Biography

I joined the School of Pharmacy in August 2006 having previously lectured at Washington and Lee University in the USA. My research expertise stems from eight years at the University of St Andrews studying supramolecular chemistry, chemical genetics and the biological importance of nitric oxide. Work on this latter topic remains my primary research focus and in particular, the design of novel NO-releasing compounds with the potential to treat a variety of conditions, including peripheral vascular disorders. In terms of teaching, my main pedagogical research focuses on the use of clicker technology in problem-based learning to improve peer instruction and student engagement.

Research and scholarship

My primary research focuses on the biological importance of nitric oxide and in particular, the design of novel NO-releasing compounds with the potential to treat a variety of conditions, including peripheral vascular disorders. My main pedagogical research focuses on the use of clicker technology in problem-based learning to improve peer instruction and student engagement.

Selected Publications

  • Pearson R and Butler A. 2021. Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules, vol. 26(21). link> doi> full text>
  • Pearson RJ. 2020. Online Chemistry Crossword Puzzles prior to and during COVID-19: Light-Hearted Revision Aids That Work. Journal of Chemical Education, 3194-3200, vol. 97(Insights Gained While Teaching Chemistry in the Time of COVID-19). doi> link> full text>
  • Pearson RJ. 2020. Clickers versus Plickers: Comparing Two Audience Response Systems in a Smartphone-Free Teaching Environment. Journal of Chemical Education, 2342-2346, vol. 97(8). doi> link> full text>
  • Pearson RJ. 2019. Exploring Peer Instruction: Should Cohort Clicker Responses Appear During or After Polling?. JOURNAL OF CHEMICAL EDUCATION, 873-879, vol. 96(5). link> doi> full text>
  • Pearson RJ. 2018. Does student voting behaviour change when using live clicker polls?. Pharmacy Education (pp. 252-253, vol. 18).

Full Publications Listshow

Journal Articles

  • Pearson R and Butler A. 2021. Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules, vol. 26(21). link> doi> full text>
  • Pearson RJ. 2020. Online Chemistry Crossword Puzzles prior to and during COVID-19: Light-Hearted Revision Aids That Work. Journal of Chemical Education, 3194-3200, vol. 97(Insights Gained While Teaching Chemistry in the Time of COVID-19). doi> link> full text>
  • Pearson RJ. 2020. Clickers versus Plickers: Comparing Two Audience Response Systems in a Smartphone-Free Teaching Environment. Journal of Chemical Education, 2342-2346, vol. 97(8). doi> link> full text>
  • Pearson RJ. 2019. Exploring Peer Instruction: Should Cohort Clicker Responses Appear During or After Polling?. JOURNAL OF CHEMICAL EDUCATION, 873-879, vol. 96(5). link> doi> full text>
  • Pearson RJ, Blake DG, Mezna M, Fischer PM, Westwood NJ, McInnes C. 2018. The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1. Cell Chem Biol, 1107-1116.e4, vol. 25(9). link> doi> full text>
  • Eilertsen M, Allin SM, Pearson RJ. 2018. New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1106-1110, vol. 28(6). link> doi> full text>
  • Pearson RJ. 2017. Tailoring Clicker Technology to Problem-Based Learning: What's the Best Approach?. JOURNAL OF CHEMICAL EDUCATION, 1866-1872, vol. 94(12). link> doi>
  • Richardson A, Curtis ADM, Moss GP, Pearson RJ, White S, Rutten FJM, Perumal D, Maddock K. 2014. Simulated drug discovery process to conduct a synoptic assessment of pharmacy students. Am J Pharm Educ, 41, vol. 78(2). link> doi>
  • Kassianidis E, Pearson RJ, Wood EA, Philp D. 2010. Designing instructable networks using synthetic replicators. FARADAY DISCUSSIONS, 235-254, vol. 145. link> doi>
  • Evans KM, Haraldsen JD, Pearson RJ, Slawin AMZ, Ward GE, Westwood NJ. 2007. Synthesis and chemical characterisation of target identification reagents based on an inhibitor of human cell invasion by the parasite Toxoplasma gondii. Org Biomol Chem, 2063-2069, vol. 5(13). link> doi>
  • Kassianidis E, Pearson RJ, Philp D. 2006. Probing structural effects on replication efficiency through comparative analyses of families of potential self-replicators. Chemistry, 8798-8812, vol. 12(34). link> doi>
  • Pearson RJ, Kassianidis E, Slawin AMZ, Philp D. 2006. Comparative analyses of a family of potential self-replicators: The subtle interplay between molecular structure and the efficacy of self-replication. CHEMISTRY-A EUROPEAN JOURNAL, 6829-6840, vol. 12(26). link> doi>
  • Kassianidis E, Pearson RJ, Philp D. 2005. Specific autocatalysis in diastereoisomeric replicators. Org Lett, 3833-3836, vol. 7(18). link> doi>
  • Pearson RJ, Evans KM, Slawin AMZ, Philp D, Westwood NJ. 2005. Controlling the outcome of an N-alkylation reaction by using N-oxide functional groups. J Org Chem, 5055-5061, vol. 70(13). link> doi>
  • Pearson RJ, Kassianidis E, Philp D. 2004. A completely selective and strongly accelerated Diels-Alder reaction mediated by hydrogen bonding. TETRAHEDRON LETTERS, 4777-4780, vol. 45(24). link> doi>
  • Pearson RJ, Kassianidis E, Slawin AMZ, Philp D. 2004. Self-replication vs. reactive binary complexes--manipulating recognition-mediated cycloadditions by simple structural modifications. Org Biomol Chem, 3434-3441, vol. 2(23). link> doi>
  • Khan F, Pearson RJ, Newton DJ, Belch JJF, Butler AR. 2003. Chemical synthesis and microvascular effects of new nitric oxide donors in humans. CLINICAL SCIENCE, 577-584, vol. 105(5). link> doi>

