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    Publications

    Logo of research group Neural Tissue Engineering 480x320 (transparent)

    1. P Yiu HH and Chari DM. 2020. How can nanoparticles help neural cell transplantation therapy? Nanomedicine, Article nnm-2020-0279. 
    2. Prager J, Adams CF, Delaney AM, Chanoit G, Tarlton JF, Wong L-F, Chari DM, Granger N. 2020. Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury. J Tissue Eng, vol. 11, 2041731420934806. 
    3. Finch, L, Harris S, Solomou, G et al. Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM for protected cell therapy applications. Journal of Controlled Release. 2020. In Press.
    4. Finch, L, Harris S, Solomou, G et al. Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM for protected cell therapy applications. Journal of Controlled Release. 2020. In Press.
    5.  Rawlinson C, Jenkins S, Thei L, Dallas ML, Chen R. 2020. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain Sci, 10(3):159.
    6. Mira A, Sainz-Urruela C, Codina H, Jenkins SI, Rodriguez-Diaz JC, Mallavia R, Falco A. 2020. Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics. Nanomaterials (Basel), 10(3):486.
    7. Evans MG, Shakli AF, Chari DM. 2019. Electrophysiological properties of neurons grown on soft polymer scaffolds reveal the potential to develop neuromimetic culture environments. Integr Biol (Camb). 2019 Dec 31;11(11):395-403
    8. Tickle JA, Chari DM. 2019. Less is more: Investigating the influence of cellular nanoparticle load on transfection outcomes in neural cells. J Tissue Eng Regen Med. 2019 June 4. doi> 
    9. Price JP, Levett SJ, Radu V, Simpson DA, Mogas Barcons A, Adams  CF, Mather ML. 2019. Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers. Small, vol. 15(22). doi> full text>
    10. Adams CF, Jenkins SI. 2019. Nanoengineering neural cells for regenerative medicine. Book chapter: 21st Century Nanoscience. In press
    11. Adams CF, Delaney AM, Carwardine DR, Tickle J, Granger N, Chari DM. 2019. Nanoparticle-Based Imaging of Clinical Transplant Populations Encapsulated in Protective Polymer Matrices. Macromol Biosci, vol. 19(2), e1800389. link> doi> full text>
    12. Jenkins SI and Chari DM. 2018. A Stoichiometrically Defined Neural Coculture Model to Screen Nanoparticles for Neurological Applications. Book chapter: Neuromethods: Nanoparticles in Neuroscience.Santamaria F and Peralta X (Eds.). Humana Press, Inc.. doi> link> full text>
    13. Tickle JA, Poptani H, Taylor A, Chari DM. 2018. Noninvasive imaging of nanoparticle-labeled transplant populations within polymer matrices for neural cell therapy. Nanomedicine (Lond), vol. 13(11), 1333-1348. link> doi>
    14. Al-Mayyahi RS, Sterio LD, Connolly JB, Adams CF, Al-Tumah WA, Sen J, Emes RD, Hart SR, Chari DM. 2018. A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells. Mol Cell Neurosci, vol. 86, 30-40. link> doi> full text>
    15. Adams CF, Sen J, Tickle JA, Tzerakis N, Chari DM. 2017. Developing human dish models of neurological pathology. Midlands Medicine. full text>
    16. Delaney AM, Adams CF, Fernandes AR, Al-Shakli AF, Sen J, Carwardine DR, Granger N, Chari DM. 2017. A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells. Nanoscale, vol. 9(25), 8560-8566. link> doi>
    17. Evans MG, Al-Shakli A, Jenkins SI, Chari DM. 2017. Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles. NANO RESEARCH, vol. 10(8), 2881-2890. link> doi> full text>
    18. Pickard MR, Adams CF, Chari DM. 2017. Magnetic Nanoparticle-Mediated Gene Delivery to Two- and Three-Dimensional Neural Stem Cell Cultures: Magnet-Assisted Transfection and Multifection Approaches to Enhance Outcomes. Curr Protoc Stem Cell Biol, vol. 40, 2D.19.1-2D.19.16. link> doi> full text>
    19. Adams CF, Dickson AW, Kuiper J-H, Chari DM. 2016. Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology. Nanoscale, vol. 8(41), 17869-17880. link> doi> full text>
    20. Fernandes AR and Chari DM. 2016. Part II: functional delivery of a neurotherapeutic gene to neural stem cells using minicircle DNA and nanoparticles: Translational advantages for regenerative neurology. Journal of Controlled Release. doi> link> full text>
    21. Fernandes AR and Chari DM. 2016. Part I: Minicircle vector technology limits DNA size restrictions on ex vivo gene delivery using nanoparticle vectors: Overcoming a translational barrier in neural stem cell therapy. Journal of Controlled Release. doi> full text>
    22. Adams C, Israel LL, Ostrovsky S, Taylor A, Poptani H, Lellouche J-P, Chari D. 2016. Development of multifunctional magnetic nanoparticles for genetic engineering and tracking of neural stem cells. Adv Healthc Mater, vol. 5(7), 841-849. link> doi>
    23. Tickle J, Jenkins SI, Polyak B, Pickard MR, Chari DM. 2016. Endocytotic potential governs magnetic particle loading in dividing neural cells: Studying modes of particle inheritance. Nanomedicine, vol. 11(4), 348-358. doi> full text>
    24. Jenkins SI, Weinberg D, Al-Shakli AF, Fernandes AR, Yiu HHP, Telling ND, Roach P, Chari DM. 2016. 'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release, vol. 224, 136-145. link> doi> full text>
    25. Weightman AP, Jenkins SI, Chari DM. 2016. Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake. Nano Research. doi> link> full text>
    26. Weinberg D, Adams CF, Chari DM. 2015. Deploying clinical grade magnetic nanoparticles with magnetic fields to magnetolabel neural stem cells in adherent versus suspension cultures. RSC ADVANCES, vol. 5(54), 43353-43360. link> doi> full text>
    27. Pickard MR, Adams CF, Barraud P, Chari DM. 2015. Using magnetic nanoparticles for gene transfer to neural stem cells: Stem cell propagation method influences outcomes. J Funct Biomater, vol. 6(2), 259-276. link> doi> full text>
    28. Jenkins SI, Roach P, Chari DM. 2015. Development of a nanomaterial bio-screening platform for neurological applications. Nanomedicine, vol. 11(1), 77-87. link> doi> full text>
    29. Fernandes AR, Adams CF, Furness DN, Chari DM. 2015. Early membrane responses to magnetic particles are predictors of particle uptake in neural stem cells. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, vol. 32(6), 661-667. link> doi>
    30. Adams CF, Rai A, Sneddon G, Yiu HHP, Polyak B, Chari DM. 2015. Increasing magnetite contents of polymeric magnetic particles dramatically improves labeling of neural stem cell transplant populations. Nanomedicine, vol. 11(1), 19-29. link> doi>
    31. Jenkins SI, Yiu HHP, Rosseinsky MJ, Chari DM. 2014. Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Mol Cell Ther, vol. 2, 23. link> doi> full text>
    32. Fernandes AR and Chari DM. 2014. A multicellular, neuro-mimetic model to study nanoparticle uptake in cells of the central nervous system. Integr Biol (Camb), vol. 6(9), 855-861. link> doi>
    33. Tickle JA, Jenkins SI, Pickard MR, Chari DM. 2014. Influence of amplitude of oscillating magnetic fields on magnetic nanoparticle-mediated gene transfer to astrocytes. NanoLife. doi>
    34. Chari DM. 2014. How do corticosteroids influence myelin genesis in the central nervous system?. Neural Regen Res, vol. 9(9), 909-911. link> doi>
    35. Chari DM and Hider S. 2014. Developing the Keele Medical Research Pathway: Challenges For a Young Medical School. Midlands Medicine, vol. 27(3), 140.
    36. Jenkins SI, Pickard MR, Khong M, Smith HL, Mann CLA, Emes RD, Chari DM. 2014. Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS Chem Neurosci, vol. 5(1), 51-63. link> doi> full text>
    37. Weightman AP, Pickard MR, Yang Y, Chari DM. 2014. An in vitro spinal cord injury model to screen neuroregenerative materials. Also see News and Views: Spinal cord injury model (Feature on the screening model developed by Chari laboratory). 2014. Alternatives To Laboratory Animals (ATLA; published by Fund For Reduction of Animals in Medical Experiments; FRAME). 42: 1. Biomaterials, vol. 35(12), 3756-3765. link> doi>
    38. Weightman AP, Jenkins SI, Pickard MR, Chari DM, Yang Y. 2014. Alignment of multiple glial cell populations in 3D nanofiber scaffolds: toward the development of multicellular implantable scaffolds for repair of neural injury. Image featured on MRC forum Biomedical Picture of the Day (BPoD) in Nanobiotechnology Week http://bpod.mrc.ac.uk/archive/2014/4/4. Nanomedicine: Nanotechnology, Biology and Medicine, vol. 2(10), 291-295. doi>
    39. Adams CF, Pickard MR, Chari DM. 2013. Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields. Nanomedicine-Nanotechnology Biology And Medicine, vol. 9(6), 737-741. link> doi>
    40. Jenkins SI, Pickard MR, Furness DN, Yiu HHP, Chari DM. 2013. Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine (Lond), vol. 8(6), 951-968. link> doi> full text>
    41. Jenkins SI, Pickard MR, Chari DM. 2012. Magnetic nanoparticle mediated gene delivery in oligodendroglial cells: a comparison of differentiated versus precursor forms. NanoLIFE, vol. 3(1243001).
    42. Weightman A, Pickard M, Jenkins S, Chari D, Yang Y. 2012. Development of 3D co-culture of aligned glial cells in nanofibre scaffolds for implantation into neural injury sites. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, 88-89. link>
    43. Yiu HH, Pickard MR, Olariu CI, Williams SR, Chari DM, Rosseinsky MJ. 2012. Fe3O4-PEI-RITC magnetic nanoparticles with imaging and gene transfer capability: development of a tool for neural cell transplantation therapies. Also see Putting the Nanoscience in Neuroscience: Magnetic attraction (Feature on research in the Chari laboratory).2012. British Neuroscience Association Bulletin. Issue no 66, p12. http://www.bna.org.uk/about/bna-bulletin.html. Pharm Res, vol. 29(5), 1328-1343. link> doi>
    44. Jenkins SI, Pickard MR, Granger N, Chari DM. 2011. Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies. ACS Nano, vol. 5(8), 6527-6538. link> doi>
    45. Chari DM. Transcriptional effects of corticosteroid therapy on myelin genesis and neuronal health. Midlands Medicine. Midlands Medicine, vol. 26(3).
    46. Pickard MR, Barraud P, Chari DM. 2011. The transfection of multipotent neural precursor/stem cell transplant populations with magnetic nanoparticles. Biomaterials, vol. 32(9), 2274-2284. link> doi>
    47. Pickard MR, Jenkins SI, Koller CJ, Furness DN, Chari DM. 2011. Magnetic nanoparticle labeling of astrocytes derived for neural transplantation. Tissue Eng Part C Methods, vol. 17(1), 89-99. link> doi>
    48. Pickard MR and Chari DM. 2010. Robust uptake of magnetic nanoparticles (MNPs) by central nervous system (CNS) microglia: implications for particle uptake in mixed neural cell populations. Int J Mol Sci, vol. 11(3), 967-981. link> doi> full text>
    49. Pickard M and Chari DM. 2010. Enhancement of magnetic nanoparticle-mediated gene transfer to astrocytes by `magnetofection': effects of static and oscillating fields. Nanomedicine, vol. 5(2), 217-232. doi>
    50. Pickard M and Chari D. 2010. Enhancement of magnetic nanoparticle-mediated gene transfer to astrocytes by 'magnetofection': effects of static and oscillating fields. Nanomedicine (Lond), vol. 5(2), 217-232. link> doi>
    51. Jeffery ND, McBain SC, Dobson J, Chari DM. 2009. Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI). J Tissue Eng Regen Med, vol. 3(2), 153-157. link> doi>
    52. Chari DM. 2007. Remyelination in multiple sclerosis. Int Rev Neurobiol, vol. 79, 589-620. link> doi>
    53. CHARI DM, Blakemore WF, Kotter MR, Zhao C. 2006. Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system. Journal of Neuroscience Research, vol. 83(4), 594-605. doi>
    54. Chari DM, Gilson JM, Franklin RJM, Blakemore WF. 2006. Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS. Exp Neurol, vol. 198(1), 145-153. link> doi>
    55. Chari DM, Huang WL, Blakemore WF. 2003. Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue. J Neurosci Res, vol. 73(6), 787-793. link> doi>
    56. CHARI DM, Blakemore WF, Crang AJ. 2003. Decline in rate of colonisation of Oligodendrocyte progenitor cell (OPC) depleted tissue by adult OPCs with age. J Neuropath Exp Neurol, vol. 62(9), 908-916. link> doi>
    57. Chari DM, Huang WL, Blakemore WF. 2003. Repopulation of oligodendrocyte progenitor cell (OPC) depleted areas may be inhibited by the presence of a dysfunctional OPC population in depleted areas. Neuroscience Research, vol. 73, 787-793.
