David Thompson

Biography

I was appointed as a lecturer at Keele in August 2012. Prior to this I had completed a PhD in analytical chemistry in a collaborative project between Keele University and AstraZeneca. This focused on developing novel analytical methods, using inductively coupled plasma-mass spectrometry (ICP-MS), for the early stage detection of cancer biomarkers. My first degree was in chemistry and forensic science which was obtained in 2007 from Keele University. My current research interests focus on the forensic applications of global metabolic profiling techniques, particularly applications associated with the putrefaction of organic material.

Research and scholarship

My previous research has focused on the development of novel analytical techniques for the detection of blood-borne biomarkers related to early stage tumour formation. Mainly this involved using inductively coupled plasma-mass spectrometry (ICP-MS) but also included some time of flight-mass spectrometry. This research led to the development of both single and multi-analyte immunoassay systems that incorporated novel metal labels and were detected by ICP-MS. One of these systems has also been validated for clinical use. Other research focused on the application of metabonomics to aid biomarker discovery for a range of conditions. This work included the development of phosphorus specific metabonomics using ultra performance liquid chromatography (UPLC) ICP-MS.

My current research interests include the application of metabonomics to forensic analysis, particularly in the discovery of buried remains and determination of post-mortem interval.

Teaching

CHE-10040 : Crime, Science and Investigation
CHE-30010 : Forensic Toxicology (Module leader)
CHE-30028 : Interpretation, Evaluation and Presentation of Evidence
CHE-30011 : Forensic Science Team Project

Selected Publications

Johnson AE, Sidwick KL, Pirgozliev VR, Edge A, Thompson DF. 2019. The use of metabonomics to uncover differences between the small molecule profiles of eggs from cage and barn housing systems. Food Control. doi> link> full text>
Adesina-Georgiadis KN, Gray N, Plumb RS, Thompson DF, Holmes E, Nicholson JK, Wilson ID. 2018. The Metabolic Fate and Effects of 2-Bromophenol in Male Sprague-Dawley Rats. Xenobiotica, 1-22. link> doi> full text>
Johnson AE, Sidwick KL, Pirgozliev VR, Edge A, Thompson DF. 2018. Metabonomic Profiling of Chicken Eggs during Storage Using High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Anal Chem, vol. 90(12), 7489-7494. link> doi> full text>
Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. ANALYTICAL CHEMISTRY, vol. 89(22), 12131-12136. link> doi>
Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. Anal Chem, vol. 89(22), 12131-12136. link> doi> full text>

Full Publications List show

Journal Articles

Johnson AE, Sidwick KL, Pirgozliev VR, Edge A, Thompson DF. 2019. The use of metabonomics to uncover differences between the small molecule profiles of eggs from cage and barn housing systems. Food Control. doi> link> full text>
Adesina-Georgiadis KN, Gray N, Plumb RS, Thompson DF, Holmes E, Nicholson JK, Wilson ID. 2018. The Metabolic Fate and Effects of 2-Bromophenol in Male Sprague-Dawley Rats. Xenobiotica, 1-22. link> doi> full text>
Johnson AE, Sidwick KL, Pirgozliev VR, Edge A, Thompson DF. 2018. Metabonomic Profiling of Chicken Eggs during Storage Using High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Anal Chem, vol. 90(12), 7489-7494. link> doi> full text>
Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. ANALYTICAL CHEMISTRY, vol. 89(22), 12131-12136. link> doi>
Sidwick KL, Johnson AE, Adam CD, Pereira L, Thompson DF. 2017. Use of Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and Metabonomic Profiling To Differentiate between Normally Slaughtered and Dead on Arrival Poultry Meat. Anal Chem, vol. 89(22), 12131-12136. link> doi> full text>
Mendecki L, Chen X, Callan N, Thompson DF, Schazmann B, Granados-Focil S, Radu A. 2016. Simple, Robust, and Plasticizer-Free Iodide-Selective Sensor Based on Copolymerized Triazole-Based Ionic Liquid. Anal Chem, vol. 88(8), 4311-4317. link> doi> full text>
Thompson DF. 2014. Rapid production of cyclonic spray chambers for inductively coupled plasma applications using low cost 3D printer technology. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, vol. 29(12), 2262-2266. link> doi> link> full text>
Thompson DF, Michopoulos F, Smith CJ, Duckett CJ, Wilkinson RW, Jarvis P, Wilson ID. 2013. Phosphorus and sulfur metabonomic profiling of tissue and plasma obtained from tumour-bearing mice using ultra-performance liquid chromatography/inductively coupled plasma mass spectrometry. Rapid Commun Mass Spectrom, vol. 27(22), 2539-2545. link> doi>
Thompson DF, Michopoulos F, Smith CJ, Duckett CJ, Wilkinson RW, Jarvis P, Wilson ID. 2011. Profiling biological samples using ultra performance liquid chromatography-inductively coupled plasma-mass spectrometry (UPLC-ICP-MS) for the determination of phosphorus and sulfur-containing metabolites. Mol Biosyst, vol. 7(4), 1149-1157. link> doi>
Thompson DF, Eborall W, Dinsmore A, Smith CJ, Duckett CJ. 2010. Development and validation of a NANOGold immunoassay for the detection of vascular endothelial growth factor (VEGF) in human serum using inductively coupled plasma mass spectrometry. Rapid Commun Mass Spectrom, vol. 24(7), 927-932. link> doi>
Thompson DF, Sidwick K, Pereira L. FORTHCOMING: Evaluation into the effect of column chemistry on the equilibration time required for metabonomic studies. Analytical Chemistry.
Thompson DF, Sidwick K, Pereira L. FORTHCOMING: The use of metabonomic profiling to differentiate between dead on arrival and normally slaughtered poultry.

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Dr David Thompson