Biography
Dr Wu studied Medicine at the University of Edinburgh and did her clinical training in Obstetrics and Gynaecology in Edinburgh and Oxford, followed by a National Training number in the Eastern Deanery.
Taking time out of programme for an MD(Res) degree at Imperial College London, Dr Wu was funded by Wellbeing of Women to assess the potential intrauterine cell transplantation in treating muscular dystrophy. Dr Wu completed her clinical training in Glasgow, subspecialising in Maternal Fetal Medicine, and was appointed as a Lecturer at Keele University and Honorary Consultant Obstetrician at University Hospital of North Midlands in 2013. Since then, she has been promoted to Senior Lecturer.
Research and scholarship
Dr Wu's interests are in pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes and preterm labour, and their long-term health impact. Her research has been supported by a National Institute for Health Research (NIHR) Transitional Research Fellowship as well as funding from various charities.
She has been the Clinical Specialty lead in Reproductive health and childbirth for NIHR Clinical Research Network West Midlands. Currently she is a member of the National Institute for Health and Care Excellence (NICE) multiple Obstetric guidelines updates committee as well as a member of the social media committee at the American Journal of Obstetrics and Gynaecology.
Teaching
Dr Wu leads and co-supervises a number of masters and doctoral students. She undertakes clinical teaching for clinical trainees and is an educational supervisor for Obstetric Academic Foundation Trainees and Academic Clinical Fellows. Dr Wu teaches undergraduates on the Women’s Health module and supervises the 4-week Student Selected Component in Fetal medicine. She is a personal development tutor for undergraduates and a medical student examiner.
Selected Publications
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Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research & Therapy, vol. 11(1), Article 319. doi> link> full text>2020.
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Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality. Int J Clin Pract, e13768. link> doi> full text>2020.
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Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes. Clinical Science, vol. 134(18), 2435-2445. link> doi> link> full text>2020.
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Hypertensive disorders of pregnancy and impact on in-hospital cardio-obstetric outcomes. European Society of Cardiology. link> full text>2020.
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Temporal Trends in Pregnancy-Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy. J Am Heart Assoc, vol. 9(15), e016182. link> doi> full text>2020.
Full Publications List show
Journal Articles
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Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research & Therapy, vol. 11(1), Article 319. doi> link> full text>2020.
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Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality. Int J Clin Pract, e13768. link> doi> full text>2020.
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Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes. Clinical Science, vol. 134(18), 2435-2445. link> doi> link> full text>2020.
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Temporal Trends in Pregnancy-Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy. J Am Heart Assoc, vol. 9(15), e016182. link> doi> full text>2020.
- 2020.
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Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes. Am J Cardiol, vol. 125(10), 1508-1516. link> doi> full text>2020.
- 2020.
- 2020.
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Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening. Mathematics, vol. 7(12), 1170. doi> full text>2019.
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Chorionic and amniotic placental membrane-derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities. J Tissue Eng Regen Med, vol. 14(2), 243-256. link> doi> full text>2020.
- 2019.
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Chorionic and amniotic membrane-derived stem cells have distinct, and gestational diabetes mellitus independent, proliferative, differentiation, and immunomodulatory capacities. Stem Cell Res, vol. 40, 101537. link> doi> full text>2019.
- 2019.
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Dietary components and risk of cardiovascular disease and all-cause mortality: a review of evidence from meta-analyses. Eur J Prev Cardiol, vol. 26(13), 1415-1429. link> doi> full text>2019.
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Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis. Heart, vol. 104(23), 1937-1948. link> doi> full text>2018.
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Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Sci Rep, vol. 8(1), 6586. link> doi> full text>2018.
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Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. Journal of the American Heart Association. doi> link> full text>2018.
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Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis. J Am Heart Assoc, vol. 7(2). link> doi> full text>2018.
- 2018.
- 2017.
- 2017.
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Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes, vol. 10(2). link> doi> full text>2017.
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Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, vol. 59(12), 2518-2526. link> doi> full text>2016.
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Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer. Oncotarget, vol. 8(19), 30844-30858. link> doi> full text>2017.
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Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, vol. 13(2), 122-128. link> doi> full text>2018.
- 2015.
- 2015.
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Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis. Int J Mol Sci, vol. 16(9), 23035-23056. link> doi> full text>2015.
- 2014.
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Preimplantation Genetic Diagnosis. Obstetrics, Gynaecology and Reproductive Medicine, vol. 24(3), 67-73. doi>2014.
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Prothymosin α overexpression contributes to the development of pulmonary emphysema. Nat Commun, vol. 4, 1906. link> doi> full text>2013.
- 2013.
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First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. BMJ Case Reports. doi>2011.
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Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Cell Res, vol. 20(4), 434-444. link> doi> full text>2010.
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Group A streptococcal puerperal sepsis: The return of a potentially fatal disease. Journal of Obstetrics and Gynaecology, vol. 25(8), 806-808. doi>2009.
- 2008.
- 2008.
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A Computerized Management System for Cell Bank. Analytical Biochemistry, vol. 275(2), 260-262. doi>1999.
- 1998.
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Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Therapy (Basingstoke), vol. 5(11), 1571-1574.1998.
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Menopausal Hormone Therapy: a Comprehensive Review. Curr Atheroscler Rep, vol. 22(8), 33. link> doi> full text>2020.
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Obstetrics and Gynecologic History - A Missed Opportunity for Cardiovascular Risk Assessment. JACC: Case Reports. full text>
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Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics. Journal of Women's Health. full text>
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Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics. J Womens Health (Larchmt), vol. 28(8), 1037-1050. link> doi> full text>2019.
Other
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Hypertensive disorders of pregnancy and impact on in-hospital cardio-obstetric outcomes. European Society of Cardiology. link> full text>2020.
- 2019.
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Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. HUMAN GENE THERAPY (vol. 29, p. A48). link>2018.
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Biological activity of additional AAV subpopulation in AAV gene therapy product. HUMAN GENE THERAPY (vol. 29, p. A44). link>2018.
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CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE. PLACENTA (vol. 69, p. E44). link>2018.
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Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (vol. 125, p. 86). link>2018.
- 2017.
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Lentivirus-mediated silencing of prothymosin a expression ameliorates high-fat diet-induced insulin resistance in mice. HUMAN GENE THERAPY (vol. 27, pp. A177-A178). link>2016.
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Women at high risk for gestational diabetes but with normal glucose tolerance test - do they have more adverse outcomes than women at low risk for gestational diabetes?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (vol. 123, p. 35). link>2016.
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The role of hepassocin in gestational diabetes mellitus. DIABETOLOGIA (vol. 58, p. S491). link>2015.
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Oct-3/4 expression reflects clinical tumor progression and regulates motility of bladder cancer cells. HUMAN GENE THERAPY (vol. 19, p. 405). link>2008.
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Tumor-selective replication of an oncolytic adenovirus carrying Oct-3/4 response elements in metastatic bladder cancers. HUMAN GENE THERAPY (vol. 18, p. 1067). link>2007.