Flow chemistry synthesises important drug scaffolds
Dr Matt O’Brien and Dr Gavin Miller have published their collaborative research project in Tetrahedron (https://doi.org/10.1016/j.tet.2018.09.025). They have developed a gas-liquid flow hydrogenolysis technology to synthesise a pharmaceutically important heterocyle.
Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence.