Biography

Ying Chen obtained his BSc in Biotechnology from Yangzhou University (2002 - 2006), and MRes in Biomedical Sciences from the University of Glasgow (2006 - 2007).

Thereafter, he was awarded the Dorothy Hodgkin Postgraduate Award during that he studied for a PhD in Genetic Epidemiology at Keele University (2008 - 2012).

Following the study, he worked as an epidemiologist for the Roy Castle Lung Cancer Research Programme at the University of Liverpool (2012 - 2013) before taking up the current position at Keele.

Selected Publications

  • Chen Y, Farooq S, Edwards J, Chew-Graham CA, Shiers D, Frisher M, Hayward R, Sumathipala A, Jordan KP. 2019. Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records. BMC Med, 227, vol. 17(1). link> doi> full text>
  • Chen Y, Bedson J, Hayward RA, Jordan KP. 2018. Trends in prescribing of non-steroidal anti-inflammatory drugs in patients with cardiovascular disease: influence of national guidelines in UK primary care. Fam Pract, 426-432, vol. 35(4). link> doi> full text>
  • Chen Y, Campbell P, Strauss VY, Foster NE, Jordan KP, Dunn KM. 2018. Trajectories and predictors of the long-term course of low back pain: cohort study with 5-year follow-up. Pain, 252-260, vol. 159(2). link> doi> full text>
  • Bedson J, Chen Y, Hayward RA, Ashworth J, Walters K, Dunn KM, Jordan KP. 2016. Trends in long-term opioid prescribing in primary care patients with musculoskeletal conditions: an observational database study. PAIN, 1525-1531, vol. 157(7). link> doi> full text>
  • Chen Y, Yu Z, Packham JC, Mattey DL. 2013. Influence of Adult Height on Rheumatoid Arthritis: Association with Disease Activity, Impairment of Joint Function and Overall Disability. Plos One, vol. 8. doi>

