Average symptom trajectories following incident radiographic knee osteoarthritis
Chief Investigator: |
Prof George Peat |
Principal Investigator: |
Mrs Rebecca Whittle |
Funder name / reference number: | National Institute for Health Research (NIHR) Research Methods Fellowship. (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) |
Year | 2014-2016 |
Study design
A cohort study from the incidence cohort of the Osteoarthritis Initiative (OAI) public use datasets. Multi-level models were used to estimate the length of the prodromal phases.
1) To investigate the existence, duration and nature of a prodromal symptomatic phase preceding incident radiographic knee osteoarthritis (ROA)
2) To investigate the trajectory of self-reported pain, stiffness, function and other symptoms following the incidence of radiographic knee osteoarthritis (ROA).
Multi-level models were used to estimate the length of the prodromal phases.
Primary objective
In order to gain a better understanding of the timing of emergent symptoms of osteoarthritis, we sought to investigate the existence, duration and nature of a prodromal symptomatic phase preceding incident radiographic knee osteoarthritis (ROA).
Previous research has identified the existence of a prodromal phase of symptom worsening beginning on average 2-3 years prior to the first appearance of radiographic knee osteoarthritis (OA). The current study extends these observations to investigate the trajectory of self-reported pain, stiffness, function and other symptoms following the incidence of radiographic OA.
Interventions
NONE