New Resource: Predictive Methods in Percutaneous Absorption


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Predictive Methods in Percutaneous Absorption
Posted on 11 June 2015
▶ Provides a comprehensive critique of models of percutaneous absorption, their source data and both their limitations and correct use
▶ Enriches readers’ understanding of the implications of various models
▶ Shows how to tailor models to particular circumstances and accurately interpret the results
▶ Will be of interest to researchers in academic and industry working in the fields of pharmaceuticals, occupational exposure, risk assessment and cosmetics

Predictive Methods in Percutaneous Absorption

Details of Dr Gary Moss's new publication "Predictive Methods in Percutaneous Absorption":

"This book sheds new light on the development and use of quantitative models to describe  the process of skin permeation. It critically reviews the development of quantitative  predictive models of skin absorption and discusses key recommendations for model  development. Topics presented include an introduction to skin physiology; the underlying  theories of skin absorption; the physical laboratory-based processes used to generate  skin absorption data, which is in turn used to construct mathematical models describing  the skin permeation process; algorithms of skin permeability including quantitative  structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between  permeability and molecular properties; the development of formulation-focused  approaches to models of skin permeability prediction; the use of artificial membranes,  e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of  novel Machine Learning methods in developing the next generation of predictive skin  permeability models." 

"The book will be of interest to all researchers in academia and industry working  in pharmaceutical discovery and development, as well as readers from the field of  occupational exposure and risk assessment, especially those whose work involves  agrochemicals, bulk chemicals and cosmetics. "


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