QUIDS

Study design

Individual Participant Data (IPD) meta-analysis of existing studies and new cohort study. To see if Quantitative Fetal Fibronectin.(qfFN) can accurately rule out spontaneous preterm delivery. We will use our findings to develop decision support tool, to help women and clinicians assess how likely preterm delivery is, and decide whether to start treatment or not.

Primary objective

To develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using Quantitative Fetal Fibronectin (qfFN) .

Part 1 of the QUIDS study, we will perform IPD meta-analysis of existing data sets to develop a prognostic model using qfFN and other clinical risk factors. We will also perform focus group consultation to assess decisional needs in relation to threatened preterm labour. 

Part 2 of the study we will validate the prognostic model and decision support tool using data collected in a prospective cohort study.