Pensee Wu

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Biography

Dr Wu studied Medicine at the University of Edinburgh and did her clinical training in Obstetrics and Gynaecology in Edinburgh and Oxford, followed by a National Training number in the Eastern Deanery.

Taking time out of programme for an MD(Res) degree at Imperial College London, Dr Wu was funded by Wellbeing of Women to assess the potential intrauterine cell transplantation in treating muscular dystrophy. Dr Wu completed her clinical training in Glasgow, subspecialising in Maternal Fetal Medicine, and was appointed as a Lecturer at Keele University and Honorary Consultant Obstetrician at University Hospital of North Midlands in 2013. Since then, she has been promoted to Senior Lecturer.

Research and scholarship

Dr Wu's interests are in pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes and preterm labour, and their long-term health impact. Her research has been supported by a National Institute for Health Research (NIHR) Transitional Research Fellowship as well as funding from various charities.

She has been the Clinical Specialty lead in Reproductive health and childbirth for NIHR Clinical Research Network West Midlands. Currently she is a member of the National Institute for Health and Care Excellence (NICE) multiple Obstetric guidelines updates committee as well as a member of the social media committee at the American Journal of Obstetrics and Gynaecology.

Teaching

Dr Wu leads and co-supervises a number of masters and doctoral students. She undertakes clinical teaching for clinical trainees and is an educational supervisor for Obstetric Academic Foundation Trainees and Academic Clinical Fellows. Dr Wu teaches undergraduates on the Women’s Health module and supervises the 4-week Student Selected Component in Fetal medicine. She is a personal development tutor for undergraduates and a medical student examiner.

Selected Publications

Chen L, Wang C-T, Forsyth NR, Wu P. 2020. Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research & Therapy, vol. 11(1), Article 319. doi> link> full text>
Heald AH, Stedman M, Tian Z, Wu P, Fryer AA. 2020. Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality. Int J Clin Pract, e13768. link> doi> full text>
Wu H-T, Kang L, Su Y-C, Ou H-Y, Chan F-Y, Chen Y-C, Su B-H, Wang Y-S, Wu C-L, Shiau A-L, Wu P. 2020. Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes. Clinical Science, vol. 134(18), 2435-2445. link> doi> link> full text>
Wu P, Chew-Graham C, Maas A, Chappell L, Potts J, Gulati M, Jordan K, Mamas M. 2020. Hypertensive disorders of pregnancy and impact on in-hospital cardio-obstetric outcomes. European Society of Cardiology. link> full text>
Wu P, Jordan KP, Chew-Graham CA, Coutinho T, Lundberg GP, Park KE, Chappell LC, Myint PK, Maas AHEM, Mamas MA. 2020. Temporal Trends in Pregnancy-Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy. J Am Heart Assoc, vol. 9(15), e016182. link> doi> full text>