Full Publications Listshow

Journal Articles

  • Bullock L, Bedson J, Chen Y, Chew-Graham CA, Campbell P. 2021. Comparative differences in musculoskeletal pain consultation and analgesic prescription for people with dementia. Pain. doi> link> full text>
  • Li G, Yang J, Zhao G, Shen Z, Yang K, Tian L, Zhou Q, Chen Y, Huang Y. 2021. Dysregulation of ferroptosis may involve in the development of non‐small‐cell lung cancer in Xuanwei area. Journal of Cellular and Molecular Medicine, 2872-2884, vol. 25(6). doi> link> full text>
  • Hill J, Garvin S, Chen Y, Cooper V, Wathall S, Bartlam B, Saunders B, Lewis M, Protheroe J, Chudyk A, Birkinshaw H, Dunn KM, Jowett S, Oppong R, Hay E, van der Windt D, Mallen C, Foster NE. 2020. Computer-Based Stratified Primary Care for Musculoskeletal Consultations Compared With Usual Care: Study Protocol for the STarT MSK Cluster Randomized Controlled Trial. JMIR Res Protoc, e17939, vol. 9(7). link> doi> full text>
  • Bishop A, Chen Y, Protheroe J, Ogollah RO, Bailey J, Lewis M, Jordan K, Foster NE. 2021. Providing patients with direct access to musculoskeletal physiotherapy: the impact on general practice musculoskeletal workload and resource use. The STEMS-2 study. Physiotherapy, 48-56, vol. 111. link> doi> full text>
  • Chen Y, Hayward R, Chew-Graham CA, Hubbard R, Croft P, Sims K, Jordan KP. 2020. Prognostic value of firs recorded breathlessness for future chronic respiratory and heart disease: a cohort study using a UK national primary care database. BRITISH JOURNAL OF GENERAL PRACTICE, E264-E273, vol. 70(693). link> doi> full text>
  • Hill JC, Garvin S, Chen Y, Cooper V, Wathall S, Saunders B, Lewis M, Protheroe J, Chudyk A, Dunn KM, Hay E, van der Windt D, Mallen C, Foster NE. 2020. Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial. BMC Fam Pract, 30, vol. 21(1). link> doi> full text>
  • Chen Y, Farooq S, Edwards J, Chew-Graham CA, Shiers D, Frisher M, Hayward R, Sumathipala A, Jordan KP. 2019. Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records. BMC Med, 227, vol. 17(1). link> doi> full text>
  • Andreucci A, Campbell P, Richardson E, Chen Y, Dunn KM. 2020. Sleep problems and psychological symptoms as predictors of musculoskeletal conditions in children and adolescents. Eur J Pain, 354-363, vol. 24(2). link> doi> full text>
  • Campbell P, Lewis M, Chen Y, Lacey RJ, Rowlands G, Protheroe J. 2019. Can patients with low health literacy be identified from routine primary care health records? A cross-sectional and prospective analysis. BMC Fam Pract, 101, vol. 20(1). link> doi> full text>
  • Bedson J, Hill J, White D, Chen Y, Wathall S, Dent S, Cooke K, van der Windt D. 2019. Development and validation of a pain monitoring app for patients with musculoskeletal conditions (The Keele pain recorder feasibility study). BMC Med Inform Decis Mak, 24, vol. 19(1). link> doi> full text>
  • Bedson J, Chen Y, Ashworth J, Hayward RA, Dunn KM, Jordan KP. 2019. Risk of adverse events in patients prescribed long-term opioids: A cohort study in the UK Clinical Practice Research Datalink. Eur J Pain, 908-922, vol. 23(5). link> doi> full text>
  • Shang J, He Q, Chen Y, Yu D, Sun L, Cheng G, Liu D, Xiao J, Zhao Z. 2019. miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA. J Cell Physiol, 9746-9755, vol. 234(6). link> doi> full text>
  • Wynne-Jones G, Chen Y, Croft P, Peat G, Wilkie R, Jordan K, Petersson IF. 2018. Secular trends in work disability and its relationship to musculoskeletal pain and mental health: a time-trend analysis using five cross-sectional surveys (2002-2010) in the general population. Occup Environ Med, 877-883, vol. 75(12). link> doi> full text>
  • Yu D, Chen Y, Chen T, Cai Y, Qin R, Jiang Z, Zhao Z. 2018. Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population. J Phys Act Health, 600-604, vol. 15(8). link> doi> full text>
  • Chen Y, Bedson J, Hayward RA, Jordan KP. 2018. Trends in prescribing of non-steroidal anti-inflammatory drugs in patients with cardiovascular disease: influence of national guidelines in UK primary care. Fam Pract, 426-432, vol. 35(4). link> doi> full text>
  • Burton CL, Chesterton LS, Chen Y, van der Windt DA. 2018. Predicting surgical intervention in patients presenting with carpal tunnel syndrome in primary care. Clin Epidemiol, 739-748, vol. 10. link> doi> full text>
  • Burton CL, Chen Y, Chesterton LS, van der Windt DA. 2018. Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. BMJ Open, e020166, vol. 8(6). link> doi> full text>
  • Richardson E, Bedson J, Chen Y, Lacey R, Dunn KM. 2018. Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: A matched cohort study in the Clinical Practice Research Datalink. Eur J Pain, 1701-1708, vol. 22(9). link> doi> full text>
  • Zhang X, Chen Y, Cai Y, Tian X, Xiao J, Zhao Z, Yu D. 2018. Characteristics of Patients Initializing Peritoneal Dialysis Treatment From 2007 to 2014: Analysis From Henan Peritoneal Dialysis Registry data. Iran J Kidney Dis, 178-184, vol. 12(3). link> full text>
  • Chen Y, Campbell P, Strauss VY, Foster NE, Jordan KP, Dunn KM. 2018. Trajectories and predictors of the long-term course of low back pain: cohort study with 5-year follow-up. Pain, 252-260, vol. 159(2). link> doi> full text>
  • Yu D, Cai Y, Chen Y, Chen T, Qin R, Zhao Z, Simmons D. 2018. Development and validation of risk prediction models for cardiovascular mortality in Chinese people initialising peritoneal dialysis: a cohort study. Sci Rep, 1966, vol. 8(1). link> doi> full text>
  • Xiao J, Gong Y, Chen Y, Yu D, Wang X, Zhang X, Dou Y, Liu D, Cheng G, Lu S, Yuan W, Li Y, Zhao Z. 2017. IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 signaling pathway. Am J Physiol Renal Physiol, F310-F318, vol. 313(2). link> doi> full text>
  • Roddy E, Jordan KP, Oppong R, Chen Y, Jowett S, Dawes P, Hider SL, Packham J, Stevenson K, Zwierska I, Hay EM. 2016. Reconsultation, self-reported health status and costs following treatment at a musculoskeletal Clinical Assessment and Treatment Service (CATS): a 12-month prospective cohort study. BMJ Open, e011735, vol. 6(10). link> doi> full text>
  • Wersocki E, Bedson J, Chen Y, LeResche L, Dunn KM. 2017. Comprehensive systematic review of long-term opioids in women with chronic noncancer pain and associated reproductive dysfunction (hypothalamic-pituitary-gonadal axis disruption). Pain, 8-16, vol. 158(1). link> doi> full text>
  • Ahmed N, Prior JA, Chen Y, Hayward R, Mallen CD, Hider SL. 2016. Prevalence of cardiovascular-related comorbidity in ankylosing spondylitis, psoriatic arthritis and psoriasis in primary care: a matched retrospective cohort study. Clin Rheumatol, 3069-3073, vol. 35(12). link> doi> full text>
  • Bedson J, Chen Y, Hayward RA, Ashworth J, Walters K, Dunn KM, Jordan KP. 2016. Trends in long-term opioid prescribing in primary care patients with musculoskeletal conditions: an observational database study. PAIN, 1525-1531, vol. 157(7). link> doi> full text>
  • Jordan KP, Tan V, Edwards JJ, Chen Y, Englund M, Hubertsson J, Jöud A, Porcheret M, Turkiewicz A, Peat G. 2016. Influences on the decision to use an osteoarthritis diagnosis in primary care: a cohort study with linked survey and electronic health record data. Osteoarthritis Cartilage, 786-793, vol. 24(5). link> doi> full text>
  • Burton CL, Chesterton LS, Chen Y, van der Windt DA. 2016. Clinical Course and Prognostic Factors in Conservatively Managed Carpal Tunnel Syndrome: A Systematic Review. Arch Phys Med Rehabil, 836-852.e1, vol. 97(5). link> doi> full text>
  • Brenner DR, Amos CI, Brhane Y, Timofeeva MN, Caporaso N, Wang Y, Christiani DC, Bickeböller H, Yang P, Albanes D, Stevens VL, Gapstur S, McKay J, Boffetta P, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Skorpen F, Gabrielsen ME, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Vooder T, Välk K, Nelis M, Metspalu A, Broderick P, Eisen T, Wu X, Zhang D, Chen W, Spitz MR, Wei Y, Su L, Xie D, She J, Matsuo K, Matsuda F, Ito H, Risch A, Heinrich J, Rosenberger A, Muley T, Dienemann H, Field JK, Raji O, Chen Y, Gosney J, Liloglou T, Davies MPA, Marcus M, McLaughlin J, Orlow I, Han Y, Li Y, Zong X, Johansson M, EPIC Investigators, Liu G, Tworoger SS, Le Marchand L, Henderson BE, Wilkens LR, Dai J, Shen H, Houlston RS, Landi MT, Brennan P, Hung RJ. 2015. Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis, 1314-1326, vol. 36(11). link> doi>
  • Hayward R, Chen Y, Croft P, Jordan K. 2015. Presentation of respiratory symptoms prior to diagnosis in general practice: a case–control study examining free text and morbidity codes. BMJ Open. doi> full text>
  • Marcus MW, Chen Y, Raji OY, Duffy SW, Field JK. 2015. LLPi: Liverpool Lung Project Risk Prediction Model for Lung Cancer Incidence. Cancer Prev Res (Phila), 570-575, vol. 8(6). link> doi>
  • Marcus MW, Chen Y, Duffy SW, Field JK. 2015. Impact of comorbidity on lung cancer mortality - a report from the Liverpool Lung Project. Oncol Lett, 1902-1906, vol. 9(4). link> doi>
