Dr Frank Rutten CChem MRSC

Title: Lecturer in Physical Chemistry
Phone: 01782 733521
Email: f.j.m.rutten@keele.ac.uk
Location: Hornbeam building, Room 2.30 / Birchall Centre in the Lennard Jones Laboratories
Role: ISTM Research theme: Healthcare Technologies
Contacting me: Try my office or arrange an appointment via e-mail
Frank Rutten

I was appointed as lecturer in Physical Chemistry in the School of Pharmacy in September 2006. Prior to that I was the Senior Research Fellow responsible for the ToF-SIMS instrumentation at the University of Nottingham and worked as Postdoctoral Research Associate in the groups of Prof. Mike Chesters at the University of Nottingham and Prof. Richard Lambert at the University of Cambridge. I gained my Masters degree in 1991 from Leiden University, The Netherlands, where I also obtained a PhD in surface chemistry in 1999 with Profs. Vladimir Ponec and Ben Nieuwenhuys (Leiden University) and Mike Chesters (University of Nottingham).

I am a full member of the Royal Society of Chemistry with Chartered Chemist status. As member of the steering group of the British Mass Spectrometry Society – Special Interest Group for Ambient Ionisation, I have hosted national meetings at Keele.  I am also committee member of the Surface Science of Biologically Important Interfaces (SSBII) group.

ISTM Research theme: Healthcare Technologies

The physico-chemical properties of surfaces are crucial in a wide range of processes. My various research projects revolve around the detailed chemical characterisation, including imaging, of these surfaces through advanced analytical techniques such as surface mass spectrometry and imaging by ambient mass spectrometry techniques, in particular PADI-MS, and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). As stand-alone techniques both are very powerful, but more often than not application of complementary techniques is crucial to resolve complex surface chemical questions. I therefore complement surface mass spectrometry with, in particular, vibrational spectroscopy (mid-and near-IR and Raman spectroscopy and microscopy) and X-ray photoelectron spectroscopy (XPS).

PADI-MS (short for plasma-assisted desorption-ionisation mass spectrometry) is a very versatile and powerful technique I developed together with colleagues from Nottingham and Heriot-Watt universities. A low power ambient temperature plasma is used to very rapidly yield highly informative mass spectra from (semi-) solid surfaces under ambient conditions. Slightly higher powers allow detailed analysis of polymers surfaces. Our original publication of this technique (Ratcliffe et al., 2007) was highlighted in the RSC and ACS journals Chemistry World and C&E News and has been referenced well over 100 times to date. Donation of equipment by Astra Zeneca and additional funding by the EPSRC-funded 3ME initiative allowed construction of two PADI-MS systems at Keele, a “workhorse” system employing a Waters ZQ single quadrupole, and a second systems for more detailed investigations, based around a Thermo LTQ-XL Orbitrap capable of MS/MS and accurate mass measurements . Current research using these systems focuses on rapid monitoring of pharmaceutically relevant reactions, establishing basic principles behind the desorption/ionisation processes with a view to further enhancing the sensitivity for a wide range of materials, and exploring and implementing rapid ambient MS imaging.

Selected Publications

  • Rutten FJM, Briggs D, Henderson J, Roe MJ. 2009. THE APPLICATION OF TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY (ToF-SIMS) TO THE CHARACTERIZATION OF OPAQUE ANCIENT GLASSES*. ARCHAEOMETRY, vol. 51, 966-986. link> doi>
  • Gadegaard N, Chen X, Rutten FJM, Alexander MR. 2008. High-energy electron beam lithography of octadecylphosphonic acid monolayers on aluminum. LANGMUIR, vol. 24(5), 2057-2063. link> doi>
  • Ratcliffe LV, Rutten FJM, Barrett DA, Whitmore T, Seymour D, Greenwood C, Aranda-Gonzalvo Y, Robinson S, McCoustra M. 2007. Surface analysis under ambient conditions using plasma-assisted desorption/ionization mass spectrometry. Anal Chem, vol. 79(16), 6094-6101. link> doi>
  • Rutten FJM, Tadesse H, Licence P. 2007. Rewritable imaging on the surface of frozen ionic liquids. Angew Chem Int Ed Engl, vol. 46(22), 4163-4165. link> doi>
  • RUTTEN FJM, Chalmers JM, Chesters MA, Tobin MJ. 2004. Infrared microscopy of epithelial cancer cells in whole tissues and in tissue culture, using synchrotron radiation. Faraday Discussions, vol. 126, 27-39. doi>

