Haj AJ, Harrison P, Whiteley NM. 1992. Regulation of muscle gene expression in Crustacea over the moult cycle. Symp Soc Exp Biol, vol. 46, 151-165. link>
  • Rawlinson SC, el-Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE. 1991. Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling?. J Bone Miner Res, vol. 6(12), 1345-1351. link> doi>
  • el Haj AJ, Minter SL, Rawlinson SC, Suswillo R, Lanyon LE. 1990. Cellular responses to mechanical loading in vitro. J Bone Miner Res, vol. 5(9), 923-932. link> doi>
  • Skerry TM, Suswillo R, el Haj AJ, Ali NN, Dodds RA, Lanyon LE. 1990. Load-induced proteoglycan orientation in bone tissue in vivo and in vitro. Calcif Tissue Int, vol. 46(5), 318-326. link>
  • Robinson J, Canavan JP, el Haj AJ, Goldspink DF. 1988. Maternal diabetes in rats. I. Effects on placental growth and protein turnover. Diabetes, vol. 37(12), 1665-1670. link>
  • Goldspink DF, el Haj AJ, Lewis SE, Merry BJ, Holehan AM. 1987. The influence of chronic dietary intervention on protein turnover and growth of the diaphragm and extensor digitorum longus muscles of the rat. Exp Gerontol, vol. 22(1), 67-78. link>
  • el Haj AJ, Lewis SE, Goldspink DF, Merry BJ, Holehan AM. 1986. The effect of chronic and acute dietary restriction on the growth and protein turnover of fast and slow types of rat skeletal muscle. Comp Biochem Physiol A Comp Physiol, vol. 85(2), 281-287. link>
  • Zhang H, Chen NH, El Haj AJ, Liu K-K. An optical-manipulation technique for cells in physiological flows. Journal of Biological Physics: an international journal for the formulation and application of physi, vol. 36, 135-143. doi>

Chapters

  • El Haj AJ. 2009. Biomechanics and Cells. In Biomechanics and Cells. Lyall F and El Haj AJ (Eds.). Cambridge Univ Pr.
  • El Haj AJ, HAMPSON K, GOGNIATH G. 2008. Bioreactors for Connective Tissue engineering: Design and Monitoring Innovations. In Advances in biochemical engineering/biotechnology. Kasper C, Griensven MV, Pörtner R, Al-Rubeai M (Eds.). doi>
  • El Haj AJ and WOZÂNIAK P. 2007. Bone regeneration and repair using tissue engineering. In Tissue Engineering using Ceramics and Polymers. BOCCACCINI AR and GOUGH JE (Eds.). North America by CRC Press LLC, 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, USA: Woodhead Publishing Limited. link>
  • Kim DK, Jo YS, Dobson J, El Haj AJ, MUHAMMED M. 2007. Nanomaterials for Controlled Release of Anticancer Agents. Wiley-VCH. doi>
  • EL HAJ AJ and Cartmell S. 2005. Mechanical Bioreactors for Bone Tissue Engineering. In Bioreactors for Tissue Engineering: Principles, Design and Operation. Chaudhuri J and Al-Rubeai M (Eds.). Springer.
  • EL HAJ AJ, Sharma P, Cartmell S. 2005. Tissue Engineering. In Applications of Cell Immobilisation Biotechnology. Nedovic V and Willaert R (Eds.). (vol. 8B). Kluwer Academic Publishers.