  • Consonni D, De Matteis S, Pesatori AC, Bertazzi PA, Olsson AC, Kromhout H, Peters S, Vermeulen RCH, Pesch B, Brüning T, Kendzia B, Behrens T, Stücker I, Guida F, Wichmann H-E, Brüske I, Landi MT, Caporaso NE, Gustavsson P, Plato N, Tse LA, Yu IT-S, Jöckel K-H, Ahrens W, Pohlabeln H, Merletti F, Richiardi L, Simonato L, Forastiere F, Siemiatycki J, Parent M-É, Tardón A, Boffetta P, Zaridze D, Chen Y, Field JK, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Lissowska J, Szeszenia-Dabrowska N, Bencko V, Foretova L, Janout V, Rudnai P, Fabiánová E, Stanescu Dumitru R, Bueno-de-Mesquita HB, Schüz J, Straif K. 2015. Lung cancer risk among bricklayers in a pooled analysis of case-control studies. Int J Cancer, 360-371, vol. 136(2). link> doi>
  • Marcus MW, Raji OY, Chen Y, Duffy SW, Field JK. 2014. Factors associated with dropout in a lung cancer high‑risk cohort--the Liverpool lung project. Int J Oncol, 2146-2152, vol. 44(6). link> doi>
  • Kim CH, Lee Y-CA, Hung RJ, McNallan SR, Cote ML, Lim W-Y, Chang S-C, Kim JH, Ugolini D, Chen Y, Liloglou T, Andrew AS, Onega T, Duell EJ, Field JK, Lazarus P, Le Marchand L, Neri M, Vineis P, Kiyohara C, Hong Y-C, Morgenstern H, Matsuo K, Tajima K, Christiani DC, McLaughlin JR, Bencko V, Holcatova I, Boffetta P, Brennan P, Fabianova E, Foretova L, Janout V, Lissowska J, Mates D, Rudnai P, Szeszenia-Dabrowska N, Mukeria A, Zaridze D, Seow A, Schwartz AG, Yang P, Zhang Z-F. 2014. Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO). Int J Cancer, 1918-1930, vol. 135(8). link> doi>
  • Chen Y, Marcus MW, Niaz A, Duffy SW, Field JK. 2014. MyLungRisk: a user-friendly, webbased calculator for risk assessment of lung cancer based on the validated Liverpool Lung Project risk prediction model. International Journal of Health Promotion and Education. doi>
  • Field JK, Chen Y, Marcus MW, Mcronald FE, Raji OY, Duffy SW. 2013. The contribution of risk prediction models to early detection of lung cancer. J Surg Oncol, 304-311, vol. 108(5). link> doi>
  • Chen Y, Yu Z, Packham JC, Mattey DL. 2013. Influence of Adult Height on Rheumatoid Arthritis: Association with Disease Activity, Impairment of Joint Function and Overall Disability. Plos One, vol. 8. doi>
  • Marcus MW, Chen Y, Liloglou T, Field JK. 2013. New perspectives to respiratory tract cancers. Head & Neck Oncology, vol. 5.
  • Chen Y and Mattey DL. 2012. Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A (VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes. Clinical and Experimental Rheumatology, 894-898, vol. 30.
  • Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeboeller H, Risch A, McKay JD, Wang Y, Dai J, Gaborieau V, McLaughlin J, Brenner D, Narod SA, Caporaso NE, Albanes D, Thun M, Eisen T, Wichmann H, Rosenberger A, Han Y, Chen W, Zhu D, Spitz M, Wu X, Pande M, Zhao Y, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njolstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Vaelk K, Nelis M, Metspalu A, Raji O, Chen Y, Gosney J, Liloglou T, Muley T, Dienemann H, Thorleifsson G, Shen H, Stefansson K, Brennan P, Amos CI, Houlston R, Landi MT, Team TRICLR. 2012. Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Human Molecular Genetics, 4980-4995, vol. 21. doi>
  • Chen Y, Nixon NB, Dawes PT, Mattey DL. 2012. Influence of variations across the MMP-1 and-3 genes on the serum levels of MMP-1 and-3 and disease activity in rheumatoid arthritis. Genes and Immunity, 29-37, vol. 13. doi>
  • Chen Y, Dawes PT, Packham JC, Mattey DL. 2012. Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Research & Therapy, vol. 14. doi>
  • Chen Y, Dawes PT, Mattey DL. 2012. Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: Differential effect of cigarette smoking. Cytokine, 390-397, vol. 58. doi>
  • Chen Y, Dawes PT, Packham JC, Mattey DL. 2011. Interaction Between Smoking and Polymorphism in the Promoter Region of the VEGFA Gene Is Associated with Ischemic Heart Disease and Myocardial Infarction in Rheumatoid Arthritis. Journal of Rheumatology, 802-809, vol. 38. doi>
  • Campos PC, Silva VG, Furtado C, Machado-Silva A, DaRocha WD, Peloso EF, Gadelha FR, Medeiros MHG, Lana GDC, Chen Y, Barnes RL, Passos-Silva DG, McCulloch R, Machado CR, Teixeira SMR. 2011. Trypanosoma cruzi MSH2: Functional analyses on different parasite strains provide evidences for a role on the oxidative stress response. Molecular and Biochemical Parasitology, 8-16, vol. 176. doi>

