Four-day course

A Practical Introduction to Running Randomised Clinical Trials

Date: 25 June - 28 June 2019
Location: David Wetherall Building, Keele University, ST5 5BG
Cost: £600.00
Accommodation is not provided, so please download our list of local hotels below.

This 4 day course will improve your knowledge and skills in the design, practical conduct, management and analysis of randomised clinical trials (RCTs). Combining talks and workshop activities, you will be guided through the principles, methodology and practical implementation of RCTs.

Project Grants

  • RfPB; Preventing pain from interefering with later life: an action-orientated qualitative study £133,919 
  • Arthritis Research UK; Missed opportunities to improve the management of common muscuoloskeletal disorders in general practice  £411,389 
  • HAZ/North Staffordshire Medical Institute - Research Design Service £1,210,411
  • RfPB; Investigating patient's health priorities and use of health services. A qualitative exploration £139,274
  • RfPB; Individualising exercise for knee osteoarthritis: developing an evidence-based impairment-targeted intervention £70,987
  • Arthritis Research UK; Integrated Clinical Arthritis Centre Grant £101,170 
  • RfPB; TENS for the management of tennis elbow; a pragmatic randomised controlled trial £259,989
  • ESRC; The meaning of wellness and resilience for older people with osteoarthritis; a qualitive longitudinal study £72,947
  • Stoke on Trent PCT and North Staffordshire PCT; Systematic review of symptom presentation and subsequent cancer diagnosis and mortality in primary care AND development of secondary analysis and audit of delays in symptom diagnosis in primary care in North Staffordshire 
  • Stoke on Trent PCT; Sickness certification in primary care; a pilot study of generl practitioners £2,086 
  • Arthritis Research UK; Increading physical activity in older people with chronic musculoskeletal pain: a brief and simple intervention to promote walking £257,419
  • Stoke on Trent PCT; Evaluation and development of enhanced pain management programmes: Haywood Hospital £160,000 
  • RfPB; Improving outcomes for patients with hip osteoarthritis: a randomised controlled trial £344,981

Trials and Intervention Studies

  • NIHR Health Technology Assessment; Chondroitin for hand osteoarthritis: a randomised, placebo-controlled trial in primary care: The FACULTY STUDY £1,092,738
  • NIHR; Treating gout in primary care. A randomised head-to-head comparison of naproxen and low-dose colchicine £769, 553
  • NIHR Health Technology Assessment; Evaluating Acupuncture and Standard care for pregnant women with low back pain (EASEBACK trial): a feasibility and pilot study £224, 950
  • Arthritis Research UK; The clinical cost effectiveness of steroid injection compared with nightsplints for carpel tunnel syndrome
  • Arthritis Research UK; Improving the effectiveness of primary care for low back pain: The Sub-grouping for Targeted Treatment (STarTBack) Trial £183, 659
  • NIHR Research for Patient Benefit; Development and validation of a core set of patient reported outcome measures for musculoskeletal conditions £173, 623
  • NIHR Health Technology Assessment; Stratified Care for Patients with Sciatica and Suspected Sciatica in Primary Care: A randomised trial (the SCOPiC trial – the Sciatica Outcomes in Primary Care) £1, 179, 586
  • NIHR Research for Patient Benefit; A feasibility and pilot trial of the effectiveness of exercise therapy and orthotics in the treatment of plantar heel pain. (TReatments of Exercise AnD Orthotics for plaNtar heel pain: The TREADON pilot feasibility trial) £249,691
  • NIHR Health Technology Assessment; Chondroitin sulphate for hand osteoarthritis: a randomised, placebo-controlled trial in primary care: The FACTUAL STUDY £1,092,738
  • NIHR Programme Grant; Stratified Primary Care for Musculoskeletal Pain £1, 911, 248


Both the School and Clinical Trials Unit have produced publications which have featured in a number of journals. Below is a selected list of publications for you to look at.


Lewis M, James M, Stokes E, Hill J, Sim J, Hay E, Dziedzic K. An economic evaluation of three physiotherapy treatments for non-specific neck disorders alongside a randomized trial. 2007;46:1701-8.

  • James M, Stokes EA, Thomas E, Dziedzic K, Hay EM. Cost minimisation analysis of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care. 2005;44:1447-51.
  • Hill J, Foster N, Hughes R, Hay E. Meeting the challenges of research governance. 2005;44:571-2.