Chapters

  • Pearson RJ. 2012. Dithiadiazolium Salts and Dithiadiazolyl-Containing Compounds. In Science of Synthesis: Knowledge Updates 2012/2. Aitken RA (Ed.). Thieme. doi>
  • Pearson RJ. 2008. 1,2,3,5-Dithiadiazoles and 1,3,2,4-Dithiadiazoles. In Comprehensive Heterocyclic Chemistry III, 15-Volume Set. Katritzky AR, Ramsden CA, Scriven EFV, Taylor RJK (Eds.). (vol. 6). Elsevier Science & Technology.
  • Pearson RJ and Butler AR. 2005. Vasodilators for biological research. In Nitric oxide donors: for pharmaceutical and biological applications. Taniguchi N, Wang PG, Cai TB (Eds.). Vch Verlagsgesellschaft Mbh.

Other

  • Pearson R. 2021. Create, share, solve: Online crossword puzzle tasks to encourage remote engagement and collaborative learning. Methods in Chemistry Education Research (MICER21). link>
  • Pearson R. 2018. Project Ponder - integrating different clicker-based methodology into PBL sessions. 25th Biennial Conference on Chemical Education (BCCE), University of Notre Dame, Indiana, USA.
  • Pearson RJ. 2018. Does student voting behaviour change when using live clicker polls?. Pharmacy Education (pp. 252-253, vol. 18).
  • Pearson RJ. 2017. Project Ponder - using clicker technology to encourage in-class engagement. Pharmacy Education (p. 184, vol. 17).
  • Hills D, Mohseni M, Dowler J, Greenwood I, Fielder M, Pearson R, Perumal D. 2014. Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds. NITRIC OXIDE-BIOLOGY AND CHEMISTRY (p. 126, vol. 42). link> doi>
  • Richardson M, Robinson E, Turner C, Allin S, Richardson A, Pearson R. 2012. Novel heterocyclic NO-donors as potential anti-cancer agents. NITRIC OXIDE-BIOLOGY AND CHEMISTRY (p. S37, vol. 27). link> doi>
  • Pearson R, Butler A, Belch J, Khan F, Newton D. 2000. Transdermal delivery of NO-donor drugs for peripheral vasodilatation. BIOLOGY OF NITRIC OXIDE, PT 7 (p. 142, vol. 16). link>
  • Butler AR, Ekins-Daukes S, Pearson R. 2000. Transfer of nitric oxide from sulfur to iron: a kinetic study. BIOLOGY OF NITRIC OXIDE, PT 7 (p. 113, vol. 16). link>

School address:
School of Pharmacy and Bioengineering
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Keele University
Staffordshire
ST5 5BG

Research centre address:
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Guy Hilton Research Centre
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ST4 7QB
Tel: +44 (0) 1782 674988

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