Other

  • Chen Y, Hayward R, Chew-Graham C, Hubbard R, Sims K, Jordan K. Increased risk of mortality following recorded presentation of symptoms of breathlessness and wheeze in primary care: a matched cohort study using electronic health records.
  • Bedson J, Chen Y, Haywood R, Dunn KM, Jordan KP. 2016. LONG-TERM OPIOID PRESCRIBING AND THE RISK OF ADVERSE EVENTS IN PATIENTS WITH MUSCULOSKELETAL PAIN: A COHORT STUDY. RHEUMATOLOGY (p. 51, vol. 55). link>
  • Chen Y, Hayward R, Chew-Graham C, Hubbard R, Sims K, Jordan K. 2016. Future diagnosis following recorded presentation of symptoms of breathlessness and wheeze in primary care.
  • Bedson J, Chen Y, Hayward RA, Ashworth J, Walters K, Dunn KM, Jordan KP. 2016. Trends in long-term opioid prescribing in primary care patients with musculoskeletal conditions: an observational database study. Pain (pp. 1525-1531, vol. 157). link> doi> full text>
  • Chen Y, Bedson J, Hayward R, Jordan K. 2016. Trends in prescribing of NSAIDs in primary care in patients with and without CVD: an observational database study. Rheumatology. Oxford University Press (OUP): Policy B - Oxford Open Option B. doi> full text>
  • Hayward RA, Chen Y, Croft P, Jordan K. WONCA 2015 Istanbul Presentation of respiratory symptoms prior to diagnosis in general practice: a case control study examining free text and morbidity codes. full text>
  • Raji OY, Chen Y, Duffy SW, Agbaje OF, Baker SG, Consortium EUELC, Christiani DC, Cassidy A, Field JK. 2014. Predictive Accuracy and Utility of the Liverpool Lung Project Risk Model Using Population-Based Data from Europe and North America.
  • Sherratt F, Field J, Robinson J, Chen Y. 2014. Exploring Reactions to Risk and Uncertainty in the Context of Smoking and Lung Cancer.
  • Marcus M, Chen Y, De Souza N, Duffy S, Field J. 2013. Impact of comorbidity on overall and lung cancer-specific mortality – a report from the Liverpool Lung Project.
  • Field JK, Niaz A, Farley J, Hodge N, Raji OY, Duffy SW, Marcus MW, Chen Y. 2013. MyLungRisk calculator: a user-friendly, web-based questionnaire for risk prediction of lung cancer based on the validated Liverpool Lung Project model. Lung Cancer (p. S18, vol. 79).
  • Chen Y. 2012. Determinants of severity and co-morbidity in rheumatoid arthritis : influence of genetic variation and smoking.
  • Chen Y, Packham JC, Dawes PT, Mattey DL. 2011. INTERACTION BETWEEN SMOKING AND POLYMORPHISM IN THE VEGF GENE IS ASSOCIATED WITH ISCHAEMIC HEART DISEASE AND MYOCARDIAL INFARCTION IN RA. RHEUMATOLOGY (pp. 60-61, vol. 50). link>
  • Chen Y, Dawes PT, Mattey DL. 2011. POLYMORPHISM IN THE PROMOTER REGION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR GENE IS ASSOCIATED WITH SERUM VEGF LEVEL AND DISEASE ACTIVITY IN RA. RHEUMATOLOGY (p. 60, vol. 50). link>
  • Chen Y, Dawes PT, Mattey DL. 2010. A SPECIFIC MMP1-MMP3 HAPLOTYPE IS ASSOCIATED WITH HIGH LEVELS OF MMP-1 AND SHOWS INTERACTION WITH SMOKING IN RELATION TO EROSIVE DISEASE IN RHEUMATOID ARTHRITIS. Rheumatology (pp. I9-I10, vol. 49).