Full Publications List show

Journal Articles

  • Rutten FJM, Jamur J, Roach P. 2015. Fast and versatile ambient surface analysis by plasma-assisted desorption/ionisation mass spectrometry. Spectroscopy Europe, vol. 27(6).
  • Richardson A, Curtis ADM, Moss GP, Pearson RJ, White S, Rutten FJM, Perumal D, Maddock K. 2014. Simulated drug discovery process to conduct a synoptic assessment of pharmacy students. Am J Pharm Educ, vol. 78(2), 41. link> doi>
  • Duckworth CN, Henderson J, Rutten FJM, Nikita K. 2012. Opacifiers in Late Bronze Age glasses: the use of ToF-SIMS to identify raw ingredients and production techniques. JOURNAL OF ARCHAEOLOGICAL SCIENCE, vol. 39(7), 2143-2152. link> doi>
  • Rupani A, Hidalgo-Bastida LA, Rutten F, Dent A, Turner I, Cartmell S. 2012. Osteoblast activity on carbonated hydroxyapatite. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 100A(4), 1089-1096. link> doi>
  • Rutten FJM, Thrower JD, Collings MP, McCoustra MRS. 2011. Highly efficient electron-stimulated desorption of benzene from amorphous solid water ice. Chemical Physics Letters, vol. 505, 106-111. doi>
  • Thrower J, Collings M, Rutten F, McCoustra M. 2009. Thermal desorption of C6H6 from surfaces of astrophysical relevance. Journal of Chemical Physics, vol. 131, 244711-244720. doi>
  • Rutten FJM, Briggs D, Henderson J, Roe MJ. 2009. THE APPLICATION OF TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY (ToF-SIMS) TO THE CHARACTERIZATION OF OPAQUE ANCIENT GLASSES*. ARCHAEOMETRY, vol. 51, 966-986. link> doi>
  • Thrower J, Connock MJ, Savage P, Rutten FJM, McKeever T. 2009. Laboratory investigations of the interaction between benzene and bare silicate grain surfaces. Mon.Not.R.Astron.Soc., vol. 394, 1510. doi>
  • Rutten F, Briggs D, Henderson J, Roe MJ. 2009. The application of time-of-flight secondary ion mass spectrometry. Archaeometry, vol. 51, 966-986.
  • Perkins MC, Bell G, Briggs D, Davies MC, Friedman A, Hart CA, Roberts CJ, Rutten FJM. 2008. The application of ToF-SIMS to the analysis of herbicide formulation penetration into and through leaf cuticles. Colloids Surf B Biointerfaces, vol. 67(1), 1-13. link> doi>
  • Gadegaard N, Chen X, Rutten FJM, Alexander MR. 2008. High-energy electron beam lithography of octadecylphosphonic acid monolayers on aluminum. LANGMUIR, vol. 24(5), 2057-2063. link> doi>
  • Kalaskar DM, Gough JE, Ulijn RV, Sampson WW, Scurr DJ, Rutten FJ, Alexander MR, Merry CLR, Eichhorn SJ. 2008. Controlling cell morphology on amino acid-modified cellulose. SOFT MATTER, vol. 4(5), 1059-1065. link> doi>
  • Kalaskar D, Eichhorn SJ, Gough JE, Ulijn RV, Sampson WW, Alexander MR, Rawsterne R, Rutten FJM. 2008. Controlling fibroblast morphology by the chemical modification of cellulose fiber scaffolds. Soft Matter, vol. 4, 1059-1065.
  • Gadegaard N, Chen X, Rutten FJM, Alexander MR. 2008. High energy electron beam lithography of octadecyl phosphonic acid monolayers on aluminium: grain limit to resolution. Langmuir, vol. 24, 2057-2063.
  • Rawsterne RE, Todd SJ, Gough JE, Farrar D, Rutten FJM, Alexander MR, Ulijn RV. 2007. Cell spreading correlates with calculated logP of amino acid-modified surfaces. ACTA BIOMATERIALIA, vol. 3(5), 715-721. link> doi>
  • Ratcliffe LV, Rutten FJM, Barrett DA, Whitmore T, Seymour D, Greenwood C, Aranda-Gonzalvo Y, Robinson S, McCoustra M. 2007. Surface analysis under ambient conditions using plasma-assisted desorption/ionization mass spectrometry. Anal Chem, vol. 79(16), 6094-6101. link> doi>
  • Perkins MC, Briggs D, Rutten FJM, Roberts CJ, Davies MC. 2007. Cathionisation of oligometric alkylethoxylate surfactants to ToF-SIMS analysis. Surface and Interface Analysis, vol. 39, 644-647. doi>
  • Montague M, Manning RJ, Ducker E, Chong KSL, Rutten FJM, Davies MC, Leggett GJ. 2023. Fabrication of biomolecular nanostructures by scanning near-field photolithoghraphy of oligo(ethylene glycol) termination self-assembled monolayers. Langmuir, vol. 23, 7328-7337. doi>
  • Rawsterne RE, Gough JE, Farrar D, Rutten FJM, Alexander MR, Ulijn RV, Todd SJ. 2007. Cell spreading correlates with LogP of amino acid surfaces. Acta Biomaterialia, vol. 3, 715-721.
  • Rutten FJM, Tadesse H, Licence P. 2007. Rewritable imaging on the surface of frozen ionic liquids. Angew Chem Int Ed Engl, vol. 46(22), 4163-4165. link> doi>
  • Rawsterne RE, Gough JE, Rutten FJM, Pham NT, Poon WCK, Flitsch SL, Maltman B, Alexander MR, Ulijn RV. 2006. Controlling protein retention on enzyme-responsive surfaces. Surface and Interface Analysis, vol. 38, 1505. doi>
  • Smith EF, Rutten FJM, Villar-Garcia IJ, Briggs D, Licence P. 2006. Ionic liquids in vacuo: analysis of liquid surfaces using ultra-high-vacuum techniques. Langmuir, vol. 22(22), 9386-9392. link> doi>
  • Al-Harahsheh M, Rutten F, Kingman S. 2006. ToF-SIMS and SEM study on the preferential oxidation of chalcopyrite. International Journal of Mineral Processing, vol. 80(2-4), 205-214. doi>
  • Pinna R, Jamme F, Rutten F, Smith E, Willis M, Briggs D, McCoustra M. 2006. Towards a fully optimised organic LED device: Analysis of surface synthesis using coupling reactions by ToF-SIMS. Applied surface science, vol. 252(19), 6672-6675. doi>
  • Al-Harahsheh M, Rutten F, Briggs D, Kingman S. 2006. Preferential oxidation of chalcopyrite surface facets characterized by ToF-SIMS and SEM. Applied surface science, 7155-7158. doi>
  • Hou Q, Rutten FJM, Smith EF, Briggs D, Davies MC, Buttery LDK, Freeman R, Shkesheff KM. 2005. Surface characterization of preformed alginate fibres incorporated with protein by a novel entrapment process. Surface and Interface Analysis, vol. 37, 1077. doi>
  • Rutten F, Henderson J, Briggs D. 2005. Unlocking the secrets of ancient glass technology using ToF-SIMS. SPECTROSCOPY EUROPE, vol. 17, 24-30.
  • RUTTEN FJM, Chalmers JM, Chesters MA, Tobin MJ. 2004. Infrared microscopy of epithelial cancer cells in whole tissues and in tissue culture, using synchrotron radiation. Faraday Discussions, vol. 126, 27-39. doi>
  • RUTTEN FJM, Chesters MA, Hatton RA, Willis MR. 2003. Enhanced Hole injection in Organic Light-emitting Diodes Using a SAM-derivatised Ultra-thin Gold Anode Supported on ITO Glass. Journal of Materials Chemistry, vol. 13, 38-43. doi>
  • Oakes DJ, Newell HE, Rutten FJM, McCoustra MRS, Chesters MA. 1996. An experimental study of vibrational enhancement of the dissociative chemisorption of ethane on Pt(111). CHEMICAL PHYSICS LETTERS, vol. 253(1-2), 123-128. link> doi>
  • Siera J, rutten F, Nieuwenhuys BE. 1991. The CO-NO and CO-O2 reactions studied over Pt-Rh single crystal surfaces under steady state conditions. Catal. Today, vol. 10, 353.
  • Rutten FJM, Thrower JD, Abdulgalil AGM, Collings MP, McCoustra MRS, Burke DJ, Brown WA, Dawes A, Holtom PJ, Kendall P, Mason NJ, Jamme F, Fraser HJ. Photon- and electron-stimulated desorption from laboratory models of interstellar ice grains. Journal of Vacuum Science & Technology A, vol. 28, 799.