Other

  • Yang Y, Iftimia A, Jia Y, Gould T, El Haj A, Wang RK. 2010. The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE IV (vol. 7566). link> doi>
  • Yang Y, Aydin HM, Piskin E, El Haj AJ. 2009. Assessment of a new biomimetic scaffold and its effects on bone formation by OCT. OPTICS IN BONE BIOLOGY AND DIAGNOSTICS (vol. 7166). link> doi>
  • Yang Y, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Characterisation of scaffold architecture and tendons using optical coherence tomography and polarisation-sensitive optical coherence tomography. IET OPTOELECTRONICS (vol. 2, pp. 188-194). link> doi>
  • Bölgen N, Yang Y, Korkusuz P, Güzel E, El Haj AJ, Pişkin E. 2008. Three-dimensional ingrowth of bone cells within biodegradable cryogel scaffolds in bioreactors at different regimes. Tissue Eng Part A (vol. 14, pp. 1743-1750). link> doi>
  • Wang QG, El Haj AJ, Kuiper NJ. 2008. Characterisation of the glycosaminoglycans in the pericellular matrix of chondrons and chondrocytes following enzymatic isolation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A6-A7). link>
  • Bagnaninchi PO, Churmakov D, Bonesi M, Yang Y, Phelan C, Maffulli N, Meglinski I, El Haj A. 2008. Tendon collagen orientation and crimp pattern characterized by PSOCT. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (vol. 89, pp. A28-A29). link>
  • Araujo JV, Cunha-Reis C, Gogniat G, Yang Y, Ashammakhi N, Reis RL, El Haj AJ, Neves NM. 2008. Dynamic studies of biomimetic coated polycaprolactone nanofiber meshes as bone extracellular matrix analogues. TISSUE ENGINEERING PART A (vol. 14, pp. 723-724). link>
  • El Haj AJ. 2008. Linking the physical environment to cell behaviour - Applications for tissue engineering and regenerative medicine. TISSUE ENGINEERING PART A (vol. 14, p. 752). link>
  • Cunha-Reis C, El Haj AJ, Yang Y. 2008. Real time monitoring of scaffold degradation under culture conditions. TISSUE ENGINEERING PART A (vol. 14, p. 903). link>
  • Hampson K, Kuiper JH, El Haj AJ. 2008. The validation of a novel compression bioreactor to ensure the accurate application of loading regimes. TISSUE ENGINEERING PART A (vol. 14, p. 919). link>
  • Yang Y, Ahearne M, Bagnaninchi PO, El Haj AJ. 2008. Visualization of structural evolution in tissue engineering tendon. TISSUE ENGINEERING PART A (vol. 14, p. 795). link>
  • Yang Y, Ahearne M, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. 2008. Application of polarization OCT in tissue engineering - art. no. 68580K. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE II (vol. 6858, p. K8580). link> doi>
  • Bagnaninchi PO, Churmakov D, Bonesi M, Yang Y, Phelan C, Maffulli N, Meglinski I, El Haj A. 2008. Optical properties of human tendons characterized by PSOCT and their relation to tendinopothy: A clinical study - art. no. 68541C. OPTICAL INTERACTIONS WITH TISSUE AND CELLS XIX (vol. 6854, p. C8541). link> doi>
  • Kirkham GR, Elliot KJ, Knight M, Keramane A, Akhtar B, Salter DM, Dobson J, El Haj AJ, Cartmell SH. 2007. Electrophysiological responses of HMSCs and bone cells to magnetic particle tagging. TISSUE ENGINEERING (vol. 13, p. 1684). link>
  • Cunha-Reis C, Bagnaninchi PO, El Haj AJ, Yang Y. 2007. Exploring fluorescence as a tool for real-time monitoring of scaffolds degradation. TISSUE ENGINEERING (vol. 13, p. 1694). link>
  • Sura HS, Magnay J, Dobson J, El-Haj AJ. 2007. Gene expression in stem cells following stimulation using magnetic particle technology. TISSUE ENGINEERING (vol. 13, p. 1699). link>
  • Bolgen N, Yang Y, Korkusuz P, El Haj AJ, Piskin E. 2007. Interaction of cells with novel biodegradable cryogels in bioreactors. TISSUE ENGINEERING (vol. 13, p. 1718). link>
  • Sura HS, Dobson J, El Haj AJ. 2007. Targeting stem cells transfected with magnetic nanoparticles in a flow system. TISSUE ENGINEERING (vol. 13, p. 1760). link>
  • Jones G, Marshall M, El Haj AJ, Motta A, Cartmell S. 2007. The use of osteoblast/osteoclast co-cultures on PLLA, silk and dentine scaffolds. TISSUE ENGINEERING (vol. 13, pp. 1765-1766). link>
  • Cunha-Reis C, TuzlaKoglu K, Baas E, Yang Y, El Haj A, Reis RL. 2007. Influence of porosity and fibre diameter on the degradation of chitosan fibre-mesh scaffolds and cell adhesion. J Mater Sci Mater Med (vol. 18, pp. 195-200). link> doi>
  • Yang Y, Bagnaninchi PO, Cunha-Reis C, Aydin HM, Piskin E, El Haj A. 2007. Characterisation of scaffold architecture by optical coherence tomography - art. no. 64390G. Optics in Tissue Engineering and Regenerative Medicine (vol. 6439, p. G4390). link> doi>
  • Bagnaninchi PO, Yang Y, El Haj A, Hinds MT, Wang RK. 2007. Characterization of local fluid flow in 3D porous construct characterized by fourier domain doppler optical coherence tomography - art. no. 64390H. Optics in Tissue Engineering and Regenerative Medicine (vol. 6439, p. H4390). link> doi>
  • Bagnaninchi PO, El Haj A, Yang Y. 2007. Continuous monitoring of tissue growth inside a perfusion bioreactor by optical coherence tomography - art. no. 643903. Optics in Tissue Engineering and Regenerative Medicine (vol. 6439, p. 43903). link> doi>
  • Bagnaninchi PO, Yang Y, Maffulli N, Wang RK, El Haj A. 2006. Monitoring tissue formation and organization of engineered tendon by optical coherence tomography - art. no. 608419. Optical Interactions with Tissue and Cells XVII (vol. 6084, p. 8419). link> doi>
  • Yang Y, Hoban PR, Sule-Suso J, Holley S, El Haj AJ, Bahrami F, Wang RK. 2006. Study cell invasion by optical techniques - art. no. 60841A. Optical Interactions with Tissue and Cells XVII (vol. 6084, p. A841). link> doi>