    58. Chari DM and Blakemore WF. 2002. New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation. Mult Scler, vol. 8(4), 271-277. link> doi>
    59. Blakemore WF, Chari DM, Gilson JM, Crang AJ. 2002. Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia, vol. 38(2), 155-168. link> doi>
    60. Chari DM and Blakemore WF. 2002. Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia, vol. 37(4), 307-313. link> doi>
    61. Hinks GL, Chari DM, O'Leary MT, Zhao C, Keirstead HS, Blakemore WF, Franklin RJ. 2001. Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS. Neuropathol Appl Neurobiol, vol. 27(1), 59-67. link> doi>
    62. Book chapter on Models of Traumatic Brain injury for a Springer Nature collection on Regenerative Medicine and Brain Repair (Editor Phillip Peplow, University of Otago, New Zealand, submitted, 2023 In Press)
    63. Mogas Barcons A, Chari DM, Adams C. In vitro model of neurotrauma using the chick embryo to test bioimplant modulation of neuroregeneration. ALTEX. 2023, In Press
    64. Mogas Barcons A, Chowdhury F, Chari DM, Adams C. Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials (Basel). 2022 Dec 23;16(1):124
    65. RH Basit, J Wiseman F Chowdhury, DM Chari. 2022. Simulating traumatic brain injury in vitro: developing high throughput models to test biomaterial-based therapies. Perspective article. Neural Regeneration Research. In press
    66. J Prager, J Fenn, M Plested, L Escauriaza, T van der Merwe, B King, D Chari, LF Wong, N Granger. 2022. Transplantation of encapsulated autologous olfactory ensheathing cell populations expressing chondroitinase for spinal cord injury: a safety and feasibility study in companion dogs. Journal of Tissue Engineering and Regenerative Medicine.
    67. Tickle JA, Sen J, Adams C, Price R, Kandula V, Tzerakis N, Chari DM. 2022. Benchtop brain injury model using resected donor tissue from Chiari malformation patients: A 'proof-of-concept' study. Neural Regeneration Research. In press.
    68. Jenkins SI, Zhu L, Dallas M and Chen R (2022), Editorial: Neuroinflammation in hypoxia and ischaemia. Front Mol Biosci 9:1066818.
    69. Butcher JB, Sims RE, Ngum, N, Bazzari AH, Jenkins SI et al. A requirement for astrocyte IP3R2 signaling for whisker experience-dependent depression and homeostatic upregulation in the mouse barrel cortex. Front Cell Neurosci (2022) 16:905285
    70. Woods WA, Evans DE, Barcons A, Tzerakis N, Adams C, Chari DM. 2021. Stem Cell Sprays for Neurological Injuries: A Perspective. Invited article for Emerging Topics in Life Sciences. In press.
    71. Basit RH, Tzerakis N, Jenkins S, Chari DM. 2021. In vitro penetrating traumatic brain injury model to screen surgical biomaterials for regenerative applications. Materials Science and Engineering C. In Press
    72. Woods WA, Choudhary F, Tzerakis N, Adams C, Chari DM. 2021. Developing A New Strategy for Delivery of Neural Transplant Populations using Precursor Cell Sprays and Specialised Cell Media. Advanced Nanobiomed Res. In press.
    73. Prager, J., Ito, D., Carwardine, D. R., Jiju, P., Chari, D. M., Granger, N., & Wong, L. F. 2021. Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury. Experimental Neurology, 340, 113660. doi:10.1016/j.expneurol.2021.113660
    74. Mogas Barcons, A., Chari, D. M., & Adams, C. F. (2021). Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering. Mater Sci Eng C Mater Biol Appl, 123, 111931. doi:10.1016/j.msec.2021.111931
    75. Patabendige, Singh, Jenkins, Sen, Chen. Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. Intl J Mol Sci (2021) 1-22, vol. 22(8)
    76. Prager J, Adams C, Delaney A, Chanoit G, Tarlton J, Wong LF, Chari DM, Granger N. 2020. Stiffness- matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a ‘target’ stiffness for hydrogel synthesis in spinal cord injury. Journal of Tissue Engineering. https://doi.org/10.1177/2041731420934806
    77. Singh A, Chow O, Jenkins SI, Zhu L, Rose, E, Astbury K, Chen R. Characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons. Neuroscience (2020)
    78. Rawlinson C, Jenkins SI, Thei L, Dallas ML, Chen R. Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy. Brain Sciences (2020) 10:3.
    79. Mira A, Sainz-Urruela C, Codina H, Jenkins SI, Rodriguez-Diaz JC, Mallavia R, Falco A. Physico-chemically distinct nanomaterials synthesized from derivates of a poly(anhydride) diversify the spectrum of loadable antibiotics. Nanomaterials (Basel) (2020) 10(3):486.