Full Publications List show

Journal Articles

Chen L, Wang C-T, Forsyth NR, Wu P. 2020. Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research & Therapy, vol. 11(1), Article 319. doi> link> full text>
Heald AH, Stedman M, Tian Z, Wu P, Fryer AA. 2020. Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality. Int J Clin Pract, e13768. link> doi> full text>
Wu H-T, Kang L, Su Y-C, Ou H-Y, Chan F-Y, Chen Y-C, Su B-H, Wang Y-S, Wu C-L, Shiau A-L, Wu P. 2020. Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes. Clinical Science, vol. 134(18), 2435-2445. link> doi> link> full text>
Wu P, Jordan KP, Chew-Graham CA, Coutinho T, Lundberg GP, Park KE, Chappell LC, Myint PK, Maas AHEM, Mamas MA. 2020. Temporal Trends in Pregnancy-Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy. J Am Heart Assoc, vol. 9(15), e016182. link> doi> full text>
Wilkinson M and Wu P. 2020. Suspected Fetal Anomalies. Obstetrics, Gynaecology and Reproductive Medicine. doi> link> full text>
Wu P, Chew-Graham CA, Maas AH, Chappell LC, Potts JE, Gulati M, Jordan KP, Mamas MA. 2020. Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes. Am J Cardiol, vol. 125(10), 1508-1516. link> doi> full text>
Park K, Wu P, Gulati M. 2020. Obstetrics and Gynecological History. JACC: Case Reports, vol. 2(1), 161-163. doi> link> full text>
Kang L, Li H-Y, Ou H-Y, Wu P, Wang S-H, Chang C-J, Lin S-Y, Wu C-L, Wu H-T. 2020. Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research. doi> link>
Jinsakul N, Tsai C-F, Tsai C-E, Wu P. 2019. Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening. Mathematics, vol. 7(12), 1170. doi> full text>
Chen L, Forsyth NR, Wu P. 2020. Chorionic and amniotic placental membrane-derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities. J Tissue Eng Regen Med, vol. 14(2), 243-256. link> doi> full text>
Webster K, Fishburn S, Maresh M, Findlay SC, Chappell LC, Guideline Committee. 2019. Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. BMJ, vol. 366, l5119. link> doi>
Chen L, Merkhan MM, Forsyth NR, Wu P. 2019. Chorionic and amniotic membrane-derived stem cells have distinct, and gestational diabetes mellitus independent, proliferative, differentiation, and immunomodulatory capacities. Stem Cell Res, vol. 40, 101537. link> doi> full text>
Kuo Y-H, Shiau A-L, Tung C-L, Su Y-C, Li C-F, Su B-H, Tsao C-J, Wu C-L, Feng Y-H, Wu P. 2019. Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking. Oncol Lett, vol. 17(6), 5740-5746. link> doi>
Kwok CS, Gulati M, Michos ED, Potts J, Wu P, Watson L, Loke YK, Mallen C, Mamas MA. 2019. Dietary components and risk of cardiovascular disease and all-cause mortality: a review of evidence from meta-analyses. Eur J Prev Cardiol, vol. 26(13), 1415-1429. link> doi> full text>
Wong CW, Kwok CS, Narain A, Gulati M, Mihalidou AS, Wu P, Alasnag M, Myint PK, Mamas MA. 2018. Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis. Heart, vol. 104(23), 1937-1948. link> doi> full text>
Su Y-C, Feng Y-H, Wu H-T, Huang Y-S, Tung C-L, Wu P, Chang C-J, Shiau A-L, Wu C-L. 2018. Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Sci Rep, vol. 8(1), 6586. link> doi> full text>
Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O’Brien S, Chew-Graham C, Verma G, Kadam U, Mamas M. 2018. Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. Journal of the American Heart Association. doi> link> full text>
Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O'Brien S, Chew-Graham CA, Verma G, Kadam UT, Mamas MA. 2018. Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. J Am Heart Assoc, vol. 7(2). link> doi> full text>
Heald AH, Livingston M, Holland D, Robinson J, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA. 2018. Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Int J Clin Pract, vol. 72(1). link> doi>
Livingston M, Holland D, Kalansooriya A, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA, Heald AH. 2017. Polycystic ovarian syndrome: Social situation influences outcome. Int J Clin Pract, vol. 71(8). link> doi>
Ou H-Y, Wu H-T, Lin C-H, Du Y-F, Hu C-Y, Hung H-C, Wu P, Li H-Y, Wang S-H, Chang C-J. 2017. The hepatic protection effects of hepassocin in hyperglycemic crisis. Journal of Clinical Endocrinology and Metabolism. link> doi> link>
Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MA. 2017. Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi> full text>
Wu P, Kwok CS, Haththotuwa R, Kotronias RA, Babu A, Fryer AA, Myint PK, Chew-Graham CA, Mamas MA. 2016. Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi> full text>
Lu C-S, Shieh G-S, Wang C-T, Su B-H, Su Y-C, Chen Y-C, Su W-C, Wu P, Yang W-H, Shiau A-L, Wu C-L. 2017. Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer. Oncotarget, vol. 8(19), 30844-30858. link> doi> full text>
Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW, Fryer AA. 2018. Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, vol. 13(2), 122-128. link> doi> full text>
Su Y-C, Ou H-Y, Wu H-T, Wu P, Chen Y-C, Su B-H, Shiau A-L, Chang C-J, Wu C-L. 2015. Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance. Journal of Clinical Endocrinology and Metabolism, vol. 100(11), 4114-4123. link> doi>
Su B-H, Tseng Y-L, Shieh G-S, Chen Y-C, Wu P, Shiau A-L, Wu C-L. 2015. Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema. Journal of Pathology, vol. 238(3), 412-422. link> doi>
Wu P, van den Berg C, Alfirevic Z, O'Brien S, Röthlisberger M, Baker PN, Kenny LC, Kublickiene K, Duvekot JJ. 2015. Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis. Int J Mol Sci, vol. 16(9), 23035-23056. link> doi> full text>
Shiau AL, Su YC, Feng YH, Wu HT, Huang YS, Wu P, Chang CJ, Wu CL. 2014. Elovl6 overexpression promotes liver carcinogenesis. European Journal of Cancer, vol. 50, S75. link> doi>
Wu P, Whiteford M, Cameron A. 2014. Preimplantation Genetic Diagnosis. Obstetrics, Gynaecology and Reproductive Medicine, vol. 24(3), 67-73. doi>
Su B-H, Tseng Y-L, Shieh G-S, Chen Y-C, Shiang Y-C, Wu P, Li K-J, Yen T-H, Shiau A-L, Wu C-L. 2013. Prothymosin α overexpression contributes to the development of pulmonary emphysema. Nat Commun, vol. 4, 1906. link> doi> full text>
Wu P, Poole TC, Pickett JA, Bhat A, Lees CC. 2013. Current obstetric guidelines on thromboprophylaxis in the United Kingdom: evidence based medicine?. Eur J Obstet Gynecol Reprod Biol, vol. 168(1), 7-11. link> doi>
Shaw C, Wu P, Sriemevan A. 2011. First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. BMJ Case Reports. doi>
Morganstein DL, Wu P, Mane MR, Fisk NM, White R, Parker MG. 2010. Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Cell Res, vol. 20(4), 434-444. link> doi> full text>
Abouzeid H, Wu P, Mohammed N, Al-Samarrai M. 2009. Group A streptococcal puerperal sepsis: The return of a potentially fatal disease. Journal of Obstetrics and Gynaecology, vol. 25(8), 806-808. doi>
Chang C-C, Shieh G-S, Wu P, Lin C-C, Shiau A-L, Wu C-L. 2008. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res, vol. 68(15), 6281-6291. link> doi>
Wu C-L, Shieh G-S, Chang C-C, Yo Y-T, Su C-H, Chang M-Y, Huang Y-H, Wu P, Shiau A-L. 2008. Tumor-selective replication of an oncolytic adenovirus carrying oct-3/4 response elements in murine metastatic bladder cancer models. Clin Cancer Res, vol. 14(4), 1228-1238. link> doi>
Wu CL, Wu P, Shiau AL. 1999. A Computerized Management System for Cell Bank. Analytical Biochemistry, vol. 275(2), 260-262. doi>
Lawrie SM, Martin K, McNeill G, Drife J, Chrystie P, Reid A, Wu P, Nammary S, Ball J. 1998. General practitioners' attitudes to psychiatric and medical illness. Psychol Med, vol. 28(6), 1463-1467. link> doi>
Shiau AL, Yang HM, Wu P, Wu CL. 1998. Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Therapy (Basingstoke), vol. 5(11), 1571-1574.
Lundberg G, Wu P, Wenger N. 2020. Menopausal Hormone Therapy: a Comprehensive Review. Curr Atheroscler Rep, vol. 22(8), 33. link> doi> full text>
Park K, Wu P, Gulati M. Obstetrics and Gynecologic History - A Missed Opportunity for Cardiovascular Risk Assessment. JACC: Case Reports. full text>
Wu P, Mamas M, Gulati M. Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics. Journal of Women's Health. full text>
Wu P, Mamas MA, Gulati M. 2019. Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics. J Womens Health (Larchmt), vol. 28(8), 1037-1050. link> doi> full text>

Other

Wu P, Chew-Graham C, Maas A, Chappell L, Potts J, Gulati M, Jordan K, Mamas M. 2020. Hypertensive disorders of pregnancy and impact on in-hospital cardio-obstetric outcomes. European Society of Cardiology. link> full text>
Kwok CS, Gulati M, Michos E, Frates EP, Potts J, Wu P, Watson L, Loke YK, Mallen CD, Mamas MA. 2019. RELATIONSHIP BETWEEN COMPONENTS OF DIET AND CARDIOVASCULAR DISEASE AND MORTALITY: AN OVERVIEW OF CURRENT EVIDENCE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (vol. 73, p. 1806). link> doi>
Shiau AL, Su YC, Feng YH, Huang YS, Wu P, Wu CL. 2018. Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. HUMAN GENE THERAPY (vol. 29, p. A48). link>
Bort JH, Kraus B, Fiedler C, Buengener C, Mayrhofer J, Lengler J, Schlager R, Bendik M. 2018. Biological activity of additional AAV subpopulation in AAV gene therapy product. HUMAN GENE THERAPY (vol. 29, p. A44). link>
Chen L, Merkhan M, Forsyth NR, Wu P. 2018. CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE. PLACENTA (vol. 69, p. E44). link>
Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O'Brien S, Chew-Graham C, Verma G, Kadam U, Mamas M. 2018. Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (vol. 125, p. 86). link>
Heald A, Livingstone M, Holland D, Robinson J, Moreno G, Donnahey G, Duff C, Wu P, Fryer A. 2017. Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Endocrine Abstracts. doi> link>
Wu CL, Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Chang CJ, Shiau AL. 2016. Lentivirus-mediated silencing of prothymosin a expression ameliorates high-fat diet-induced insulin resistance in mice. HUMAN GENE THERAPY (vol. 27, pp. A177-A178). link>
Fernando T, Nayak A, Indusekhar R, Varadhan L, Wu P. 2016. Women at high risk for gestational diabetes but with normal glucose tolerance test - do they have more adverse outcomes than women at low risk for gestational diabetes?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (vol. 123, p. 35). link>
Wu H-T, Su M-T, Tsai P-Y, Ou H-Y, Chang C-J, Wu C-L, Wu P. 2015. The role of hepassocin in gestational diabetes mellitus. DIABETOLOGIA (vol. 58, p. S491). link>
Wu CL, Chang CC, Shieh GS, Wu P, Shiau AL. 2008. Oct-3/4 expression reflects clinical tumor progression and regulates motility of bladder cancer cells. HUMAN GENE THERAPY (vol. 19, p. 405). link>
Wu C-L, Shieh G-S, Chang M-Y, Huang Y-H, Chang C-C, Wu P, Shiau A-L. 2007. Tumor-selective replication of an oncolytic adenovirus carrying Oct-3/4 response elements in metastatic bladder cancers. HUMAN GENE THERAPY (vol. 18, p. 1067). link>

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Dr Pensee Wu