  • Yang Y, Wang RKK, Guyot E, El Haj A, Dubois A. 2005. Application of optical coherence tomography for issue engineering. Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX (vol. 5690, pp. 18-23). link> doi>
  • Yang Y, Bagnaninch PO, Wood MA, El Haj AJ, Guyot E, Dubois A, Wang RKK. 2005. Monitoring cell profile in tissue engineered constructs by OCT. Optical Interactions with Tissue and Cells XVI (vol. 5695, pp. 51-57). link> doi>
  • CARTMELL SH, WOOD I, DOBSON J, EL HAJ AJ. 2004. Use of magnetic particles to apply forces for bone tissue engineering purposes. Proceedings of the 5th International Conference on Fine Particle Magnetism. doi>
  • CARTMELL SH, MAGNAY J, EL HAJ AJ, DOBSON J. 2004. A novel mechanical conditioning regime for tissue engineered constructs. International Journal of Experimental Pathology.
  • HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. A study of the effects of seeding density, media flow and biochemical stimuli on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of the Combined Meeting of the Tissue Engineering Society International ? European Tissue Engineering Society Meeting.
  • SULE-SUSO J, SKINGSLEY D, SOCKALINGUM G, KOHLER A, KEGELAER G, MANFAIT M, EL HAJ A. 2004. FTIR microspectrosocopy as a tool to assess tumour response to chemotherapy in lung cancer cells. Spec2004. Shedding new light on disease: optical diagnosis for the new millennium. Newark, USA. July 2004.
  • CARTMELL SH, WOOD I, DOBSON J, EL HAJ AJ. 2004. Microarray analysis of mechanically and chemically induced primary human stem cell differentiation. Proceedings of the European Tissue Engineering Society Conference.
  • CARTMELL S, MAGNAY J, DOBSON J, EL HAJ A. 2004. Novel mechanical conditioning of 3D bone tissue engineered constructs. Proceedings of the European Tissue Engineering Society Conference.
  • HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. The effects of a 3D environment on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of Tissue and Cell Engineering Society Spring Meeting.
  • HAMPSON K, CARTMELL SH, YANG Y, ASHTON B, EL HAJ A. 2004. The effects of a 3D environment on the osteogenic differentiation of Mesenchymal Stem Cells. Transactions of Tissue and Cell Engineering Society Spring Meeting.
  • CARTMELL SH, WOOD I, DOBSON J, EL HAJ AJ. 2004. Use of magnetic particles to apply forces for bone tissue engineering purposes. Proceedings of the 5th International Conference on Fine Particle Magnetism.
  • Then KY, Yang Y, Curtis A, Monaghan W, Shah S, McDonnell P, El Haj AJ. 2003. Effect of microtopographical cue on human corneal keratocytes orientation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (vol. 44, p. U254). link>
  • Cartmell SH, Allen JT, Wood I, Dobson J, El Haj AJ. 2003. Mechanical conditioning of bone cells for tissue engineering strategies. Proceedings of the International Conference on Cellular Engineering, Sydney, Australia - 20th - 22nd August 2003.
  • Cartmell SH, Allen JT, Wood I, Dobson J, El Haj AJ. 2003. Mechanical conditioning of bone cells for tissue engineering strategies. Proceedings of the International Conference on Cellular Engineering, Sydney, Australia - 20th - 22nd August 2003.
  • Then KY, Yang Y, Shah S, McDonnell P, El Haj AJ, IPD, IPD. 2003. Reconstruction of 3D human cornea using processed porcine cornea as a biological scaffold. SOE 2003: XIV CONGRESS OF THE EUROPEAN SOCIETY OF OPHTHALMOLOGY (pp. 275-280). link>
  • Cartmell SH, Magnay J, Wood I, Dobson J, El Haj AJ. 2003. Use of Magnetic Microparticles to Apply Mechanical Forces to 3D Bone Tissue Engineered Constructs. Proceedings of the World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia.
  • Cartmell SH, Hughes S, Dobson J, El Haj A. 2002. Preliminary analysis of magnetic particle techniques for activating mechanotransduction in bone cell. Proceedings of the IEEE-EMBS Conference on Molecular, Cellular & Tissue Engineering, Genoa, Italy.
  • Whiteley NM, Robertson RF, Meagor J, El Haj AJ, Taylor EW. 2001. Protein synthesis and specific dynamic action in crustaceans: effects of temperature. Comp Biochem Physiol A Mol Integr Physiol (vol. 128, pp. 595-606). link>
  • El Haj AJ. 1999. Regulation of muscle growth and sarcomeric protein gene expression over the intermolt cycle. AMERICAN ZOOLOGIST (vol. 39, pp. 570-579). link>
  • Cowell A, Yang Y, Rolfe P, El Haj AJ. 1998. In vitro monitoring of cytochrome oxidase activity in neuronal cells. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2939-2940). link>
  • Walker LM, Holm A, Oberg A, Sundqvist T, El Haj AJ. 1998. Mechanical manipulation of human osteoblast and chondrocyte cells with 'optical tweezers'. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2957-2959). link>
  • Martinoia S, Bove M, Tedesco M, Margesin B, Rolfe P, El Haj AJ, Cowell A, Grattarola M. 1998. Patterning of populations of spinal cord neurons on silicon micromachined substrates by means of a microfluidic system. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 2945-2948). link>
  • Alford K, Wickramasinghe Y, El Haj AJ. 1998. Quantitation of brain oxygenation and blood volume using a new intensity modulated NIR instrument. PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6 (vol. 20, pp. 1851-1854). link>
  • SMITH ME and El Haj AJ. In The Same Room - practical methods to encourage collaboration across scientific disciplines. link> full text>

1997- 2013, Courses/Keele University   

  • Bioreactor & Growth Environments for Tissue Engineering Training Course

I have established an MSc course in Biomedical engineering and an MSc course in Cell and Tissue engineering in 1999 which has now taken its fourteenth year of intake.

 

1990-1997, Courses/Birmingham University                                                        

1st Year         Cell Biology and Molecular Biology:Cell Division and Differentiation

2nd Year        Development 5 week option Molecular and Cell Biology; co-option leader: 

* Animal Gene Regulation/Drosophila genetics

 * Evolutionary Developmental Biology

3rd Year        Cell Biology of Development - Option Leader

       Biology of Animal Growth - Option Leader

Current Issues in Biomedical Sciences - Option leader

All 3 years involve lectures and practicals.  Tutorials were held for all 3 years. Where option leader is noted - this involved design and development of a new course

Recent Research grants held at Keele awarded by:

 Current Awarded & Applied Grants for Professor Alicia J. El Haj

Recent external appointments:

  • Fellow of the Society of Biology (FSB), 2011 to date

  • Medical Research Council, Developmental Pathway Funding Scheme Panel Member (DPFS), 2011 to date

  • UK HEFCE 2014 Research Excellence Framework (REF), Member of Sub-panel 15: General Engineering, 2011 to date                

  • EU Chair-Elect for TERMIS, 2011 to date

  • EPSRC:

    * Strategic Advisory Network Member, 2011 to date

    * Healthcare Strategic Advisory Team Member, 2011 to date

  • Honorary UHNS Clinical Contract, 2011 to date

  • Adjunct Professor, Universiti KebangsaanTissue Engineering Centre, Faculty of Medicine, Malaysia, 2011 to date

  • Council Member, European Chapter of the TERMIS (Tissue Engineering and Regenerative Medicine International Society), 2008 to date

  • UK HEFCE RAE Panel member, General Engineering – G25, 2005-2008 & 2008 - 2009

  • UK Bioengineering Society,Member of Founding Committee, 2008 to date

  • UKSCN Stem Cell Advisory Board Member 2008 to 2011

  • Deputy Chair / Chair of Engineering and Bioscience Panel (EBS) BBSRC, 2006 - 2009