British Medical Journal

  • Chesterton LS, Lewis AM, Sim J, Mallen CD, EE Mason, Hay EM, van der Windt DA. Transcutaneous electrical nerve stimulation as adjunct to primary care management for tennis elbow: pragmatic randomised controlled trial (TATE trial). 2013; 347:f5160
  • Salisbury C, Montgomery AA, Hollinghurst S, Hopper C, Bishop A, Franchini A, Kaur S, Coast J, Hall J, Grove S, Foster NE. Effectiveness of PhysioDirect telephone assessment and advice services for patients with musculoskeletal problems; pragmatic randomised controlled trial. 2013; 346:f43.
  • Foster N, Thomas E, Barlas P, Hill J, Mason L, Young J, Hay EM. A randomised controlled trial of acupuncture as an adjunct to exercisebased physiotherapy for knee osteoarthritis. 2007;335:436-40.
  • Hay EM, Foster NE, Thomas E, Peat G, Phelan M, Yates H, Blenkinsopp A, Sim J. Effectiveness of community physiotherapy and enhanced pharmacy review for knee pain in people aged over 55 presenting to primary care: pragmatic randomised trial. 2006;333:995-8.
  • Hay EM, Paterson SM, Lewis M, Hosie G, Croft P. Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. 1999;319:964-8.

Arthritis & Rheumatism

  • Whitehurst DGT, Lewis M, Bryan S, Raftery JP, Yao GL, Mullis R, Hay EM. A brief pain management program compared with physical therapy for low back pain: Results from an economic analysis alongside a randomized clinical trial. 2007;57:466-73.
  • Dziedzic K, Hill J, Lewis M, Sim J, Daniels J, Hay EM. Effectiveness of manual therapy or pulsed shortwave diathermy in addition to advice and exercise for neck disorders: a pragmatic randomized controlled trial in physical therapy clinics. 2005;53:214-22.

Annals of the Rheumatic Diseases

  • Dziedzic K. Self Management in OA: Evidence for the role of the multidisciplinary team. Ann Rheum Dis 2012 ; 71:20
  • Whitehurst DG, Bryan S, Lewis M, Hill J, Hay EM. Exploring the cost-utility of stratified primary care management for low back pain compared with current best practice within risk-defined subgroups. Ann Rheum Dis 2012 ; 71:1796-802.
  • Hay EM, Thomas E, Paterson SM, Dziedzic K, Croft PR. A pragmatic randomised controlled trial of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care. 2003;62:394-9.

Physical Therapy

  • Whitehurst DG, Bryan S, Hay EM, Thomas E, Young J, Foster NE. Cost-effectiveness of acupuncture care as an adjunct to exercise-based physical therapy for osteoarthritis of the knee. 2011;91:630-41.

The Lancet

  • Hill JC, Whitehurst DG, Lewis M, Bryan S, Dunn KM, Foster NE, Konstantinou K, Main CJ, Mason E, Somerville S, Sowden G, Vohora K, Hay EM. Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial. 2011;378:1560-71.
  • Hay EM, Mullis R, Lewis M, Vohora K, Main CJ, Watson P, Dziedzic KS, Sim J, Minns Lowe C, Croft PR. Comparison of physical treatments versus a brief pain-management programme for back pain in primary care: a randomised clinical trial in physiotherapy practice. 2005;365:2024-30.


Any registration amendments and/or cancellations must be notified in writing to the Course Administrator Sue Weir (

Course registration cancellations received in writing before 29 May 2018 will be refunded in full less an administrative fee of 20% of the registration amount. Cancellations received after that date will not receive refunds. Substitute delegates are welcome without penalty up until two weeks before the Course begins, but please advise the Course Administrator of the changes.

In the event that the meeting is cancelled by the organisers, or if for any reason or any factor outside the control of the organisers the conference/ course cannot take place, the amount of the registration fee shall be refunded, less an administrative fee of 20% of the registration amount. The liability of the organisers shall be limited to that refund and neither shall be liable for any other loss, cost or expense, however caused, incurred or arising. In particular, neither the organisers shall be liable to refund any travel or hotel costs incurred by delegates or their organisations.

Non-payment will result in cancellation of registration and denial of entry into the event. No-shows or cancellations after 29 May 2018 will not be reimbursed.

Please contact the course administrator, Mrs Sue Weir for all initial enquiries:

If you'd like to speak to someone in person, then please call Sue on +44 (0) 1782 733 922 and she will be able to direct your call appropriately.

If you need to send your registration form or payment in the post, please use the following address:

Mrs Sue Weir
School of Primary, Community and Social Care
David Wetherall Building
Keele University

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