Other

  • Duckworth CN, Henderson J, Rutten FJM. 2012. Time of Flight Secondary Ion Mass Spectrometry examination of ancient and historical opaque glasses. INTEGRATED APPROACHES TO THE STUDY OF HISTORICAL GLASS - IAS12 (vol. 8422). link> doi>
  • Rutten FJM, Brima E, MCCoustra MRS, Barrett DA. 2010. PADI-MS: ambient complement for ToF-SIMS?.
  • Thrower JD, Abdulgalil AGM, Collings MP, McCoustra MRS, Burke DJ, Brown WA, Dawes A, Holtom PJ, Kendall P, Mason NJ, Jamme F, Fraser HJ, Rutten FJM. 2010. Photon- and electron-stimulated desorption from laboratory models of interstellar ice grains. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A (vol. 28, pp. 799-806). link> doi>
  • Rutten FJM, Roe MJ, Henderson J, Briggs D. 2006. Surface analysis of ancient glass artefacts with ToF-SIMS: a novel tool for provenacing?. Applied Surface Science (vol. 252, p. 7124). doi>
  • Tsouraspas G, Rutten FJM, Briggs D, Davies MC, Shakesheff KM. 2006. Surface spectroscopic imaging of PEG-PLA tissue engineering constructs with ToF-SIMS. Applied Surface Science (vol. 252, p. 6693). doi>
  • Pinna R, Jamme F, Rutten FJM, Smith EF, Willis MR, Briggs D, McCoustra MRS. 2007. Towards a fully optimised organic LED device: analysis of surface synthesis using coupling reactions by ToF-SIMS. Applied Surface Science (p. 6672). doi>
  • Villar Garcia IJ, Rutten FJM, Smith EF, Briggs D, Licence P. 2006. Ionic liquids in-vacuo: the analysis of liquid surfaces using UHV techniques.
  • Al-Harahsheh M, Rutten FJM, Briggs D, Kingman S. 2006. Oxidation of chalcopyrite surface facets characterized by ToF-SIMS ans SEM.
  • Al-Harahsheh M, Rutten F, Briggs D, Kingman S. 2006. Preferential oxidation of chalcopyrite surface facets characterized by ToF-SIMS and SEM.
  • Tobin MJ, Chester MA, Chalmers J, Fisher SE, Rutten FJM, Symonds IM, Hitchcock A, Maclennan KA, Allibone R, Dias-gunasekara S. 2004. Infrared microspectroscopy in cancer diagnosis. BRITISH JOURNAL OF CANCER (vol. 91, p. S44). link>
  • Tobin MJ, Chesters MA, Chalmers J, Fisher SE, Rutten FJM, Symonds IM, Hitchcock A, MacLennan KA, Allibone R, Dias-gunasekara S. 2004. Infrared microspectroscopy in cancer diagnosis.
  • Tobin MJ, Rutten FJM, Chesters MA, Chalmers J, Symonds I, Fisher SE, Allibone R, Hitchcock A. 2002. Investigating the potential for infrared microanalysis in cancer screening.
  • Rutten FJM. 2000. Adsorption and Reaction of Carbon Monoxide and Nitric Oxide on a Platinum-Rhodium Alloy Surface - A study of the interactions of automotive pollutants with a model three-way catalyst.
  • Rutten FJM, Nieuwenhuys BE, McCoustra MRS, Chesters MA, Hollins P. 1997. Interaction of carbon monoxide with a platinum(0.25)-rhodium(0.75)(111) single crystal surface. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS (vol. 15, pp. 1619-1623). link> doi>
  • Oakes DJ, Newell HE, Rutten FJM, McCoustra MRS, Chesters MA. 1996. The chemistry of simple alkyl species on Pt(111) generated by hyperthermal collisions. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS (vol. 14, pp. 1439-1447). link> doi>
  • Newell HE, Oakes DJ, Rutten FJM, McCoustra MRS, Chesters MA. 1996. Impact-induced dissociation of methane and ethane on Pt(111) and Pt0.25Rh0.75(111). FARADAY DISCUSSIONS (vol. 105, pp. 193-207). link> doi>
  • Siera J, Silfhout RV, rutten F, Nieuwenhuys BE. 1991. A comparative kinetic study of the CO-O2 reaction over Pt-Rh(111), (100), (410) and (210) single crystal surfaces. Catalysis and Automotive Pollution Control II (p. 395). Amsterdam: Elsevier.

MPharm Stage 1: Mathematics, Physical Chemistry (Thermodynamics, Kinetics)

MPharm Stage 2: Pharmaceutical Analytical Methods, QA/QC, Pharmaceutics

MPharm Stage 3 & 4: Research Projects

MPharm Stage 3: Option Topics (Pharmaceutical Detectives)

Forensics Stage 3: CHE30034 Forensic Geoscience – Analysis of Heritage Objects