  • BBSRC BioIndustry Panel Member, 2010 to date

  • President -  UK Cell & Tissue Engineering (TCES), 2003 - 2008

  • UK Cell & Tissue Engineering (TCES), Member of committee, 2009 to date

  • EPSRC College and Panel Member/Chairman, 1997 to date

  • MRC College of Experts, 2003 to date       

  • BBSRC Member of Engineering and Bioscience Panel (EBS) 2006

  • Member Academic Advisory Group – Institute of Physics and Engineering in Medicine – 2006 to date

  • Women’s Working Party of the IFMBE – 2004 to date

  • Strategic Advisory Team member – Life Sciences interface – 2003 

  • International Science Committee of ICCE Advisory Board 2003 

 

Patents:

UK/International patents:

  • Stem cell conditioning. WO 2005059118 2003

  • Culturing tissue using magnetic gen mech stress. WO 2004/00369 2002

  • Magnetic nanoparticles as ion channel agonists. WO 02/051985 2002

 

Details of Awarded Grants:

Engineering & Physical Sciences Research Council (EPSRC), UK
  • 2011-2012 £50,000 EPSRC Bridging the gaps sponsorship- for further information, please visit the Bridging the Gaps website. 
  • 2011-2012 £102,015, Creativity@Home - Designer magnetic particle tagging and activation of mechano-sensitive receptors for remote control of cell signalling and behaviour. (Prof Alicia J. El Haj, Prof Jon Dobson and Dr Paul Roach)
  • 2011-2016 £310,000, E-TERM Programme-Collaborative programme between 2 Doctoral Training Centres in Regenerative Medicine including Keele, Loughborough, Sheffield, Leeds and York
  • 2010-2015, £620,000, EPSRC Innovative Manufacturing Centre in Regenerative Medicine -  Joint  bid with Loughborough University (Lead  PI) and Nottingham University- please click on the following link to download the EPSRC Centre annual review
  • 2008-2013 £750,000 Doctoral Training Centre in Regenerative Medicine with Nottingham and Loughborough universities - see website for the DTC in Regenerative Medicine.
  • 2008-2011 £285,272 3ME - Modelling Methods for Medical Engineering (with Prof Jon Dobson, Prof Peter Styles and Prof Graham Rogerson  to foster collaboration between medical engineering, applied mathematics and geophysics - see website for 3ME Initiative.
  • 2005-2008 £382,912 Micromechanical analysis of chondrocytes – the role of the pericellular matrix. (Dr Nicola Kuiper (nee Goodstone) and Prof Alicia El Haj). A collaboration with Dr Zhang, Prof Thomas, Chemical Engineering,  Birmingham University 
  • 2004 – 2006 £215,356 Development of a mechano-active scaffold for skeletal tissue. (with Dr Ying Yang). 
  • 2001 – 2004 £238,156 High resolution optical tomographic imaging of in vivo micro-circulation. 
  • 2001 - 2003 £62,205 Development of novel magnetic force bioreactor for tissue engineering. 
  • 1999 - 2002 £258,854 Development of the TSIFT for breath analysis and analysis of headspace above cells in vitro. (with Prof David Smith).
Biotechnology & Biological Sciences Research Council (BBSRC), UK 
  • 2008-2013 £758,000 of £3m total, LOLA: Combining Stem Cell Science and Tissue Engineering to study the development and repair of human skeletal tissues with Imperial College London (Prof Molly Stevens), Nottingham University (Prof Kevin Shakesheff) and Southampton University (Prof Richard Oreffo)
  • 2006 – 2007 £14,600 Masters Level Training for Industry – Bioreactor Development. (Dr Sarah Cartmell and Prof Alicia El Haj). 
  • 2006 – 2009 £347,381 Nano-optical-mechanical manipulation of bone marrow stem cells in physiological flows: design principles for delivering stem cell therapy. (Dr Isaac Liu, Prof Alicia El Haj, Dr Yibin Fu) 
  • 2004 – 2007 £335,435 Development of magnetic nanoparticle strategies for manipulation and activation of stem cells in vitro and in vivo. (Prof Alicia El  Haj and Prof Jon Dobson), collaboration with Prof Richard Oreffo , Southampton University.
  • 2004 – 2006 £170,806 Quantitative on-line assessment of collagen fibre organisation in connective tissues in vivo and during tissue engineering in vitro. (Prof Alicia El Haj, Dr Ying Yang, Prof Nicola Maffulli) Collaboration with Ritchie, Cranfield University.
European Commission 7th Framework Programme
  • 2011-2015 £460,000 BIODESIGN-Coordinated by Upsalla University with 19 partners
  • 2008-2012 374,400 Euro Hyaluronan-based injectable material for tissue engineering (HYANJI-SCAFFOLD) - Prof Alicia El Haj and Dr Nicholas R. Forsyth: Project Co-ordinators. An IRSES exchange programme with Italian and Chinese partners, for details see the HYANJI SCAFFOLD website.
European Commission 6th Framework Programme 
  • 2005 - 2009 £250,000 EXPERTISSUES, Network of Excellence –(Prof Alicia El Haj lead for WP8)  Total value of grant 7 million Euro
  • 2007-2010 £650,000 NEST project – MYJOINT,Lead by Keil Germany and Keele UK with 6 partners.
  • 2005 – 2007 €346,436 Marie Curie Multicentre Training Grant (ALEA JACTA) in regenerative medicine.
European Commission 5th Framework Programme
  • 2001 - 2004 £165,145 European Partnership for Autologous Chrondrocye Implantation (EUROCELL). (Prof Alicia El Haj, Prof James Richardson et al, 8 lead investigators in total) 
  • 2000 - 2002 £254,706 Biomedical interactions in tissue engineering and tissue engineering in surgical repair (BITES) - Prof Alicia El Haj: Project Co-ordinator. Total value of grant 2,104,999 Euro
Arthritis Research UK
Wellcome Trust, UK
  • 2011 £1440 Vacation Scholarship 2011: Tendon Tissue Engineering.
  • 2002 – 2004 £125,000 Sir Henry Wellcome Showcase Award - Biomagnetic strategies for therapeutics in bone. (Prof Alicia El Haj and Prof Jon Dobson)
MRC
  • 2012-2013 £30,000 MRC Centenary AWARD
    2013-2017 £326,095 Acellular Approaches for Therapeutic Delivery:UK Regenerative Medicine Platform Hub Application
    2013-2017 £23,833 A hub for Engineering and exploiting the stem cell niche: UK Regenerative Medicine Platform Hub Application

Royal Society

  • 2013-2018 £50,000 Wolfson Research Merit Awards- Engineering cells and tissues for regenerative medicine and stem cell therapies

 

 

 

Professor Alicia J. El Haj's Research Group: 

Postdoctoral Researchers and Fellows:

Dr. James Henstock: PhD - University of Nottingham

Dr. Yvonne Reinwald: PhD - University of Nottingham

Dr. Ian Wimpenny: PhD - Keele University

Dr. Thomas Chippendale: PhD - Keele University

Current Students: 

Mr Michael Rotherham - PhD studies in Biomedical Engineering - Keele University

Ms Hareklea Markides - PhD Title: Magnetic tagging of donor cells for use in Autologous Chrondrocyte implantation - Keele University

Ms Bin Hu - PhD studies in Biomedical Engineering - Keele University

Mr Thomas Kwan Intercalated PhD Students - PhD Title: The Influence Of Erythrocyte-Derived Fluid Viscosity And Shear On The Circulatory Magnetic Trapping Of Stem Cells For Localised Therapy - Keele University

Mr Joshua Price - PhD Title: Physiological and physical characterisation of the cell response to hydrostatic Force - Keele University

Ms Yanny Marliana Baba Ismail - PhD Title: Multi-Substituted Hydroxyapatite as Three-Dimensional Scaffold for Bone Tissue Engineering Applications - Keele & Newcastle University

Ms Folashade Kuforiji - PhD Title: The importance of biomaterial surface characteristics in tissue engineering - Keele University (Co-Supervisor) 

Mr William R Webb - PhD Title: Growth factor medicated tenogenic differentiation of human stem cells- Keele University (Co-Supervisor) 

Mr Kai Tsang - PhD Title: spinal deformity and bio-mechanics related to posterior instrumentation for spinal fusion- Keele University (Co-Supervisor) 

Ms Sandhya Moise - PhD Title: Tailored magnetic nanotechnology for regenerative medicine: Preparation, characterisation and application- Keele University (Co-Supervisor) 

Visiting Researchers:

Mr Li Deng - HYANJI Scaffold exchange researcher from Sichuan University